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1. Full Text STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels
by Huang, Guo N and Yuan, Joseph P and Zeng, Weizhong and Worley, Paul F and Muallem, Shmuel
Nature Cell Biology, ISSN 1465-7392, 06/2007, Volume 9, Issue 6, pp. 636 - 645
Stromal interacting molecule 1 (STIM1) is a Ca2+ sensor that conveys the Ca2+ load of the endoplasmic reticulum to store-operated channels (SOCs) at the plasma... 
CATION CHANNELS | HEK-293 CELLS | CA2+ ENTRY | ACTIVATION | MECHANISM | ORAI1 | DEPLETION | PLASMA-MEMBRANE | TRANSIENT RECEPTOR | CRAC CHANNEL | CELL BIOLOGY | Protein Subunits - drug effects | Gadolinium - pharmacology | TRPC Cation Channels - drug effects | Calcium - metabolism | Calcium Signaling - physiology | Humans | Endoplasmic Reticulum - metabolism | Protein Transport - physiology | Protein Transport - drug effects | Neoplasm Proteins - metabolism | Protein Subunits - metabolism | Binding Sites - physiology | Cell Membrane - metabolism | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | TRPC Cation Channels - genetics | Cholinergic Agonists - pharmacology | Protein Subunits - genetics | Stromal Interaction Molecule 1 | Cell Line | Membrane Proteins - genetics | Calcium Signaling - drug effects | TRPC Cation Channels - metabolism | Macromolecular Substances - metabolism | Protein Binding - physiology | Physiological aspects | Ion channels | Genetic aspects | Research | Genetic regulation
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2. Full Text TRP channels
by Venkatachalam, Kartik and Montell, Craig
Annual Review of Biochemistry, ISSN 0066-4154, 2007, Volume 76, Issue 1, pp. 387 - 417
The TRP (Transient Receptor Potential) superfamily of cation channels is remarkable in that it displays greater diversity in activation mechanisms and... 
Kidney disease | Mucolipidosis type iv | Calcium | Sensory transduction | Diacylglycerol | Phospholipase c | phospholipase C | calcium | NONSELECTIVE CATION CHANNEL | MUCOLIPIDOSIS TYPE-IV | BIOCHEMISTRY & MOLECULAR BIOLOGY | kidney disease | ACTIVATED CALCIUM-CHANNEL | mucolipidosis type IV | HEAT-EVOKED ACTIVATION | sensory transduction | NERVE GROWTH CONES | POLYCYSTIC-KIDNEY-DISEASE | INOSITOL TRISPHOSPHATE RECEPTOR | DROSOPHILA PHOTORECEPTOR CELLS | diacylglycerol | RECEPTOR POTENTIAL CHANNEL | INTEGRAL MEMBRANE-PROTEIN | Amino Acid Sequence | Sensation - physiology | TRPC Cation Channels - classification | Humans | Multiprotein Complexes | Models, Molecular | Molecular Sequence Data | Genetic Diseases, Inborn | Phylogeny | TRPC Cation Channels - chemistry | Sequence Alignment | Animals | Protein Isoforms - metabolism | Protein Isoforms - classification | Protein Isoforms - chemistry | Protein Structure, Quaternary | TRPC Cation Channels - metabolism | TRPC Cation Channels - genetics | Protein Isoforms - genetics
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3. Full Text TRPC3 and TRPC4 associate to form a redox-sensitive cation channel: Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells
by Poteser, Michael and Graziani, Annarita and Rosker, Christian and Eder, Petra and Derler, Isabella and Kahr, Heike and Zhu, Michael X and Romanin, Christoph and Groschner, Klaus
Journal of Biological Chemistry, ISSN 0021-9258, 05/2006, Volume 281, Issue 19, pp. 13588 - 13595
Canonical transient receptor potential proteins (TRPC) have been proposed to form homo- or heteromeric cation channels in a variety of tissues, including the... 
OPERATED HTRP3 CHANNELS | DIACYLGLYCEROL | CA2+ ENTRY | ACTIVATION | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM | PROTEINS | RECEPTORS | STRESS | BRAIN | Cell Line | Oxidation-Reduction | Oxidative Stress | Endothelial Cells - metabolism | Humans | Gene Expression Regulation | TRPC Cation Channels - chemistry | Animals | Membrane Potentials | Swine | Protein Structure, Quaternary | TRPC Cation Channels - metabolism | Protein Binding | Mice | TRPC Cation Channels - genetics
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4. Full Text TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
by Obata, Koichi and Katsura, Hirokazu and Mizushima, Toshiyuki and Yamanaka, Hiroki and Kobayashi, Kimiko and Dai, Yi and Fukuoka, Tetsuo and Tokunaga, Atsushi and Tominaga, Makoto and Noguchi, Koichi
Journal of Clinical Investigation, ISSN 0021-9738, 09/2005, Volume 115, Issue 9, pp. 2393 - 2401
Cold hyperalgesia is a well-documented symptom of inflammatory and neuropathic pain; however, the underlying mechanisms of this enhanced sensitivity to cold... 
