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Arylfurans as potential Trypanosoma cruzi trypanothione reductase inhibitors, 12/2006
The natural lignans veraguensin and grandisin have been reported to be active against Trypanosoma cruzi bloodstream forms. Aiming at the total synthesis of... 
tropical diseases - Chagas disease - arylfurans - trypanothione reductase
Journal
8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a Non-competitive Inhibitor of Trypanothione Reductase, 12/2003
The enzyme trypanothione reductase is a recognised drug target in trypanosomatids and has been used in the search of new compounds with potential activity... 
trypanothione reductase - Trypanosoma cruzi - Leishmania - enzyme inhibitors - naphthoquinone
Journal
Redox Biology, ISSN 2213-2317, 09/2019, Volume 26, p. 101231
Trypanothione (T(SH) ) is the main antioxidant metabolite for peroxide reduction in ; therefore, its metabolism has attracted attention for therapeutic... 
Benznidazol | Gamma-glutamylcysteine synthetase | Trypanothione synthetase | Flux control coefficient | Tryparedoxin | Trypanothione | Trypanothione reductase
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 05/2019, Volume 63, Issue 5
A novel series of thirty-one N-substituted urea, thiourea, and selenourea derivatives containing diphenyldiselenide entities were synthesized, fully... 
IN-VITRO | thiourea | INHIBITION | selenium | INFANTUM TRYPANOTHIONE REDUCTASE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | trypanothione reductase | N-FORMYLATION | UPDATE | selenourea | urea
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2007, Volume 403, Issue 2, pp. 323 - 334
Trypanosoma cruzi undergo PCD (programmed cell death) under appropriate stimuli, the mechanisms of which remain to be established. In the present study, we... 
Free radicals | Mitochondrial superoxide dismutase | Reactive oxygen species (ROS) | Programmed cell death (PCD) | Trypanosoma cruzi | APOPTOSIS | free radicals | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BRUCEI | HOST | reactive oxygen species (ROS) | TRYPANOTHIONE | CYTOCHROME-C | METABOLISM | RESPIRATION | NITRIC-OXIDE | LEISHMANIA-DONOVANI | mitochondrial superoxide dismutase | programmed cell death (PCD) | Immunohistochemistry | Superoxide Dismutase - genetics | Glutathione - analogs & derivatives | Oxidative Stress | Glutathione - metabolism | Trypanosoma cruzi - metabolism | Cytochromes c - metabolism | Spermidine - analogs & derivatives | Spermidine - metabolism | Trypanosoma cruzi - genetics | Mitochondria - metabolism | Gene Expression Regulation, Enzymologic | Animals | Superoxides - metabolism | NADH, NADPH Oxidoreductases - metabolism | Trypanosoma cruzi - cytology | Superoxide Dismutase - metabolism | Apoptosis | Cytoprotection | RA, reverse addition | PCD, programmed cell death | TcSODA, T. cruzi mitochondrial SOD | TR, trypanothione reductase | TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling | DiBAC4, bis-(1,3-dibutylbarbituric acid)trimethine oxonol | DMPO, 5,5-dimethylpyrroline-N-oxide | MitoSOX, 3,8-phenanthridinediamine, 5-(6′-triphenylphosphoniumhexyl)-5,6 dihydro-6-phenyl | ΔΨp, plasma membrane potential | T(SH)2, reduced trypanothione | TS2, oxidized trypanothione | JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide | VDAC, voltage-dependent anion channel | DEVD-CHO, acetyl-Asp-Glu-Val-Asp aldehyde | ROS, reactive oxygen species | PTP, permeability transition pore | FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone | PI, propidium iodide | AIF, apoptosis inducing factor | KH, Krebs–Henseleit | ANT, adenine nucleotide translocase | DMNQ, 2,3-dimethoxy-1,4-naphthoquinone | ΔΨm, mitochondrial membrane potential | oxMitoSOX, oxidized MitoSOX | Tet, tetracycline | PS, phosphatidylserine | SOD, superoxide dismutase | PPP, pentose phosphate pathway | AT, atractyloside | FeSOD, iron superoxide dismutase | FHS, fresh human serum | cyt c, cytochrome c | IHS, heat-inactivated human serum
Journal Article
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2019, Volume 24, Issue 18, p. 3216
Leishmanicidal drugs have many side effects, and drug resistance to all of them has been documented. Therefore, the development of new drugs and the... 
trypanothione reductase | molecular docking | leishmanicidal activity | enzyme inhibitors
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2011, Volume 438, Issue 2, pp. 229 - 244
New drugs are urgently needed for the treatment of tropical and subtropical parasitic diseases, such as African sleeping sickness. Chagas' disease,... 
