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PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e15394
Autophagy is a highly orchestrated intracellular bulk degradation process that is activated by various environmental stresses. The serine/threonine kinase... 
COMPLEX | ACTIVATED PROTEIN-KINASE | METABOLISM | PHOSPHORYLATION | MACHINERY | BIOLOGY | INHIBITS CELL-GROWTH | INDUCTION | SACCHAROMYCES-CEREVISIAE | ATG13 | DEGENERATION | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Immunoprecipitation | Humans | Multiprotein Complexes | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy | Protein Subunits - metabolism | Autophagy-Related Protein-1 Homolog | Mechanistic Target of Rapamycin Complex 1 | Transfection | RNA Interference | HEK293 Cells | Regulatory-Associated Protein of mTOR | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | 14-3-3 Proteins - genetics | Protein Subunits - genetics | Cell Line | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Mice, Knockout | 14-3-3 Proteins - metabolism | Proteins - genetics | Animals | Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Protein Binding | Mice | TOR Serine-Threonine Kinases | Mutation | Adaptor Proteins, Signal Transducing - metabolism | AMP-Activated Protein Kinases - genetics | Microscopy, Fluorescence | TOR protein | Yeast | Homology | Kinases | Inactivation | Proteins | Cell growth | Cell cycle | Binding | Biodegradation | Deactivation | Threonine | Pharmacology | Metabolism | Mammals | Environmental stress | Medicine | TSC2 protein | 14-3-3 protein | Insects | Environmental degradation | Protein-serine/threonine kinase | Regulation | Phagocytosis | Cancer | Apoptosis
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 7/2018, Volume 75, Issue 14, pp. 2663 - 2680
Primary cilia are sensory organelles that coordinate multiple cellular signaling pathways, including Hedgehog (HH), Wingless/Int (WNT) and Transforming Growth... 
Biomedicine, general | Biochemistry, general | TSC | LC3b | Primary cilia | TGF-β signaling | WNT5a | Hedgehog signaling | Autophagy | Cell Biology | Life Sciences | Life Sciences, general | mTOR | GLI1 EXPRESSION | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | PROTEIN-COUPLED RECEPTORS | CELL-SIZE | CELL BIOLOGY | TSC1-TSC2 COMPLEX | TGF-beta signaling | GROWTH-FACTOR-BETA | MEDIATORS | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cells, Cultured | Gene Expression Regulation | Hedgehog Proteins - metabolism | Smoothened Receptor - metabolism | Smoothened Receptor - genetics | Cilia - metabolism | Mice, Knockout | Zinc Finger Protein Gli2 - metabolism | Animals | Tuberous Sclerosis Complex 2 Protein | Hedgehog Proteins - genetics | RNA Interference | Embryo, Mammalian - cytology | Tumor Suppressor Proteins - genetics | Tuberous Sclerosis Complex 1 Protein | Zinc Finger Protein Gli2 - genetics | Fibroblasts - metabolism | Tuberous sclerosis | Bone morphogenetic proteins | Protein biosynthesis | Molecular genetics | Transforming growth factors | TOR protein | Tuberous sclerosis 2 protein | Phosphorylation | Wnt protein | Transforming growth factor | Hamartin | Kinases | TSC1 protein | Proteins | Signal transduction | Smad2 protein | Fibroblasts | Elongation | Cilia | Phenotypes | Rapamycin | Embryo fibroblasts | Organelles | Embryos | TSC2 protein | Signaling | Protein synthesis | Hedgehog protein | Dismantling | Original
Journal Article
The EMBO Journal, ISSN 0261-4189, 12/2017, Volume 36, Issue 24, pp. 3650 - 3665
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2007, Volume 2, Issue 11, p. e1217
Journal Article
Human Genetics, ISSN 0340-6717, 9/2017, Volume 136, Issue 9, pp. 1143 - 1154
Changes in mRNA splice patterns have been associated with key pathological mechanisms in prostate cancer progression. The androgen receptor (abbreviated AR)... 