MEDICINE, RESEARCH & EXPERIMENTAL | Neurons, Afferent - cytology | Cold Temperature | MAP Kinase Signaling System - physiology | Nerve Growth Factor - metabolism | Calcium Channels - metabolism | TRPC Cation Channels | Rats | Male | Ganglia, Spinal - cytology | Inflammation | Rats, Sprague-Dawley | Hyperalgesia | Glial Cell Line-Derived Neurotrophic Factor - metabolism | Animals | In Situ Hybridization | TRPA1 Cation Channel | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Neurons, Afferent - pathology | TRPM Cation Channels - genetics | Ankyrins | TRPM Cation Channels - metabolism | Neurons, Afferent - metabolism | Pain Measurement | Calcium Channels - genetics
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5. Full Text (−)‐Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels
by Akbulut, Yasemin and Gaunt, Hannah J and Muraki, Katsuhiko and Ludlow, Melanie J and Amer, Mohamed S and Bruns, Alexander and Vasudev, Naveen S and Radtke, Lea and Willot, Matthieu and Hahn, Sven and Seitz, Tobias and Ziegler, Slava and Christmann, Mathias and Beech, David J and Waldmann, Herbert
Angewandte Chemie International Edition, ISSN 1433-7851, 03/2015, Volume 54, Issue 12, pp. 3787 - 3791
Current therapies for common types of cancer such as renal cell cancer are often ineffective and unspecific, and novel pharmacological targets and approaches... 
natural products | calcium ions | ion channels | antitumor agents | Ion channels | Antitumor agents | Natural products | Calcium ions | NATURAL-PRODUCTS | BIOLOGY-ORIENTED SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | ENGLERIN | DISCOVERY | Cell Survival - drug effects | Sesquiterpenes, Guaiane - pharmacology | Sesquiterpenes, Guaiane - chemistry | TRPC Cation Channels - agonists | Calcium - metabolism | Sesquiterpenes, Guaiane - metabolism | Stereoisomerism | Humans | HT29 Cells | HEK293 Cells | TRPC Cation Channels - metabolism | Cell Line, Tumor | TRPC Cation Channels - genetics
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6. Full Text An internal thermal sensor controlling temperature preference in Drosophila
by Hamada, Fumika N and Rosenzweig, Mark and Kang, Kyeongjin and Pulver, Stefan R and Ghezzi, Alfredo and Jegla, Timothy J and Garrity, Paul A
Nature, ISSN 0028-0836, 07/2008, Volume 454, Issue 7201, pp. 217 - 220
Animals from flies to humans are able to distinguish subtle gradations in temperature and show strong temperature preferences(1-4). Animals move to... 
THERMOTAXIS | ANTENNAL LOBE | FLY | THERMOSENSATION | GENETICS | MULTIDISCIPLINARY SCIENCES | NEURONS | SENSATION | ION CHANNELS | MELANOGASTER | Temperature | Avoidance Learning | Drosophila melanogaster - physiology | Oocytes - metabolism | Xenopus laevis | Molecular Sequence Data | Body Temperature | Drosophila Proteins - metabolism | Animals | Larva | TRPA1 Cation Channel | TRPC Cation Channels - metabolism | Choice Behavior - physiology | Drosophila melanogaster - growth & development | Female | Neurons - metabolism | Drosophila Proteins - genetics | TRPC Cation Channels - genetics | Brain | Insects | Neurons | Animal behavior | body temperature | thermal preference | TRP | TRPA1 | thermosensation
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7. Full Text An introduction to TRP channels
by Ramsey, I. Scott and Delling, Markus and Clapham, David E
Annual Review of Physiology, ISSN 0066-4278, 2006, Volume 68, Issue 1, pp. 619 - 647
The aim of this review is to provide a basic framework for understanding the function of mammalian transient receptor potential (TRP) channels, particularly as... 