Polyamine | Spermidine synthase | α-difluoromethylornithine | Trypanosoma | Malaria | Leishmania | S-adenosylmethionine decarboxylase (AdoMetDC) | Ornithine decarboxylase (ODC) | MAMMALIAN ORNITHINE-DECARBOXYLASE | HUMAN AFRICAN TRYPANOSOMIASIS | spermidine synthase | BIOCHEMISTRY & MOLECULAR BIOLOGY | DL-ALPHA-DIFLUOROMETHYLORNITHINE | malaria | FALCIPARUM SPERMIDINE SYNTHASE | polyamine | ADENOSYL-L-METHIONINE | alpha-difluoromethylornithine | ornithine decarboxylase (ODC) | LEISHMANIA-DONOVANI PROMASTIGOTES | PARASITE PLASMODIUM-FALCIPARUM | S-ADENOSYLMETHIONINE DECARBOXYLASE | TRYPANOSOMA-BRUCEI-BRUCEI | ARSENITE-RESISTANT LEISHMANIA | Parasites - drug effects | Animals | Parasites - metabolism | Humans | Parasites - pathogenicity | Antiprotozoal Agents - chemistry | Host-Pathogen Interactions - drug effects | Homeostasis - drug effects | Antiprotozoal Agents - pharmacology | Polyamines - metabolism | TS2, trypanothione disulfide | Review | MDL73811, 5′-{[(Z)-4-amino-2-butenyl]methylamino}-5′-deoxyadenosine | AdoMet, S-adenosylmethionine | DFMO, α-difluoromethylornithine | AdoMao, S-(5′-deoxy-5′-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene | WHO, World Health Organization | AdoDATO, S-adenosyl-1,8-diamino-3-thiooctane | SpmS, spermine synthase | TryR, trypanothione reductase | OAT, ornithine aminotransferase | TSA, TryS-amidase | PAT, putative amino acid transporter | 4MCHA, 4-methylcyclohexylamine | DAB, 1,4-diamino-2-butanone | MGBG, methylglyoxal bis(guanylhydrazone) | ODC, ornithine decarboxylase | APA, 1-amino-oxy-3-aminopropane | CNS, central nervous system | T(SH)2, dihydrotrypanothione | AdoMetDC, AdoMet decarboxylase | CHA, cyclohexylamine | TryS, trypanothione synthetase | MTA, 5′-methylthioadenosine | LDC, lysine decarboxylase | dcAdoMet, decarboxylated AdoMet | SpdS, spermidine synthase | PLP, pyridoxal-5′-phosphate | Biological Sciences | Naturvetenskap | Biokemi och molekylärbiologi | Biologiska vetenskaper | Biochemistry and Molecular Biology | Natural Sciences
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2005, Volume 391, Issue 2, pp. 425 - 432
Journal Article
Nature Reviews Microbiology, ISSN 1740-1526, 03/2017, Volume 15, Issue 4, pp. 217 - 231
The WHO recognizes human African trypanosomiasis, Chagas disease and the leishmaniases as neglected tropical diseases. These diseases are caused by parasitic... 
RESISTANCE MECHANISMS | IN-VITRO | TRYPANOTHIONE REDUCTASE | CLINICAL DEVELOPMENT | N-MYRISTOYLTRANSFERASE INHIBITORS | CHAGAS-DISEASE | SELECTIVE INHIBITORS | MICROBIOLOGY | GENETIC VALIDATION | PROTEOMIC ANALYSIS | EXPERIMENTAL-MODELS | Forecasts and trends | Public health | Drug discovery
Journal Article
FEBS LETTERS, ISSN 0014-5793, 12/2017, Volume 591, Issue 23, pp. 3881 - 3894
Buthionine sulfoximine (BSO) induces decreased glutathione (GSH) and trypanothione [T(SH)(2)] pools in trypanosomatids, presumably because only... 
CRUZI | Trypanosomacruzi | glutathione | BIOCHEMISTRY & MOLECULAR BIOLOGY | VALIDATION | trypanothione | TOXICITY | gamma-glutamylcysteine synthetase | GLUTATHIONE SYNTHESIS | buthionine sulfoximine | NIFURTIMOX | REDOX BIOLOGY | CELL BIOLOGY | TRANSPORT | trypanothione synthetase | BIOPHYSICS | METABOLISM | SYNTHETASE | BENZNIDAZOLE
Journal Article