Human Genetics | Gene Function | Molecular Medicine | Biomedicine | Metabolic Diseases | ANDROGEN RECEPTOR | RE AR-V7 | SRPK1 INHIBITION | VARIANTS | GENETICS & HEREDITY | RESISTANCE | EXPRESSION | BINDING | ENZALUTAMIDE | ABIRATERONE | Prostatic Neoplasms - metabolism | RNA-Binding Proteins - genetics | Humans | Gene Expression Regulation, Neoplastic | Male | Serine-Arginine Splicing Factors - genetics | RNA, Neoplasm - metabolism | Prostatic Neoplasms - therapy | RNA-Binding Proteins - biosynthesis | RNA Splicing | Prostatic Neoplasms - genetics | Nerve Tissue Proteins - biosynthesis | Neoplasm Proteins - genetics | Neoplasm Proteins - biosynthesis | Protein-Serine-Threonine Kinases - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Protein-Serine-Threonine Kinases - biosynthesis | Serine-Arginine Splicing Factors - biosynthesis | Animals | Adaptor Proteins, Signal Transducing - genetics | RNA, Neoplasm - genetics | Adaptor Proteins, Signal Transducing - biosynthesis | Mice | DNA-Binding Proteins - biosynthesis | RNA, Messenger | Proteins | Androgens | Messenger RNA | Genes | Development and progression | Drug resistance | Prostate cancer | Protein kinases | Alternative splicing | Animal models | Invasiveness | Solitary tract nucleus | Kinases | Promoters | Pathology | TSC2 protein | Protein kinase | Isoforms | Fusion protein | Prostate | Steroid hormones | Tumors | Review
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2008, Volume 412, Issue 2, pp. 179 - 190
TSC1 and TSC2 are the tumour-suppressor genes mutated in the tumour syndrome TSC (tuberous sclerosis complex). Their gene products form a complex that has... 
Cell growth control | Tuberous sclerosis complex (TSC) | Mammalian target of rapamycin complex 1 (mTORC1) | Hamartin (TSC1) | Tuberin (TSC2) | Ras homologue enriched in brain (Rheb) | MAMMALIAN TARGET | RHEB GTPASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | hamartin (TSC1) | TSC2 GENE | cell growth control | P70 S6 KINASE | tuberin (TSC2) | TUBEROUS SCLEROSIS COMPLEX | mammalian target of rapamycin complex 1 (mTORC1) | PULMONARY LYMPHANGIOLEIOMYOMATOSIS | TUMOR-SUPPRESSOR PROTEINS | AMINO-ACID SUFFICIENCY | GENE-PRODUCTS | tuberous sclerosis complex (TSC) | RAPAMYCIN ANALOG CCI-779 | Protein Kinases - metabolism | Protein Kinases - genetics | Ribosomal Protein S6 Kinases - metabolism | Humans | Molecular Sequence Data | Ras Homolog Enriched in Brain Protein | Insulin-Like Growth Factor I - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Tumor Suppressor Proteins - genetics | Neuropeptides - genetics | Genes, Tumor Suppressor | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Neuropeptides - metabolism | Monomeric GTP-Binding Proteins - genetics | Transcription Factors - genetics | Cell Growth Processes | Transcription Factors - metabolism | Insulin - metabolism | Sequence Alignment | Animals | Monomeric GTP-Binding Proteins - metabolism | Cell Cycle - physiology | Signal Transduction - physiology | TOR Serine-Threonine Kinases | Ribosomal Protein S6 Kinases - genetics | Insulin-Like Growth Factor I - metabolism
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 2011, Volume 17, Issue 12, pp. 734 - 742
The mTOR signaling network functions as a pivotal regulatory cascade during the development of the cerebral cortex. Aberrant hyperactivation of mTOR as a... 
Pathology | MAMMALIAN TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | BALLOON CELLS | NEURONAL POLARIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCAL CORTICAL DYSPLASIAS | GIANT-CELLS | PROTEIN-SYNTHESIS | CELL BIOLOGY | TUBEROUS SCLEROSIS COMPLEX | MOUSE MODEL | GENE-EXPRESSION | RECEPTOR SUBUNIT | Autistic Disorder - pathology | Autistic Disorder - physiopathology | Autistic Disorder - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Multiprotein Complexes | Adaptor Proteins, Vesicular Transport - genetics | Cerebral Cortex - pathology | Epilepsy - metabolism | Epilepsy - physiopathology | Adaptor Proteins, Vesicular Transport - metabolism | Cerebral Cortex - metabolism | Cerebral Cortex - physiopathology | Mechanistic Target of Rapamycin Complex 1 | TOR Serine-Threonine Kinases - genetics | Tumor Suppressor Proteins - genetics | Malformations of Cortical Development - physiopathology | Cerebral Cortex - drug effects | Malformations of Cortical Development - drug therapy | Malformations of Cortical Development - pathology | Molecular Targeted Therapy - methods | Biomarkers - metabolism | PTEN Phosphohydrolase - genetics | Sirolimus - therapeutic use | Tumor Suppressor Proteins - metabolism | Malformations of Cortical Development - metabolism | PTEN Phosphohydrolase - metabolism | Signal Transduction - genetics | Proteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sirolimus - administration & dosage | Animals | Proteins - metabolism | Protein Kinase Inhibitors - therapeutic use | Epilepsy - drug therapy | Mice | Mutation | Autistic Disorder - drug therapy | Epilepsy - pathology | Proteins - antagonists & inhibitors | TOR protein | Brain | Signal transduction | TSC2 protein | Reviews | Epilepsy | biomarkers | Cortex | Point mutation | TSC1 protein | Age | PTEN protein
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2006, Volume 103, Issue 42, pp. 15552 - 15557
Journal Article