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Autophagy, ISSN 1554-8627, 05/2015, Volume 11, Issue 5, pp. 812 - 832
By monitoring the fragmentation of a GST-BHMT (a protein fusion of glutathionine S-transferase N-terminal to betaine-homocysteine S-methyltransferase) reporter... 
GST-BHMT, a fusion protein of glutathionine S-transferase N-terminal to betaine-homocysteine S-methyltransferase | ATF4, activating transcription factor 4 | MTORC1, MTOR complex 1 | LSCS, linker-specific cleavage site | selective macroautophagy | RPS6KB1, ribosomal protein S6 kinase, 70kDa, polypeptide 1 | UPR, unfolded protein response | ATG7, autophagy-related 7 | ULK1, unc-51 like autophagy activating kinase 1 | TSC1/2, tuberous sclerosis 1/2 | BCL2, B-cell CLL/lymphoma 2 | XBP1, X-box binding protein 1 | ACACA/B, acetyl-CoA carboxylase α/β | BECN1, Beclin 1, autophagy-related | MTOR, mechanistic target of rapamycin (serine/threonine kinase) | 1 | SQSTM1, sequestosome 1 | HA, hemagglutinin | BHMT, betaine-homocysteine S-methyltransferase | GST-BHMT | DDIT3, DNA-damage-inducible transcript 3 | ATF6, activating transcription factor 6 | EBSS, Earle's Balanced Salt Solution | Cvt, cytoplasm-to-vacuole-targeting | RM, rich medium | proteasome inhibition | GST, glutathionine S-transferase | FRAG | MAP1LC3, microtubule-associated protein 1 light chain 3 | PRKAA, protein kinase, AMP-activated, α catalytic subunit | an autophagy-mediated cleavage product of the GST-BHMT reporter | NBR1, neighbor of BRCA1 gene 1 | ERN1, endoplasmic reticulum to nucleus signaling 1 | P4HB, prolyl 4-hydroxylase, β polypeptide | MAP2K7, mitogen-activated protein kinase kinase 7 | Baf A1, bafilomycin A | UPS, ubiquitin proteasome system | PRKAA/AMPK | EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1 | ACTB, actin, β | HSPA5, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | MTOR | BHMT | EIF2AK3, eukaryotic translation initiation factor 2-α, kinase 3 | RHEB, Ras homolog enriched in brain | MAPK8, mitogen-activated protein kinase 8 | cargo receptors SQSTM1/p62 and NBR1 | ER, endoplasmic reticulum | CTNNB1, catenin (cadherin-associated protein), β 1, 88kDa | SIGNALING PATHWAYS | ER STRESS | KINASE | ENDOPLASMIC-RETICULUM STRESS | SELECTIVE AUTOPHAGY | CELL BIOLOGY | UNFOLDED PROTEIN RESPONSE | MONITORING AUTOPHAGY | FUSION PROTEIN | BETAINE HOMOCYSTEINE METHYLTRANSFERASE | MAINTAINS ENERGY | AMP-Activated Protein Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Sequestosome-1 Protein | Humans | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Lysosomes - metabolism | Ubiquitination - drug effects | Protein Processing, Post-Translational - drug effects | Protein Binding - drug effects | HEK293 Cells | Membrane Proteins - metabolism | Betaine-Homocysteine S-Methyltransferase - metabolism | Protein-Serine-Threonine Kinases - metabolism | Beclin-1 | Lysosomes - drug effects | Protein Structure, Tertiary | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Proteasome Inhibitors - pharmacology | Mitogen-Activated Protein Kinase 8 - metabolism | Glutathione Transferase - metabolism | Apoptosis Regulatory Proteins - metabolism | Leupeptins - pharmacology | Proteins - metabolism | Signal Transduction - drug effects | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Protein Multimerization - drug effects
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2004, Volume 101, Issue 37, pp. 13489 - 13494
Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in either of the two tumor suppressor genes TSC1 or TSC2, which encode hamartin and... 
Proteins | Phorbol esters | Biological Sciences | Phosphorylation | Cell growth | HEK293 cells | Roux | Tuberous sclerosis | Antibodies | Insulin | Tumors | MAMMALIAN TARGET | PROTEIN | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | PHOSPHOINOSITIDE 3-KINASE/AKT PATHWAY | GENE-PRODUCTS | TSC1 | CELL-GROWTH | IDENTIFICATION | HETEROZYGOSITY | MTOR | Protein Kinases - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Molecular Sequence Data | Tetradecanoylphorbol Acetate - analogs & derivatives | Phosphatidylinositol 3-Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | MAP Kinase Signaling System | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Repressor Proteins - chemistry | Tumor Suppressor Proteins - metabolism | Repressor Proteins - genetics | Serine - genetics | Mutation - genetics | Phosphoserine - metabolism | Tuberous Sclerosis - enzymology | Serine - metabolism | Tuberous Sclerosis - genetics | Proteins - genetics | Proto-Oncogene Proteins c-akt | Animals | Proteins - metabolism | Tuberous Sclerosis - metabolism | Models, Biological | Protein Binding | TOR Serine-Threonine Kinases | Enzyme Activation | Proteins - antagonists & inhibitors | Oncogene Protein p21(ras) - genetics | Esters | Research
Journal Article
Journal Article
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 2011, Volume 17, Issue 12, pp. 734 - 742
The mTOR signaling network functions as a pivotal regulatory cascade during the development of the cerebral cortex. Aberrant hyperactivation of mTOR as a... 
