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1. Molecular targeting and signal transduction
by Kumar, Rakesh, Ph. D and SpringerLink (Online service)
2004, Cancer treatment and research, ISBN 1402078226, Volume 119, viii, 331
Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human... 
Genetic Markers | Signal Transduction | therapy | Neoplasms | Drug targeting | Cellular signal transduction | Oncology | Cancer Research
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2. Mechanistic toxicology
: the molecular basis of how chemicals disrupt biological targets
by Boelsterli, Urs A
2007, 2nd ed., ISBN 0849372720, 399
Molecular toxicology
Book
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3. Status signals
: a sociological study of market competition
by Podolny, Joel M. (Joel Marc)
2005, ISBN 9780691117003, xvi, 287
Why are elite jewelers reluctant to sell turquoise, despite strong demand? Why did leading investment bankers shun junk bonds for years, despite potential... 
Market segmentation | Social status | Social aspects | Target marketing | Business & Management | Economics | Sociology | Management & Organizational Behavior | Markets | Social networks | Social values | Sociological aspects
Book
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4. Full Text Cotranslational signal-independent SRP preloading during membrane targeting
by Chartron, Justin W and Hunt, Katherine C. L and Frydman, Judith
Nature, ISSN 0028-0836, 08/2016, Volume 536, Issue 7615, pp. 224 - 228
Ribosome-associated factors must properly decode the limited information available in nascent polypeptides to direct them to their correct cellular fate(1). It... 
YEAST | TRANSLOCATION | LOCALIZATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GLOBAL ANALYSIS | PROTEIN BIOGENESIS FACTORS | ENDOPLASMIC-RETICULUM | RECOGNITION PARTICLE | TRANSLATION | RIBOSOME | Protein Biosynthesis | Protein Sorting Signals - physiology | Saccharomyces cerevisiae - genetics | Signal Recognition Particle - metabolism | RNA, Messenger - genetics | Endoplasmic Reticulum - metabolism | Ribosomes - metabolism | Substrate Specificity | Saccharomyces cerevisiae Proteins - biosynthesis | RNA, Messenger - metabolism | HSP70 Heat-Shock Proteins - metabolism | Protein Transport | RNA, Fungal - metabolism | Saccharomyces cerevisiae - cytology | Saccharomyces cerevisiae - metabolism | Saccharomyces cerevisiae Proteins - secretion | Peptides - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Hydrophobic and Hydrophilic Interactions | Cytosol - metabolism | Peptides - secretion | RNA, Fungal - genetics | Kinetics | Intracellular Membranes - metabolism | Physiological aspects | Gene targeting | Genetic translation | Methods | Ribosomes | Proteins | Membranes | Cellular biology | Endoplasmic reticulum
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5. Sparking Signals
: Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation
by Baier,Gottfried Volume Editor and Schraven,Burkhart Volume Editor and Zügel,Ulrich Volume Editor and Bonin,Arne von Volume Editor
11/2010, Ernst Schering Foundation Symposium Proceedings Ser., ISBN 3642092624, Volume 2007/3
Annotation The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent... 
Anti-inflammatory Agents | Science | Cellular Signal Transduction | Medical | Drug Targeting
Web Resource
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6. Sparking Signals
: Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation
by Baier,Gottfried Volume Editor and Schraven,Burkhart Volume Editor and Zügel,Ulrich Volume Editor and Bonin,Arne von Volume Editor
11/2010, Ernst Schering Foundation Symposium Proceedings Ser., ISBN 3642092624, Volume 2007/3
Annotation The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent... 
Anti-inflammatory Agents | Science | Cellular Signal Transduction | Medical | Drug Targeting
Web Resource
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7. Targeted interference with signal transduction events
by Groner, B. (Bernd)
2007, 1. Aufl., Recent results in cancer research, ISBN 9783540312086, Volume 172, ix, 188
Sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new,... 
