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Kidney International, ISSN 0085-2538, 2014, Volume 85, Issue 2, pp. 393 - 403
Journal Article
Journal Article
Journal Article
Journal Article
Blood, ISSN 0006-4971, 06/2011, Volume 117, Issue 22, pp. 5941 - 5952
The mechanisms by which sphingosine kinase-1 (SK-1)/sphingosine 1-phosphate (S1P) activation contributes to imatinib resistance in chronic myeloid leukemia... 
CHRONIC MYELOGENOUS LEUKEMIA | CANCER-CELLS | GENE | ABL TYROSINE KINASE | BCR-ABL | SPHINGOSINE-1-PHOSPHATE | MECHANISMS | INHIBITOR STI571 | HEMATOLOGY | IMATINIB-INDUCED APOPTOSIS | CHRONIC MYELOID-LEUKEMIA | Piperazines - administration & dosage | Lysophospholipids - metabolism | RNA, Small Interfering - genetics | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Drug Resistance, Neoplasm | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Ubiquitination | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Receptors, Lysosphingolipid - genetics | Sphingosine - metabolism | Phosphorylation - drug effects | Receptors, Lysosphingolipid - metabolism | Fusion Proteins, bcr-abl - chemistry | Signal Transduction | Pyrimidines - administration & dosage | Protein Phosphatase 2 - genetics | Phosphotransferases (Alcohol Group Acceptor) - genetics | Mice, SCID | Imatinib Mesylate | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Fusion Proteins, bcr-abl - genetics | Sphingosine - analogs & derivatives | Animals | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Benzamides | Fusion Proteins, bcr-abl - metabolism | Myeloid Neoplasia
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 06/2004, Volume 64, Issue 12, pp. 4309 - 4318
The blockade of Akt activation through the inhibition of 3-phosphoinositide-dependent kinase-1 (PDK-1) represents a major signaling mechanism whereby celecoxib... 
PHOSPHOINOSITIDE 3-KINASE PATHWAY | SURVIVAL | APOPTOSIS | ABL-POSITIVE CELLS | SIGNALING PATHWAYS | ACTIVATION | ONCOLOGY | PHOSPHORYLATION | TYROSINE KINASE | ANTICANCER AGENTS | PROSTATE-CANCER CELLS
Journal Article
Journal Article