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Journal Article
Science, ISSN 0036-8075, 02/2018, Volume 359, Issue 6375, pp. 582 - 587
CD8(+) T cell-dependent killing of cancer cells requires efficient presentation of tumor antigens by human leukocyte antigen class I (HLA-I) molecules.... 
HIV-1 | METASTATIC MELANOMA | CTLA-4 BLOCKADE | THERAPY | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | MUTATIONAL LANDSCAPE | RESISTANCE | IDENTIFICATION | HISTOCOMPATIBILITY ANTIGENS | MOLECULES | Immunotherapy - methods | Humans | Middle Aged | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Young Adult | Cancer Vaccines - therapeutic use | Antigen Presentation | Melanoma - genetics | Skin Neoplasms - mortality | Adult | Skin Neoplasms - immunology | Skin Neoplasms - therapy | Antigens, Neoplasm - immunology | Treatment Outcome | Histocompatibility Antigens Class I - genetics | Histocompatibility Antigens Class I - chemistry | Cancer Vaccines - immunology | Melanoma - immunology | Skin Neoplasms - genetics | Protein Conformation | Aged | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Melanoma - therapy | Genetic Carrier Screening | Cohort Studies | Melanoma - mortality | Care and treatment | Histocompatibility antigens | Immunotherapy | HLA histocompatibility antigens | Genotype | Genetic aspects | Health aspects | Cancer | Peptides | CD8 antigen | Genes | Molecular dynamics | Cytotoxicity | Lymphocytes T | Vaccines | Homozygosity | Cancer vaccines | Cell recognition | Genotype & phenotype | Lymphocytes | Genotypes | Immune system | Antigen presentation | Antigens | Melanoma | Epitopes | Patients | Survival | Loci | Heterozygosity | White blood cells | Immune checkpoint | Cell death | Antigen (tumor-associated) | Loss of heterozygosity | Histocompatibility antigen HLA | Mutation | Recognition | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 43, pp. 18599 - 18604
Most antigenic peptides presented by MHC class I molecules result from the degradation of intracellular proteins by the proteasome. In lymphoid tissues and... 
T lymphocytes | Antigens | Dendritic cells | HEK293 cells | Liver | Melanoma | Cell lines | Antibodies | Cellular immunity | Tumors | MAGE | Antigenic peptide | Tumor antigen | Immunoproteasome | Antigen processing | immunoproteasome | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | CYTOLYTIC T-LYMPHOCYTES | antigenic peptide | SUBUNIT COMPOSITION | CLEAVAGE | 20S PROTEASOME | tumor antigen | ANGSTROM RESOLUTION | GENERATION | antigen processing | STANDARD PROTEASOME | TUMOR-ASSOCIATED ANTIGEN | Recombinant Proteins - metabolism | Amino Acid Sequence | Antigens, Neoplasm - genetics | Protein Subunits | Humans | Molecular Sequence Data | Proteasome Endopeptidase Complex - chemistry | Recombinant Proteins - genetics | Neoplasm Proteins - metabolism | Mice, Knockout | Histocompatibility Antigens Class I - metabolism | Proteasome Endopeptidase Complex - genetics | Sequence Homology, Amino Acid | Animals | Antigen Presentation | Recombinant Proteins - immunology | Antigens, Neoplasm - metabolism | Cell Line, Tumor | Mice | Proteasome Endopeptidase Complex - metabolism | Neoplasm Proteins - genetics | Proteasome Endopeptidase Complex - classification | Research | Ubiquitin-proteasome system | Properties | Tumor antigens | Methods | Immunological research | CD8 antigen | Tumor cells | proteasomes | Lymphocytes T | Lymphoid tissue | Small intestine | Kidney | Major histocompatibility complex | Antigen (tumor-associated) | Histocompatibility antigen HLA | Colon | Catalytic subunits | Biological Sciences
Journal Article
Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 48, pp. 8802 - 8826
Journal Article
The International journal of biological markers, ISSN 0393-6155, 1986
Journal
Cancer Research, ISSN 0008-5472, 12/2017, Volume 77, Issue 24, pp. 7049 - 7058
T cell-based immunotherapies are a promising approach for patients with advanced cancers. However, various obstacles limit T-cell efficacy, including... 
RECRUITMENT | MECHANISMS | THERAPY | ONCOLOGY | MACROPHAGES | Neoplasms - metabolism | Recombinant Fusion Proteins - immunology | Recombinant Fusion Proteins - pharmacology | Dendritic Cells - immunology | Humans | Neoplasms - genetics | Myeloid Differentiation Factor 88 - immunology | CD8-Positive T-Lymphocytes - metabolism | Dendritic Cells - drug effects | Cytotoxicity, Immunologic - drug effects | Dendritic Cells - metabolism | Immune Tolerance - drug effects | Cytotoxicity, Immunologic - genetics | Antigens, Neoplasm - immunology | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Gene Expression Regulation, Neoplastic - immunology | Mice, Transgenic | Antigen Presentation - immunology | CD8-Positive T-Lymphocytes - physiology | CD8 Antigens - immunology | Animals | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | CD8 Antigens - genetics | Immune Tolerance - genetics | Recombinant Fusion Proteins - genetics | Antigen Presentation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Cell proliferation | CD8 antigen | Activation | Lymphocytes T | Macrophages | Immunity | Metastases | Anticancer properties | Proteins | T-cell receptor | Cell activation | Lymphocytes | Toll-like receptors | Fusion protein | Immune system | Antigen presentation | Antigens | T cell receptors | Costimulator | Signaling | Immunosuppression | Immunogenicity | Exhaustion | Antigen (tumor-associated) | MyD88 protein | Antitumor activity | Infiltration | Histocompatibility antigen HLA | Tumors | Cancer
Journal Article
Autoimmunity Reviews, ISSN 1568-9972, 2016, Volume 15, Issue 5, pp. 477 - 483
Journal Article
Leukemia, ISSN 0887-6924, 08/2014, Volume 29, Issue 3, pp. 647 - 659
Identification of physiologically relevant peptide vaccine targets calls for the direct analysis of the entirety of naturally presented human leukocyte antigen... 
