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Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 299 - 305
For most types of cancers, the cell at the origin of tumour initiation is still unknown. Here, we used mouse genetics to identify cells at the origin of basal... 
POPULATION | STEM-CELLS | SONIC HEDGEHOG | EPIDERMIS | HAIR FOLLICLE BULGE | KERATINOCYTES | CANCER | EXPRESSION | HUMAN HOMOLOG | MOUSE SKIN | CELL BIOLOGY | Epithelial Cells - metabolism | Cadherins - metabolism | Receptors, G-Protein-Coupled - metabolism | Skin - metabolism | Cell Count | Ear, External - pathology | Integrin beta4 - metabolism | Tail - pathology | Hair Follicle - pathology | Hedgehog Proteins - genetics | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Neoplastic Stem Cells - pathology | Cell Differentiation | Patched Receptors | Skin - pathology | Keratin-10 - metabolism | Epidermis - metabolism | Epidermis - pathology | RNA, Untranslated | Bacterial Proteins - genetics | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Genes, Reporter - genetics | Mice, Transgenic | Carcinoma, Basal Cell - pathology | Mice, Inbred Strains | Clone Cells - metabolism | Keratin-14 - genetics | Carcinoma, Basal Cell - metabolism | Keratin-15 - metabolism | Keratin-19 - genetics | Proteins - genetics | Cell Lineage | Animals | Clone Cells - pathology | Proteins - metabolism | Models, Biological | Hair Follicle - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Integrases - genetics | Keratin-15 - genetics | Luminescent Proteins - metabolism | Basal cell carcinoma | Stem cells | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2010, Volume 115, Issue 6, pp. 1299 - 1308
P>In recent decades, the study of the amyloid precursor protein (APP) and of its proteolytic products carboxy terminal fragment (CTF), APP intracellular... 
APP | CTF | Alzheimer | AICD | Fe65 | Shc | CYTOPLASMIC DOMAIN | RECEPTOR-RELATED PROTEIN | TYROSINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | DEPENDENT REGULATION | TERMINAL FRAGMENTS | NEUROBLASTOMA SH-SY5Y CELLS | SCAFFOLD PROTEINS | GAMMA-SECRETASE | INTRACELLULAR DOMAIN | Phosphorylation - physiology | Peptide Fragments - metabolism | Transcription Factors - physiology | Humans | Transcription Factors - genetics | Alzheimer Disease - pathology | Peptide Fragments - physiology | Transcription Factors - metabolism | Intracellular Space - chemistry | Amyloid beta-Protein Precursor - genetics | Animals | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Signal Transduction - physiology | Intracellular Space - physiology | Adaptor Proteins, Signal Transducing - metabolism | Transduction, Genetic - methods | Protein Structure, Tertiary - physiology | Tyrosine | Analysis | Amyloid beta-protein | Physiological aspects | Genetic aspects | Phosphotransferases | Alzheimer's disease | Index Medicus | Amyloidogenesis | Phosphorylation | Neurodegenerative diseases | Threonine | Transcription | Serine | MAP kinase | beta -Amyloid | Ras protein | adaptor proteins | Amyloid precursor protein | Tails | Grb2 protein | Signal transduction | Neurotoxicity | Reviews | Proteolysis | Protein-tyrosine kinase receptors | Shc protein | Protein-tyrosine kinase | Secretase
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 536, Issue 7616, pp. 298 - 303
The changes in cell dynamics after oncogenic mutation that lead to the development of tumours are currently unknown. Here, using skin epidermis as a model, we... 
ORIGIN | MODEL | INTESTINAL STEM-CELLS | LINEAGE | MULTIDISCIPLINARY SCIENCES | PROGRESSION | Clonal selection theory | Cell proliferation | Analysis | Rodents | Research | Health aspects | Skin tumors | Signal transduction | Cell cycle | Stem cells | Homeostasis | Skin | Tumors | Apoptosis | Skin cancer
Journal Article
Journal Article
Microvascular Research, ISSN 0026-2862, 2006, Volume 72, Issue 3, pp. 161 - 171
Journal Article
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 11, p. e49940
Introduction: Lymphedema is a chronic disorder that occurs commonly after lymph node removal for cancer treatment and is characterized by swelling, fibrosis,... 
BREAST-CANCER | IMMUNE PROTEINS | PERIPHERAL LYMPH | REGENERATION | MULTIDISCIPLINARY SCIENCES | INSUFFICIENCY | SKIN | FILARIAL LYMPHEDEMA | EXPRESSION | WOUND REPAIR | Adaptive Immunity | CD8-Positive T-Lymphocytes - cytology | Inflammation - pathology | Interleukin-2 Receptor alpha Subunit | Lymph Nodes - pathology | Lymphedema - immunology | Lymphedema - pathology | Lymph Nodes - surgery | Humans | CD4-Positive T-Lymphocytes - metabolism | Tail - immunology | Inflammation - immunology | Tail - pathology | CD4-Positive T-Lymphocytes - immunology | Animals | Flow Cytometry | Lymphangiogenesis - immunology | T-Lymphocytes, Helper-Inducer - immunology | Fibrosis - immunology | T-Lymphocytes, Helper-Inducer - cytology | Mice | Fibrosis - pathology | CD8-Positive T-Lymphocytes - immunology | Single-Cell Analysis | Viral antibodies | Medical research | Care and treatment | Dendritic cells | Analysis | Fibrosis | Physiological aspects | Medicine, Experimental | Antibodies | Inflammation | Cancer | Flow cytometry | Animal models | CD8 antigen | Helper cells | Inflammatory response | Infections | Arthritis | Macrophages | Cancer therapies | Tails | Lymph nodes | Lymphedema | Rodents | CD25 antigen | Dissection | Deposition | Lymphatic system | Wound healing | Immune response | Plastic surgery | Leukocytes (neutrophilic) | Radiation therapy | CD4 antigen | Studies | Cell suspensions | Pathology | Cytometry | Depletion | Biopsy | Infiltration | Lymph
Journal Article
Journal Article