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Biophysical Journal, ISSN 0006-3495, 02/2019, Volume 116, Issue 3, pp. 469 - 476
Transient receptor potential melastatin member 4 (TRPM4) channels are nonselective monovalent cationic channels found in human atria and conduction system.... 
CHANNEL TRPM4 | GAIN | BIOPHYSICS
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 2014, Volume 171, Issue 7, pp. X1600 - 1613
Journal Article
Journal Article
Toxicology Letters, ISSN 0378-4274, 09/2019, Volume 312, pp. 98 - 108
To investigate the effect of Arsenic Trioxide (ATO) on endothelial cells injury and explore the role of transient receptor potential melastatin 4 channel... 
Arsenic trioxide | 9-phenanthrol | Human umbilical vein endothelial cells | Endothelial injury | TRPM4 | MIGRATION | APOPTOSIS | CELLS | OXIDATIVE STRESS | NONSELECTIVE CATION CHANNEL | ANGIOGENESIS | INHIBITION | ENHANCEMENT | TRPM4 CHANNELS | TOXICOLOGY | CYTOTOXICITY | Arsenic | Physiological aspects | Endothelium
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2018, Volume 96, Issue 10, pp. 1022 - 1029
The role of transient receptor potential melastatin 4 (TRPM4) channels has been frequently tested using their inhibitor 9-phenanthrol in various cardiac... 
canaux TRPM4 | cardiac ionic currents | 9-phénanthrol | canine myocytes | potentiels d’action cardiaques | 9-phenanthrol | courants ioniques cardiaques | cardiac action potentials | cardiomyocytes ventriculaires canins | TRPM4 channels
Journal Article
Cell Reports, ISSN 2211-1247, 07/2018, Volume 24, Issue 3, pp. 724 - 731
A gain-of-function mutation in the Ca -activated transient receptor potential melastatin member 4 (TRPM4 ) is linked to life-threatening cardiac conduction... 
flash photolysis | mutation | patch clamp | calcium | inherited human disease | cardiac arrhythmia | molecular modeling | disease mechanism | membrane current | TRPM4 | CATION CHANNEL TRPM4 | POLYMORPHIC VENTRICULAR-TACHYCARDIA | BRUGADA-SYNDROME | MYOCYTES | CA2 | CALCIUM | DISEASE | ION-CHANNEL | PHOTOLYSIS | FAMILIAL HEART-BLOCK | CELL BIOLOGY | Index Medicus
Journal Article
Neurotherapeutics, ISSN 1933-7213, 1/2012, Volume 9, Issue 1, pp. 65 - 72
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2019, Volume 294, Issue 3, pp. 816 - 826
Regulated mucin secretion is essential for the formation of the mucus layer that protects the underlying epithelial cells from foreign particles. Alterations... 
transient receptor potential channels (TRP channels) | MUC2 | secretion | cystic fibrosis | mucin | goblet cell | TRPM5 | MUC5AC | sodium-calcium exchange | TRPM4
Journal Article
Human Mutation, ISSN 1059-7794, 01/2012, Volume 33, Issue 1, pp. 109 - 117
Very recently, mutations in the TRPM4 gene have been identified in four pedigrees as the cause of an autosomal dominant form of cardiac conduction disease. To... 
right‐bundle branch block | cardiac conduction disease | atrioventricular block | TRPM4 | BRUGADA-SYNDROME | MAPS | DISEASE | GENETICS & HEREDITY | right-bundle branch block | FAMILIAL HEART-BLOCK
Journal Article
BMB Reports, ISSN 1976-6696, 2015, Volume 48, Issue 1, p. 1
Transient Receptor Potential, Melastatin-related, member 4(TRPM4) channels are Ca2+-activated Ca2+-impermeable cationchannels. These channels are expressed in... 
Phosphorylation | Heteromerization | Trafficking | Glycosylation | SUMOylation | 14-3-3γ | TRPM4
Journal Article
Cell Calcium, ISSN 0143-4160, 2011, Volume 51, Issue 1, pp. 82 - 93
Abstract The melastatin transient receptor potential (TRP) channel, TRPM4, is a critical regulator of smooth muscle membrane potential and arterial tone.... 
Advanced Basic Science | Calcium buffering | Cerebral artery smooth muscle cells | TRPM4 | PHYSIOLOGICAL ROLES | CA2+-ACTIVATED K+ CHANNELS | PHOSPHOLIPASE-C | SARCOPLASMIC-RETICULUM | CELL BIOLOGY | CYCLOPIAZONIC ACID | CATION CHANNEL TRPM4 | SINGLE CALCIUM-CHANNELS | RYANODINE RECEPTORS | XENOPUS OOCYTES | ION CHANNELS
Journal Article
LANGMUIR, ISSN 0743-7463, 08/2019, Volume 35, Issue 33, pp. 10772 - 10779
Probing a switch on biomimic membrane surfaces would offer some references to the research on permeability of cytomembranes. In this work, a mixed... 
RECTIFICATION | GOLD | ACID | MEDIATION | FILM | MATERIALS SCIENCE, MULTIDISCIPLINARY | GRAPHENE | CHEMISTRY, PHYSICAL | CHEMISTRY, MULTIDISCIPLINARY | CHANNEL | TITRATION | CHARGE | TRPM4
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 04/2019, Volume 20, Issue 8, p. 2012
Transient receptor potential melastatin member 4 (TRPM4) and 5 (TRPM5) channels are Ca2+-activated nonselective cation channels. Intracellular Ca2+ is the most... 
Patch clamp | TRPM5 | Site-directed mutagenesis | PIP2 | binding site | TRPM4 | site-directed mutagenesis | patch clamp | Ca2+-binding site | PI(4,5)P2
Journal Article
The FEBS Journal, ISSN 1742-464X, 02/2018, Volume 285, Issue 3, pp. 599 - 613
The transient receptor potential channel of melastatin 4 (TRPM4) belongs to a group of large ion receptors that are involved in countless cell signalling... 
ligand‐binding domains | calmodulin | S100A1 | fluorescence anisotropy | TRPM4 channel | ligand-binding domains | CALCIUM-BINDING PROTEINS | CENTRAL HELIX | NMR-SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | 3-DIMENSIONAL SOLUTION STRUCTURE | CATION CHANNEL TRPM4 | ELECTRON CRYOMICROSCOPY | RYANODINE RECEPTOR | ION-CHANNEL | Calmodulin - genetics | Expert Systems | Humans | S100 Proteins - chemistry | S100 Proteins - genetics | Databases, Protein | Conserved Sequence | Protein Interaction Domains and Motifs | Calmodulin - chemistry | Binding Sites | Peptide Fragments - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Peptide Fragments - metabolism | Calmodulin - metabolism | TRPM Cation Channels - chemistry | Computational Biology | Models, Molecular | Recombinant Proteins - chemistry | S100 Proteins - metabolism | Epitopes | Peptide Fragments - chemical synthesis | Peptide Fragments - chemistry | TRPM Cation Channels - genetics | Ligands | Protein Conformation | Molecular Docking Simulation | TRPM Cation Channels - metabolism | Kinetics | Mutation | Fluorescence Polarization | Amino Acid Substitution | Calmodulin | Antigenic determinants | Computer-aided manufacturing | Protein binding | Calcium | Peptides | Fluorescence | Cardiomyocytes | Hydrophobicity | Tissues | Channels | Human tissues | Modulators | Mimicry | Transient receptor potential proteins | Signaling | Receptors | Allosteric properties | Molecular modelling | Cascades | Calcium-binding protein | Modulation | Intracellular | Binding sites
Journal Article