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Nature, ISSN 0028-0836, 05/2009, Volume 459, Issue 7245, pp. 433 - 436
Fungal infections represent a serious threat, particularly in immunocompromised patients. Interleukin-1 (IL-1 ) is a key pro-inflammatory factor in innate... 
RHEUMATOID-ARTHRITIS | CELLS | ACTIVATION | CANDIDA-ALBICANS | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | INNATE IMMUNE-RESPONSE | RECEPTOR | MICE | INHIBITOR | NALP3 INFLAMMASOME | Potassium - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Humans | Caspase 1 - metabolism | Monocytes - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Protein-Tyrosine Kinases - deficiency | Intracellular Signaling Peptides and Proteins - deficiency | Protein-Tyrosine Kinases - genetics | Candida albicans - physiology | Interleukin-1beta - biosynthesis | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | Signal Transduction | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Interleukin-1beta - immunology | Inflammation - immunology | Candida albicans - immunology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Mice | Nigericin - pharmacology | Enzyme Activation | Protein-Tyrosine Kinases - antagonists & inhibitors | Mycoses | Research | Properties | Phosphotransferases | Cellular control mechanisms | Proteins | Studies | Fungi | E coli | Research & development--R&D | Clinical trials | Pattern recognition | Kinases | Cells
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2019, Volume 294, Issue 19, pp. 7658 - 7668
Journal Article
Immunity, ISSN 1074-7613, 2012, Volume 36, Issue 1, pp. 32 - 42
C-type lectin receptors (CLRs) that couple with the kinase Syk are major pattern recognition receptors for the activation of innate immunity and host defense.... 
CELLS | RESPONSES | ACTIVATION | CANDIDA-ALBICANS | PATTERN-RECOGNITION RECEPTOR | TYROSINE KINASE | HOST-DEFENSE | DECTIN-2 | IMMUNOLOGY | T-LYMPHOCYTES | FUNGAL-INFECTIONS
Journal Article
European Journal of Immunology, ISSN 0014-2980, 2008, Volume 38, Issue 2, pp. 500 - 506
Journal Article
Immunity, ISSN 1074-7613, 04/2017, Volume 46, Issue 4, pp. 635 - 648
Mice carrying a hypomorphic point mutation in the gene ( mice) develop an inflammatory skin disease that resembles neutrophilic dermatosis in humans. Here, we... 
myeloid cells | SYK | RIPK3 | MLKL | autoinflammation | Ptpn6 | IL-1β | IL-1α | MyD88 | SHP1 | TAK1 | necrosis | RIPK1 | MOTH-EATEN MICE | SIGNALING PATHWAYS | STERILE INFLAMMATION | GENE | APOPTOTIC CELL-DEATH | PHOSPHATASE | IN-VIVO | IMMUNOLOGY | SHP-1 | NF-KAPPA-B | AUTOINFLAMMATORY DISEASE | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Phosphorylation | Interleukin-1alpha - immunology | Skin Diseases - genetics | Humans | Immunoblotting | Interleukin-1alpha - metabolism | Syk Kinase - immunology | Signal Transduction - immunology | Inflammation - metabolism | Flow Cytometry | Syk Kinase - genetics | HEK293 Cells | Myeloid Differentiation Factor 88 - immunology | Interleukin-1alpha - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Skin Diseases - metabolism | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | Myeloid Differentiation Factor 88 - genetics | Skin Diseases - immunology | Inflammation - immunology | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Models, Immunological | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Syk Kinase - metabolism | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Inflammation - genetics | Mutation | Myeloid Differentiation Factor 88 - metabolism | Disease | SHP-1 protein | Crosstalk | Interleukin | Licenses | Interleukin 1 receptors | Kinases | Phosphatase | Inflammatory diseases | Proteins | Coding | Rodents | Interleukin 1 | Post-translation | Bone marrow | Skin diseases | Tumor necrosis factor-TNF | Protein-tyrosine kinase | Activation analysis | Immune system | Tyrosine | TAK1 protein | Neutrophils | Leukocytes (neutrophilic) | Inflammation | Roles | Scaffolding | Point mutation | MyD88 protein | Syk protein
Journal Article
Journal of Immunology, ISSN 0022-1767, 2013, Volume 191, Issue 3, pp. 1287 - 1299
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 09/2019, Volume 294, Issue 36, pp. 13378 - 13395
Spleen tyrosine kinase (SYK) plays a major role in inflammation and in adaptive immune responses and could therefore contribute to the neuroinflammation... 
MAMMALIAN TARGET | tauopathy | autophagy | MICROGLIAL ACTIVATION | PROTEIN | Tau degradation | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MTOR PATHWAY | mammalian target of rapamycin (mTOR) | spleen tyrosine kinase (Syk) | S6K | Akt PKB | INSOLUBLE TAU | INHIBITION | Tau protein (Tau) | MOUSE MODEL | Tg Tau P301S | Alzheimer's disease | LC3 | STRESS GRANULES
Journal Article
Immunity, ISSN 1074-7613, 11/2008, Volume 29, Issue 5, pp. 807 - 818
Journal Article