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Cancer Immunology, Immunotherapy, ISSN 0340-7004, 4/2014, Volume 63, Issue 4, pp. 395 - 406
The programmed death-1 (PD-1) molecule is mainly expressed on functionally “exhausted” CD8+ T cells, dampening the host antitumor immune response. We evaluated... 
Immunology | Medicine & Public Health | Oncology | Cancer Research | Breast cancer | Immune evasion | Regulatory T cells | Cancer immunotherapy | PD-1 | APOPTOSIS | PROGNOSIS | TUMOR | RISK | ANTIBODY | IMMUNOLOGY | CHEMOTHERAPY | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | IMMUNOTHERAPY | CD8(+) T-LYMPHOCYTES | B7-H1 | Carcinoma, Lobular - pathology | Follow-Up Studies | Breast Neoplasms - immunology | Humans | Middle Aged | Programmed Cell Death 1 Receptor - analysis | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Antigens, Differentiation, T-Lymphocyte - analysis | Aged, 80 and over | Carcinoma, Ductal, Breast - pathology | Lymphocytes, Tumor-Infiltrating - chemistry | T-Lymphocytes, Regulatory - chemistry | Carcinoma, Lobular - immunology | CD8-Positive T-Lymphocytes - chemistry | Combined Modality Therapy | Carcinoma, Lobular - radiotherapy | T-Lymphocyte Subsets - pathology | Carcinoma, Ductal, Breast - radiotherapy | Forkhead Transcription Factors - analysis | Survival Analysis | CD8-Positive T-Lymphocytes - immunology | Lymphocytes, Tumor-Infiltrating - immunology | T-Lymphocyte Subsets - immunology | Breast Neoplasms - surgery | CD8-Positive T-Lymphocytes - pathology | Prognosis | Carcinoma, Ductal, Breast - immunology | Carcinoma, Ductal, Breast - mortality | Carcinoma, Lobular - mortality | T-Lymphocytes, Cytotoxic - pathology | T-Lymphocyte Subsets - chemistry | Mastectomy | Adult | Female | Radiotherapy, Adjuvant | T-Lymphocytes, Cytotoxic - immunology | Carcinoma, Ductal, Breast - surgery | Carcinoma, Lobular - surgery | Kaplan-Meier Estimate | Disease-Free Survival | Breast Neoplasms - radiotherapy | T-Lymphocytes, Cytotoxic - chemistry | Apoptosis - immunology | Lymphocytes, Tumor-Infiltrating - pathology | Breast Neoplasms - pathology | Lymphocyte Count | Breast Neoplasms - mortality | Aged | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 02/2011, Volume 71, Issue 4, pp. 1263 - 1271
The tumor microenvironment includes a complex network of immune T-cell subpopulations. In this study, we systematically analyzed the balance between cytotoxic... 
BREAST-CANCER | SURVIVAL | LUNG-CANCER | FOXP3 EXPRESSION | RECRUITMENT | ONCOLOGY | GASTRIC-CANCER | EOSINOPHILS | MACROPHAGES | CARCINOMA | LYMPHOCYTES | Th1 Cells - pathology | Th1 Cells - physiology | Prognosis | Th2 Cells - physiology | Tissue Array Analysis | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma - mortality | Gene Expression Profiling | Th2 Cells - immunology | Th1 Cells - immunology | Colorectal Neoplasms - diagnosis | Lymphocytes, Tumor-Infiltrating - physiology | T-Lymphocytes, Cytotoxic - pathology | Th1 Cells - metabolism | Th17 Cells - metabolism | Forkhead Transcription Factors - metabolism | Microarray Analysis | T-Lymphocytes, Helper-Inducer - immunology | Lymphocytes, Tumor-Infiltrating - metabolism | T-Lymphocytes, Helper-Inducer - pathology | Interleukin-4 - genetics | Th2 Cells - pathology | Th17 Cells - pathology | Colorectal Neoplasms - mortality | T-Lymphocytes, Cytotoxic - immunology | Th17 Cells - physiology | T-Lymphocytes, Helper-Inducer - metabolism | Carcinoma - immunology | Interleukin-4 - metabolism | Carcinoma - diagnosis | Forkhead Transcription Factors - genetics | Th2 Cells - metabolism | T-Lymphocytes, Cytotoxic - physiology | T-Lymphocytes, Helper-Inducer - physiology | Colorectal Neoplasms - immunology | Lymphocytes, Tumor-Infiltrating - pathology | T-Lymphocytes, Cytotoxic - metabolism | Survival Analysis | Th17 Cells - immunology | Carcinoma - genetics | Cohort Studies | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus
Journal Article
European Journal of Immunology, ISSN 0014-2980, 07/2016, Volume 46, Issue 7, pp. 1770 - 1782
We previously demonstrated an accumulation of tumor‐reactive CD4 + CD8 + double positive (DP) T cells within melanoma‐infiltrating lymphocytes, supporting... 
