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Circulation Research, ISSN 0009-7330, 10/2004, Volume 95, Issue 7, pp. 726 - 733
Altered gap junction coupling of cardiac myocytes during ischemia may contribute to development of lethal arrhythmias. The phosphoprotein connexin 43 (Cx43) is... 
Ischemia | Gap junctions | Glycolysis | Okadaic acid | Protein phosphatases | Connexin43 | Protein phosphorylation | AMP kinase | gap junctions | PROTEIN-KINASE-C | CARDIAC & CARDIOVASCULAR SYSTEMS | connexin43 | PHOSPHORYLATION | GAP JUNCTIONAL COMMUNICATION | glycolysis | CARDIAC MYOCYTES | ACTIN GENE | protein phosphorylation | okadaic acid | ischemia | IN-VITRO | INTERCELLULAR COMMUNICATION | PERIPHERAL VASCULAR DISEASE | JUN KINASE | protein phosphatases | RAT VENTRICULAR MYOCYTES | HEMATOLOGY | ADRENERGIC REGULATION | Okadaic Acid - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Recombinant Fusion Proteins - physiology | Myocardial Contraction - drug effects | Brefeldin A - pharmacology | Phenanthridines - pharmacology | Antimycin A - pharmacology | Aminoimidazole Carboxamide - pharmacology | Cell Hypoxia | Ribonucleotides - pharmacology | Alkaloids | Protein Processing, Post-Translational - drug effects | Adenosine Triphosphate - metabolism | Deoxyglucose - pharmacology | Tacrolimus - pharmacology | Indoles - pharmacology | Flavonoids - pharmacology | Potassium Cyanide - pharmacology | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | Ouabain - pharmacology | Cells, Cultured - drug effects | Connexin 43 - metabolism | Rats | Imidazoles - pharmacology | Cycloheximide - pharmacology | Pyrroles - pharmacology | Animals | Myocytes, Cardiac - drug effects | Aminoimidazole Carboxamide - analogs & derivatives | Benzophenanthridines | JNK Mitogen-Activated Protein Kinases - physiology | Myocytes, Cardiac - metabolism | Cells, Cultured - metabolism | Pyridines - pharmacology | Carbazoles - pharmacology | Staurosporine - pharmacology | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPTOR | BINDING PARTNER | RAG GTPASES | TOS MOTIF | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | PIK-RELATED KINASES | CELL-GROWTH | P70 S6 KINASE | RAPAMYCIN COMPLEX-1 | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2004, Volume 24, Issue 28, pp. 6352 - 6361
Hippocampal long-term depression (LTD) is a long-lasting decrease in synaptic strength that is most commonly studied at glutamatergic inputs to pyramidal cells... 
CA1 | Phosphorylation | Protein kinase | Hippocampus | Synaptic plasticity | Translation initiation | MAMMALIAN TARGET | MESSENGER-RNA TRANSLATION | hippocampus | PHOSPHATIDYLINOSITOL 3-KINASE | translation initiation | HIPPOCAMPAL CA1 REGION | AREA CA1 | NEUROSCIENCES | protein kinase | X MENTAL-RETARDATION | PROTEIN-KINASE B | P70 S6 KINASE | synaptic plasticity | phosphorylation | DHPG-INDUCED LTD | Glycine - analogs & derivatives | Pyramidal Cells - metabolism | Synaptosomes - drug effects | Receptors, Metabotropic Glutamate - physiology | Male | Tacrolimus - analogs & derivatives | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Resorcinols - pharmacology | Protein Processing, Post-Translational - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Tacrolimus - pharmacology | Receptor, Metabotropic Glutamate 5 | Pyramidal Cells - drug effects | Phosphorylation - drug effects | Chromones - pharmacology | Pyramidal Cells - ultrastructure | 3-Phosphoinositide-Dependent Protein Kinases | Dendrites - drug effects | Dendrites - metabolism | Long-Term Synaptic Depression - physiology | Protein Kinases - drug effects | Protein-Serine-Threonine Kinases - physiology | Synaptosomes - physiology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Hippocampus - cytology | Sirolimus - pharmacology | Proto-Oncogene Proteins c-akt | Animals | Androstadienes - pharmacology | Glycine - pharmacology | Signal Transduction - drug effects | Protein Kinases - physiology | Wortmannin | Proto-Oncogene Proteins - physiology | Benzoates - pharmacology | Phosphatidylinositol 3-Kinases - physiology | Mice | Pyridines - pharmacology | TOR Serine-Threonine Kinases | Hippocampus - physiology | Receptors, Metabotropic Glutamate - agonists | Index Medicus | Cellular | Molecular
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2012, Volume 56, Issue 11, pp. 5728 - 5734
Journal Article
05/2018, Contributions to Nephrology, ISBN 3318063495, Volume 195, 12
Amelioration of podocyte injury, which can lead to podocyte detachment, is the target of therapeutic intervention in glomerular diseases. Since podocytes are... 
