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NATURE COMMUNICATIONS, ISSN 2041-1723, 03/2019, Volume 10, Issue 1, pp. 1129 - 13
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e91940
Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor, yet with no targeted therapy with substantial survival benefit. Recent studies on... 
CELL LUNG-CANCER | GENE FUSIONS | PROTEIN | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | RECEPTOR | IDENTIFICATION | INHIBITOR | FAMILY | Cell Adhesion Molecules - chemistry | NIH 3T3 Cells | Cell Adhesion Molecules - genetics | Oncogene Proteins, Fusion - metabolism | Molecular Sequence Data | Male | Nerve Growth Factors - metabolism | Brain Neoplasms - metabolism | Oncogene Proteins, Fusion - chemistry | Base Sequence | Glioblastoma - metabolism | Brevican - genetics | Amino Acid Sequence | Nerve Growth Factors - chemistry | Brevican - chemistry | Cell Adhesion Molecules - metabolism | Carcinogenesis - pathology | Animals | Receptor, trkA - metabolism | Brevican - metabolism | Mice, Nude | Nerve Growth Factors - genetics | Oncogene Proteins, Fusion - genetics | Receptor, trkA - chemistry | Receptor, trkA - genetics | Mice | Mice, Inbred BALB C | Surveys | RNA sequencing | RNA | Genes | Brain tumors | Genomics | Nerve growth factor | Genomes | Genetic aspects | Glioblastoma multiforme | Neurophysiology | Cancer | Cell proliferation | Brain | Biomedical research | Exons | Brain cancer | Lung cancer | Glioblastoma | Science | Kinases | Proteins | Signal transduction | Animal tissues | TrkA protein | Protein-tyrosine kinase receptors | TrkA receptors | Fusion protein | Protein-tyrosine kinase | Tyrosine | Medical research | Immunoglobulins | Agar | Data processing | Gene expression | Ribonucleic acid--RNA | Survival | Signaling | Gene amplification | Solid tumors | Tumors | Ribonucleic acid
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2012, Volume 448, Issue 2, pp. 213 - 220
To investigate the range of autoinhibitory mechanisms used by TKDs (tyrosine kinase domains) from the insulin receptor family of RTKs (receptor tyrosine... 
X-ray crystallography | Insulin receptor kinase | Autoinhibition | Receptor tyrosine kinase (RTK) | Receptor tyrosine kinase-like orphan receptor 2 (Ror2) | Tropomyosin receptor kinase A (TrkA) | ALK | ACTIVATION | CRYSTAL-STRUCTURE | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC DOMAIN | autoinhibition | receptor tyrosine kinase-like orphan receptor 2 (Ror2) | CANCER | ANAPLASTIC LYMPHOMA KINASE | insulin receptor kinase | receptor tyrosine kinase (RTK) | MUTATIONS | INHIBITOR | tropomyosin receptor kinase A (TrkA) | EGF RECEPTOR | Neoplasms - metabolism | Humans | Receptor, trkA - antagonists & inhibitors | Crystallography, X-Ray | Antigens, CD - genetics | Antigens, CD - metabolism | Neoplasms - genetics | Receptor, Insulin - genetics | Protein Structure, Quaternary | Antigens, CD - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Recombinant Proteins - antagonists & inhibitors | Receptor Tyrosine Kinase-like Orphan Receptors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Receptor, Insulin - antagonists & inhibitors | Amino Acid Motifs | Receptor Tyrosine Kinase-like Orphan Receptors - antagonists & inhibitors | Receptor Tyrosine Kinase-like Orphan Receptors - chemistry | Receptor, trkA - metabolism | Receptor, Insulin - chemistry | Receptor, trkA - chemistry | Receptor, trkA - genetics | Receptor Tyrosine Kinase-like Orphan Receptors - genetics | Receptor, Insulin - metabolism | Mutation | Enzyme Activation - genetics | In Vitro Techniques | ALK, anaplastic lymphoma kinase | FGFR, fibroblast growth factor receptor | Trk, tropomyosin receptor kinase | C-lobe, C-terminal lobe | EGFR, epidermal growth factor receptor | TKD, tyrosine kinase domain | DTT, dithiothreitol | NSCLC, non-small-cell lung cancer | TCEP, tris-(2-carboxyethyl)phosphine | COSMIC, Catalogue Of Somatic Mutations In Cancer | Ni-NTA, Ni2+-nitrilotriacetate | N-lobe, N-terminal lobe | RTK, receptor tyrosine kinase | CDK, cyclin-dependent kinase | IGF1R, insulin-like growth factor 1 receptor | MuSK, muscle-specific kinase | IRK, insulin receptor kinase | Ror, receptor tyrosine kinase-like orphan receptor