CD4 | double‐positive T lymphocyte | CD8 | TIL | Melanoma | IL‐9R | IL‐9 | IL-9R | double-positive T lymphocyte | IL-9 | TH9 CELLS | CD8(+) | INDUCED APOPTOSIS | INTERLEUKIN-9 | RECEPTOR | PERIPHERAL-BLOOD | IMMUNOLOGY | CYTOKINE EXPRESSION | IN-VIVO | CD4(+) CD8(+) double-positive T lymphocyte | GROWTH-FACTOR | LYMPHOCYTES | T-Lymphocyte Subsets - immunology | Apoptosis - drug effects | Humans | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Interleukin-9 - pharmacology | Melanoma - genetics | T-Lymphocyte Subsets - drug effects | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Cytotoxicity, Immunologic - drug effects | Melanoma - metabolism | Receptors, Interleukin-9 - metabolism | Gene Expression | Cytokines - metabolism | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | Cell Survival - immunology | Apoptosis - immunology | Receptors, Interleukin-9 - genetics | Lymphocyte Activation - drug effects | Melanoma - immunology | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - immunology | Interleukin-9 - immunology | CD4-Positive T-Lymphocytes - drug effects | Lymphocytes, Tumor-Infiltrating - immunology | Parrots | T cells | Tumors | Index Medicus | Life Sciences | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 06/2013, Volume 73, Issue 12, pp. 3591 - 3603
Tumor progression is facilitated by regulatory T cells (Treg) and restricted by effector T cells. In this study, we document parallel regulation of CD8(+) T... 
DISTINCT MECHANISMS | ONCOLOGY | PROGRAMMED DEATH-1 | IMMUNE ESCAPE | MYELOID-LEUKEMIA | SYNGENEIC MOUSE MODEL | REGULATORY T | GROWTH-FACTOR | CHRONIC VIRAL-INFECTION | ANTITUMOR-ACTIVITY | HUMAN OVARIAN-CANCER | T-Lymphocytes, Regulatory - metabolism | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antibodies, Blocking - pharmacology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Neoplasms, Experimental - pathology | Flow Cytometry | T-Lymphocytes - metabolism | Neoplasms, Experimental - immunology | CD8-Positive T-Lymphocytes - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Cytokines - immunology | Cytokines - metabolism | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Neoplasms, Experimental - therapy | CTLA-4 Antigen - metabolism | Lymphocytes, Tumor-Infiltrating - transplantation | Programmed Cell Death 1 Receptor - metabolism | Combined Modality Therapy | CTLA-4 Antigen - immunology | B7-H1 Antigen - immunology | Cancer Vaccines - immunology | B7-H1 Antigen - metabolism | Animals | Antibodies, Blocking - immunology | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Lymphocytes, Tumor-Infiltrating - immunology | Tumor Burden - immunology | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2015, Volume 194, Issue 7, pp. 3475 - 3486
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2011, Volume 108, Issue 26, pp. 10656 - 10661
Journal Article
Pancreas, ISSN 0885-3177, 01/2004, Volume 28, Issue 1, pp. e26 - 31
Journal Article
British Journal of Cancer, ISSN 0007-0920, 04/2015, Volume 112, Issue 9, pp. 1501 - 1509
Journal Article
Journal Article