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European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2014, Volume 87, pp. 89 - 124
Journal Article
Journal of Natural Products, ISSN 0163-3864, 2019, Volume 82, Issue 4, pp. 840 - 849
A series of functionalized sesquiterpenoids derived from benzocyclooctene, including natural parvifoline (1), isoparvifoline (3), epoxyparvifoline (5),... 
SESQUITERPENES | PROVIDE | COLCHICINE BINDING-SITE | CHEMISTRY, MEDICINAL | ALPHA-TUBULIN | PHARMACOLOGY & PHARMACY | PLANT SCIENCES
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2018, Volume 28, Issue 18, pp. 3057 - 3063
A series of 4-phenylamino-substituted naphthalene-1,2-dione derivatives were prepared and evaluated as effective antiproliferative agents. MTT assays showed... 
Reactive oxygen species | Antitumor agents | Tubulin polymerization inhibitors | Mechanism | APOPTOSIS | MPC-6827 | CHEMISTRY, MEDICINAL | MICROTUBULES | HEALTH-CARE-SYSTEM | CHEMISTRY, ORGANIC | CANCER | TRIAL | GLIOBLASTOMA | CARBOXYLESTERASE | DRUGS | SELECTIVE INHIBITORS | Polymerization | Tubulins | Analysis
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2017, Volume 128, pp. 1 - 12
A series of C -tethered Indolyl-3-glyoxylamide derivatives were synthesized and evaluated for their cytotoxic activity against DU145 (prostate), PC-3... 
Indolyl-3-glyoxylamide | Anticancer | Tubulin polymerization inhibitor | Apoptosis | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 163, pp. 896 - 910
In current work, a class of novel 4,5-dihydro-1 -pyrazole-1-carboxylate derivatives ( ) were designed, synthesized and evaluated. Among them, the most potent... 
Mitotic catastrophe | Chemotherapy | Pharmacokinetics | Tubulin polymerization inhibitors | Xenograft tumors | CHEMISTRY, MEDICINAL | MICROTUBULE DYNAMICS | INSIGHT | CANCER | DISCOVERY | CELL-DEATH | RESISTANT | COLCHICINE | BIOLOGICAL EVALUATION | TUMOR-GROWTH | DERIVATIVES
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2018, Volume 61, Issue 4, pp. 1704 - 1718
We report the design, synthesis, and biological evaluation of heterocyclic-fused pyrimidines as tubulin polymerization inhibitors targeting the colchicine... 
CANCER-CELLS | METASTATIC MELANOMA | CHEMISTRY, MEDICINAL | TAXANE RESISTANCE | PACLITAXEL RESISTANCE | TUMOR-VASCULATURE | ANTICANCER AGENTS | VASCULAR-DISRUPTING AGENTS | MICROTUBULE DESTABILIZING AGENT | BIOLOGICAL EVALUATION | III BETA-TUBULIN
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2017, Volume 128, p. 1
A series of C.sub.5-tethered Indolyl-3-glyoxylamide derivatives were synthesized and evaluated for their in vitro cytotoxic activity against DU145 (prostate),... 
Polymerization | Tubulins | Superoxide
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2013, Volume 56, Issue 1, pp. 123 - 149
Journal Article