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Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPAMYCIN | RAPTOR | BINDING PARTNER | RAG GTPASES | RHEB | PATHWAY | TOR | MULTIDISCIPLINARY SCIENCES | CELL-GROWTH | P70 S6 KINASE | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure
Journal Article
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 06/2015, Volume 1851, Issue 6, pp. 746 - 758
Polyphosphoinositides (PPIn) are an important family of phospholipids located on the cytoplasmic leaflet of eukaryotic cell membranes. Collectively, they are... 
Membrane | Phosphoinositide | PH-domain | Fluorescence imaging | PX-domain | Phospholipase C | PROTEIN-KINASE-B | PLECKSTRIN-HOMOLOGY-DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIGH-AFFINITY BINDING | PLASMA-MEMBRANE | CELL BIOLOGY | BRUTONS TYROSINE KINASE | BIOPHYSICS | BABY HAMSTER-KIDNEY | PHOSPHATIDYLINOSITOL 4-PHOSPHATE | IN-VIVO | PHOSPHATIDIC-ACID | Adaptor Proteins, Signal Transducing - chemistry | Tacrolimus Binding Proteins - chemistry | Phosphatidylinositols - analysis | Humans | Type C Phospholipases - metabolism | Molecular Imaging | Green Fluorescent Proteins - genetics | Tacrolimus Binding Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Cell Membrane - chemistry | Molecular Probes - metabolism | Guanine Nucleotide Exchange Factors - metabolism | Phosphatidylinositols - metabolism | Cell Membrane - metabolism | Green Fluorescent Proteins - chemistry | Protein Structure, Tertiary | Green Fluorescent Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Recombinant Fusion Proteins - chemistry | Type C Phospholipases - chemistry | Tacrolimus Binding Proteins - genetics | Molecular Probes - chemistry | Animals | Adaptor Proteins, Signal Transducing - genetics | Biosensing Techniques | Protein Binding | Recombinant Fusion Proteins - genetics | Type C Phospholipases - genetics | Adaptor Proteins, Signal Transducing - metabolism | Guanine Nucleotide Exchange Factors - chemistry | Physiological aspects | Cellular proteins | Lipids | Inositol | Biological products | Cells
Journal Article
Protein Science, ISSN 0961-8368, 02/2018, Volume 27, Issue 2, pp. 546 - 560
Increased efforts have been undertaken to better understand the formation of signaling complexes at cellular membranes. Since the preparation of proteins... 
Saccharomyces cerevisiae Proteins/chemistry | Molecular Biology | Humans | Tacrolimus Binding Proteins/chemistry | protein membrane anchoring | Biochemistry | Journal Article | membrane mimetic | protein–membrane interactions | Micelles | Nuclear Magnetic Resonance, Biomolecular | Protein Domains | Phosphatidylinositol 3-Kinases/chemistry | Liposomes/metabolism | Recombinant Fusion Proteins/chemistry | Circular Dichroism | protein–lipid interactions | Models, Molecular | Molecular Dynamics Simulation | Research Support, Non-U.S. Gov't | Cell Membrane/metabolism | Protein Conformation | Mutation | NMR spectroscopy | Saccharomyces cerevisiae/chemistry | MAMMALIAN TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | PIK-RELATED KINASES | BINDING DOMAIN | SUBCELLULAR-LOCALIZATION | protein-membrane interactions | protein-lipid interactions | CD SPECTROSCOPY | NMR | CONFORMATIONAL-CHANGES | AMINO-ACIDS | LIPID-BINDING | PHOSPHATIDIC-ACID | Tacrolimus Binding Proteins - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Phosphatidylinositol 3-Kinases - metabolism | Tacrolimus Binding Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Saccharomyces cerevisiae - chemistry | Tacrolimus Binding Proteins - genetics | Phosphatidylinositol 3-Kinases - genetics | Saccharomyces cerevisiae - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Recombinant Fusion Proteins - genetics | Liposomes - metabolism | Cell Membrane - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Case studies | Nuclear magnetic resonance spectroscopy | Usage | Protein binding | TOR protein | Membranes | Salts | Yeast | Peptides | Data processing | Reducing agents | Rapamycin | Sodium chloride | pH effects | Calcium chloride | Magnetic resonance spectroscopy | Signaling | Tacrolimus-binding protein | Spectrum analysis | Titration | Liposomes | Localization | Chemical synthesis | Anchoring | Methods and Applications
Journal Article
AAPS PharmSciTech, ISSN 1530-9932, 10/2016, Volume 17, Issue 5, pp. 1075 - 1085
The most successful treatment strategy for arthritis is intra-articular injections that are costly and have reduced patient compliance. The purpose of the... 
