X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (26070) 26070
Book Review (3967) 3967
Publication (2436) 2436
Book Chapter (399) 399
Conference Proceeding (175) 175
Dissertation (77) 77
Newsletter (41) 41
Magazine Article (28) 28
Book / eBook (12) 12
Web Resource (11) 11
Newspaper Article (9) 9
Data Set (5) 5
Paper (4) 4
Trade Publication Article (4) 4
Streaming Video (2) 2
Government Document (1) 1
Technical Report (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (18799) 18799
humans (13918) 13918
alzheimer's disease (10313) 10313
neurosciences (10229) 10229
animals (9230) 9230
tau (8129) 8129
tau proteins - metabolism (7410) 7410
alzheimers-disease (6508) 6508
male (6358) 6358
phosphorylation (5886) 5886
female (5786) 5786
tau protein (4769) 4769
aged (4580) 4580
clinical neurology (4298) 4298
brain (4213) 4213
mice (4017) 4017
biochemistry & molecular biology (3930) 3930
alzheimer disease - metabolism (3920) 3920
pathology (3772) 3772
alzheimer disease - pathology (3549) 3549
dementia (3498) 3498
middle aged (3481) 3481
tau proteins - genetics (3268) 3268
neurofibrillary tangles (3138) 3138
proteins (3136) 3136
neurodegenerative diseases (3023) 3023
neurodegeneration (2835) 2835
brain - metabolism (2755) 2755
paired helical filaments (2649) 2649
aged, 80 and over (2589) 2589
neurology (2506) 2506
brain - pathology (2487) 2487
neurons (2266) 2266
cell biology (2218) 2218
rats (2182) 2182
alzheimers disease (2179) 2179
amyloid beta-peptides - metabolism (2169) 2169
disease models, animal (2130) 2130
alzheimer’s disease (2036) 2036
protein (2002) 2002
neurons - metabolism (1983) 1983
mice, transgenic (1950) 1950
analysis (1933) 1933
biomarkers (1929) 1929
immunohistochemistry (1859) 1859
alzheimer disease - genetics (1838) 1838
tau proteins - cerebrospinal fluid (1776) 1776
cerebrospinal fluid (1744) 1744
transgenic mice (1712) 1712
amyloid precursor protein (1709) 1709
tau-protein (1706) 1706
article (1691) 1691
research (1689) 1689
mild cognitive impairment (1622) 1622
mutation (1621) 1621
mouse model (1579) 1579
frontotemporal dementia (1546) 1546
amyloid (1538) 1538
oxidative stress (1498) 1498
diagnosis (1458) 1458
tau proteins (1437) 1437
expression (1433) 1433
adult (1426) 1426
a-beta (1412) 1412
amyloid-beta (1405) 1405
disease (1395) 1395
progressive supranuclear palsy (1349) 1349
biomarkers - cerebrospinal fluid (1343) 1343
alzheimer disease (1337) 1337
mental disorders (1334) 1334
amyloid beta-peptides - cerebrospinal fluid (1330) 1330
alzheimer disease - cerebrospinal fluid (1288) 1288
neurons - pathology (1274) 1274
tau proteins - chemistry (1259) 1259
cells, cultured (1187) 1187
neurofibrillary tangles - pathology (1184) 1184
cognitive ability (1171) 1171
physiological aspects (1163) 1163
alzheimer disease - diagnosis (1135) 1135
cerebrospinal-fluid (1132) 1132
alpha-synuclein (1117) 1117
in-vivo (1115) 1115
memory (1113) 1113
geriatrics & gerontology (1106) 1106
hippocampus (1085) 1085
psychiatry (1074) 1074
multidisciplinary sciences (1047) 1047
protein-tau (1043) 1043
aging (1037) 1037
alzheimer disease - physiopathology (1014) 1014
apoptosis (1011) 1011
tauopathy (1009) 1009
rodents (999) 999
nervous system diseases (995) 995
in-vitro (984) 984
abridged index medicus (981) 981
alzheimer disease - drug therapy (981) 981
microtubules - metabolism (968) 968
hippocampus - metabolism (954) 954
molecular sequence data (943) 943
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (25707) 25707
Japanese (225) 225
French (151) 151
Chinese (147) 147
German (110) 110
Spanish (73) 73
Polish (29) 29
Czech (21) 21
Russian (20) 20
Portuguese (14) 14
Korean (13) 13
Swedish (11) 11
Hungarian (7) 7
Dutch (3) 3
Italian (3) 3
Norwegian (3) 3
Croatian (2) 2
Danish (2) 2
Slovak (2) 2
Turkish (2) 2
Finnish (1) 1
Persian (1) 1
Serbian (1) 1
Slovenian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Neuron, ISSN 0896-6273, 2002, Volume 34, Issue 4, pp. 509 - 519
Pathologic alterations in the microtubule-associated protein tau have been implicated in a number of neurodegenerative disorders, including Alzheimer's disease... 
