X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
down syndrome (363) 363
animals (353) 353
mice (314) 314
index medicus (288) 288
neurosciences (286) 286
disease models, animal (260) 260
humans (203) 203
down syndrome - genetics (200) 200
male (169) 169
ts65dn mouse (161) 161
ts65dn (143) 143
female (134) 134
ts65dn mouse model (130) 130
long-term potentiation (128) 128
alzheimers-disease (127) 127
analysis (125) 125
down syndrome - pathology (107) 107
down syndrome - physiopathology (107) 107
ts65dn mice (107) 107
brain (100) 100
mouse model (99) 99
mice, transgenic (87) 87
memory (85) 85
down-syndrome (83) 83
mice, inbred c57bl (82) 82
hippocampus (81) 81
trisomy (80) 80
down's syndrome (79) 79
down syndrome - metabolism (76) 76
synaptic plasticity (73) 73
article (72) 72
alzheimer's disease (71) 71
neurogenesis (71) 71
neurology (61) 61
biochemistry & molecular biology (59) 59
genetics & heredity (58) 58
phenotype (56) 56
down syndrome - complications (53) 53
amyloid precursor protein (52) 52
neurons (52) 52
down syndrome - drug therapy (51) 51
behavioral sciences (49) 49
deficits (49) 49
abnormalities (48) 48
research (48) 48
gene expression (47) 47
mental-retardation (46) 46
rodents (44) 44
trisomy 21 (41) 41
brain - metabolism (40) 40
cognitive ability (40) 40
animal models (39) 39
cognitive deficits (39) 39
brain - pathology (38) 38
cell biology (38) 38
down syndrome - psychology (38) 38
mice, mutant strains (37) 37
transgenic mice (37) 37
dentate gyrus (36) 36
gene-expression (36) 36
genes (36) 36
children (35) 35
model (35) 35
syndrome critical region (35) 35
cognition (34) 34
gaba (34) 34
expression (33) 33
mice, inbred c3h (33) 33
spatial memory (33) 33
trisomy - genetics (33) 33
clinical neurology (32) 32
hippocampus - metabolism (32) 32
learning (32) 32
physiological aspects (32) 32
aneuploidy (31) 31
behavioral-assessment (31) 31
environmental enrichment (31) 31
genetic aspects (31) 31
intellectual disability (31) 31
maze learning - physiology (31) 31
mental retardation (31) 31
chromosome 21 (30) 30
gene dosage (30) 30
models (30) 30
mouse models (30) 30
neuroscience (30) 30
proteins (30) 30
dementia (29) 29
mice, neurologic mutants (29) 29
phosphorylation (29) 29
aging (28) 28
dyrk1a (28) 28
inhibition (28) 28
behavioral abnormalities (27) 27
chromosomes (27) 27
hippocampus - pathology (27) 27
multidisciplinary sciences (27) 27
pharmacology & pharmacy (27) 27
psychiatry (27) 27
neurons - pathology (26) 26
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


NATURE MEDICINE, ISSN 1078-8956, 04/2015, Volume 21, Issue 4, pp. 318 - 318
Down syndrome (DS) is the most frequent genetic cause of intellectual disability, and altered GABAergic transmission through Cl- permeable GABA(A) receptors... 
MEDICINE, RESEARCH & EXPERIMENTAL | TS65DN MOUSE | CATION-CHLORIDE COTRANSPORTERS | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | INHIBITION | SYNDROME MICE | NKCC1 | DEFICITS | MEDIATED NEUROTRANSMISSION | HIPPOCAMPAL INTERNEURONS | DIURETIC BUMETANIDE
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 02/2013, Volume 33, Issue 9, pp. 3953 - 3966
Down syndrome (DS) is associated with neurological complications, including cognitive deficits that lead to impairment in intellectual functioning. Increased... 
TS65DN MOUSE | PLACE NAVIGATION | MORRIS WATER MAZE | INVERSE AGONIST | ADULT HIPPOCAMPAL NEUROGENESIS | LONG-TERM POTENTIATION | ELEVATED PLUS-MAZE | BEHAVIORAL-ASSESSMENT | SYNAPTIC PLASTICITY | NEUROSCIENCES | COGNITIVE DEFICITS
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 07/2012, Volume 32, Issue 27, pp. 9217 - 9227
Cognitive impairment in Down syndrome (DS) is characterized by deficient learning and memory. Mouse genetic models of DS exhibit impaired cognition in... 