Journal Article
Laboratory Investigation, ISSN 0023-6837, 11/2017, Volume 97, Issue 11, pp. 1268 - 1270
Neurotrophic tyrosine kinase genes encode for the Trk-family proteins TrkA, TrkB, and TrkC, which have an important role in the development of the nervous... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADVANCED SOLID TUMORS | ENTRECTINIB | ORAL PAN-TRK | RELEVANT MOLECULAR ALTERATIONS | PATHOLOGY | ALK INHIBITOR | ROS1 | EXPRESSION | Lung Neoplasms - drug therapy | Oncogene Proteins, Fusion - metabolism | Membrane Glycoproteins - metabolism | Humans | Lung Neoplasms - metabolism | Receptor, trkA - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Receptor, trkB - genetics | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Antineoplastic Agents - adverse effects | Neoplasms, Squamous Cell - drug therapy | Receptor, trkB - antagonists & inhibitors | Lung Neoplasms - genetics | Molecular Targeted Therapy - adverse effects | Receptor, trkC - antagonists & inhibitors | Membrane Glycoproteins - genetics | Animals | Neoplasms, Squamous Cell - genetics | Receptor Protein-Tyrosine Kinases - genetics | Receptor, trkA - metabolism | Oncogene Proteins, Fusion - genetics | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Receptor, trkB - metabolism | Receptor, trkC - metabolism | Neoplasms, Squamous Cell - metabolism | Toxicity | Lung cancer | Clinical trials | Fluorescence | Nervous system | Kinases | Proteins | Fluorescence in situ hybridization | TrkA protein | TrkA receptors | Protein-tyrosine kinase | Tyrosine | Medical research | Squamous cell carcinoma | Invasiveness | Feasibility studies | Lung carcinoma | Patients | Brain-derived neurotrophic factor | Inhibitors | TrkB receptors | Solid tumors | Tumors | Cancer | Plastic foam | Index Medicus
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2017, Volume 7, Issue 4, pp. 400 - 409
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two phase I studies in patients with advanced or... 
REARRANGEMENT | ONCOGENE | ONCOLOGY | ANALOG SECRETORY CARCINOMA | LANDSCAPE | KINASE FUSIONS | SARCOMAS | ETV6-NTRK3 GENE FUSION | CRIZOTINIB | GENOMIC ALTERATIONS | CLINICAL-RESPONSE | Benzamides - pharmacokinetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Receptor, trkA - antagonists & inhibitors | Male | Receptor, trkB - genetics | Indazoles - administration & dosage | Protein Kinase Inhibitors - adverse effects | Mammary Analogue Secretory Carcinoma - genetics | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Anaplastic Lymphoma Kinase | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Receptor, trkB - antagonists & inhibitors | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Benzamides - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Crizotinib | Protein Kinase Inhibitors - pharmacokinetics | Proto-Oncogene Proteins - antagonists & inhibitors | Pyridines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Receptor, trkC - antagonists & inhibitors | Melanoma - pathology | Mammary Analogue Secretory Carcinoma - drug therapy | Membrane Glycoproteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sequestosome-1 Protein - genetics | Pyrazoles - administration & dosage | Indazoles - pharmacokinetics | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Melanoma - drug therapy | Adolescent | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Indazoles - adverse effects | Colorectal Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 5241 - 9
Journal Article
Cancer Discovery, ISSN 2159-8274, 09/2017, Volume 7, Issue 9, pp. 963 - 972
Journal Article
Journal Article
Molecular Oncology, ISSN 1574-7891, 12/2014, Volume 8, Issue 8, pp. 1495 - 1507
Journal Article
Human Mutation, ISSN 1059-7794, 01/2017, Volume 38, Issue 1, pp. 55 - 63
ABSTRACT Hereditary sensory and autonomic neuropathy type IV (HSAN IV) is an autosomal recessive disorder characterized by a complete lack of pain perception... 
CIPA | neuropathy | pain | TRKA | NGF | CONGENITAL INSENSITIVITY | KINASE | ACTIVATION LOOP TYROSINES | TRK | FACTOR RECEPTOR | NERVE GROWTH-FACTOR | ANHIDROSIS CIPA | GENETICS & HEREDITY | AUTOPHOSPHORYLATION | Nerve growth factor | Genetic aspects | Muscle proteins | Analysis | Kinases | Mutation
Journal Article