Pathology | MAMMALIAN TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | BALLOON CELLS | NEURONAL POLARIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCAL CORTICAL DYSPLASIAS | GIANT-CELLS | PROTEIN-SYNTHESIS | CELL BIOLOGY | TUBEROUS SCLEROSIS COMPLEX | MOUSE MODEL | GENE-EXPRESSION | RECEPTOR SUBUNIT | Autistic Disorder - pathology | Autistic Disorder - physiopathology | Autistic Disorder - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Multiprotein Complexes | Adaptor Proteins, Vesicular Transport - genetics | Cerebral Cortex - pathology | Epilepsy - metabolism | Epilepsy - physiopathology | Adaptor Proteins, Vesicular Transport - metabolism | Cerebral Cortex - metabolism | Cerebral Cortex - physiopathology | Mechanistic Target of Rapamycin Complex 1 | TOR Serine-Threonine Kinases - genetics | Tumor Suppressor Proteins - genetics | Malformations of Cortical Development - physiopathology | Cerebral Cortex - drug effects | Malformations of Cortical Development - drug therapy | Malformations of Cortical Development - pathology | Molecular Targeted Therapy - methods | Biomarkers - metabolism | PTEN Phosphohydrolase - genetics | Sirolimus - therapeutic use | Tumor Suppressor Proteins - metabolism | Malformations of Cortical Development - metabolism | PTEN Phosphohydrolase - metabolism | Signal Transduction - genetics | Proteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sirolimus - administration & dosage | Animals | Proteins - metabolism | Protein Kinase Inhibitors - therapeutic use | Epilepsy - drug therapy | Mice | Mutation | Autistic Disorder - drug therapy | Epilepsy - pathology | Proteins - antagonists & inhibitors | TOR protein | Brain | Signal transduction | TSC2 protein | Reviews | Epilepsy | biomarkers | Cortex | Point mutation | TSC1 protein | Age | PTEN protein
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2008, Volume 412, Issue 2, pp. 179 - 190
TSC1 and TSC2 are the tumour-suppressor genes mutated in the tumour syndrome TSC (tuberous sclerosis complex). Their gene products form a complex that has... 
Cell growth control | Tuberous sclerosis complex (TSC) | Mammalian target of rapamycin complex 1 (mTORC1) | Hamartin (TSC1) | Tuberin (TSC2) | Ras homologue enriched in brain (Rheb) | MAMMALIAN TARGET | RHEB GTPASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | hamartin (TSC1) | TSC2 GENE | cell growth control | P70 S6 KINASE | tuberin (TSC2) | TUBEROUS SCLEROSIS COMPLEX | mammalian target of rapamycin complex 1 (mTORC1) | PULMONARY LYMPHANGIOLEIOMYOMATOSIS | TUMOR-SUPPRESSOR PROTEINS | AMINO-ACID SUFFICIENCY | GENE-PRODUCTS | tuberous sclerosis complex (TSC) | RAPAMYCIN ANALOG CCI-779 | Protein Kinases - metabolism | Protein Kinases - genetics | Ribosomal Protein S6 Kinases - metabolism | Humans | Molecular Sequence Data | Ras Homolog Enriched in Brain Protein | Insulin-Like Growth Factor I - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Tumor Suppressor Proteins - genetics | Neuropeptides - genetics | Genes, Tumor Suppressor | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Neuropeptides - metabolism | Monomeric GTP-Binding Proteins - genetics | Transcription Factors - genetics | Cell Growth Processes | Transcription Factors - metabolism | Insulin - metabolism | Sequence Alignment | Animals | Monomeric GTP-Binding Proteins - metabolism | Cell Cycle - physiology | Signal Transduction - physiology | TOR Serine-Threonine Kinases | Ribosomal Protein S6 Kinases - genetics | Insulin-Like Growth Factor I - metabolism
Journal Article
The EMBO Journal, ISSN 0261-4189, 12/2017, Volume 36, Issue 24, pp. 3650 - 3665
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2002, Volume 99, Issue 21, pp. 13571 - 13576
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 11/2019, Volume 9, Issue 1, pp. 1 - 14
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, p. e9199
The IGF/mTOR pathway, which is modulated by nutrients, growth factors, energy status and cellular stress regulates aging in various organisms. SIRT1 is a NAD+... 
NAD | MULTIDISCIPLINARY SCIENCES | DISEASE | DOWN-REGULATION | EXTENDS LIFE-SPAN | TOXICITY | MICE | CELL-GROWTH | SACCHAROMYCES-CEREVISIAE | MTOR | CALORIE RESTRICTION | Sirtuin 1 - metabolism | Immunoprecipitation | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Stilbenes - pharmacology | Sirtuin 1 - genetics | RNA Interference | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Jurkat Cells | Cells, Cultured | Antioxidants - pharmacology | Blotting, Western | Mice, Knockout | Animals | Signal Transduction - drug effects | Models, Biological | Fibroblasts - drug effects | Sirtuin 1 - physiology | Protein Binding | Signal Transduction - physiology | Fibroblasts - cytology | Mice | TOR Serine-Threonine Kinases | HeLa Cells | Niacinamide - pharmacology | Type 2 diabetes | Niacinamide | Rapamycin | Analysis | Resveratrol | NADPH | TOR protein | Phosphorylation | Tuberous Sclerosis Complex 2 | Yeast | Neuropathology | Cytotoxicity | Insulin-like growth factors | Kinases | TSC1 protein | Autophagy | Proteins | Dietary restrictions | Genotype & phenotype | Signal transduction | Cell growth | Rodents | Fibroblasts | Aging | Nutrients | Telomerase | Growth factors | Stresses | Insulin | SIRT1 protein | Stress | Energy balance | Signaling | Insects | Protein synthesis | Nicotinamide | Mutation | Alzheimers disease | Cellular stress response
Journal Article