TS65DN MOUSE | OBJECT RECOGNITION MEMORY | MENTAL-RETARDATION | IMMUNOHISTOCHEMICAL LOCALIZATION | SPINAL-CORD | RAT HIPPOCAMPUS | LONG-TERM POTENTIATION | MURINE MODELS | NEUROSCIENCES | K+ CHANNELS | CRITICAL REGION
Journal Article
Neuroscience Letters, ISSN 0304-3940, 10/2019, p. 134569
Journal Article
Science Translational Medicine, ISSN 1946-6234, 11/2009, Volume 1, Issue 7, pp. 7ra17 - 7ra17
Down syndrome (trisomy 21) is the most common cause of mental retardation in children and leads to marked deficits in contextual learning and memory. In... 
DONEPEZIL | MEDICINE, RESEARCH & EXPERIMENTAL | TS65DN MOUSE | COERULEUS | ALZHEIMERS-DISEASE | HIPPOCAMPAL | NEURONS | COGNITIVE IMPAIRMENT | LOCUS-CERULEUS | DEFICITS | DOPA DECARBOXYLASE | CELL BIOLOGY | Animals | Learning Disorders | Norepinephrine - physiology | Memory | Down Syndrome - physiopathology | Mice | Down Syndrome - psychology | Disease Models, Animal
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2015, Volume 35, Issue 4, pp. 1343 - 1353
Journal Article
Brain Behavior and Immunity, ISSN 0889-1591, 01/2019, Volume 75, pp. 163 - 180
Down Syndrome (DS), the most common cause of genetic intellectual disability, is characterized by over-expression of the and genes, located on the triplicated... 
Down Syndrome | Astrocytes | Vaccine | Amyloid-β | Ts65Dn | Alzheimer's disease | Microglia | TS65DN MOUSE | NONDEMENTED ADULTS | PSYCHIATRY | ALZHEIMERS-DISEASE | MEMORY DEFICITS | CELL-PROLIFERATION | IMMUNOLOGY | BEHAVIORAL-ASSESSMENT | NEUROSCIENCES | A-BETA | LONG-TERM POTENTIATION | DENTATE GYRUS | Amyloid-beta | Oligomers | Down syndrome | Analysis | Vaccination | DNA | Alzheimer’s disease
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e106572
Down syndrome (DS) phenotypes result from the overexpression of several dosage-sensitive genes. The DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation... 
TS65DN MOUSE | MURINE MODEL | WATER-MAZE | MULTIDISCIPLINARY SCIENCES | ADULT HIPPOCAMPAL NEUROGENESIS | NEURONAL DIFFERENTIATION | INHIBITS PROLIFERATION | CELL-SURVIVAL | SYNAPTIC PLASTICITY | EXPRESSION | WORKING-MEMORY | Down Syndrome - metabolism | Protein-Tyrosine Kinases - metabolism | Protein-Serine-Threonine Kinases - genetics | Male | Mice, Transgenic | Down Syndrome - physiopathology | Long-Term Potentiation - genetics | Protein-Tyrosine Kinases - genetics | Animals | Down Syndrome - genetics | Cognition - physiology | Long-Term Potentiation - physiology | Female | Mice | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Memory - physiology | GABA | Brain | Down syndrome | Neurophysiology | Potentiation | Cell proliferation | Phosphorylation | Hyperactivity | Copy number | Memory | Genes | Cognitive ability | Disabilities | Kinases | Dosage | Neurogenesis | Proteins | Learning | γ-Aminobutyric acid | Alterations | Cell growth | Down's syndrome | Transgenic animals | Rodents | Physiology | Conditioning | Tyrosine | Gene dosage | Granule cells | Long-term potentiation | Attention | Pharmacology | Fear conditioning | Medicine | Studies | Progeny | Dentate gyrus | Genetic crosses | Glutamatergic transmission | Laboratory animals | Females | Differentiation | Hippocampus | Animal cognition
Journal Article