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Clinical Science, ISSN 0143-5221, 10/2017, Volume 131, Issue 20, pp. 2489 - 2501
Cardiovascular disease (CVD) is the most prevalent cause of mortality among patients with type 1 or type 2 diabetes, due to accelerated atherosclerosis. Recent... 
MEDICINE, RESEARCH & EXPERIMENTAL | OBESITY | PTP1B | HIGH-FAT DIET | INFLAMMATION | ENDOTHELIAL-CELLS | HEART-FAILURE | MACROPHAGE | GENE DELETION | KNOCKOUT MICE | INSULIN SENSITIVITY | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Atherosclerosis - genetics | Cholesterol - blood | Homeostasis | Male | Enzyme Inhibitors - administration & dosage | Atherosclerosis - enzymology | Time Factors | Diet, High-Fat | Receptors, LDL - deficiency | Aortic Diseases - prevention & control | Aortic Diseases - enzymology | Chemokine CCL2 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Aorta - enzymology | Spermine - analogs & derivatives | Aortic Diseases - pathology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Genetic Predisposition to Disease | Drug Administration Schedule | Spermine - administration & dosage | Aorta - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Biomarkers - blood | Plaque, Atherosclerotic | Mice, Knockout | Aorta - pathology | Blood Glucose - drug effects | Aortic Diseases - genetics | Phenotype | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Animals | Signal Transduction - drug effects | Weight Loss | Triglycerides - blood | Cholestanes - administration & dosage | Blood Glucose - metabolism | Atherosclerosis - prevention & control
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 11/2013, Volume 49, Issue 5, pp. 721 - 730
Protein phosphatase-2A (PP2A) is a primary serine-threonine phosphatase that modulates inflammatory responses in asthma and chronic obstructive pulmonary... 
Phosphorylation | Inflammation | Oxidation | Kinase | PROTEIN PHOSPHATASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | oxidation | INNATE IMMUNE | CERAMIDE | CELL BIOLOGY | kinase | OBSTRUCTIVE PULMONARY-DISEASE | inflammation | RESPIRATORY SYSTEM | EMPHYSEMA | CIGARETTE-SMOKE | MICE | phosphorylation | EXPRESSION | LUNG INFLAMMATION | Smoking - adverse effects | Oxidative Stress | Humans | Pneumonia - pathology | Pneumonia - prevention & control | Pulmonary Disease, Chronic Obstructive - pathology | Pulmonary Alveoli - enzymology | Case-Control Studies | Gene Knockdown Techniques | Respiratory Mucosa - pathology | Transfection | RNA Interference | Mice, Inbred CBA | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Glutathione Peroxidase - deficiency | Pneumonia - genetics | Cell Line | Glutathione Peroxidase - metabolism | Pneumonia - etiology | Pulmonary Alveoli - pathology | Oxidation-Reduction | Signal Transduction | Pneumonia - enzymology | Mice, Inbred C57BL | Respiratory Mucosa - enzymology | Pulmonary Emphysema - pathology | Glutathione Peroxidase - genetics | Mice, Knockout | Pulmonary Disease, Chronic Obstructive - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Animals | Protein Phosphatase 2 - metabolism | Protein Binding | Mice | Enzyme Activation | Pulmonary Emphysema - enzymology
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 02/2018, Volume 26, Issue 3, pp. 737 - 746
displayed significant inhibition against protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase, both of which are key target enzymes to attenuate diabetes... 
Cratoxylum cochinchinense | Protein tyrosine phosphatase 1B | α-Glucosidase | Alkylated xanthones | CHEMISTRY, MEDICINAL | BARK | BIOCHEMISTRY & MOLECULAR BIOLOGY | GERANYLATED FLAVONOIDS | CHEMISTRY, ORGANIC | PRENYLATED XANTHONES | GLYCOSYLATION | STEMS | alpha-Glucosidase | DERIVATIVES | CONSTITUENTS
Journal Article
Journal Article
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2015, Volume 63, Issue 12, pp. 998 - 1014
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 08/2017, Volume 65, Issue 30, pp. 6211 - 6221
The polyphenolic profiles of four berries (blueberry, bilberry, mulberry, and cranberry) in China were investigated using Fourier transform-ion cyclotron... 