Chemotherapy | physiopathology | drug therapy | Signal Transduction | therapy | Cell Communication | physiology | Gene therapy | Neoplasms | Cancer | Cancer Research | Oncology | Molecular Medicine | Biomedicine
Book
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8. Sparking signals
: kinases as molecular signaltransducers and pharmacological drug targets in inflammation
by Baier, G. (Gottfried) and Ernst Schering Research Foundation and ebrary, Inc
2008, Ernst Schering Foundation symposium proceedings, ISBN 9783540735007, Volume 2007/3
Drug targeting | Cellular signal transduction | Pharmacokinetics | Protein kinases | Anti-inflammatory agents
Web Resource
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9. Sparking signals
: kinases as molecular signatransducers and pharmacological drug targets in inflammation
by Baier, G. (Gottfried) and Ernst Schering Research Foundation
2008, Ernst Schering Foundation symposium proceedings, ISBN 3540735011, Volume 2007/3
Protein Kinase Inhibitors | drug therapy | Protein Kinases | Anti-Inflammatory Agents | Drug targeting | drug effects | Inflammation | Cellular signal transduction | Pharmacokinetics | therapeutic use
Web Resource
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10. Full Text EZH2, an on–off valve in signal network of tumor cells
by Sun, Shanshan and Yu, Feng and Zhang, Lun and Zhou, Xuan
Cellular Signalling, ISSN 0898-6568, 05/2016, Volume 28, Issue 5, pp. 481 - 487
Enhancer Zeste 2 (EZH2) is a histone methyltransferase catalyzing histone H3K27me3 to mediate gene silence. It is implicated in governing various biological... 
Signaling | Tumor | Histone modulation | Double facet | EZH2 | STEM-CELLS | INHIBITOR 3-DEAZANEPLANOCIN | ZESTE HOMOLOG 2 | TARGETING EZH2 | GASTRIC-CANCER CELLS | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | LONG NONCODING RNA | PROSTATE-CANCER | HISTONE METHYLTRANSFERASE EZH2 | Neoplasms - metabolism | Enhancer of Zeste Homolog 2 Protein - metabolism | Phosphorylation | Signal Transduction | Humans | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Gene Silencing | MicroRNAs - metabolism | Enhancer of Zeste Homolog 2 Protein - physiology | Animals | Neoplasms - genetics | Mice | Histones | Valves | Genetic engineering | Tumors | Epigenetic inheritance | Medical colleges | Human acts | Cells | Prevention | MicroRNA | Methyltransferases | Human behavior | Health aspects | Cancer | Cellular | Genes | Strategy | Switching
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11. Full Text Protein targeting by the signal recognition particle
by Grudnik, Przemyslaw and Bange, Gert and Sinning, Irmgard
Biological Chemistry, ISSN 1431-6730, 08/2009, Volume 390, Issue 8, pp. 775 - 782
Protein targeting by the signal recognition particle (SRP) is universally conserved and starts with the recognition of a signal sequence in the context of a... 
Signal sequence | SRP | SRP receptor | Guanosine triphosphatase (GTPase) | Protein targeting | Membrane protein insertion | Signal recognition particle (SRP) | Chloroplast SRP | DOMAIN | GTPASE ACTIVATION | RNA | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2 DISTINCT | ESCHERICHIA-COLI SRP | signal sequence | signal recognition particle (SRP) | MEMBRANE-BINDING | FTSY | guanosine triphosphatase (GTPase) | membrane protein insertion | protein targeting | RECEPTOR COMPLEX | ENDOPLASMIC-RETICULUM | chloroplast SRP | Animals | GTP Phosphohydrolases - metabolism | Humans | Models, Molecular | Receptors, Cytoplasmic and Nuclear - physiology | Escherichia coli Proteins - physiology | Signal Recognition Particle - physiology | Bacterial Proteins - physiology | Chloroplasts - metabolism | Protein Transport - genetics | Biochemistry | Research | Chemical properties | Carrier proteins | Observations | Protein-protein interactions
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12. Full Text Shredding the signal: targeting peptide degradation in mitochondria and chloroplasts
by Kmiec, Beata and Teixeira, Pedro F and Glaser, Elzbieta and Institutionen för biokemi och biofysik and Stockholms universitet and Naturvetenskapliga fakulteten
Trends in Plant Science, ISSN 1360-1385, 12/2014, Volume 19, Issue 12, pp. 771 - 778
The biogenesis and functionality of mitochondria and chloroplasts depend on the constant turnover of their proteins. The majority of mitochondrial and... 
