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The Journal of clinical investigation, ISSN 0021-9738, 2015, Volume 125, Issue 3, pp. 1269 - 1285
Cholangiocarcinoma (CC) is typically diagnosed at an advanced stage and is refractory to surgical intervention and chemotherapy. Despite a global increase in... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | INTRAHEPATIC CHOLANGIOCARCINOMA | THIOACETAMIDE | PORCUPINE | LIVER | BILIARY | BETA-CATENIN | RAT CHOLANGIOCARCINOMA | PROGRESSION | CANCER STEM-CELLS | Anisoles - pharmacology | Humans | Male | Cholangiocarcinoma - metabolism | Bile Ducts, Intrahepatic - metabolism | Keratins - metabolism | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzeneacetamides - pharmacology | Wnt Signaling Pathway | Bile Duct Neoplasms - drug therapy | Cell Survival - drug effects | Aniline Compounds - pharmacology | Bile Duct Neoplasms - metabolism | Pyrimidines - pharmacology | Rats, Sprague-Dawley | beta Catenin - metabolism | Heterocyclic Compounds, 2-Ring - pharmacology | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Macrophages - metabolism | Animals | Cholangiocarcinoma - drug therapy | Mice, Nude | Tamoxifen - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Cell Proliferation - drug effects | Clodronic Acid - administration & dosage | Pyridines - pharmacology | Liposomes | Physiological aspects | Research | Tumor proteins | Wnt proteins | Oncology, Experimental | Cancer | Heparan sulfate | Medical research | Liver | Gene expression | Cancer therapies | Studies | Councils | Medical prognosis | Cell cycle | Ligands | Mutation | Tumors
Journal Article
Cancer Letters, ISSN 0304-3835, 2012, Volume 320, Issue 1, pp. 104 - 110
Abstract Molecularly targeted therapies have emerged as the leading theme in cancer therapeutics. Multi-cytotoxic drug regimens have been highly successful,... 
Hematology, Oncology and Palliative Medicine | Combination index | Dasatinib | Molecular targeted therapy | Rapamycin | ACTIVATION | SRC | BCR-ABL | TUMOR | MECHANISMS | SIMULATION | CHEMOTHERAPY | ONCOLOGY | RESISTANCE | SYSTEMS | KINASES | Niacinamide - analogs & derivatives | Paclitaxel - pharmacology | Nitriles - pharmacology | Humans | Epothilones - pharmacology | Thiazoles - administration & dosage | Chromones - administration & dosage | Phenylurea Compounds | Benzenesulfonates - administration & dosage | Tamoxifen - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Nitriles - administration & dosage | Benzenesulfonates - pharmacology | Female | Chromones - pharmacology | Paclitaxel - administration & dosage | Butadienes - pharmacology | Pyridines - administration & dosage | Pyrimidines - administration & dosage | Morpholines - administration & dosage | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Pyrimidines - pharmacology | Breast Neoplasms - drug therapy | Sirolimus - pharmacology | Drug Synergism | Sirolimus - administration & dosage | Signal Transduction - drug effects | Butadienes - administration & dosage | Epothilones - administration & dosage | Tamoxifen - pharmacology | Cell Line, Tumor | Pyridines - pharmacology | Thiazoles - pharmacology | Care and treatment | Oncology, Experimental | Genes | Breast cancer | Research | Tamoxifen | Cancer | Index Medicus
Journal Article
Blood, ISSN 1528-0020, 2009, Volume 114, Issue 11, pp. 2236 - 2243
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 2/2016, Volume 55, Issue 2, pp. 249 - 255
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e69150
O-GlcNAcylation (addition of N-acetyl-glucosamine on serine or threonine residues) is a post-translational modification that regulates stability, activity or... 
TRANSCRIPTION FACTORS | GLCNAC MODIFICATION | INSULIN-RECEPTOR | TYROSINE-PHOSPHATASE 1B | SP1 | MULTIDISCIPLINARY SCIENCES | FOXO1 INCREASES | CYCLE ARREST | C-MYC | LINKED N-ACETYLGLUCOSAMINE | GENE-TRANSCRIPTION | Insulin-Like Growth Factor I - pharmacology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Breast Neoplasms - metabolism | MCF-7 Cells | Protein Processing, Post-Translational - drug effects | Acetylglucosamine - analogs & derivatives | Estrogen Receptor alpha - metabolism | Female | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Promoter Regions, Genetic | Antineoplastic Agents, Hormonal - pharmacology | Acetylglucosamine - pharmacology | Biosynthetic Pathways | Phenylcarbamates - pharmacology | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Signal Transduction - drug effects | Tamoxifen - pharmacology | Oximes - pharmacology | Tamoxifen - analogs & derivatives | Hexosamines - biosynthesis | Selective Estrogen Receptor Modulators - pharmacology | Therapy | Phosphorylation | Glucosamine | N-Acetylglucosamine | Estrogens | Serine | Estrogen | AKT protein | mRNA | Kinases | Proteins | Cell growth | Post-translation | Inhibition | Localization | Sensitivity analysis | Cell survival | N-Acetylglucosaminidase | Threonine | Phosphatidylinositol 3,4,5-triphosphate | Mortality | Breast cancer | siRNA | Tamoxifen | Gene expression | Sensitivity | Cell death | Cancer | Apoptosis | Life Sciences | Pharmacology | Pharmaceutical sciences
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2000, Volume 130, Issue 6, pp. 1385 - 1393
Antidepressant drugs are known to inhibit some changes evoked by glucocorticoids, as well as a hyperactivity of hypothalamic‐pituitary‐adrenal (HPA) axis,... 
