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06/2014
Neuronal vulnerability to ischemia is dependent on the balance between pro-survival and pro-death cellular signaling. In the latter, it is increasingly... 
TRPM2 NMDA | 0719 | ischemia
Dissertation
11/2011
Transient Receptor Potential Melastatin 2 (TRPM2) is a widely expressed, non-selective cationic channel with implicated roles in cell death, chemokine... 
TRPM2 | Tubulin | 0307
Dissertation
Cell Calcium, ISSN 0143-4160, 06/2019, Volume 80, pp. 8 - 17
The TRP ion channel TRPM2 has an essential function in cell survival and protects the viability of a number of cell types after oxidative stress. It is highly... 
TRPM2 | Mitochondria | HIF-1α | CREB | ROS | Cancer
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/2019, Volume 520, Issue 3, pp. 520 - 525
Membrane proteins are targeted to the surface transmembrane after folding and assembling in the endoplasmic reticulum (ER). Misfolded- and unassembled-proteins... 
ERAD | TRPM2 | Splicing variant | Protein quality control systems
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2019, Volume 143, pp. 288 - 299
Transient Receptor Potential Melastatin-2 (TRPM2) is a nonselective cation channel mediating Ca influx in response to oxidative stress. Given that insulin... 
TRPM2 | Obesity | Insulin resistance | Ca2 | Endothelium
Journal Article
International Journal of Clinical and Experimental Medicine, 11/2017, Volume 10, Issue 11, pp. 15178 - 15186
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 07/2019, Volume 1866, Issue 7, pp. 1162 - 1170
TRPM2 is a non-selective, Ca -permeable cation channel, which plays a role in cell death but also contributes to diverse immune cell functions. In addition,... 
TRPM2 | Temperature sensor | 2′-deoxy-ADPR | Calcium channel | Calmodulin-binding | CYCLIC ADP-RIBOSE | CHANNEL TRPM2 | ACTIVATION | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSOR | CELL BIOLOGY | 2 '-deoxy-ADPR | ION-CHANNEL | DIVERSITY | Sensors | Cell death | Cells | Calmodulin | Computer-aided manufacturing
Journal Article
11/2009
Calcium (Ca2+) influx through N-methyl-D-asparate receptors (NMDARs) is widely held to be the requisite step initiating delayed neuronal death following... 
TRPM2 | calcium | 0719 | pannexin | NMDA receptors | ion channels | 0317
Dissertation
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2018, Volume 504, Issue 1, pp. 321 - 327
The human nucleoside-diphosphate linked moiety–X (NUDIX) hydrolases that utilize ADP-ribose and NADH/NAD are overexpressed in cancer cells, but their roles in... 
ADP-ribose | TRPM2 | AMPK | NUDIX hydrolase | HIF-1α | OXIDATIVE STRESS | CHANNEL TRPM2 | HIF-1 alpha | ACTIVATED PROTEIN-KINASE | HIF | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | MECHANISMS | OVEREXPRESSION | BIOPHYSICS | MESSENGER-RNA | GROWTH
Journal Article
Ageing Research Reviews, ISSN 1568-1637, 11/2018, Volume 47, pp. 67 - 79
Alzheimer’s disease (AD), an age-related neurodegenerative condition, is the most common cause of dementia among the elder people, but currently there is no... 
TRPM2 channel | Neurovascular dysfunction | Neuroinflammation | Alzheimer’s disease | Oxidative damage | Neurodegeneration
Journal Article
Glia, ISSN 0894-1491, 03/2018, Volume 66, Issue 3, pp. 562 - 575
Amyloid β (Aβ)‐induced neuroinflammation plays an important part in Alzheimer's disease (AD). Emerging evidence supports a role for the transient receptor... 
TRPM2 channel | PARP‐1 | Aβ42 | TNF‐α | ROS | microglial activation | TNF-α | PARP-1
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 2011, Volume 68, Issue 8, pp. 1455 - 1466
Journal Article
Neuroscience, ISSN 0306-4522, 06/2019, Volume 408, pp. 204 - 213
Aging causes various functional changes, including cognitive impairment and inflammatory responses in the brain. Transient receptor potential melastatin 2... 
TRPM2 | cognitive impairment | cytokines | aging | microglia | white matter injury | Physiological aspects | Neurons | Inflammation
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 11/2014, Volume 742, Issue 1, pp. 22 - 30
Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress-sensitive Ca -permeable channel that controls Ca signalling. The activation of Janus... 
AG490 | TRPM2 | Oxidative stress | TRPA1 | Janus kinase 2 | POLY(ADP-RIBOSE) POLYMERASE | TRPM2 CHANNELS | ACTIVATION | RECEPTOR | ADP-RIBOSE | DORSAL-ROOT GANGLION | CELL-DEATH | CALCIUM-CHANNELS | PHARMACOLOGY & PHARMACY | HYDROGEN-PEROXIDE
Journal Article
Physiology and Behavior, ISSN 0031-9384, 02/2012, Volume 105, Issue 3, pp. 683 - 692
We aimed to investigate the protective effects of melatonin and 2.45GHz electromagnetic radiation (EMR) on brain and dorsal root ganglion (DRG) neuron... 
Oxidative stress | Melatonin | influx | Electroencephalography records | Wireless devices | Dorsal root ganglion neuron | TRPM2 channels
Journal Article