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2009, 1. Aufl., ISBN 0387896104, xiv, 296
.... Although the existence of 'stem-like' cells in cancer was hypothesized more than 150 years ago, recent discoveries have the potential to revolutionize cancer therapy... 
Stem Cell Transplantation | adverse effects | Teratoma | therapy | Neoplasms | etiology | Clinical & internal medicine | Cancer cells | Treatment | Etiology | Stem cells | Cancer
Book
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 3, p. e57020
.... Therapy resistance of a tumor is thought to be related to cancer stem cells (CSCs) within the tumors. There have been indications that the lung cancer is propagated and maintained by a small population of CSCs... 
EPITHELIAL-MESENCHYMAL TRANSITION | TRANSFORMATION | THERAPY | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | GROWTH | HMGA2 | MICE | CARCINOMA | PROGRESSION | TUMOR-INITIATING CELLS | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Cadherins - metabolism | Vimentin - metabolism | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Homeodomain Proteins - metabolism | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Antigens, CD - genetics | Antigens, CD - metabolism | Octamer Transcription Factor-3 - genetics | Small Cell Lung Carcinoma - metabolism | Adenocarcinoma - metabolism | Neoplastic Stem Cells - metabolism | Vimentin - genetics | Thy-1 Antigens - genetics | Hyaluronan Receptors - metabolism | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Adenocarcinoma - genetics | Carcinoma, Large Cell - genetics | Cadherins - genetics | Lung Neoplasms - genetics | Carcinoma, Large Cell - metabolism | Nanog Homeobox Protein | Immunophenotyping | Small Cell Lung Carcinoma - genetics | Mice, SCID | Hyaluronan Receptors - genetics | Homeodomain Proteins - genetics | Thy-1 Antigens - metabolism | Small Cell Lung Carcinoma - pathology | Animals | Octamer Transcription Factor-3 - metabolism | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Primary Cell Culture | Care and treatment | Analysis | Stem cells | Cancer cells | Physiological aspects | Research | Cancer | Adenocarcinoma | Vimentin | Cell culture | Therapy | Biotechnology | Thoracic surgery | Mesenchyme | Oct-4 protein | Lung cancer | Radiation | Population studies | Identification | Biology | mRNA | Metastasis | Cancer therapies | CD90 antigen | N-Cadherin | Immunology | CD44 antigen | Population | Medical research | Squamous cell carcinoma | Hematology | Small cell lung carcinoma | Cell division | Tumor cell lines | Gene expression | Cadherin | Spheroids | Morbidity | Medicine | Pathology | Lungs | Medical prognosis | Pancreatic cancer | Irradiation | Prostate | Tumors
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 2016, Volume 34, Issue 8, pp. 2026 - 2039
.... These efforts largely focus on activating antitumor immune responses but are confounded by multiple immune cell populations, including myeloid... 
Macrophage migration inhibitory factor | Tumor microenvironment | Immunotherapy | Glioblastoma | MIF | Cancer stem cells | Myeloid‐derived suppressor cells | Tumor immune suppression | Myeloid-derived suppressor cells | GLIOMA | SELF-RENEWAL | RECEPTOR | TUMOR-INITIATING CELLS | BRAIN-TUMORS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | IN-VITRO | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GROWTH | HEMATOLOGY | PROMOTES | PROGRESSION | Tumor Microenvironment - drug effects | Cell Survival - drug effects | Neoplastic Stem Cells - secretion | Neoplastic Stem Cells - drug effects | Humans | Mice, Inbred C57BL | Arginase - metabolism | Brain Neoplasms - pathology | Culture Media, Conditioned - pharmacology | Myeloid-Derived Suppressor Cells - drug effects | Macrophage Migration-Inhibitory Factors - secretion | Carcinogenesis - metabolism | Carcinogenesis - pathology | Animals | Brain Neoplasms - immunology | Glioblastoma - immunology | Mice, Nude | Glioblastoma - pathology | Immune Evasion - drug effects | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Female | Myeloid-Derived Suppressor Cells - metabolism | Analysis | Stem cells | T cells | Macrophages | Glioblastoma multiforme | Cancer | Cell proliferation | Populations | Leukocyte migration | Syngeneic grafts | Brain tumors | Stem cell transplantation | Cytotoxicity | Arginase | Lymphocytes T | Suppressor cells | Bearing | Rodents | Mathematical models | Immune system | Proximity | Cell survival | Immune response | Tumor cells | CXCR2 protein | Patients | Survival | Rejection | Depletion | Glioma | Migration inhibitory factor | Antitumor activity | Cell migration
Journal Article
Cancer Letters, ISSN 0304-3835, 2015, Volume 368, Issue 1, pp. 54 - 63
Highlights • NK cells ability to target osteosarcoma cells and the pathways involved were studied... 