Arabidopsis thaliana | oligopeptidases | peptide degradation | chloroplasts | targeting peptides | mitochondria | Mitochondria | Oligopeptidases | Chloroplasts | Peptide degradation | Targeting peptides | ARABIDOPSIS-THALIANA | DEGRADING PROTEASES | PROCESSING PEPTIDASE | SUBCELLULAR LOCATION | PRESEQUENCE PROTEASE | PROTEIN IMPORT APPARATUS | PLANT SCIENCES | PLANT MITOCHONDRIAL | AMYLOID-BETA-PEPTIDE | N-TERMINAL MODIFICATIONS | PRECURSOR PROTEIN | Mitochondria - metabolism | Peptides - metabolism | Chloroplasts - metabolism | Arabidopsis - metabolism | Peptide Hydrolases - metabolism | Peptides | Mitochondrial DNA | Biological Sciences | Naturvetenskap | Biologiska vetenskaper | Natural Sciences
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13. Full Text Sequential activation of human signal recognition particle by the ribosome and signal sequence drives efficient protein targeting
by Lee, Jae Ho and Chandrasekar, Sowmya and Chung, SangYoon and Fu, Yu-Hsien Hwang and Liu, Demi and Weiss, Shimon and Shan, Shu-Ou
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2018, Volume 115, Issue 24, pp. E5487 - E5496
Signal recognition particle (SRP) is a universally conserved targeting machine that mediates the targeted delivery of similar to 30% of the proteome. The... 
Fluorescence spectroscopy | Ribosome | Signal recognition particle | Protein targeting | Single-molecule spectroscopy | ENDOPLASMIC-RETICULUM MEMBRANE | signal recognition particle | COMPLEX | single-molecule spectroscopy | ANCHOR SEQUENCE | MULTIDISCIPLINARY SCIENCES | RECEPTOR | fluorescence spectroscopy | ALTERNATING-LASER EXCITATION | SINGLE MOLECULES | INDUCED CONFORMATIONAL-CHANGES | STRUCTURAL BASIS | protein targeting | ribosome | GTP HYDROLYSIS | SRP RNA | Amino acid sequence | Methods | Biological Sciences | PNAS Plus
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14. Full Text Identification and characterization of signal peptide of Mitofusin1 (Mfn1)
by Sinha, Sansrity and Aradhyam, Gopala Krishna
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2019, Volume 509, Issue 3, pp. 707 - 712
Mitofusin1 (Mfn1) mediates outer mitochondrial membrane (OMM) fusion in Opisthokonts. The uncharacterized TM comprises to two helices (namely, the TM1 and TM2)... 
Signal peptide | N-Terminal mitochondrial targeting sequence (MTS) | Internal MTS | Mitofusins (Mfn1 and Mfn2) | MITOCHONDRIAL DYNAMICS | FUSION | BIOPHYSICS | PROTEIN-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | I-TASSER | PREDICTION
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15. Full Text Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense
by Ebiloma, Godwin U and Ayuga, Teresa Díaz and Balogun, Emmanuel O and Gil, Lucía Abad and Donachie, Anne and Kaiser, Marcel and Herraiz, Tomás and Inaoka, Daniel K and Shiba, Tomoo and Harada, Shigeharu and Kita, Kiyoshi and de Koning, Harry P and Dardonville, Christophe
European Journal of Medicinal Chemistry, ISSN 0223-5234, 04/2018, Volume 150, pp. 385 - 402
African trypanosomiasis is a neglected parasitic disease that is still of great public health relevance, and a severe impediment to agriculture in endemic... 
Trypanosome alternative oxidase (TAO) | Trypanocide | Mitochondrial targeting | Parasite respiration | SHAM | Triphenylphosphonium salt (TPP) | T. b. rhodesiense | Quinolinium salt | T. congolense | Trypanosoma brucei | Lipophilic cation | Trypanosomiasis | T. congolense | T. b. rhodesiense | AFRICAN TRYPANOSOMES | TRANSLOCATION | CHEMISTRY, MEDICINAL | TRANSPORTER | GLYCEROL | ANALOGS | T congolense | ASCOFURANONE | RESPIRATION | DRUGS | RESISTANCE | BLOOD-STREAM | Oxidases | Physiological aspects | Pentamidine isethionate | Drug resistance | Parasitic diseases | Cells
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16. Sparking signals
: kinases as molecular signaltransducers and pharmacological drug targets in inflammation
by Baier, G
2008, Volume 2007-3.
