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1. Full Text A TRP channel trio mediates acute noxious heat sensing
by Vandewauw, Ine and De Clercq, Katrien and Mulier, Marie and Held, Katharina and Pinto, Silvia and Van Ranst, Nele and Segal, Andrei and Voet, Thierry and Vennekens, Rudi and Zimmermann, Katharina and Vriens, Joris and Voets, Thomas
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7698, pp. 662 - 666
Acute pain represents a crucial alarm signal to protect us from injury(1). Whereas the nociceptive neurons that convey pain signals were described more than a... 
CAPSAICIN RECEPTOR | IN-VITRO | PAIN | NOCICEPTIVE NEURONS | THERMOSENSATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | ION-CHANNEL | SENSOR | MICE | ACTS | TRPM Cation Channels - deficiency | Nociception - physiology | TRPA1 Cation Channel - deficiency | Male | TRPV Cation Channels - deficiency | TRPV Cation Channels - metabolism | Nerve Fibers - physiology | Sensory Receptor Cells - physiology | Thermosensing - genetics | Burns - prevention & control | Female | Hot Temperature - adverse effects | Thermosensing - physiology | Cold Temperature - adverse effects | TRPV Cation Channels - genetics | Mice, Knockout | Animals | Nociceptive Pain - physiopathology | Nerve Endings - physiology | Skin - innervation | TRPM Cation Channels - genetics | TRPA1 Cation Channel - genetics | Burns - physiopathology | Mice | TRPM Cation Channels - metabolism | Skin - physiopathology | TRPA1 Cation Channel - metabolism | Physiological aspects | Physiological research | Ion channels | Regulation | Research | Body temperature | Nerve endings | Pain perception | Cold | Neurons | Capsaicin receptors | Pharmacology | Fibers | Fault tolerance | Transient receptor potential proteins | Heat | Injury prevention | Pain | Rodents | Sensory neurons | Skin | Mechanical stimuli | Sensors | Burns | Index Medicus
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2. Full Text TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat
by Vriens, Joris and Owsianik, Grzegorz and Hofmann, Thomas and Philipp, Stephan E and Stab, Julia and Chen, Xiaodi and Benoit, Melissa and Xue, Fenqin and Janssens, Annelies and Kerselaers, Sara and Oberwinkler, Johannes and Vennekens, Rudi and Gudermann, Thomas and Nilius, Bernd and Voets, Thomas
Neuron, ISSN 0896-6273, 2011, Volume 70, Issue 3, pp. 482 - 494
Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca -permeable nonselective cation channel. Previous work has demonstrated robust... 
TEMPERATURE | TRPV4 | CATION CHANNEL | ION-CHANNEL | PREGNENOLONE SULFATE | VANILLOID RECEPTOR-1 | COLD | CAPSAICIN-RECEPTOR | NEUROSCIENCES | MICE LACKING | EVOKED ACTIVATION | Hyperalgesia - chemically induced | Telemetry - methods | Calcium - metabolism | Capsaicin - pharmacology | Humans | Ganglia, Spinal - cytology | Transient Receptor Potential Channels - deficiency | Inflammation - metabolism | Time Factors | Behavior, Animal - drug effects | Sensory Receptor Cells - metabolism | Disease Models, Animal | Membrane Potentials - drug effects | Plant Oils - pharmacology | Trigeminal Ganglion - cytology | Mice, Knockout | Blood Glucose - drug effects | Patch-Clamp Techniques | Hyperalgesia - genetics | Transient Receptor Potential Channels - genetics | Gene Expression Regulation - radiation effects | TRPM Cation Channels - genetics | Blood Glucose - genetics | Mice | Inflammation - chemically induced | Mustard Plant | Pain Threshold - physiology | TRPM Cation Channels - deficiency | Membrane Potentials - genetics | Pregnenolone - adverse effects | Dose-Response Relationship, Drug | Transfection - methods | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Freund's Adjuvant - adverse effects | Pain Threshold - drug effects | Nifedipine - pharmacology | Hot Temperature - adverse effects | Hyperalgesia - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Pain Measurement - drug effects | Calcium Channel Blockers - pharmacology | Pain Measurement - methods | Animals | Sensory Receptor Cells - drug effects | TRPM Cation Channels - antagonists & inhibitors | Hyperalgesia - drug therapy | TRPA1 Cation Channel | Inflammation - genetics | Acrylamides - therapeutic use | TRPM Cation Channels - metabolism | Cell Line, Transformed | Chemotherapy | Progesterone | Sulfates | Cancer | Heat | Behavior | Cold | Neurons | Rodents | Index Medicus
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3. Full Text The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation
by Di, Anke and Gao, Xiao-Pei and Qian, Feng and Kawamura, Takeshi and Han, Jin and Hecquet, Claudie and Ye, Richard D and Vogel, Stephen M and Malik, Asrar B
Nature Immunology, ISSN 1529-2908, 01/2012, Volume 13, Issue 1, pp. 29 - 34
The NADPH oxidase activity of phagocytes and its generation of reactive oxygen species (ROS) is critical for host defense, but ROS overproduction can also lead... 