Voltage dependent | Pharmacology | Axon guidance | Calcium permeable | Splice variants | Transient receptor potential | Ligand gated | PHYSIOLOGY | POLYCYSTIC KIDNEY-DISEASE | CATION CHANNEL | splice variants | calcium permeable | EPITHELIAL CA2+ CHANNEL | ACTIVATED CALCIUM-CHANNEL | CAPSAICIN-RECEPTOR | NEURONAL GROWTH CONES | TRANSIENT RECEPTOR | transient receptor potential | PROTEIN-COUPLED RECEPTOR | pharmacology | voltage dependent | ligand gated | ION-CHANNEL | RECEPTOR POTENTIAL VANILLOID-4 | axon guidance | Amino Acid Sequence | Growth Cones - physiology | Animals | Humans | Mammals - physiology | Cell Membrane - physiology | TRPC Cation Channels - genetics | TRPC Cation Channels - physiology
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8. Full Text Species differences and molecular determinant of TRPA1 cold sensitivity
by Chen, Jun and Kang, Dawon and Xu, Jing and Lake, Marc and Hogan, James O and Sun, Chaohong and Walter, Karl and Yao, Betty and Kim, Donghee
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 2501
TRPA1 is an ion channel and has been proposed as a thermosensor across species. In invertebrate and ancestral vertebrates such as fly, mosquito, frog, lizard... 
PORE REGION | ACTIVATION | ION-CHANNEL TRPA1 | PAIN | MULTIDISCIPLINARY SCIENCES | CHEMICAL NOCICEPTION | RECEPTOR POTENTIAL A1 | SENSATION | DICTATE SENSITIVITY | CONTRIBUTES | SENSORY NEURONS | Macaca mulatta - physiology | Calcium Channels - metabolism | Species Specificity | Humans | Evoked Potentials, Somatosensory - drug effects | Molecular Sequence Data | Evoked Potentials, Somatosensory - physiology | Transient Receptor Potential Channels - metabolism | TRPC Cation Channels - genetics | Calcium Channels - genetics | Isothiocyanates - pharmacology | Olfactory Perception - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Cold Temperature | Rats | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Sequence Homology, Amino Acid | Patch-Clamp Techniques | Animals | Menthol - pharmacology | Transient Receptor Potential Channels - genetics | TRPA1 Cation Channel | TRPC Cation Channels - metabolism | Mice | Ion Channel Gating | Differential Threshold - physiology | Amino Acid Substitution
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9. Full Text Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels
by Tian, Dequan and Jacobo, Sarah M. P and Billing, David and Rozkalne, Anete and Gage, Steven D and Anagnostou, Theodora and Pavenstaedt, Hermann and Hsu, Hsiang-Hao and Schlondorff, Johannes and Ramos, Arnolt and Greka, Anna
Science Signaling, ISSN 1945-0877, 10/2010, Volume 3, Issue 145, pp. ra77 - ra77
The Rho family of small guanosine triphosphatases (Rho GTPases: RhoA, Cdc42, and Rac1) regulates many aspects of cell behavior, including actin dynamics and... 
MAMMALIAN BRAIN | ACTIVATION | RECEPTOR POTENTIAL CHANNELS | CYTOSKELETON | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC-HYPERTROPHY | CATION CHANNEL | SYNAPTOPODIN | KIDNEY PODOCYTES | RHO-GTPASES | FOCAL SEGMENTAL GLOMERULOSCLEROSIS | CELL BIOLOGY | Calcium - metabolism | rho GTP-Binding Proteins - genetics | Calcium Signaling - physiology | Humans | Actins - metabolism | rac GTP-Binding Proteins - metabolism | Neuropeptides - metabolism | Cell Movement - physiology | Actins - genetics | Animals | rac GTP-Binding Proteins - genetics | rho GTP-Binding Proteins - metabolism | HEK293 Cells | TRPC Cation Channels - metabolism | Mice | Neuropeptides - genetics | rac1 GTP-Binding Protein | TRPC Cation Channels - genetics
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10. Full Text Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception
by Panzano, Vincent C and Garrity, Paul A and Pulver, Stefan R and Kang, Kyeongjin and Griffith, Leslie C and Theobald, Douglas L and Chang, Elaine C
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7288, pp. 597 - 600
Chemical nociception, the detection of tissue-damaging chemicals, is important for animal survival and causes human pain and inflammation, but its evolutionary... 