GLYCOGEN-SYNTHASE KINASE-3-BETA | SEGMENT POLARITY GENE | ALZHEIMERS-DISEASE | FRONTOTEMPORAL DEMENTIA | PAIRED HELICAL FILAMENTS | HUMAN BRAIN-TAU | DISEASE-LIKE PHOSPHORYLATION | NUCLEAR LAMIN ISOFORMS | BETA-CATENIN | NEUROSCIENCES | TRANSGENIC MICE | Neurofibrillary Tangles - genetics | Cytoskeletal Proteins - genetics | Humans | tau Proteins - metabolism | Apoptosis - genetics | Glycogen Synthase Kinase 3 | Photoreceptor Cells, Invertebrate - ultrastructure | Drosophila melanogaster - metabolism | Glycogen Synthase Kinases | tau Proteins - genetics | Armadillo Domain Proteins | Nervous System Malformations - metabolism | Cytoskeletal Proteins - metabolism | Insect Proteins - ultrastructure | Nervous System Malformations - genetics | Eye Abnormalities - metabolism | Insect Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Disease Models, Animal | Neurofibrillary Tangles - pathology | tau Proteins - ultrastructure | Drosophila Proteins | Calcium-Calmodulin-Dependent Protein Kinases - genetics | High Mobility Group Proteins - metabolism | Inhibitor of Apoptosis Proteins | beta Catenin | Animals, Genetically Modified | Nervous System Malformations - pathology | Trans-Activators | Transgenes - genetics | Protein-Serine-Threonine Kinases - genetics | Insect Proteins - genetics | Repressor Proteins - genetics | Drosophila melanogaster - ultrastructure | Eye Abnormalities - genetics | Mutation - genetics | Phenotype | Animals | Eye Abnormalities - pathology | Photoreceptor Cells, Invertebrate - pathology | Photoreceptor Cells, Invertebrate - abnormalities | Drosophila melanogaster - growth & development | Neurofibrillary Tangles - ultrastructure | Transcription Factors | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | High Mobility Group Proteins - genetics | Proteins | Pathology | Scanning electron microscopy | Genotype & phenotype | Phosphorylation | Insects | Neurodegeneration | Mutation | Kinases | Index Medicus
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 02/2013, Volume 288, Issue 6, pp. 4056 - 4065
The mechanisms underlying Tau-related synaptic and cognitive deficits and the interrelationships between Tau species, their clearance pathways, and synaptic... 