Hematology, Oncology and Palliative Medicine | Natural killer cells | Immunotherapy | Osteosarcoma tumor initiating cells | NKG2D–NKG2DL interactions | NKG2D-NKG2DL interactions | RECEPTOR | MULTIPLE-MYELOMA CELLS | CANCER STEM-CELLS | THERAPY | NK CELLS | ONCOLOGY | LEUKEMIA-CELLS | PROGNOSTIC-SIGNIFICANCE | CYTOTOXICITY | NKG2D LIGAND EXPRESSION | T-CELLS | Cell Proliferation | Bone Neoplasms - therapy | Neoplastic Stem Cells - drug effects | Coculture Techniques | Humans | NK Cell Lectin-Like Receptor Subfamily K - immunology | Neoplastic Stem Cells - immunology | Bone Neoplasms - pathology | Bone Neoplasms - metabolism | Spironolactone - pharmacology | NK Cell Lectin-Like Receptor Subfamily K - metabolism | Neoplastic Stem Cells - metabolism | Time Factors | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Osteosarcoma - metabolism | Immunotherapy, Adoptive - methods | Signal Transduction | Lymphocyte Activation | Killer Cells, Lymphokine-Activated - metabolism | Cell Communication | Bone Neoplasms - immunology | Mice, SCID | Killer Cells, Lymphokine-Activated - transplantation | Killer Cells, Lymphokine-Activated - immunology | Osteosarcoma - immunology | Animals | Cell Line, Tumor | Ligands | Mice, Inbred NOD | Osteosarcoma - therapy | Osteosarcoma - pathology | Cytotoxicity, Immunologic | Osteosarcoma | Killer cells | Tumors | Chemotherapy | Analysis | Stem cells | Metastasis | Protein binding | Cancer
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 10, p. e77053
.... GBMs contain cells with molecular and cellular characteristics of neural stem cells that drive tumour growth... 
CANCER-CELLS | SOLID TUMORS | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | HUMAN GLIOMAS | IMAGE-BASED SCREENS | CENTRAL-NERVOUS-SYSTEM | BRAIN-BARRIER MODEL | ADHERENT CULTURE | PHASE-I | TUMOR-INITIATING CELLS | Small Molecule Libraries - pharmacology | Glioblastoma - enzymology | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | Glioblastoma - genetics | Swine | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Neoplastic Stem Cells - pathology | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | Drug Screening Assays, Antitumor - methods | Cell Cycle Proteins - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Protein-Serine-Threonine Kinases - genetics | Brain Neoplasms - genetics | Thiophenes - pharmacology | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Tumor Suppressor Protein p53 - deficiency | Blood-Brain Barrier - drug effects | Neural Stem Cells - enzymology | Neural Stem Cells - pathology | Blotting, Western | Blood-Brain Barrier - metabolism | Mice, Knockout | Animals | Cell Cycle Checkpoints - drug effects | Glioblastoma - pathology | Cell Line, Tumor | Benzimidazoles - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Neoplastic Stem Cells - enzymology | Indans - pharmacology | Viral antibodies | Polo | Brain tumors | Stem cells | Antibodies | Tumor proteins | Glioblastoma multiforme | Neuroimaging | Image processing | Polo-like kinase 1 | Laboratories | p53 Protein | Brain cancer | Glioblastoma | Childrens health | Membrane permeability | Stem cell transplantation | Kinases | Cancer therapies | Defects | Allografts | Blood-brain barrier | Clonal deletion | DNA methylation | Polo-like kinase | Cyclin-dependent kinase inhibitors | Pharmaceutical industry | Bioinformatics | Pharmaceutical sciences | Medical research | Antibody microarrays | INK4 protein | Permeability | Gene expression | Medical screening | Endothelial cells | Image analysis | Sensitivity | Brain research | Inhibitors | Neural stem cells | Adults | Mutation | Molecular biology | Human behavior | Tumors | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 2, p. e16951
The cancer stem cell (CSC) theory predicts that a small fraction of cancer cells possess unique self-renewal activity and mediate tumor initiation and propagation... 