NADPH OXIDASE | OXIDATIVE STRESS | RESPIRATORY BURST | DEPOLARIZATION | VOLTAGE-DEPENDENCE | ION-CHANNEL | NEUTROPHILS | PLATELET-ACTIVATING-FACTOR | GATED PROTON CHANNELS | IMMUNOLOGY | SELECTIVITY | Inflammation - pathology | TRPM Cation Channels - deficiency | Lung Diseases - metabolism | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Calcium - metabolism | Mice, Inbred C57BL | Phagocytes - metabolism | Mice, Knockout | Inflammation - metabolism | Lung Diseases - genetics | Animals | Membrane Potentials | Inflammation - genetics | TRPM Cation Channels - genetics | Mice | TRPM Cation Channels - metabolism | Lung Diseases - pathology | Physiological aspects | Phagocytes | Reactive oxygen species | Cell membranes | Research | Mitogens | Index Medicus
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4. Full Text TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
by Obata, Koichi and Katsura, Hirokazu and Mizushima, Toshiyuki and Yamanaka, Hiroki and Kobayashi, Kimiko and Dai, Yi and Fukuoka, Tetsuo and Tokunaga, Atsushi and Tominaga, Makoto and Noguchi, Koichi
Journal of Clinical Investigation, ISSN 0021-9738, 09/2005, Volume 115, Issue 9, pp. 2393 - 2401
Cold hyperalgesia is a well-documented symptom of inflammatory and neuropathic pain; however, the underlying mechanisms of this enhanced sensitivity to cold... 
MEDICINE, RESEARCH & EXPERIMENTAL | Neurons, Afferent - cytology | Cold Temperature | MAP Kinase Signaling System - physiology | Nerve Growth Factor - metabolism | Calcium Channels - metabolism | TRPC Cation Channels | Rats | Male | Ganglia, Spinal - cytology | Inflammation | Rats, Sprague-Dawley | Hyperalgesia | Glial Cell Line-Derived Neurotrophic Factor - metabolism | Animals | In Situ Hybridization | TRPA1 Cation Channel | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Neurons, Afferent - pathology | TRPM Cation Channels - genetics | Ankyrins | TRPM Cation Channels - metabolism | Neurons, Afferent - metabolism | Pain Measurement | Calcium Channels - genetics | Index Medicus | Abridged Index Medicus
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5. Full Text The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia
by Song, Kun and Wang, Hong and Kamm, Gretel B and Pohle, Jörg and De Castro Reis, Fernanda and Heppenstall, Paul and Wende, Hagen and Siemens, Jan
Science, ISSN 0036-8075, 09/2016, Volume 353, Issue 6306, pp. 1393 - 1398
Body temperature homeostasis is critical for survival and requires precise regulation by the nervous system. The hypothalamus serves as the principal... 
CA2+ INFLUX | TEMPERATURE REGULATION | POTENTIAL CATION CHANNEL | INDUCED MEMBRANE DEPOLARIZATION | 2-AMINOETHOXYDIPHENYL BORATE | BEHAVIORAL THERMOREGULATION | MULTIDISCIPLINARY SCIENCES | CENTRAL THERMOSENSITIVITY | CENTRAL-NERVOUS-SYSTEM | BROWN ADIPOSE-TISSUE | BODY-TEMPERATURE | Body Temperature Regulation - physiology | Mice, Inbred C57BL | Hot Temperature | Preoptic Area - cytology | TRPM Cation Channels - physiology | Fever - physiopathology | Animals | Mice, Mutant Strains | Neurons - physiology | Fever - genetics | TRPM Cation Channels - genetics | Female | Mice | Body Temperature Regulation - genetics | Hypothermia - physiopathology | Preoptic Area - physiology | Physiological aspects | Ion channels | Health aspects | Hyperthermia | Fever | Hypothermia | Heat | Sensors | Body temperature | Index Medicus | Neurons | Thermoregulation | Homeostasis | Activation | Hypothalamus | Channels
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6. Full Text Human odontoblasts express functional thermo-sensitive TRP channels: Implications for dentin sensitivity
by El Karim, Ikhlas A and Linden, Gerard J and Curtis, Timothy M and About, Imad and McGahon, Mary K and Irwin, Chris R and Lundy, Fionnuala T
Pain, ISSN 0304-3959, 10/2011, Volume 152, Issue 10, pp. 2211 - 2223
Odontoblasts form the outermost cellular layer of the dental pulp where they have been proposed to act as sensory receptor cells. Despite this suggestion,... 