DOMAIN | PROTEIN | PHOSPHORYLATION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCIBLE MOUSE MODELS | PATHOLOGY | PLAQUES | DETERMINES AGGREGATION | RECEPTORS | OLIGOMERS | Disks Large Homolog 4 Protein | Solubility - drug effects | Tauopathies - genetics | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Tauopathies - pathology | tau Proteins - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Synapses - genetics | Synapses - pathology | Proto-Oncogene Proteins c-akt - genetics | Receptors, N-Methyl-D-Aspartate - genetics | Proto-Oncogene Proteins c-fyn - genetics | Heat-Shock Proteins - genetics | Proteolysis - drug effects | Synapses - metabolism | tau Proteins - genetics | Protein Multimerization - genetics | Aged, 80 and over | Behavior, Animal - drug effects | Female | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Membrane Proteins - genetics | Heat-Shock Proteins - metabolism | Curcumin - pharmacology | Mice, Transgenic | Hippocampus - pathology | Hippocampus - metabolism | Tauopathies - metabolism | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Aged | Mice | Tauopathies - drug therapy | Protein Multimerization - drug effects | Index Medicus | Hsp90 | Molecular Bases of Disease | Neurodegenerative Diseases | Human Tau Transgenic Mice | Heat Shock Proteins | Tau | Curcumin | Tau Oligomers | Alzheimer Disease | Neurological Diseases
Journal Article
PLoS Biology, ISSN 1544-9173, 12/2018, Volume 16, Issue 12, pp. e2006265 - e2006265
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2016, Volume 113, Issue 50, pp. E8187 - E8196
Tau prions are thought to aggregate in the central nervous system, resulting in neurodegeneration. Among the tauopathies, Alzheimer's disease (AD) is the most... 
Pick's disease | Tauopathies | Argyrophilic grain disease | Progressive supranuclear palsy | Corticobasal degeneration | MOUSE-BRAIN | NEUROFIBRILLARY TANGLES | corticobasal degeneration | BRAIN-INJURY | MULTIDISCIPLINARY SCIENCES | FRONTOTEMPORAL DEMENTIA | SHARE ANTIGENIC DETERMINANTS | PICKS-DISEASE | ABNORMAL PHOSPHORYLATION | argyrophilic grain disease | MICROTUBULE-ASSOCIATED PROTEIN | PAIRED HELICAL FILAMENTS | tauopathies | progressive supranuclear palsy | TRANSGENIC MICE | Up-Regulation | Chronic Traumatic Encephalopathy - metabolism | Humans | Bacterial Proteins - chemistry | tau Proteins - metabolism | Pick Disease of the Brain - genetics | Recombinant Fusion Proteins - metabolism | tau Proteins - chemistry | Protein Isoforms - metabolism | tau Proteins - genetics | Chronic Traumatic Encephalopathy - genetics | HEK293 Cells | Luminescent Proteins - chemistry | Pick Disease of the Brain - metabolism | Supranuclear Palsy, Progressive - genetics | Cell Line | Bacterial Proteins - genetics | Recombinant Fusion Proteins - chemistry | Alzheimer Disease - metabolism | Recombinant Fusion Proteins - genetics | Supranuclear Palsy, Progressive - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mutation | Alzheimer Disease - genetics | Luminescent Proteins - metabolism | Protein Isoforms - genetics | Physiological aspects | Alzheimer's disease | Health aspects | Prions | Encephalopathy | Proteins | Brain | Alzheimers disease | Cells | Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2004, Volume 90, Issue 2, pp. 352 - 358
Microtubule-associated protein tau in a hyperphosphorylated state is the major component of the filamentous lesions that define a number of neurodegenerative... 