MULTIPLE-MYELOMA | COMPLETE REMISSION | TUMOR REJECTION | ONCOLOGY | WT1 PEPTIDE | IFN-GAMMA | VACCINATION | STEM-CELL TRANSPLANTATION | HEMATOLOGY | MYELODYSPLASTIC SYNDROME | CANCER | CYTOTOXIC T-LYMPHOCYTES | CD8-Positive T-Lymphocytes - pathology | Immunoprecipitation | Humans | Neoplasm Proteins - immunology | Peptides - genetics | Molecular Sequence Data | Epitopes, T-Lymphocyte - genetics | Leukemia, Myeloid, Acute - immunology | CD4-Positive T-Lymphocytes - pathology | Case-Control Studies | CD4-Positive T-Lymphocytes - immunology | Cancer Vaccines - genetics | Peptide Mapping | Mass Spectrometry | CD8-Positive T-Lymphocytes - metabolism | Immunotherapy, Active - methods | Epitopes, T-Lymphocyte - immunology | Neoplasm Proteins - genetics | Leukemia, Myeloid, Acute - therapy | Amino Acid Sequence | Gene Expression | Peptides - chemistry | Leukemia, Myeloid, Acute - pathology | Cancer Vaccines - administration & dosage | Peptides - immunology | CD4-Positive T-Lymphocytes - metabolism | Histocompatibility Antigens Class I - immunology | Histocompatibility Antigens Class I - genetics | Histocompatibility Antigens Class II - chemistry | Histocompatibility Antigens Class I - chemistry | Epitopes, T-Lymphocyte - chemistry | Cancer Vaccines - immunology | Histocompatibility Antigens Class II - immunology | Ligands | Histocompatibility Antigens Class II - genetics | CD8-Positive T-Lymphocytes - immunology | Leukemia, Myeloid, Acute - genetics | Chromosome mapping | Histocompatibility antigens | Immunotherapy | Innovations | HLA histocompatibility antigens | Genetic aspects | Methods | Target recognition | Peptides | CD8 antigen | Leukemia | Lymphocytes T | Mapping | Vaccines | Leukocytes | Cell recognition | Epitope mapping | Enzyme-linked immunosorbent assay | Antigens | Myeloid leukemia | Mass spectroscopy | Peptide mapping | CD4 antigen | Antigen (tumor-associated) | γ-Interferon | Histocompatibility antigen HLA | Interferon | Mass spectrometry | Acute myeloid leukemia | Tumors
Journal Article
Immunity, ISSN 1074-7613, 10/2019, Volume 51, Issue 4, pp. 766 - 779.e17
Increasing evidence indicates CD4+ T cells can recognize cancer-specific antigens and control tumor growth. However, it remains difficult to predict the... 
neoantigen | phagocytosis | epitope prediction | autophagy | proteomics | MHC | antigen | SILAC | machine learning | peptide processing | RNA-Seq | HLA ligandomics | HLA class II | mass spectrometry | HLA-II | cancer | isotope labeling | UBIQUITINATION | CELLS | COMPLEX | PEPTIDES | MELANOMA | IMMUNOTHERAPY | QUANTIFICATION | DEGRADATION | INVARIANT CHAIN | IMMUNOLOGY | MOLECULES | Immunotherapy - methods | Datasets as Topic | Antigens, Neoplasm - immunology | Humans | HLA Antigens - genetics | HLA Antigens - metabolism | Antigen-Presenting Cells - immunology | CD4-Positive T-Lymphocytes - immunology | Cancer Vaccines - immunology | Neoplasms - therapy | Algorithms | Antigen Presentation | Neoplasms - immunology | Protein Interaction Domains and Motifs - genetics | Alleles | HLA-D Antigens - metabolism | Antigens, Neoplasm - metabolism | Protein Binding | Epitope Mapping - methods | Software | Histocompatibility Antigens Class II - genetics | Mass Spectrometry - methods | Binding | Antigen presentation | Antigens | Peptides | Mass spectroscopy | Lymphocytes T | Leukocytes | Manuscripts | CD4 antigen | Adenomatous polyposis coli | Datasets | Lymphocytes | Antigen-presenting cells | Immunotherapy | Antigen (tumor-associated) | Predictions | Ligands | Scientific imaging | Histocompatibility antigen HLA | Mass spectrometry | Cancer | Tumors
Journal Article