PROGENITOR CELLS | AML | SIDE POPULATION | MICROENVIRONMENT | PROSPECTIVE IDENTIFICATION | GROWTH | KINASE | BIOLOGY | RESISTANCE | ACUTE MYELOID-LEUKEMIA | TUMOR-INITIATING CELLS | RNA, Small Interfering - genetics | Side-Population Cells - enzymology | Adenocarcinoma - pathology | Cell Proliferation | Humans | rac1 GTP-Binding Protein - deficiency | Lung Neoplasms - pathology | Guanosine Triphosphate - metabolism | Cell Movement - genetics | Gene Knockdown Techniques | Lung - enzymology | Neoplasm Metastasis | Neoplastic Stem Cells - metabolism | Side-Population Cells - metabolism | Neoplastic Stem Cells - pathology | Adenocarcinoma - genetics | Lung - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Cell Adhesion - genetics | Lung - pathology | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | Neoplasm Invasiveness | Adenocarcinoma - enzymology | Side-Population Cells - pathology | Animals | Cell Line, Tumor | Mice | Carcinoma, Non-Small-Cell Lung - enzymology | Neoplastic Stem Cells - enzymology | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics | Adenocarcinoma | Care and treatment | Metastasis | Health aspects | Stem cells | Cancer | Cell proliferation | GTP | Leukocyte migration | Leukemia | Brain cancer | Lung cancer | Colorectal cancer | Kinases | Drug resistance | Cancer therapies | Experiments | Metastases | Liver cancer | Cell cycle | Population | Growth factors | Cytokines | Hematology | Developmental biology | Melanoma | Non-small cell lung carcinoma | Rac1 protein | Pharmacology | Radiation therapy | Gene expression | Children & youth | Chemotherapy | Molecular modelling | Lungs | Colonization | Binding sites | Cell migration | Guanosinetriphosphatase | Apoptosis | Tumors
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 2012, Volume 30, Issue 10, pp. 2100 - 2113
Although the concept of cancer stem cells (CSCs) is well‐accepted for many tumors, the existence of such cells in human melanoma has been the subject of debate... 
Molecular targeted therapy | Cancer stem cells | Aldehyde dehydrogenase | Melanoma | Tumor‐initiating cells | Microarray analysis | Tumor-initiating cells | INITIATING CELLS | PHASE-II | IDENTIFICATION | CHEMOTHERAPY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | BREAST-CANCER | METASTATIC MELANOMA | LUNG-CANCER | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | FUNCTIONAL MARKER | ALDEHYDE DEHYDROGENASE-ACTIVITY | HEMATOLOGY | CD133 | Neoplasm Transplantation | RNA, Small Interfering - genetics | Tretinoin - chemistry | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Aldehyde Dehydrogenase - antagonists & inhibitors | Humans | Melanoma - enzymology | Skin Neoplasms - enzymology | Cell Transformation, Neoplastic - genetics | Dacarbazine - pharmacology | Melanoma - genetics | Dacarbazine - analogs & derivatives | Aldehyde Oxidoreductases | Neoplastic Stem Cells - pathology | Female | Gene Expression Regulation, Neoplastic - drug effects | Tretinoin - pharmacology | Skin Neoplasms - pathology | Response Elements | Isoenzymes - genetics | Gene Silencing | Aldehyde Dehydrogenase - genetics | Melanoma - pathology | Mice, SCID | Animals | Skin Neoplasms - genetics | Mice, Inbred NOD | Mice | Cell Transformation, Neoplastic - drug effects | Neoplastic Stem Cells - enzymology | Isoenzymes - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Molecular genetics | Isoenzymes | Genes | Immunodeficiency | Information management | Aldehydes | Anopheles | Chemotherapy | Cell death | Analysis | Stem cells | Health aspects | Tretinoin | Tumors | Cancer | Medical research | Cell cycle | melanoma | molecular targeted therapy | microarray analysis | cancer stem cells | tumor initiating cells | aldehyde dehydrogenase
Journal Article