c-Jun N-terminal kinase | Stress-activated protein kinase | Tau protein | Tauopathy | NEUROFIBRILLARY TANGLES | NERVOUS-SYSTEM | tauopathy | ALZHEIMERS-DISEASE BRAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRONTOTEMPORAL DEMENTIA | DEPENDENT MONOCLONAL-ANTIBODY | NEUROSCIENCES | GLYCOGEN-SYNTHASE KINASE-3-BETA | FTDP-17 MUTATIONS | stress-activated protein kinase | PAIRED HELICAL FILAMENTS | SITES | tau protein | NANOELECTROSPRAY MASS-SPECTROMETRY | Phosphorylation | Epitopes - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Immunoblotting | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | tau Proteins - chemistry | Mitogen-Activated Protein Kinases - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Protein-Tyrosine Kinases - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | tau Proteins - genetics | Isoenzymes - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Protein-Tyrosine Kinases - chemistry | JNK Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Glycogen Synthase Kinase 3 - chemistry | Isoenzymes - genetics | Protein-Serine-Threonine Kinases - genetics | Recombinant Fusion Proteins - chemistry | Epitopes - genetics | Glycogen Synthase Kinase 3 - metabolism | Animals | Mitogen-Activated Protein Kinase 10 | Mitogen-Activated Protein Kinase 8 | Glycogen Synthase Kinase 3 - genetics | Mitogen-Activated Protein Kinase 9 | Recombinant Fusion Proteins - genetics | Mitogen-Activated Protein Kinases - genetics | Mice | Protein-Serine-Threonine Kinases - chemistry | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12192 - 12207
Subcellular mislocalization of the microtubule-associated protein Tau is a hallmark of Alzheimer disease (AD) and other tauopathies. Six Tau isoforms,... 
DENDRITIC SPINES | NERVOUS-SYSTEM | PROTEIN-TAU | POLARIZED NEURONS | MICROTUBULES | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIFFUSION BARRIER | MICE | HIPPOCAMPAL-NEURONS | EXPRESSION | Dendrites - pathology | Neurons - pathology | Rats, Wistar | Humans | Cerebral Cortex - pathology | tau Proteins - metabolism | Neurons - cytology | Cerebral Cortex - cytology | Recombinant Fusion Proteins - metabolism | Cerebral Cortex - metabolism | tau Proteins - chemistry | Alzheimer Disease - pathology | Microtubules - metabolism | Repetitive Sequences, Amino Acid | Axon Initial Segment - pathology | Protein Isoforms - metabolism | tau Proteins - genetics | RNA Interference | Protein Isoforms - chemistry | Gene Deletion | Neurons - metabolism | Protein Interaction Domains and Motifs | Diffusion | tau Proteins - antagonists & inhibitors | Dendrites - metabolism | Mice, Inbred C57BL | Cells, Cultured | Recombinant Fusion Proteins - chemistry | Microtubules - pathology | Mice, Knockout | Protein Transport | Axon Initial Segment - metabolism | Animals | Embryo, Mammalian - cytology | Alzheimer Disease - metabolism | Recombinant Fusion Proteins - genetics | Mutagenesis, Insertional | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics | Index Medicus | microtubule | tauopathy | Alzheimer disease | Tau protein (Tau) | neurodegeneration | cell polarity | AIS | amyloid-beta (Aβ) | Cell Biology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2012, Volume 287, Issue 19, pp. 15395 - 15408
Cellular O-linked N-acetylglucosamine (O-GlcNAc) levels are modulated by two enzymes: uridine diphosphate-N-acetyl-D-glucosamine: polypeptidyltransferase (OGT)... 
STRUCTURAL INSIGHTS | NUCLEAR | GLCNACYLATION | MECHANISM | TETRATRICOPEPTIDE REPEATS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOSOLIC PROTEINS | GLYCOSYLATION | NUCLEOCYTOPLASMIC PROTEINS | BETA | Phosphorylation | Membrane Glycoproteins - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 4 - metabolism | Humans | N-Acetylglucosaminyltransferases - genetics | Substrate Specificity | tau Proteins - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 4 - genetics | Acetylglucosamine - metabolism | Nuclear Pore Complex Proteins - genetics | tau Proteins - genetics | Mass Spectrometry | Protein-Arginine N-Methyltransferases - genetics | beta-N-Acetylhexosaminidases - genetics | Recombinant Proteins - metabolism | Nuclear Pore Complex Proteins - metabolism | beta-N-Acetylhexosaminidases - metabolism | Serine - genetics | Glycosylation | Recombinant Proteins - genetics | Serine - metabolism | Blotting, Western | N-Acetylglucosaminyltransferases - metabolism | Membrane Glycoproteins - genetics | Protein-Arginine N-Methyltransferases - metabolism | Proteins - genetics | Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Protein Processing, Post-Translational | Kinetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | Glycoside Hydrolases | Carbohydrate Glycoconjugate | Glycosyltransferases | Glycobiology and Extracellular Matrices | Carbohydrate | Glycoconjugate | Carbohydrate Biosynthesis | O-GlcNAc
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2014, Volume 111, Issue 46, pp. 16586 - 16591
Intracellular accumulation of the abnormally modified tau is hall-mark pathology of Alzheimer's disease (AD), but the mechanism leading to tau aggregation is... 
