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Immunity, ISSN 1074-7613, 04/2014, Volume 40, Issue 4, pp. 477 - 489
We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including... 
PATHWAYS | TARGET GENES | FOXP3 OCCUPANCY | T(H)17 | REGULATORY NETWORK | RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | PSORIASIS | ANTI-INTERLEUKIN-17 MONOCLONAL-ANTIBODY | TH17 CELLS | Myelin-Oligodendrocyte Glycoprotein - immunology | T-Lymphocyte Subsets - immunology | Transcription, Genetic - drug effects | Nuclear Receptor Subfamily 1, Group F, Member 3 - antagonists & inhibitors | Humans | Transcriptional Activation - drug effects | Encephalomyelitis, Autoimmune, Experimental - immunology | Structure-Activity Relationship | Gene Regulatory Networks - drug effects | Cell Lineage - drug effects | Systems Biology | Benzhydryl Compounds - chemistry | Heterocyclic Compounds, 4 or More Rings - pharmacology | Th17 Cells - drug effects | T-Lymphocyte Subsets - drug effects | Peptide Fragments - immunology | Protein Binding - drug effects | Benzeneacetamides - chemistry | Benzeneacetamides - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Cytokines - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Heterocyclic Compounds, 4 or More Rings - chemistry | Digoxin - chemistry | Digoxin - pharmacology | Mice, Knockout | Animals | Androstenols - chemistry | Cell Differentiation - drug effects | Cell Line, Tumor | Multiple Sclerosis - immunology | Th17 Cells - immunology | Benzhydryl Compounds - pharmacology | Mice | Multiple Sclerosis - drug therapy | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7713, pp. 269 - 273
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7575, pp. 672 - 677
Riboswitches are non-coding RNA structures located in messenger RNAs that bind endogenous ligands, such as a specific metabolite or ion, to regulate gene... 
FLAVIN MONONUCLEOTIDE RIBOSWITCH | RIBOFLAVIN BIOSYNTHESIS | BACILLUS-SUBTILIS | FMN RIBOSWITCH | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | TRANSCRIPTION | GENE-EXPRESSION | STREPTOMYCES-DAVAWENSIS | ANTIBIOTIC ROSEOFLAVIN | ANTIBACTERIAL DRUG TARGETS | Bacteria - drug effects | Molecular Sequence Data | Substrate Specificity | Crystallography, X-Ray | Pyrimidines - chemistry | Heat-Shock Proteins - genetics | Pyrimidines - isolation & purification | Bacteria - growth & development | Riboswitch - genetics | Base Sequence | RNA, Bacterial - genetics | Female | Mice, Inbred DBA | Escherichia coli Infections - drug therapy | Reproducibility of Results | Riboflavin - biosynthesis | Intramolecular Transferases - genetics | Aptamers, Nucleotide - chemistry | Escherichia coli Infections - microbiology | Models, Molecular | Pyrimidines - pharmacology | Gene Expression Regulation, Bacterial - drug effects | Animals | RNA, Bacterial - drug effects | Pyrimidines - therapeutic use | RNA, Bacterial - chemistry | Riboswitch - drug effects | Bacteria - cytology | Escherichia coli Proteins - genetics | Ligands | Mice | Flavin Mononucleotide - metabolism | RNA | Gene expression | Analysis | Enzymes | Metabolites | Vitamin B | Biosynthesis | Mutation | Drug resistance | Metabolism | Ribonucleic acid--RNA | Drug dosages | Biological activity | Index Medicus | BASIC BIOLOGICAL SCIENCES
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2004, Volume 101, Issue 34, pp. 12682 - 12687
Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to activation of β-catenin-responsive genes. To identify... 
T lymphocytes | Molecules | Biological Sciences | Epithelial cells | HCT116 cells | Genes | Cell lines | Colorectal cancer | Small interfering RNA | Antibodies | Cyclins | Coactivators | Wnt pathway | T cell factor | TARGET | APOPTOSIS | COMPLEX | GENE | CYCLIN D1 | COLORECTAL-CANCER | SURVIVIN | INTERACTS | MULTIDISCIPLINARY SCIENCES | EXPRESSION | COLON-CARCINOMA | Proteins | Medical research | Mutation | Cells | coactivators
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 02/2016, Volume 56, Issue 2, pp. 399 - 411
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 17, pp. 11845 - 11853
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e62721 - e62721
Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small... 
TARGET | CRYSTALLIZATION | CELL-MEMBRANE | TGF-BETA | ZEBRAFISH | MULTIDISCIPLINARY SCIENCES | ATHEROSCLEROSIS | PROMOTE PROTEIN STABILITY | RECEPTOR | BONE | FIBRODYSPLASIA OSSIFICANS PROGRESSIVA | Activin Receptors, Type I - antagonists & inhibitors | Body Patterning - drug effects | Bone Morphogenetic Proteins - antagonists & inhibitors | Neovascularization, Physiologic - drug effects | Humans | Molecular Conformation | Models, Molecular | Zebrafish | Pyrimidines - pharmacology | Aminopyridines - chemistry | Bone Morphogenetic Proteins - metabolism | Protein Kinase Inhibitors - chemistry | Animals | Signal Transduction - drug effects | Aminopyridines - pharmacology | Protein Binding | Phenols - chemistry | Protein Kinase Inhibitors - pharmacology | Bone Morphogenetic Proteins - chemistry | Smad Proteins - metabolism | Activin Receptors, Type I - chemistry | Phenols - pharmacology | Pyrazoles - pharmacology | Analysis | Crystals | Bone morphogenetic proteins | Drug discovery | Transforming growth factors | Structure | Phosphotransferases | Phosphorylation | Smad protein | Laboratories | Genomics | Identification | Kinases | Medical schools | Optimization | Proteins | Consortia | Signal transduction | Neurodegeneration | Crystal structure | Recombinant | Medical research | Complementarity | Research & development--R&D | Pharmacology | Myositis ossificans | Embryos | Signaling | Hospitals | Inhibitors | Phenols | Pharmacokinetics | Cancer | Index Medicus | Research & development | R&D
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