α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitors | molecular docking | anthocyanins | berries | antioxidant capacity | HPLC-FT-ICR MS/MS | ANTIOXIDANT ACTIVITY | BIOACTIVE COMPOUNDS | CELLS IN-VITRO | PHENOLIC-COMPOUNDS | FOOD SCIENCE & TECHNOLOGY | HPLC FT-ICR MS/MS | alpha-glycosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitors | BLUEBERRY | RED RASPBERRY | CHEMICAL-COMPOSITION | AGRICULTURE, MULTIDISCIPLINARY | CHROMATOGRAPHY-MASS SPECTROMETRY | CHEMISTRY, APPLIED | EXTRACTS | VACCINIUM-ULIGINOSUM BERRY | Plant Extracts - chemistry | Anthocyanins - isolation & purification | Fruit - chemistry | Humans | Blueberry Plants - chemistry | Glycoside Hydrolase Inhibitors - isolation & purification | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Plant Extracts - isolation & purification | Chromatography, High Pressure Liquid | Glycoside Hydrolase Inhibitors - chemistry | Anthocyanins - chemistry | Enzyme Inhibitors - isolation & purification | Vaccinium myrtillus - chemistry | Tandem Mass Spectrometry | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Enzyme Inhibitors - chemistry | Molecular Docking Simulation | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry | alpha-Glucosidases - metabolism | Morus - chemistry | alpha-Glucosidases - chemistry
Journal Article
Bioscience, Biotechnology, and Biochemistry, ISSN 0916-8451, 08/2011, Volume 75, Issue 8, pp. 1472 - 1480
The present work investigates protein tyrosine phosphatase 1B (PTP1B) and the α-glucosidase inhibitory activities of two edible brown algae, Ecklonia... 
α-glucosidase | protein tyrosine phosphatase 1B | phlorotannin | Ecklonia stolonifera | Eisenia bicyclis | Phlorotannin | Protein tyrosine phosphatase 1B | ANTIOXIDANT ACTIVITY | DIECKOL | METABOLITES | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | alpha-glucosidase | IN-VITRO | PHLOROFUCOFUROECKOL | PTP1B | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INSULIN-RESISTANCE | CAVA | ALLEVIATES POSTPRANDIAL HYPERGLYCEMIA | CHEMISTRY, APPLIED | CONSTITUENTS | Diabetes Mellitus - enzymology | Glycoside Hydrolase Inhibitors | Yeasts | Humans | Dioxins - pharmacology | Benzofurans - pharmacology | Tannins - chemistry | Phloroglucinol - chemistry | Hyperglycemia - drug therapy | Benzofurans - chemistry | Dioxins - chemistry | Complex Mixtures - pharmacology | Solutions | Enzyme Inhibitors - chemistry | Phloroglucinol - pharmacology | Hyperglycemia - physiopathology | Blood Glucose - analysis | Magnetic Resonance Spectroscopy | Diabetes Mellitus - drug therapy | Enzyme Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Complex Mixtures - chemistry | Hypoglycemic Agents - chemistry | Phaeophyta - chemistry | Hypoglycemic Agents - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Tannins - pharmacology | Diabetes Mellitus - physiopathology | Hyperglycemia - enzymology | Kinetics | Spectrophotometry | alpha-Glucosidases - metabolism
Journal Article
by Zhang, YX and Li, Q and Youn, JY and Cai, H
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 01/2017, Volume 292, Issue 2, pp. 407 - 416
Journal Article
Nature Genetics, ISSN 1061-4036, 03/2007, Volume 39, Issue 3, pp. 338 - 346
Journal Article
Journal Article