GR‐mediated gene transcription | kinase inhibitors | fibroblast cells | kinase activators | Antidepressant drugs | Fibroblast cells | GR-mediated gene transcription | Kinase inhibitors | Kinase activators | CORTICOTROPIN-RELEASING HORMONE | PROTEIN-KINASE-C | antidepressant drugs | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | SIGNAL-TRANSDUCTION | MESSENGER-RNA | PHARMACOLOGY & PHARMACY | RAT HIPPOCAMPUS | LONG-TERM TREATMENT | EXPRESSION | BINDING | BRAIN | Cyclic GMP - pharmacology | Transcription, Genetic - drug effects | Receptors, Glucocorticoid - antagonists & inhibitors | Corticosterone - pharmacology | Receptors, Steroid - metabolism | Chloramphenicol O-Acetyltransferase - drug effects | Chloramphenicol O-Acetyltransferase - metabolism | Chloramphenicol O-Acetyltransferase - genetics | Type C Phospholipases - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Cyclic AMP - analogs & derivatives | Cyclic GMP - analogs & derivatives | Time Factors | Lithium Chloride - pharmacology | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Antidepressive Agents - pharmacology | Memantine - pharmacology | DNA-Binding Proteins - drug effects | Enzyme Inhibitors - pharmacology | Receptors, Steroid - drug effects | Thionucleotides - pharmacology | Sulfonamides - pharmacology | Cyclic AMP - pharmacology | Drug Synergism | Gene Expression Regulation - drug effects | Cocaine - pharmacology | Protein Kinase Inhibitors | Animals | Tamoxifen - pharmacology | Imipramine - pharmacology | Mifepristone - pharmacology | Amantadine - pharmacology | Receptors, Glucocorticoid - physiology | Cell Line, Transformed | Papers
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 11/2011, Volume 12, Issue 10, pp. 924 - 938
Here, we show that tamoxifen resistance is induced by cancer-associated fibroblasts (CAFs). Coculture of estrogen receptor positive (ER+) MCF7 cells with... 
Warburg Effect | TIGAR | metformin | reactive oxygen species (ROS) | cancer associated fibroblasts | microenvironment | glucose uptake | drug resistance | tumor stroma | mitochondrial oxidative phosphorylation | aerobic glycolysis | tamoxifen | oxidative stress | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Oxidative stress | Reactive oxygen species (ROS) | Tumor stroma | Cancer associated fibroblasts | Microenvironment | Drug resistance | Tamoxifen | Glucose uptake | Aerobic glycolysis | Metformin | Mitochondrial oxidative phosphorylation | Warburg effect | CYCLIN D1 | TAMOXIFEN RESISTANCE | C-MYC | ENDOCRINE THERAPY | ESTROGEN-RECEPTOR | FIBROBLASTS | NEOADJUVANT CHEMOTHERAPY | CAVEOLIN-1 EXPRESSION | ONCOLOGY | NITRIC-OXIDE | Estradiol - analogs & derivatives | Apoptosis - drug effects | Coculture Techniques | Humans | Ketone Bodies - metabolism | Drug Resistance, Neoplasm | Intracellular Signaling Peptides and Proteins - metabolism | Breast Neoplasms - metabolism | Fulvestrant | Estrogen Receptor Modulators - therapeutic use | Female | Estradiol - pharmacology | Fibroblasts - metabolism | Tumor Microenvironment - drug effects | Arsenic Trioxide | Estradiol - therapeutic use | Arsenicals - pharmacology | Lactic Acid - metabolism | Metformin - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Breast Neoplasms - drug therapy | Poly(ADP-ribose) Polymerase Inhibitors | Estrogen Receptor Modulators - pharmacology | Hypoglycemic Agents - pharmacology | Oxides - pharmacology | Apoptosis Regulatory Proteins | Fibroblasts - drug effects | Tamoxifen - therapeutic use | Tamoxifen - pharmacology | Cell Line, Tumor | Doxorubicin - pharmacology | Index Medicus | Research Paper
Journal Article
Nucleic acids research, ISSN 1362-4962, 2009, Volume 37, Issue 8, pp. 2584 - 2595
Journal Article
Neuroscience, ISSN 0306-4522, 2015, Volume 289, pp. 349 - 357
Highlights • Bisphenol A (BPA) depressed synaptic reflexes in the neonatal rat spinal cord. • Equivolume of ethanol used to dissolve BPA had no effect on... 
Neurology | synaptic transmission/modulation | nitric oxide