Drug targeting | Cellular signal transduction | Pharmacokinetics | Protein kinases | Anti-inflammatory agents
Conference Proceeding
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17. Full Text Capturing the signal
by Mock, JY and Clemons, WM
ELIFE, ISSN 2050-084X, 07/2015, Volume 4
High-resolution structures provide new insights into how an RNA-protein complex recognizes the signal that targets membrane proteins to the endoplasmic... 
TRANSLOCATION | ARREST | MICROSOMAL-MEMBRANES | ELONGATION | BIOLOGY | ENDOPLASMIC-RETICULUM | RECOGNITION PARTICLE | CHAINS | PROTEINS | BINDING | RIBOSOME | Ribosomes - metabolism | Protein Biosynthesis | Ribosomes - ultrastructure | Animals | Signal Recognition Particle - chemistry | Signal Recognition Particle - metabolism | Proteins | Peptides | Ribonucleic acid--RNA | Chemical engineering | Endoplasmic reticulum | Membrane proteins
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18. Full Text Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: Modern target but ancient solution
by Aggarwal, Bharat B and Sethi, Gautam and Kwang, Seok Ahn and Sandur, Santosh K and Pandey, Manoj K and Kunnumakkara, Ajaikumar B and Sung, Bokyung and Ichikawa, Haruyo
Annals of the New York Academy of Sciences, ISSN 0077-8923, 2006, Volume 1091, pp. 151 - 169
Recent evidence indicates a convergence of molecular targets for both prevention and therapy of cancer. Signal-transducer-and-activator-of-transcription-3... 
Chemoresistance | STAT3 | Cancer | Interleukin-6 | MULTIDISCIPLINARY SCIENCES | LEUKEMIA INHIBITORY FACTOR | PROTEIN-TYROSINE KINASE | MULTIPLE-MYELOMA CELLS | interleukin-6 | DNA-BINDING ACTIVITY | SIGNALING INDUCES APOPTOSIS | chemoresistance | TRANSCRIPTION 3 STAT3 | EPIDERMAL-GROWTH-FACTOR | EMBRYONIC STEM-CELLS | SQUAMOUS-CELL CARCINOMA | cancer | STAT3 SERINE PHOSPHORYLATION | Neoplasms - metabolism | Gene Targeting - methods | Animals | STAT3 Transcription Factor - physiology | Humans | STAT3 Transcription Factor - deficiency | Neoplasms - prevention & control | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Neoplasms - drug therapy
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19. Full Text B cell receptor signal strength determines B cell fate
by Uyttersprot, Nathalie and Humme, Sibille and Kutok, Jeffery L and Rajewsky, Klaus and Carroll, Michael C and Otipoby, Kevin L and Alimzhanov, Marat and Casola, Stefano
Nature Immunology, ISSN 1529-2908, 03/2004, Volume 5, Issue 3, pp. 317 - 327
B cell receptor (BCR)-mediated antigen recognition is thought to regulate B cell differentiation. BCR signal strength may also influence B cell fate decisions.... 
ACTIVATION MOTIF | B-1 CELLS | SPLENIC MARGINAL ZONE | POSITIVE SELECTION | IMMUNE-RESPONSES | GERMINAL-CENTERS | BARR-VIRUS LMP2A | IMMUNOLOGY | MEMBRANE-PROTEIN 2A | ANTIGEN RECEPTOR | SURFACE-IMMUNOGLOBULIN | Gene Targeting | B-Lymphocytes - cytology | Viral Matrix Proteins - genetics | Signal Transduction | Germinal Center - immunology | Cells, Cultured | Male | Mice, Transgenic | Digestive System - immunology | Receptors, Antigen, B-Cell - metabolism | Animals | B-Lymphocytes - immunology | Female | Receptors, Antigen, B-Cell - genetics | Stem Cells - physiology | Viral Matrix Proteins - metabolism | Cell Differentiation | Mice | Peyer's Patches - immunology | Germinal Center - cytology | Peyer's Patches - anatomy & histology | LMP2A protein
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