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Cell Death and Differentiation, ISSN 1350-9047, 11/2010, Volume 17, Issue 11, pp. 1785 - 1794
Journal Article
SCIENCE, ISSN 0036-8075, 09/2017, Volume 357, Issue 6357, pp. 1255 - 1255
Mitochondrial and lysosomal dysfunction have been implicated in substantia nigra dopaminergic neurodegeneration in Parkinson's disease (PD), but how these... 
GLUCOCEREBROSIDASE | PACEMAKING | DJ-1 | ALPHA-SYNUCLEIN | SUBSTANTIA-NIGRA | MULTIDISCIPLINARY SCIENCES | Mitochondria - enzymology | Mesencephalon - metabolism | Humans | Protein Deglycase DJ-1 - genetics | Substantia Nigra - metabolism | Melanins - metabolism | Glucosylceramidase - deficiency | Lysosomes - metabolism | Dopaminergic Neurons - metabolism | Tacrolimus - pharmacology | Parkinson Disease - metabolism | Dopamine - metabolism | Disease Models, Animal | Substantia Nigra - enzymology | Cell Line | Calcineurin Inhibitors - pharmacology | Oxidation-Reduction | Mesencephalon - enzymology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Parkinson Disease - genetics | Mice, Knockout | Animals | Parkinson Disease - enzymology | Mice | Oxidative Stress - drug effects | alpha-Synuclein - metabolism | Oxidation-reduction reaction | Development and progression | Mitochondria | Dopamine | Parkinson's disease | Health aspects | Brain | Energy metabolism | Animal models | Target recognition | Mesencephalon | Pathogenesis | Substantia nigra | Parkinsons disease | Lysosomes | Synuclein | Accumulation | Pathways | Enzymatic activity | Neurodegeneration | Rodents | Oxidation | Degeneration | Species | Movement disorders | Dopamine receptors | Neurodegenerative diseases | Neurons | Medical treatment | Metabolism | Patients | Glucosylceramidase | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPAMYCIN | RAPTOR | BINDING PARTNER | RAG GTPASES | RHEB | PATHWAY | TOR | MULTIDISCIPLINARY SCIENCES | CELL-GROWTH | P70 S6 KINASE | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure
Journal Article
Genes and Development, ISSN 0890-9369, 04/2001, Volume 15, Issue 7, pp. 807 - 826
MESSENGER-RNA TRANSLATION | CAP-DEPENDENT INITIATION | TOR-SIGNALING PATHWAY | FACTOR 4E-BINDING PROTEIN-1 | DEVELOPMENTAL BIOLOGY | PROTEIN PHOSPHATASE 2A | PEPTIDYL-PROLYL ISOMERASE | P70 S6 KINASE | CELL BIOLOGY | CIS-TRANS ISOMERASE | GENETICS & HEREDITY | PANCREATIC BETA-CELLS | CYTOSOLIC-BINDING-PROTEIN | Protein Kinases - genetics | Protein-Serine-Threonine Kinases | Eukaryotic Cells - metabolism | Neoplasm Proteins - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Saccharomyces cerevisiae - metabolism | Eukaryotic Initiation Factors | Phosphorylation - drug effects | Chromones - pharmacology | Binding Sites | Mammals - metabolism | Enzyme Inhibitors - pharmacology | Insect Proteins - genetics | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Cell Division - physiology | Peptide Initiation Factors - metabolism | Protein Kinase Inhibitors | Signal Transduction - drug effects | Saccharomyces cerevisiae Proteins | Protein Biosynthesis - drug effects | Mice | TOR Serine-Threonine Kinases | Mammals - genetics | Species Specificity | Saccharomyces cerevisiae - genetics | Phosphoprotein Phosphatases - metabolism | Protein Biosynthesis - physiology | Protein Kinases - chemistry | Structure-Activity Relationship | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | PTEN Phosphohydrolase | Protein Processing, Post-Translational - drug effects | Antineoplastic Agents - pharmacology | Energy Metabolism - genetics | Insect Proteins - metabolism | Cell Division - genetics | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Drosophila Proteins | Insulin - pharmacology | Peptide Fragments - metabolism | RNA, Messenger - genetics | Gene Expression Regulation - physiology | Morpholines - pharmacology | Phosphotransferases (Alcohol Group Acceptor) - genetics | Sirolimus - pharmacology | Macromolecular Substances | Gene Expression Regulation - drug effects | Proto-Oncogene Proteins c-akt | Animals | Carrier Proteins - metabolism | Eukaryotic Cells - drug effects | Eukaryotic Initiation Factor-4G | Androstadienes - pharmacology | Protein Kinases - physiology | Tacrolimus Binding Protein 1A - metabolism | Phosphatidylinositol 3-Kinases - physiology | Phosphoric Monoester Hydrolases - metabolism | Tumor Suppressor Proteins | Fungal Proteins - metabolism | Cytochemistry | Cellular signal transduction | Research
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 01/2013, Volume 365, Issue 2, pp. 260 - 269
► We study CsA, tacrolimus and rapamycin effects on human adipose tissue lipid metabolism. ► Immunosuppressive agents enhance lipolysis and inhibit lipid... 
