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1981, ISBN 041215840X, Volume 12., ix, 365
Book
British Journal of Clinical Pharmacology, ISSN 0306-5251, 06/2018, Volume 84, Issue 6, pp. 1279 - 1289
AimsGemcitabine (2,2-difluoro-2-deoxycytidine; dFdC) is a prodrug that has to be phosphorylated within the tumour cell to become active. Intracellularly formed... 
pharmacokinetics | peripheral blood mononuclear cells (PBMCs) | 2′,2′‐difluorodeoxyuridine triphosphate (dFdUTP) | gemcitabine | nucleotides | 2′,2′‐difluorodeoxycytidine triphosphate (dFdCTP) | 2′,2′-difluorodeoxyuridine triphosphate (dFdUTP) | 2′,2′-difluorodeoxycytidine triphosphate (dFdCTP) | PROLONGED INFUSION | ACUTE MYELOGENOUS LEUKEMIA | PANCREATIC-CANCER | DOSE RATE INFUSION | 2 ',2 '-difluorodeoxyuridine triphosphate (dFdUTP) | TANDEM MASS-SPECTROMETRY | BLOOD MONONUCLEAR-CELLS | 2 ',2 '-difluorodeoxycytidine triphosphate (dFdCTP) | CELL LUNG-CANCER | LIQUID-CHROMATOGRAPHY | RANDOMIZED PHASE-II | PHARMACOLOGY & PHARMACY | ACCUMULATION | Activation, Metabolic | Leukocytes, Mononuclear - metabolism | Phosphorylation | Floxuridine - analogs & derivatives | Floxuridine - blood | Antimetabolites, Antineoplastic - pharmacokinetics | Deoxycytidine - administration & dosage | Humans | Uridine Triphosphate - analogs & derivatives | Breast Neoplasms - drug therapy | Deoxycytidine - blood | Uridine Triphosphate - blood | Antimetabolites, Antineoplastic - administration & dosage | Deoxycytidine - pharmacokinetics | Antimetabolites, Antineoplastic - blood | Deamination | Breast Neoplasms - blood | Cytidine Triphosphate - analogs & derivatives | Female | Breast Neoplasms - diagnosis | Deoxycytidine - analogs & derivatives | Cytidine Triphosphate - blood | Gemcitabine | Metabolites | Nucleotides | Original
Journal Article
Journal Article
Journal Article
Journal Article
10. ATP
1953, 5 p. illus., diagrs.
Book
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2013, Volume 110, Issue 5, pp. E348 - E357
Hepatitis C virus (HCV) RNA-dependent RNA polymerase replicates the viral genomic RNA and is a primary drug target for antiviral therapy. Previously, we... 
Nucleoside analog | Pyrophosphorolysis | Drug resistance | NS5B | Pre-steady-state kinetics | NS5B POLYMERASE | NUCLEOSIDE ANALOGS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DNA-POLYMERASE | DRUG-RESISTANCE | PRIMER-UNBLOCKING | pre-steady-state kinetics | pyrophosphorolysis | STATE KINETIC CHARACTERIZATION | drug resistance | HIV-1 REVERSE-TRANSCRIPTASE | AZT RESISTANCE | nucleoside analog | PHYSIOLOGICAL CONCENTRATIONS | Cytidine Monophosphate - metabolism | Uridine Triphosphate - metabolism | Models, Chemical | RNA Replicase - metabolism | Cytidine Triphosphate - metabolism | Hepacivirus - genetics | Nucleotides - genetics | Adenosine Triphosphate - genetics | Dinucleoside Phosphates - chemistry | Hepacivirus - metabolism | Nucleotides - chemistry | RNA, Viral - genetics | Adenosine Triphosphate - metabolism | Base Sequence | RNA, Viral - metabolism | Cytidine Triphosphate - genetics | Uridine Triphosphate - genetics | Uridine Triphosphate - chemistry | Dinucleoside Phosphates - metabolism | Nucleotides - metabolism | Cytidine Monophosphate - chemistry | HIV Reverse Transcriptase - metabolism | Hepacivirus - enzymology | Viral Nonstructural Proteins - metabolism | Cytidine Triphosphate - chemistry | Models, Genetic | Kinetics | Adenosine Triphosphate - chemistry | Biological Sciences | PNAS Plus | pre–steady-state kinetics
Journal Article
Journal Article