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by Chu, Y and Yang, X
Oncogene, ISSN 0950-9232, 03/2011, Volume 30, Issue 9, pp. 1108 - 1116
SUMOylation governs numerous cellular processes and is essential to most eukaryotic life. Despite increasing recognition of the importance of this process, an... 
Mdm2 | TRIM proteins | sumoylation | SUMOE3 ligase | PML | p53 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PML NUCLEAR-BODIES | DNA-DAMAGE | REGULATES P53 | FAMILY PROTEINS | SUMO E3 ligase | UBIQUITIN LIGASES | CELL BIOLOGY | RET FINGER PROTEIN | ONCOLOGY | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | C-JUN | Immunoprecipitation | Transcription Factors - chemistry | Humans | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - genetics | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Animals | Small Ubiquitin-Related Modifier Proteins - chemistry | Ubiquitin-Conjugating Enzymes - metabolism | Protein Binding | Sumoylation | RNA, Small Interfering | Ubiquitin-Protein Ligases - genetics | Microscopy, Fluorescence | Promyelocytic Leukemia Protein | Physiological aspects | Tumor suppressor genes | Research | Tumor proteins | Ligases | Proteins | Enzymes | Biochemistry | Cellular biology | Gene expression
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 04/2017, Volume 42, Issue 4, pp. 297 - 311
Tripartite motif (TRIM) family proteins, most of which have E3 ubiquitin ligase activities, have various functions in cellular processes including... 
proteasome | cancer | autophagy | immunity | TRIM | ubiquitin | U-BOX | ANTIVIRAL RESPONSE | TARGETING TAB2 | IFN-BETA PRODUCTION | NEGATIVE REGULATION | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RING FINGER | INNATE IMMUNE | NF-KAPPA-B | MOTIF | Tripartite Motif Proteins - metabolism | Autophagy | Carcinogenesis | Immunity | Humans | Ubiquitin | Protein-protein interactions | Index Medicus
Journal Article
Journal Article
Reviews in Medical Virology, ISSN 1052-9276, 03/2019, Volume 29, Issue 2, pp. e2028 - n/a
Summary Novel therapeutic options are urgently needed to improve the global treatment of viral infections. Tripartite motif (TRIM) family proteins are involved... 
therapeutics | HIV | TRIM | MLV | HCV | HSV | interplay | family | HBV | HPV | IAV | HIV-1 | HUMAN-PAPILLOMAVIRUS TYPES | MURINE LEUKEMIA-VIRUS | CERVICAL-CANCER | RESTRICTION | THERAPY | VIROLOGY | INFECTION | PATTERN-RECOGNITION RECEPTORS | HIGH PREVALENCE | CLINICAL-SIGNIFICANCE | Proteins | Antiviral agents | Papillomavirus infections | Ubiquitin | Transcription | Antiviral activity | Viruses | Innate immunity | Tumorigenesis | Infections | Autophagy | Phagocytosis | Viral infections
Journal Article
Cell Cycle, ISSN 1538-4101, 03/2015, Volume 14, Issue 6, pp. 920 - 930
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2019, Volume 14, Issue 3, p. e0212888
TRIM5 alpha is an interferon inducible restriction factor which contributes to intrinsic defense against HIV infection by targeting the HIV capsid protein CA.... 
MOLECULAR-DYNAMICS | DOMAIN | OLD-WORLD | VARIANTS | RHESUS TRIM5-ALPHA | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | PARTICLE MESH EWALD | TRIM FAMILY PROTEINS | HIV-1 INFECTION | RETROVIRAL RESTRICTION | Protein Conformation, alpha-Helical - genetics | Human Immunodeficiency Virus Proteins - immunology | Humans | Protein Domains - genetics | HIV Infections - immunology | HEK293 Cells | Capsid Proteins - immunology | Carrier Proteins - immunology | Recombinant Proteins - metabolism | HIV-1 - metabolism | Cats | Genetic Predisposition to Disease | Capsid Proteins - metabolism | HIV Infections - genetics | HIV Infections - virology | Recombinant Proteins - genetics | Molecular Dynamics Simulation | Human Immunodeficiency Virus Proteins - metabolism | Carrier Proteins - genetics | HIV-1 - immunology | Animals | Carrier Proteins - metabolism | Recombinant Proteins - immunology | Protein Structure, Quaternary - genetics | Polymorphism, Single Nucleotide | Coils | Capsid protein | Molecular structure | Leukemia | Fluorescence | Molecular dynamics | Homology | Infections | Single-nucleotide polymorphism | Glycine | Proteins | Oligomers | Immunology | Human immunodeficiency virus--HIV | Antiviral activity | Dichroism | Physiology | Aspartic acid | Fluorescence resonance energy transfer | Assemblies | Dynamic structural analysis | Computer simulation | Secondary structure | Physics | Virology | Circular dichroism | Medicine | Studies | Molecular physics | Interferon | Dimers | Protein structure | Energy transfer | Viral infections | Polymorphism | HIV | Human immunodeficiency virus
Journal Article
Future Virology, ISSN 1746-0794, 02/2019, Volume 14, Issue 2, pp. 107 - 122
Tripartite motif (TRIM) proteins have been found in a variety of physiological processes; however, the role of TRIM proteins in host defense to viral infection... 
protein interaction | innate immunity | virulence | ubiquitination | host defense | host restriction | intrinsic immunity | adaptive immunity | RING domain | KAPPA-B ACTIVATION | INFLUENZA-A | TRIM FAMILY | PROTEASOMAL DEGRADATION | I INTERFERON INDUCTION | INFLAMMASOME ACTIVATION | RIG-I | INNATE IMMUNE | NEGATIVE REGULATOR | VIROLOGY | E3 UBIQUITIN LIGASE
Journal Article