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Biogerontology, ISSN 1389-5729, 2013, Volume 14, Issue 3, pp. 303 - 323
During ageing skeletal muscles undergo a process of structural and functional remodelling that leads to sarcopenia, a syndrome characterized by loss of muscle... 
Life Sciences | Sarcopenia | FoxO | Geriatrics/Gerontology | Ageing | mTOR | IGF1 | Akt | Developmental Biology | Cell Biology | LIFE-SPAN | IGF-I | ALPHA-V-BETA-3 INTEGRIN | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | GERIATRICS & GERONTOLOGY | GROWTH-HORMONE | MESSENGER-RNA | GENETIC-DETERMINANTS | FAST-TWITCH | CELL-CYCLE | S6 KINASE | Microtubule-Associated Proteins - genetics | SKP Cullin F-Box Protein Ligases - genetics | Humans | SKP Cullin F-Box Protein Ligases - physiology | Male | Forkhead Transcription Factors - physiology | Ubiquitin-Protein Ligases - physiology | Tripartite Motif Proteins | Young Adult | Aged, 80 and over | Adult | Female | Mice, Inbred DBA | Models, Animal | TOR Serine-Threonine Kinases - physiology | Muscle Proteins - physiology | Serpin E2 - physiology | Mice, Inbred C57BL | Mice, Transgenic | Proto-Oncogene Proteins c-akt - physiology | Muscle, Skeletal - physiology | Mice, Knockout | Microtubule-Associated Proteins - physiology | Muscle Proteins - genetics | Autophagy-Related Protein 7 | Sarcopenia - physiopathology | Serpin E2 - genetics | Animals | Aging - physiology | Insulin-Like Growth Factor I - physiology | Adolescent | Signal Transduction - physiology | Aged | Forkhead Box Protein O1 | Mice | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Muscles | Ligases | Proteolysis | Analysis | SKP Cullin F-Box Protein Ligases | Muscle Proteins | Aging | Serpin E2 | Signal Transduction | Biochemistry, Molecular Biology | Microtubule-Associated Proteins | Insulin-Like Growth Factor I | Proto-Oncogene Proteins c-akt | Ubiquitin-Protein Ligases | TOR Serine-Threonine Kinases | Muscle, Skeletal | Forkhead Transcription Factors | Clinical Medicine | Neurology | Neurologi | Medical and Health Sciences | Medicin och hälsovetenskap | Clinical Neurophysiology | Klinisk neurofysiologi | Klinisk medicin
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, pp. e0164951 - e0164951
Background Disuse muscle atrophy is a major comorbidity in patients with chronic diseases including cancer. We sought to explore the kinetics of molecular... 
MORTALITY | CANCER CACHEXIA | OXIDATIVE STRESS | SKELETAL TROPONIN-I | ATROPHY | MITOCHONDRIAL | MULTIDISCIPLINARY SCIENCES | AUTOPHAGY | DISUSE | UBIQUITIN-PROTEASOME | PROTEIN-SYNTHESIS | Muscular Atrophy - metabolism | Mice, Inbred C57BL | Mitochondria, Muscle - metabolism | Muscle, Skeletal - metabolism | Immobilization - adverse effects | Animals | Muscular Atrophy - physiopathology | Time Factors | DNA - analysis | Proteolysis | Muscle, Skeletal - chemistry | Muscle, Skeletal - physiopathology | Mitochondria, Muscle - physiology | Troponin I - analysis | Female | Mice | Muscle, Skeletal - pathology | Chronic Disease | Real-Time Polymerase Chain Reaction | Disease Models, Animal | Muscle Strength - physiology | Ubiquitin | Exercise | Comorbidity | Analysis | Myosin | Chronic diseases | Physical activity | Lung cancer | Immobilization | Mitochondrial DNA | Proteins | Mitochondria | Alterations | Chronic obstructive pulmonary disease | Grip strength | Heart failure | Tyrosine | Medical research | Contractility | Exposure | Gene expression | Patients | Diseases | Injury prevention | Hospitals | Molecular modelling | Troponin I | Protein synthesis | Respiratory diseases | Proteasomes | Kinetics | Morphometry | Oxidative stress | Biomedical research | Biosynthesis | Atrophy | Rodents | Calcium-binding protein | Gastrocnemius muscle | Malnutrition | Chronic illnesses | Phenotypes | Invasiveness | Muscles | Unloading | Muscle contraction | Regeneration | Musculoskeletal system | Troponin | Plastics | Cancer | Index Medicus | Malalties cròniques | Músculs
Journal Article
STEM CELLS, ISSN 1066-5099, 07/2017, Volume 35, Issue 7, pp. 1815 - 1834
Recently, we found that resident myogenic stem satellite cells upregulate a multi‐functional secreted protein, semaphorin 3A (Sema3A), exclusively at the... 
Regeneration | Muscle endurance | Myogenin | Resident myogenic stem satellite cells | Slow‐twitch myofiber | Semaphorin 3A | Slow-twitch myofiber | HEPATOCYTE GROWTH-FACTOR | POSSIBLE MECHANISM | STRETCH-INDUCED ACTIVATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | MUSCLE SATELLITE CELLS | ONCOLOGY | NEURAL CHEMOREPELLENT SEMA3A | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | NITRIC-OXIDE | FIBER-TYPE | GENE-EXPRESSION | PROLIFERATION IN-VITRO | HEMATOLOGY | NORMAL SKELETAL-MUSCLE | Neuropilin-2 - metabolism | RNA, Small Interfering - genetics | MEF2 Transcription Factors - genetics | Myosin Heavy Chains - genetics | Male | Muscle, Skeletal - metabolism | Muscle Fibers, Slow-Twitch - metabolism | Muscle, Skeletal - injuries | Myogenin - genetics | Muscle Fibers, Slow-Twitch - drug effects | Semaphorin-3A - metabolism | Myosin Heavy Chains - metabolism | Myoblasts - drug effects | Myoblasts - metabolism | Regeneration - genetics | Muscle, Skeletal - drug effects | Neuropilin-2 - genetics | Myoblasts - cytology | Cell Differentiation | Semaphorin-3A - antagonists & inhibitors | Semaphorin-3A - genetics | Signal Transduction | Satellite Cells, Skeletal Muscle - secretion | Mice, Inbred C57BL | Satellite Cells, Skeletal Muscle - cytology | Gene Expression Regulation | Receptors, Cell Surface - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Satellite Cells, Skeletal Muscle - drug effects | Regeneration - drug effects | Animals | Tamoxifen - pharmacology | MEF2 Transcription Factors - metabolism | Mice | Primary Cell Culture | Myogenin - metabolism | Cardiotoxins - administration & dosage | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | RNA | Stem cells | Myosin | Physiological aspects | Muscles | Disease susceptibility | Muscle proteins | Energy metabolism | Stem cell transplantation | Satellite cells | Signal transduction | Transfection | Fatigue strength | Rodents | Aging | Physiology | Endurance | Gastrocnemius muscle | Active satellites | Contractility | Fatigue | Cultures | siRNA | Injection | Metabolism | Tamoxifen | Ribonucleic acid--RNA | Muscle contraction | Skeletal muscle | Semaphorins | Cells (biology) | Differentiation | Index Medicus
Journal Article