Chapter | GLUCOCORTICOID-RECEPTORS | CYCLOSPORINE-A | PROTECTS PODOCYTES | STEROID-RESISTANT | RITUXIMAB | UROLOGY & NEPHROLOGY | PROTEINURIA | KIDNEY | SIROLIMUS | Abatacept - pharmacology | Ribonucleosides - therapeutic use | Glucocorticoids - therapeutic use | Adjuvants, Immunologic - pharmacology | Humans | Immunosuppressive Agents - therapeutic use | Nephrotic Syndrome - drug therapy | TOR Serine-Threonine Kinases - antagonists & inhibitors | Levamisole - therapeutic use | Rituximab - therapeutic use | Ribonucleosides - pharmacology | Glomerulonephritis, Membranous - immunology | Mycophenolic Acid - pharmacology | Glomerulosclerosis, Focal Segmental - drug therapy | Tacrolimus - pharmacology | Nephrosis, Lipoid - drug therapy | Everolimus - therapeutic use | Adjuvants, Immunologic - therapeutic use | Immunosuppressive Agents - pharmacology | Calcineurin Inhibitors - pharmacology | Sirolimus - therapeutic use | Everolimus - pharmacology | Glomerulonephritis, Membranous - pathology | Nephrotic Syndrome - pathology | Glomerulonephritis - immunology | Podocytes - pathology | Sirolimus - pharmacology | Glomerulonephritis - drug therapy | Levamisole - pharmacology | Nephrotic Syndrome - immunology | Rituximab - pharmacology | Tacrolimus - therapeutic use | Mycophenolic Acid - therapeutic use | Nephrosis, Lipoid - pathology | Podocytes - drug effects | Glomerulonephritis, Membranous - drug therapy | Glomerulosclerosis, Focal Segmental - immunology | Nephrosis, Lipoid - immunology | Abatacept - therapeutic use | Calcineurin Inhibitors - therapeutic use | Glomerulonephritis - pathology | Podocytes - immunology | Glucocorticoids - pharmacology | Glomerulosclerosis, Focal Segmental - pathology | Immunologic Factors - pharmacology | Immunologic Factors - therapeutic use
Book Chapter
Journal of Neurochemistry, ISSN 0022-3042, 09/2004, Volume 90, Issue 5, pp. 1025 - 1035
Changes in mitochondrial integrity, reactive oxygen species release and Ca2+ handling are proposed to be involved in the pathogenesis of many neurological... 
Electron transport chain | Metabolic disease | Energy metabolism | Free radicals | Calcium | Respiration | electron transport chain | free radicals | TOXIN 3-NITROPROPIONIC ACID | OXIDATIVE STRESS | calcium | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTECTS MITOCHONDRIA | respiration | metabolic disease | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | CEREBELLAR GRANULE CELLS | BRAIN MITOCHONDRIA | ACUTE GLUTAMATE EXCITOTOXICITY | CYCLOSPORINE-A | CYTOCHROME-C RELEASE | METHYLMALONIC ACIDEMIA | energy metabolism | Catalase - pharmacology | Propionates - pharmacology | Uncoupling Agents - pharmacology | Neurons - cytology | Malonates - pharmacology | Electron Transport Complex II - antagonists & inhibitors | Cyclosporins - pharmacology | PC12 Cells | Antimycin A - pharmacology | Dose-Response Relationship, Drug | Tetrazolium Salts | Drug Interactions | Rotenone - pharmacology | Tacrolimus - pharmacology | Thiazoles | Female | NADP - metabolism | Neurons - drug effects | Ionophores - pharmacology | Membrane Potentials - drug effects | Cell Survival - drug effects | Brain - cytology | Permeability - drug effects | Calcium - pharmacology | Antimycin A - analogs & derivatives | Enzyme Inhibitors - pharmacology | Rats | Bongkrekic Acid - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Calcimycin - pharmacology | Animals | Oxygen Consumption - drug effects | Nitro Compounds | Methylmalonic Acid - pharmacology | In Vitro Techniques | Index Medicus
Journal Article
Cardiovascular Research, ISSN 0008-6363, 2002, Volume 55, Issue 3, pp. 534 - 543
Journal Article
Journal Article
Journal Article
Journal Article
Pharmacological Research, ISSN 1043-6618, 09/2012, Volume 66, Issue 3, pp. 226 - 234
Serotonin (5-HT) exerts multiple physiological functions not only in the central and peripheral nervous systems but also in the gastrointestinal tract, and... 
5-HT receptor subtyeps | Mosapride | Indomethacin-induced intestinal lesions | Dual role of serotonin | Ondansetron | TACROLIMUS FK506 | RAT | NITRIC-OXIDE SYNTHASE | MOUSE | NICOTINIC ACETYLCHOLINE-RECEPTORS | MUCOSA | SMALL-BOWEL INJURY | EXPERIMENTAL COLITIS | INFLAMMATION | PHARMACOLOGY & PHARMACY | ENDOCRINE-CELLS | Ondansetron - pharmacology | Intestinal Diseases - chemically induced | Intestine, Small - pathology | Male | Serotonin Receptor Agonists - pharmacology | Ulcer - pathology | Ulcer - drug therapy | Anti-Ulcer Agents - pharmacology | Indoles - pharmacology | Benzamides - pharmacology | Fenclonine - pharmacology | Ulcer - metabolism | Receptors, Nicotinic - metabolism | Mice, Inbred C57BL | Intestinal Diseases - drug therapy | Morpholines - pharmacology | Aconitine - analogs & derivatives | Aconitine - pharmacology | Serotonin Antagonists - pharmacology | Sulfonamides - pharmacology | Intestinal Diseases - metabolism | Ulcer - chemically induced | Receptors, Serotonin - metabolism | Animals | Intestine, Small - drug effects | Receptors, Serotonin, 5-HT3 - metabolism | Serotonin - metabolism | Receptors, Serotonin, 5-HT4 - metabolism | Mice | Indomethacin | Intestine, Small - metabolism | Intestinal Diseases - pathology | alpha7 Nicotinic Acetylcholine Receptor | Phosphates | Nitrogen oxide | Serotonin | Nitric oxide | Phenols | Tryptophan | Macrophages | Index Medicus
Journal Article