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1. Full Text TRPA1: a molecular view
by Meents, Jannis E and Ciotu, Cosmin I and Fischer, Michael J M
Journal of neurophysiology, ISSN 0022-3077, 02/2019, Volume 121, Issue 2, pp. 427 - 443
nociceptor | pain | TRPA1 | ion channel | Neurosciences | Physiology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | TRPA1 Cation Channel - genetics | Animals | Ion Channel Gating | Humans | TRPA1 Cation Channel - chemistry | TRPA1 Cation Channel - metabolism | Index Medicus
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2. Full Text Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model
by Wang, Muyun and Zhang, Yanbei and Xu, Mengmeng and Zhang, Hai and Chen, Yuqing and Chung, Kian Fan and Adcock, Ian M and Li, Feng
Free radical biology & medicine, ISSN 0891-5849, 04/2019, Volume 134, pp. 229 - 238
Oxidative stress | TRPA1 | Mitochondria damage | TRPV1 | Airway epithelial cell injury | Cigarette smoke | COPD | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Inflammation - chemically induced | Inflammation - pathology | Epithelial Cells - metabolism | Oxidative Stress | Antioxidants - metabolism | Epithelial Cells - drug effects | Humans | Bronchi - drug effects | TRPV Cation Channels - metabolism | Inflammation - metabolism | Mitochondrial Proteins - metabolism | TRPV Cation Channels - antagonists & inhibitors | Pulmonary Alveoli - metabolism | Bronchi - metabolism | Pulmonary Alveoli - drug effects | TRPA1 Cation Channel - antagonists & inhibitors | Bronchi - pathology | Pulmonary Alveoli - pathology | Smoke - adverse effects | Cells, Cultured | Epithelial Cells - pathology | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | TRPV Cation Channels - genetics | TRPA1 Cation Channel - genetics | TRPA1 Cation Channel - metabolism | Apoptosis | Antioxidants | Proteins | RNA | Gene expression | Genes | Smoking | Index Medicus
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3. Full Text Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance
by Takahashi, Nobuaki and Chen, Hsing-Yu and Harris, Isaac S and Stover, Daniel G and Selfors, Laura M and Bronson, Roderick T and Deraedt, Thomas and Cichowski, Karen and Welm, Alana L and Mori, Yasuo and Mills, Gordon B and Brugge, Joan S
Cancer cell, ISSN 1535-6108, 06/2018, Volume 33, Issue 6, pp. 985 - 1003.e7
TRP channel | anti-apoptosis | chemotherapy resistance | tumor progression | Ca2+ signaling | NRF2 | TRPA1 | anchorage-independent growth | oxidative stress | signaling | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | A549 Cells | Cell Line | Oxidation-Reduction | Oxidative Stress | Humans | Gene Expression Regulation, Neoplastic | Mice, SCID | Xenograft Model Antitumor Assays - methods | Mice, Knockout | Neoplasms - drug therapy | Animals | Neoplasms - genetics | RNA Interference | Adaptation, Physiological - genetics | NF-E2-Related Factor 2 - metabolism | Cell Line, Tumor | Female | Mice, Inbred NOD | NF-E2-Related Factor 2 - genetics | TRPA1 Cation Channel - genetics | Neurons - metabolism | Neurons - drug effects | TRPA1 Cation Channel - metabolism | Medical colleges | Chemotherapy | Defense programs | Neurons | Lung cancer | Development and progression | Histochemistry | Cancer | Index Medicus
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4. Full Text Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice
by De Logu, Francesco and Nassini, Romina and Materazzi, Serena and Carvalho Gonçalves, Muryel and Nosi, Daniele and Rossi Degl'Innocenti, Duccio and Marone, Ilaria M and Ferreira, Juliano and Li Puma, Simone and Benemei, Silvia and Trevisan, Gabriela and Souza Monteiro De Araújo, Daniel and Patacchini, Riccardo and Bunnett, Nigel W and Geppetti, Pierangelo
Nature communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1887 - 16
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | TRPA1 Cation Channel - immunology | Neuralgia - genetics | Oxidative Stress | Humans | Mice, Inbred C57BL | Male | NADPH Oxidase 1 - genetics | Schwann Cells - immunology | Sciatic Nerve - immunology | Neuralgia - immunology | Animals | NADPH Oxidase 2 - immunology | NADPH Oxidase 1 - immunology | TRPA1 Cation Channel - genetics | Mice | NADPH Oxidase 2 - genetics | Macrophages - immunology | Oxidative stress | Pain perception | Hydrogen peroxide | Schwann cells | Paracrine signalling | Inflammation | Neuropathy | Macrophages | NAD(P)H oxidase | Transient receptor potential proteins | Cell activation | Pain | Rodents | CYBB protein | Nociceptors | Infiltration | Ankyrin | Sciatic nerve | Index Medicus
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5. Full Text Role of TRPA1 receptors in skin inflammation induced by volatile chemical irritants in mice
by Norões, Maíra Macedo and Santos, Larissa Gonzaga and Gavioli, Elaine Cristina and de Paula Soares Rachetti, Vanessa and Otuki, Michel Fleith and de Almeida Cabrini, Daniela and da Silveira Prudente, Arthur and Oliveira, Janiana Raíza Jentsch Matias and de Carvalho Gonçalves, Muryel and Ferreira, Juliano and Preti, Delia and De Logu, Francesco and Nassini, Romina and André, Eunice