Biochemistry, general | alginate | Biotechnology | chitosan | topical | Biomedicine | inflammation | Pharmacy | hyaluronan | drug delivery | Pharmacology/Toxicology | dodecyl- l -pyroglutamate | dodecyl-l-pyroglutamate | ACID | HUMAN SKIN | SURFACTANTS | SIZE | dodecyl-L-pyroglutamate | NANOPARTICLES | NANOLIPID CARRIER APPLICATION | PHARMACOLOGY & PHARMACY | RADICALS | TACROLIMUS | Polyelectrolytes - chemistry | Chemistry, Pharmaceutical - methods | Nanoparticles - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Pyrrolidonecarboxylic Acid - analogs & derivatives | Indomethacin - administration & dosage | Drug Carriers - chemistry | Membranes - metabolism | Cellulose - chemistry | Inflammation - drug therapy | Gels - chemistry | Glucuronic Acid - chemistry | Pyrrolidonecarboxylic Acid - chemistry | Gels - administration & dosage | Hyaluronic Acid - chemistry | Hexuronic Acids - chemistry | Permeability | Particle Size | Chitosan - chemistry | Alginates - chemistry | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Arthritis - drug therapy | Drug Liberation | Indomethacin - chemistry | Nanoparticles - administration & dosage | Administration, Topical | Drug Delivery Systems - methods | Surface active agents | Analysis | Cellulose | Antiarthritic agents | Polyelectrolytes | Arthritis | Inflammation | Hyaluronic acid | Patient compliance | Transdermal medication
Journal Article
International journal of pharmaceutical compounding, ISSN 1092-4221, 11/2018, Volume 22, Issue 6, p. 516
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 08/2012, Volume 161, Issue 3, pp. 735 - 745
The objective of the present study was to investigate the effect of polyarginine chain length on topical delivery of surface modified NLCs. Design of... 
Nanostructured lipid carriers (NLC) | Cell penetrating peptide (CPP) | Polyarginine peptide | Skin delivery | Allergic contact dermatitis (ACD) | DRUG-DELIVERY | CHITOSAN CROSS-LINKING | TRANSDERMAL DELIVERY | MEFLOQUINE HYDROCHLORIDE MICROPARTICLES | CELL-PENETRATING PEPTIDES | TACROLIMUS OINTMENT | CHEMISTRY, MULTIDISCIPLINARY | DERMAL DELIVERY | PHARMACOLOGY & PHARMACY | H-II MESOPHASES | SUBSTANCE-P | SPANTIDE-II | Nanoparticles - chemistry | Drug Carriers - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Drug Carriers - chemistry | Peptides - administration & dosage | Ketoprofen - chemistry | Allergens - administration & dosage | Lipids - chemistry | Rats, Hairless | Skin Absorption - drug effects | Substance P - analogs & derivatives | Oligopeptides - chemistry | Cell-Penetrating Peptides - chemistry | Dermatitis, Allergic Contact - drug therapy | Peptides - chemistry | Mice, Inbred C57BL | Ketoprofen - administration & dosage | Rats | Lipids - administration & dosage | Dinitrofluorobenzene - administration & dosage | Animals | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Mice | Nanoparticles - administration & dosage | Oligopeptides - administration & dosage | Cell-Penetrating Peptides - administration & dosage | Administration, Topical | Substance P - chemistry | Substance P - administration & dosage | Usage | Peptides | Dermatology | Analysis | Formulae, receipts, prescriptions | Dermatologic agents | Skin | Raman spectroscopy | Transdermal medication | polyarginine peptide | cell penetrating peptide (CPP) | nanostructured lipid carriers (NLC) | allergic contact dermatitis (ACD)
Journal Article
Journal Article
Nature Chemistry, ISSN 1755-4330, 03/2019, Volume 11, Issue 3, pp. 254 - 263
Journal Article