Odontoblast | TRP channels | Dental pulp | NEUROGENIC INFLAMMATION | RECEPTOR | COLD TEMPERATURES | TOOTH PAIN | MECHANISMS | PULP | NEUROSCIENCES | SENSORY NEURONS | CLINICAL NEUROLOGY | IN-VITRO | ACTIVATED ION-CHANNEL | EPITHELIAL-CELLS | ANESTHESIOLOGY | Humans | Transient Receptor Potential Channels - biosynthesis | TRPM Cation Channels - biosynthesis | Calcium Channels - physiology | TRPV Cation Channels - biosynthesis | Thermosensing - genetics | Nerve Tissue Proteins - biosynthesis | Transient Receptor Potential Channels - physiology | Calcium Channels - genetics | Dentin Sensitivity - genetics | Nociceptors - pathology | Nerve Tissue Proteins - physiology | TRPV Cation Channels - physiology | Odontoblasts - metabolism | Hot Temperature - adverse effects | Dentin Sensitivity - metabolism | Nerve Tissue Proteins - genetics | TRPM Cation Channels - physiology | Cold Temperature - adverse effects | TRPV Cation Channels - genetics | Transient Receptor Potential Channels - genetics | TRPA1 Cation Channel | TRPM Cation Channels - genetics | Calcium Channels - biosynthesis | Dentin Sensitivity - pathology | Nociceptors - metabolism | Primary Cell Culture | Odontoblasts - pathology | Immunohistochemistry | Index Medicus
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7. Full Text Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent
by Davis, F.M and Azimi, I and Faville, R.A and Peters, A.A and Jalink, K and Putney Jr, J.W and Goodhill, G.J and Thompson, E.W and Roberts-Thomson, S.J and Monteith, G.R
Oncogene, ISSN 0950-9232, 05/2014, Volume 33, Issue 18, pp. 2307 - 2316
Signals from the tumor microenvironment trigger cancer cells to adopt an invasive phenotype through epithelial-mesenchymal transition (EMT). Relatively little... 
Vimentin | Epithelial-mesenchymal transition | Signal transduction | Breast cancer | Calcium | STAT3 | MIGRATION | ACTIVATION | calcium | METASTASIS | signal transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHENOTYPE | breast cancer | vimentin | CELL BIOLOGY | ONCOLOGY | GENETICS & HEREDITY | GENE-EXPRESSION | epithelial-mesenchymal transition | TRPM7 | CHANNELS | UP-REGULATION | CONTRIBUTES | PROGRESSION | RNA, Small Interfering - genetics | Phosphorylation | Vimentin - biosynthesis | Calcium - metabolism | Epithelial-Mesenchymal Transition - physiology | Humans | Protein-Serine-Threonine Kinases | Epidermal Growth Factor - metabolism | Epithelial-Mesenchymal Transition - drug effects | Epithelial-Mesenchymal Transition - genetics | Breast Neoplasms - metabolism | Cell Hypoxia | TRPM Cation Channels - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - metabolism | Breast Neoplasms - pathology | Cell Line, Tumor | TRPM Cation Channels - genetics | Female | TRPM Cation Channels - metabolism | Epidermal Growth Factor - pharmacology | Calcium Signaling | STAT3 Transcription Factor - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Care and treatment | Calcium channels | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Risk factors | Cellular biology | Index Medicus | Epithelial-mesenchymal transition (EMT)
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8. Full Text The TRPM2 ion channel is required for sensitivity to warmth
by Tan, Chun-Hsiang and McNaughton, Peter A
Nature, ISSN 0028-0836, 08/2016, Volume 536, Issue 7617, pp. 460 - 463
Thermally activated ion channels are known to detect the entire thermal range from extreme heat (TRPV2), painful heat (TRPV1, TRPM3 and ANO1), non-painful... 
CA2+ INFLUX | 2-AMINOETHOXYDIPHENYL BORATE | NOCICEPTIVE NEURONS | ROOT GANGLION NEURONS | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | TRPV3 | ADP-RIBOSE | CAPSAICIN-RECEPTOR | NOXIOUS HEAT | MICE LACKING | TRPM Cation Channels - deficiency | Avoidance Learning | Calcium - metabolism | Mice, Inbred C57BL | Electrophysiology | Male | Calcium - analysis | Hot Temperature | Animals | Sequence Analysis, RNA | TRPM Cation Channels - genetics | Mice | Neurons - metabolism | TRPM Cation Channels - metabolism | Calcium Signaling | Physiological aspects | Physiological research | Ion channels | Neurons | Heat | Temperature | Rodents | Index Medicus
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9. Full Text High salt recruits aversive taste pathways
by Oka, Yuki and Butnaru, Matthew and Von Buchholtz, Lars and Ryba, Nicholas J. P and Zuker, Charles S
Nature, ISSN 0028-0836, 02/2013, Volume 494, Issue 7438, pp. 472 - 475
In the tongue, distinct classes of taste receptor cells detect the five basic tastes; sweet, sour, bitter, sodium salt and umami(1,2). Among these qualities,... 
