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Journal Article
Molecular systems biology, ISSN 1744-4292, 03/2017, Volume 13, Issue 3, pp. 916 - n/a
... , ). The underlying molecular mechanisms leading to the occurrence of HS and its transition to severe liver disorders remain elusive, which limits the identification of drug... 
serine | NAFLD | personalized genome‐scale metabolic modeling | glutathione | personalized genome-scale metabolic modeling | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Glycine - blood | Liver - enzymology | Non-alcoholic Fatty Liver Disease - genetics | Glutathione - metabolism | Serine - blood | Humans | Liver - metabolism | Middle Aged | Male | Non-alcoholic Fatty Liver Disease - metabolism | Patient-Specific Modeling | Metabolomics - methods | Gene Expression Regulation, Enzymologic | Serine - administration & dosage | Animals | Lipoproteins - metabolism | Female | Mice | Non-alcoholic Fatty Liver Disease - diet therapy | Genome | NAD - metabolism | Serine - therapeutic use | Disease Models, Animal | Genomes | Metabolites | Metabolism | Liver | Rodents | Serine | Lipids | Biosynthesis | Glycine | Body mass index | Fatty liver | Precursors | Supplementation | Glutathione | Level (quantity) | Liver diseases | Fasting | Demand analysis | Dietary supplements | Triglycerides | Fluxes | Apolipoproteins | Gene expression | Cholesterol | Steatosis | NAD | Molecular modelling | Insulin resistance | Plasma levels | Laboratory animals | Index Medicus | Life Sciences | Biochemistry, Molecular Biology | zefsky t | hepatocellular-carcinoma | british journal of nutrition | urenberg p | genome-scale | drug targets | adipose-tissue | 1976 | muscle | 1991 | Biochemistry and Molecular Biology | v57 | obesity | amino-acid-metabolism | journal of clinical investigation | fatty liver-disease | tissue blood-flow | insulin-resistance | v65 | Biokemi och molekylärbiologi | p105 | p444
Journal Article
Current topics in medicinal chemistry, ISSN 1568-0266, 12/2016, Volume 16, Issue 30, pp. 3636 - 3645
... rare. In order to discover novel indications, potential target identification is a necessary step... 
Drug | Drug repurposing | Docking | Target | Target identification | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Humans | Molecular Docking Simulation | Drug Repositioning
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 10, pp. e76476 - e76476
The chemotherapeutic compound, cisplatin causes various kinds of DNA lesions but also triggers other pertubations, such as ER and oxidative stress. We and... 
proline | mass-spectrometry | profiling reveals | dna-damage response | gene | modified nucleosides | arginine metabolism | cancer | platinum anticancer drugs | resistance | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Embryonic Stem Cells - metabolism | Metabolomics | Proline - metabolism | Purines - metabolism | Pluripotent Stem Cells - enzymology | Transcriptome - drug effects | Transcriptome - genetics | Cisplatin - pharmacology | Pyrimidines - metabolism | Pluripotent Stem Cells - metabolism | Animals | Embryonic Stem Cells - drug effects | Metabolome - drug effects | Signal Transduction - drug effects | Pluripotent Stem Cells - drug effects | Mice | Metabolic Networks and Pathways - drug effects | Arginine - metabolism | Enzymes | Chemotherapy | Metabolites | DNA damage | Stem cells | Genetic transcription | Tumor proteins | Cisplatin | Cancer | Oxidative stress | Reactive oxygen species | Adenosylmethionine | Target recognition | Disease | p53 Protein | Genotoxicity | Oxygen enrichment | Proline | Amino acids | Polyamines | Cancer therapies | Ovarian cancer | Signal transduction | Toxicology | Alterations | Pathways | Arginine | Cell cycle | DNA methylation | Post-translation | Lesions | Repair | Deoxyribonucleic acid--DNA | Oxygen | Mass spectroscopy | Metabolism | S-Adenosylmethionine | Urea | Signaling | Metabolic pathways | Food safety | Mutation | Methylation | Mass spectrometry | Pluripotency | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PloS one, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e61551 - e61551
Journal Article