European journal of pharmacology, ISSN 0014-2999, 09/2019, Volume 858, pp. 172460 - 172460
Chemical irritants | Inflammatory skin disease | Irritant contact dermatitis | Transient receptor potential ankyrin 1 | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Inflammation - chemically induced | Edema - genetics | Mice, Inbred C57BL | TRPA1 Cation Channel - deficiency | Gene Knockout Techniques | Edema - metabolism | Inflammation - metabolism | Animals | Volatilization | Nociception - drug effects | TRPA1 Cation Channel - genetics | Mice | Edema - chemically induced | TRPA1 Cation Channel - antagonists & inhibitors | Toluene - pharmacology | Edema - pathology | Skin - drug effects | TRPA1 Cation Channel - metabolism | Xylenes - pharmacology | Index Medicus
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6. Full Text Isothiocyanates and Glucosinolates from Sisymbrium officinale (L.) Scop. (“the Singers’ Plant”): Isolation and in vitro assays on the somatosensory and pain receptor TRPA1 channel
by Borgonovo, Gigliola and Zimbaldi, Nathan and Guarise, Marta and De Nisi, Patrizia and De Petrocellis, Luciano and Moriello, Aniello Schiano and Bassoli, Angela
Molecules (Basel, Switzerland), ISSN 1420-3049, 2019, Volume 24, Issue 5, p. 949
Glucosinolates | Sisymbrium officinale | TRPA1 ion channel | Somatosensory perception | Isothiocyanates | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Brassicaceae - genetics | Isothiocyanates - metabolism | Glucosinolates - metabolism | TRPA1 Cation Channel - genetics | Brassicaceae - metabolism | TRPA1 Cation Channel - metabolism | Index Medicus | isothiocyanates | somatosensory perception | glucosinolates
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7. Full Text Triterpene Glycosides Isolated from the Edible Sea Cucumber Bohadschia vitiensis and Their Antagonistic Activity against Transient Receptor Potential Ankyrin 1
by Choi, Hansol and Oh, Chulhong and Hyun, JeongMi and Yang, Jeungeun and Song, Myung Jin and Lee, Hyi-Seung and Lee, Yeon-Ju
Journal of agricultural and food chemistry, ISSN 0021-8561, 05/2020, Volume 68, Issue 19, pp. 5349 - 5355
Sea Cucumbers - chemistry | Triterpenes - pharmacology | Humans | Glycosides - pharmacology | Triterpenes - chemistry | Animals | Glycosides - isolation & purification | HEK293 Cells | Triterpenes - isolation & purification | TRPA1 Cation Channel - genetics | Molecular Structure | TRPA1 Cation Channel - antagonists & inhibitors | Glycosides - chemistry | TRPA1 Cation Channel - metabolism | Index Medicus
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8. Full Text The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel
by De Logu, Francesco and Li Puma, Simone and Landini, Lorenzo and Tuccinardi, Tiziano and Poli, Giulio and Preti, Delia and De Siena, Gaetano and Patacchini, Riccardo and Tsagareli, Merab G and Geppetti, Pierangelo and Nassini, Romina
Pharmacological research, ISSN 1043-6618, 04/2019, Volume 142, pp. 127 - 139
Inflammation | TRPA1 | Inflammatory pain | Ibuprofen-acyl glucuronide | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Analgesics - pharmacology | Ibuprofen - therapeutic use | Epithelial Cells - metabolism | Calcium - metabolism | Epithelial Cells - drug effects | Humans | Male | Pain - metabolism | Ibuprofen - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Glucuronates - pharmacology | Glucuronates - therapeutic use | Pain - drug therapy | Neurons - metabolism | Interleukin-8 - metabolism | Neurons - drug effects | Analgesics - therapeutic use | Cell Line | Ibuprofen - pharmacology | Hyperalgesia - metabolism | Mice, Inbred C57BL | Rats, Sprague-Dawley | Mice, Knockout | Dinoprostone - metabolism | Animals | Hyperalgesia - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | TRPA1 Cation Channel - genetics | TRPA1 Cation Channel - metabolism | Cysteine | Carrageenin | Metabolites | Lysine | Analysis | Ibuprofen | Peroxides | Formaldehyde | Index Medicus
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9. Full Text N-Cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites
by Chandrabalan, Arundhasa and McPhillie, Martin J and Morice, Alyn H and Boa, Andrew N and Sadofsky, Laura R
European journal of medicinal chemistry, ISSN 0223-5234, 05/2019, Volume 170, pp. 141 - 156
Calcium signaling | Tranilast | TRP | TRPA1 | N-Cinnamoylanthranilic acid | Transient receptor potential ankyrin 1 | Binding site | Non-covalent | Guinea Pigs | ortho-Aminobenzoates - chemistry | ortho-Aminobenzoates - pharmacology | Humans | ortho-Aminobenzoates - chemical synthesis | Male | Structure-Activity Relationship | Cinnamates - pharmacology | Animals | Calcium Signaling - drug effects | TRPA1 Cation Channel - agonists | HEK293 Cells | Cinnamates - chemical synthesis | Molecular Docking Simulation | Cinnamates - chemistry | TRPA1 Cation Channel - antagonists & inhibitors | TRPA1 Cation Channel - metabolism | Aldehydes | Index Medicus
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10. Full Text TRPA1