CARBONIC-ANHYDRASE-IV | BITTER TASTE | CELLS | DISCRIMINATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NACL | AMILORIDE | RECEPTOR | TRANSDUCTION | MICE | Phospholipase C beta - metabolism | Appetite - genetics | TRPM Cation Channels - deficiency | Sodium Chloride, Dietary - pharmacology | Gene Silencing | Sodium Chloride, Dietary - administration & dosage | Appetite - drug effects | Taste Buds - cytology | Mutation - genetics | Taste - physiology | Feeding Behavior - physiology | Feeding Behavior - drug effects | Mice, Knockout | Phospholipase C beta - genetics | Taste Buds - metabolism | Animals | Taste - drug effects | TRPM Cation Channels - genetics | Phospholipase C beta - deficiency | Appetite - physiology | Mice | TRPM Cation Channels - metabolism | Taste - genetics | Taste Buds - drug effects | Taste buds | Taste | Research | Observations | Rodents | Index Medicus
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10. Full Text TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis
by Schattling, Benjamin and Steinbach, Karin and Thies, Edda and Kruse, Martin and Menigoz, Aurélie and Ufer, Friederike and Flockerzi, Veit and Brück, Wolfgang and Pongs, Olaf and Vennekens, Rudi and Kneussel, Matthias and Freichel, Marc and Merkler, Doron and Friese, Manuel A
Nature Medicine, ISSN 1078-8956, 12/2012, Volume 18, Issue 12, pp. 1805 - 1811
In multiple sclerosis, an inflammatory disease of the central nervous system (CNS), axonal and neuronal loss are major causes for irreversible neurological... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | MODEL | LESIONS | CELL BIOLOGY | GLUTAMATE | DISABILITY | GRAY-MATTER ATROPHY | MITOCHONDRIAL DYSFUNCTION | MICE | CELL-ACTIVATION | BRAINS | Immunohistochemistry | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | DNA Primers - genetics | Nerve Degeneration - metabolism | Flow Cytometry | In Situ Hybridization | Glyburide - pharmacology | T-Lymphocytes - drug effects | Real-Time Polymerase Chain Reaction | Multiple Sclerosis - metabolism | Enzyme-Linked Immunosorbent Assay | Axons - drug effects | Axons - metabolism | Blotting, Western | Mice, Knockout | Patch-Clamp Techniques | Animals | TRPM Cation Channels - antagonists & inhibitors | Analysis of Variance | T-Lymphocytes - cytology | TRPM Cation Channels - genetics | Cell Proliferation - drug effects | Mice | TRPM Cation Channels - metabolism | Multiple sclerosis | Encephalomyelitis | Physiological aspects | Development and progression | Nervous system | Genetic aspects | Ion channels | Degeneration | Research | Encephalitis | Autoimmune diseases | Neurons | Index Medicus
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11. Full Text Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains
by Kunert-Keil, Christiane and Bisping, Frederike and Krüger, Jana and Brinkmeier, Heinrich
BMC Genomics, ISSN 1471-2164, 06/2006, Volume 7, Issue 1, pp. 159 - 159
Background: The purpose of this work was to study the gene expression of transient receptor potential (TRP) channels in the mouse. The application of a... 
SKELETAL-MUSCLE | SMOOTH-MUSCLE | INFLUX | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CATION CHANNEL | CALCIUM | INVOLVEMENT | GENETICS & HEREDITY | ION | SUPERFAMILY | FUNCTIONAL-CHARACTERIZATION | HOMOLOGS | Species Specificity | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | RNA, Messenger - metabolism | TRPV Cation Channels - metabolism | Kidney - metabolism | Myocardium - metabolism | Reverse Transcriptase Polymerase Chain Reaction - methods | Transient Receptor Potential Channels - metabolism | TRPC Cation Channels - genetics | In Situ Hybridization - methods | Cell Line | Telencephalon - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Profiling - methods | TRPV Cation Channels - genetics | Animals | Transient Receptor Potential Channels - genetics | TRPC Cation Channels - metabolism | TRPM Cation Channels - genetics | Mice, Inbred NOD | Mice | Mice, Inbred BALB C | TRPM Cation Channels - metabolism | Index Medicus
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