Lipid storage | Rapamycin | Cyclosporin A | Adipocytes | Tacrolimus | Lipolysis | HORMONE-SENSITIVE LIPASE | FATTY-ACID-METABOLISM | RENAL-TRANSPLANT RECIPIENTS | CELL BIOLOGY | ENDOCRINE ORGAN | IN-VITRO | ADIPOCYTE LIPOLYSIS | MTOR INHIBITION | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | PERILIPIN-A | GLUCOSE-UPTAKE | Tumor Necrosis Factor-alpha - metabolism | Lipolysis - drug effects | Gene Expression - drug effects | TOR Serine-Threonine Kinases - metabolism | Cyclosporine - pharmacology | Humans | Middle Aged | Sterol Esterase - metabolism | Tumor Necrosis Factor-alpha - genetics | Male | Intra-Abdominal Fat - cytology | Adipocytes - drug effects | Phosphoproteins - metabolism | Lipolysis - genetics | Young Adult | Subcutaneous Fat, Abdominal - cytology | Adiponectin - genetics | Tacrolimus - pharmacology | Adiponectin - metabolism | Adult | Female | Lipid Metabolism - genetics | Immunosuppressive Agents - pharmacology | Interleukin-6 - metabolism | Cell Survival - drug effects | Interleukin-6 - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Cells, Cultured | Sirolimus - pharmacology | Carrier Proteins - metabolism | Glycerol - metabolism | Adipocytes - metabolism | Adolescent | Lipid Metabolism - drug effects | Aged | Perilipin-1 | Adipose tissues | Neurosciences | Low density lipoproteins | Genes | Lipoprotein lipase | Triglycerides | Fatty acids | Immunosuppressive agents | Synthesis | Physiological aspects | Genetic research | Diabetes | Protein kinases | Protein binding | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Science, ISSN 0036-8075, 11/2007, Volume 318, Issue 5852, pp. 977 - 980
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2008, Volume 283, Issue 45, pp. 30482 - 30492
Signaling through mammalian target of rapamycin complex 1 (mTORC1) is stimulated by amino acids and insulin. Insulin inactivates TSC1/2, the GTPase-activator... 
POLYPEPTIDE-CHAIN INITIATION | NUCLEOTIDE-EXCHANGE FACTOR | HAMSTER OVARY CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSFER-RNA-SYNTHETASES | SMALL GTPASE RHEB | BCL-2 REGULATOR FKBP38 | PROTEIN-SYNTHESIS | P70 S6 KINASE | AMINO-ACID AVAILABILITY | TRANSLATIONAL CONTROL | Cricetulus | Hypoglycemic Agents - metabolism | Humans | Multiprotein Complexes - genetics | Ras Homolog Enriched in Brain Protein | Tacrolimus Binding Proteins - metabolism | Amino Acids - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Proteins | Amino Acids - metabolism | Multiprotein Complexes - metabolism | Telomerase - genetics | Leucine-tRNA Ligase - metabolism | Tumor Suppressor Proteins - genetics | Biomarkers, Tumor - metabolism | RNA, Transfer - genetics | Telomerase - metabolism | Neuropeptides - genetics | CHO Cells | Insulin - pharmacology | Cricetinae | Tumor Suppressor Proteins - metabolism | RNA, Transfer - metabolism | Neuropeptides - metabolism | Monomeric GTP-Binding Proteins - genetics | Transcription Factors - genetics | Leucine-tRNA Ligase - genetics | Hypoglycemic Agents - pharmacology | Tacrolimus Binding Proteins - genetics | Transcription Factors - metabolism | Insulin - metabolism | Animals | Monomeric GTP-Binding Proteins - metabolism | Signal Transduction - physiology | Biomarkers, Tumor - genetics | TOR Serine-Threonine Kinases | Mutation | Protein Binding - physiology | Mechanisms of Signal Transduction
Journal Article
EMBO reports, ISSN 1469-221X, 06/2017, Volume 18, Issue 6, pp. 947 - 961
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 11/2006, Volume 175, Issue 3, pp. 377 - 382
Journal Article
FEBS Letters, ISSN 0014-5793, 03/2017, Volume 591, Issue 5, pp. 728 - 736
Macrophages and osteoclasts are thought to derive from CD68 lineage marker‐positive common myeloid precursors. We used the CD68 promoter to drive an inducible... 
CD68 | osteoclast precursors | RANK | PROGENITORS | DENDRITIC CELLS | KEY REGULATOR | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | IDENTIFICATION | CELL BIOLOGY | BIOPHYSICS | MURINE BONE-MARROW | OSTEOPROTEGERIN LIGAND | OSTEOPETROSIS | COLONY-STIMULATING FACTOR-1 | Myeloid Cells - cytology | Spleen - drug effects | Tacrolimus Binding Proteins - metabolism | Tacrolimus - analogs & derivatives | Osteoclasts - cytology | Antigens, CD - genetics | Recombinant Fusion Proteins - metabolism | Antigens, CD - metabolism | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 9 - genetics | Peritoneal Cavity - cytology | Mitogen-Activated Protein Kinase 1 - genetics | Tacrolimus - pharmacology | Bone Marrow Cells - drug effects | Myeloid Cells - drug effects | Receptor Activator of Nuclear Factor-kappa B - metabolism | Promoter Regions, Genetic | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Bone Marrow Cells - cytology | Gene Expression Regulation | Mice, Transgenic | Spleen - cytology | Macrophages - cytology | Osteoclasts - metabolism | Antigens, Differentiation, Myelomonocytic - genetics | Tacrolimus Binding Proteins - genetics | Cathepsin K - genetics | Macrophages - metabolism | Animals | Cathepsin K - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Spleen - metabolism | Cell Differentiation - drug effects | Antigens, Differentiation, Myelomonocytic - metabolism | Receptor Activator of Nuclear Factor-kappa B - genetics | Myeloid Cells - metabolism | Recombinant Fusion Proteins - genetics | Macrophages - drug effects | Mice | Bone Marrow Cells - metabolism | Osteoclasts - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Nature Cell Biology, ISSN 1465-7392, 02/2004, Volume 6, Issue 2, pp. 97 - 105
Journal Article