MAXIMUM-LIKELIHOOD | ACTIVATION | CHEMOSENSATION | MULTIDISCIPLINARY SCIENCES | COVALENT MODIFICATION | ION CHANNELS | PAINLESS | RECEPTORS | MULTIPLE SEQUENCE ALIGNMENT | CHANNEL TRPA1 | EXPRESSION | Amino Acid Sequence | Humans | Gene Expression Regulation | Molecular Sequence Data | Drosophila melanogaster - classification | Gene Expression Profiling | Drosophila Proteins - chemistry | Phylogeny | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | TRPC Cation Channels - chemistry | Drosophila melanogaster - metabolism | Taste Perception - physiology | Animals | TRPA1 Cation Channel | TRPC Cation Channels - metabolism | Conserved Sequence | Sensory Receptor Cells - metabolism | Drosophila Proteins - genetics | Mutation | TRPC Cation Channels - genetics | Evolution, Molecular | Nociceptors | Physiological aspects | Evolution | Genetic aspects | Research | Drosophila | Proteins | Legs | Vertebrates | Mosquitoes | Amino acids | Standard deviation | Bayesian analysis | Chemicals | Index Medicus | electrophile | pungency | TRP channel | pain | irritation
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11. Full Text Transient Receptor Potential Canonical-3 Channel-Dependent Fibroblast Regulation in Atrial Fibrillation
by Harada, Masahide and Luo, Xiaobin and Qi, Xiao Yan and Tadevosyan, Artavazd and Maguy, Ange and Ordog, Balazs and Ledoux, Jonathan and Kato, Takeshi and Naud, Patrice and Voigt, Niels and Shi, Yanfen and Kamiya, Kaichiro and Murohara, Toyoaki and Kodama, Itsuo and Tardif, Jean-Claude and Schotten, Ulrich and Van Wagoner, David R and Dobrev, Dobromir and Nattel, Stanley
Circulation, ISSN 0009-7322, 10/2012, Volume 126, Issue 17, pp. 2051 - +
Background-Fibroblast proliferation and differentiation are central in atrial fibrillation (AF)-promoting remodeling. Here, we investigated fibroblast... 
remodeling | calcium | arrhythmia | ion channels | fibrillation | FIBROSIS | CELLS | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | MECHANISMS | RAT CARDIAC FIBROBLASTS | HYPERTROPHY | RELEVANCE | TRPC3 CHANNELS | PERIPHERAL VASCULAR DISEASE | Atrial Fibrillation - pathology | Cell Proliferation | Goats | Humans | Cells, Cultured | Rats | Atrial Fibrillation - genetics | Fibroblasts - pathology | Gene Knockdown Techniques - methods | Down-Regulation - genetics | Atrial Function, Right - genetics | Atrial Fibrillation - metabolism | Animals | Dogs | HEK293 Cells | TRPC Cation Channels - genetics | TRPC Cation Channels - physiology | Fibroblasts - metabolism | Atrial fibrillation | Physiological aspects | Fibroblasts | Genetic aspects | Ion channels | Research | Genetic regulation
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12. Full Text Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons
by Griesi-Oliveira, K and Acab, A and Gupta, A.R and Sunaga, D.Y and Chailangkarn, T and Nicol, X and Nunez, Y and Walker, M.F and Murdoch, J.D and Sanders, S.J and Fernandez, T.V and Ji, W and Lifton, R.P and Vadasz, E and Dietrich, A and Pradhan, D and Song, H and Ming, G.-L and Gu, X and Haddad, G and Marchetto, M.C.N and Spitzer, N and Passos-Bueno, M.R and State, M.W and Muotri, A.R
Molecular Psychiatry, ISSN 1359-4184, 11/2015, Volume 20, Issue 11, pp. 1350 - 1365
An increasing number of genetic variants have been implicated in autism spectrum disorders ( ASDs), and the functional study of such variants will be critical... 
RETT-SYNDROME | PSYCHIATRY | HIDDEN-MARKOV MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPECTRUM DISORDERS | ELEMENT-BINDING PROTEIN | NEUROSCIENCES | MOUSE MODELS | PLURIPOTENT STEM-CELLS | MECP2 MUTANT MICE | DE-NOVO MUTATIONS | SNP GENOTYPING DATA | NEWLY GENERATED NEURONS | Neurons - pathology | Autistic Disorder - pathology | Autistic Disorder - physiopathology | Embryo, Mammalian | Humans | Male | Cell Differentiation - genetics | Inhibitory Postsynaptic Potentials - genetics | Neurons - metabolism | TRPC Cation Channels - genetics | Child | Disease Models, Animal | Autistic Disorder - genetics | Cell Line | Cell Proliferation - genetics | TRPC6 Cation Channel | Antineoplastic Combined Chemotherapy Protocols - metabolism | Induced Pluripotent Stem Cells - physiology | Mitoxantrone - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Etoposide - metabolism | Mice, Transgenic | Signal Transduction - genetics | Mutation - genetics | Carboplatin - metabolism | Animals | TRPC Cation Channels - metabolism | Prednisolone - metabolism | Mice | In Vitro Techniques | Autism | Gene mutations | Neurons | Physiological aspects | Genetic aspects | Research | Health aspects | Risk factors | Index Medicus | induced pluripotent stem cells | autism | disease modeling
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