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Journal Article
Cancer Cell, ISSN 1535-6108, 04/2015, Volume 27, Issue 4, pp. 516 - 532
Journal Article
Nature, ISSN 0028-0836, 09/2012, Volume 489, Issue 7414, pp. 155 - 159
The identification of somatic activating mutations in JAK2 (refs 1-4) and in the thrombopoietin receptor gene (MPL)(5) in most patients with myeloproliferative... 
MYELOFIBROSIS | LUNG-CANCER | POLYCYTHEMIA-VERA | GEFITINIB | MYELOPROLIFERATIVE DISORDERS | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | MUTATION | RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Myeloproliferative Disorders - enzymology | Phosphorylation | Protein Biosynthesis | Humans | Protein Multimerization | STAT Transcription Factors - metabolism | TYK2 Kinase - metabolism | Janus Kinase 1 - deficiency | TYK2 Kinase - deficiency | Myeloproliferative Disorders - pathology | Janus Kinase 1 - biosynthesis | Gene Knockdown Techniques | Janus Kinase 2 - deficiency | Janus Kinase 1 - metabolism | Granulocytes - drug effects | RNA Interference | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Myeloproliferative Disorders - metabolism | Granulocytes - metabolism | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Cell Line | Janus Kinase 2 - genetics | Myeloproliferative Disorders - drug therapy | Enzyme Activation - drug effects | TYK2 Kinase - biosynthesis | Granulocytes - enzymology | Animals | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Mice | TYK2 Kinase - genetics | Drug Resistance, Neoplasm - drug effects | Enzyme inhibitors | Gene mutations | Cancer cells | Dosage and administration | Genetic aspects | Cellular signal transduction | Identification and classification | Physiological aspects | Care and treatment | Research | Myeloproliferative disorders | Cancer | Index Medicus | tyrosine kinase inhibitors | persistence | MPN | JAK2 | resistance
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 02/2013, Volume 52, Issue 2, pp. 155 - 166
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is involved in immune function and cell growth. We evaluated... 
cigarette smoking | STAT | estrogen | JAK | colon cancer | NSAIDs | rectal cancer | SOCS | Colon cancer | Rectal cancer | Estrogen | Cigarette smoking | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | RISK | ENERGY-BALANCE | INHIBITION | ONCOLOGY | JANUS KINASES | COLORECTAL-CANCER | INFLAMMATION | PHYSICAL-ACTIVITY | Smoking - adverse effects | Colonic Neoplasms - genetics | Receptors, Estrogen - metabolism | Colorectal Neoplasms - genetics | Humans | Middle Aged | STAT Transcription Factors - metabolism | STAT4 Transcription Factor - metabolism | TYK2 Kinase - metabolism | Suppressor of Cytokine Signaling 1 Protein | Male | Janus Kinases - metabolism | Interferon-gamma - metabolism | Case-Control Studies | Colonic Neoplasms - metabolism | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | Rectal Neoplasms - genetics | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Adult | Female | Interferon-gamma - genetics | Interleukin-6 - metabolism | Colorectal Neoplasms - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Colonic Neoplasms - mortality | Genetic Predisposition to Disease | Interleukin-6 - genetics | Janus Kinases - genetics | Signal Transduction | Janus Kinase 2 - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Survival Rate | STAT1 Transcription Factor - genetics | Rectal Neoplasms - mortality | STAT Transcription Factors - genetics | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | STAT4 Transcription Factor - genetics | Aged | Polymorphism, Single Nucleotide | Rectal Neoplasms - metabolism | Suppressor of Cytokine Signaling Proteins - metabolism | TYK2 Kinase - genetics | Aspirin | Analysis | Oncology, Experimental | Research | Public health | Smoking | Cancer | Genetic diversity | Kinases | Risk factors | Colorectal cancer | Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 03/2019, Volume 33, Issue 3, pp. 696 - 709
TYK2 is a member of the JAK family of tyrosine kinases that is involved in chromosomal translocation-induced fusion proteins found in anaplastic large cell... 
NPM-ALK | ACTIVATION | FUSION | CYTOKINE RESPONSES | GENE | ONCOLOGY | STAT1 | TYROSINE KINASE | T-CELL | TYK2 | HEMATOLOGY | EXPRESSION | Apoptosis - drug effects | Humans | Cell Survival - genetics | Apoptosis - genetics | Translocation, Genetic - drug effects | Anaplastic Lymphoma Kinase - genetics | Phosphorylation - genetics | Protein-Tyrosine Kinases - genetics | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | Lymphoma, Large-Cell, Anaplastic - genetics | Cell Survival - drug effects | Signal Transduction - genetics | STAT1 Transcription Factor - genetics | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Animals | Signal Transduction - drug effects | Lymphoma, Large-Cell, Anaplastic - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | TYK2 Kinase - genetics | Translocation, Genetic - genetics | Non-Hodgkin's lymphomas | Research | Drug therapy | Gene expression | Tyk2 protein | Phosphorylation | Interleukin 22 | Kinases | Proteins | Receptors | Cell activation | Dependence | Autocrine signalling | Stat1 protein | Protein-tyrosine kinase | Tyrosine | Translocation | Cell survival | Stat3 protein | Survival | Lymphoma | Mcl-1 protein | Inhibitors | Cell lines | Interleukin 10 | Lymphomas | Anaplastic large-cell lymphoma | Tumors | Apoptosis | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2014, Volume 193, Issue 7, pp. 3278 - 3287
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2015, Volume 195, Issue 10, pp. 5011 - 5024
Journal Article
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 2005, Volume 76, Issue 3, pp. 528 - 537
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 10/2011, Volume 7, Issue 10, pp. e1002341 - e1002341
Journal Article