Aggregation | Phosphorylation | HEK293 cells | Neurons | Ubiquitins | Microtubules | Antibodies | Alzheimers disease | Tau proteins | Western blotting | PROTEIN-TAU | PHOSPHATASE 2A | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | tau | degradation | ABNORMAL PHOSPHORYLATION | SUMO-1 MODIFICATION | HYPERPHOSPHORYLATED-TAU | ubiquitination | DISEASE | PAIRED HELICAL FILAMENTS | SUMOylation | phosphorylation | ALZHEIMER NEUROFIBRILLARY DEGENERATION | AGGREGATION | Amyloid beta-Peptides - pharmacology | Humans | Middle Aged | Cerebral Cortex - pathology | Maleimides - pharmacology | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Male | Peptide Fragments - pharmacology | Mutation, Missense | Recombinant Fusion Proteins - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Salicylates - pharmacology | Ubiquitination | tau Proteins - genetics | SUMO-1 Protein - genetics | Proteolysis | HEK293 Cells | Female | Indoles - pharmacology | Mutagenesis, Site-Directed | Solubility | Rats | Glycogen Synthase Kinase 3 - metabolism | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Point Mutation | Animals | Androstadienes - pharmacology | Alzheimer Disease - metabolism | Sumoylation | Protein Processing, Post-Translational | SUMO-1 Protein - metabolism | Proteasome Endopeptidase Complex - metabolism | Amino Acid Substitution | Protein research | Research | Protein-protein interactions | Proteins | Brain | Mutagenesis | Index Medicus | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76657 - e76657
Background: Tau protein is implicated in the pathogenesis of neurodegenerative disorders such as tauopathies including Alzheimer disease, and Tau... 
THIOREDOXIN-LIKE DOMAINS | APOPTOTIC CELL-DEATH | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | PAIRED HELICAL FILAMENTS | NEURODEGENERATION | ENDOPLASMIC-RETICULUM STRESS | AMYOTROPHIC-LATERAL-SCLEROSIS | MISFOLDED PROTEINS | BINDING SITE | AGGREGATION | Protein Structure, Secondary | Humans | Endoplasmic Reticulum - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Endoplasmic Reticulum - ultrastructure | Protein Folding | tau Proteins - chemistry | Thermodynamics | Peptide Fragments - chemistry | Protein Disulfide-Isomerases - genetics | Neurons - ultrastructure | tau Proteins - genetics | Escherichia coli - genetics | Escherichia coli - metabolism | Thiazoles | Cell Line, Tumor | Protein Binding | Protein Disulfide-Isomerases - chemistry | Neurons - metabolism | Protein Interaction Domains and Motifs | Kinetics | Binding Sites | Peptide Fragments - genetics | Nervous system diseases | Physiological aspects | Development and progression | Genetic aspects | Research | Tau proteins | Protein binding | Neuroprotection | Nucleation | Immunoprecipitation | Laboratories | Toxicity | Pathogenesis | Confocal microscopy | Biochemistry | Thioredoxin | Neuroblastoma cells | Proteins | Fibrillogenesis | Neurotoxicity | Ischemia | Protein folding | Physiology | Life sciences | Catalysis | Alzheimer's disease | Elongation | Enzymes | Neurodegenerative diseases | Medical treatment | Titration calorimetry | Amyotrophic lateral sclerosis | Molecular chains | Virology | Transmission electron microscopy | Microscopy | Tau protein | Plasmids | Ionic strength | Affinity | Calorimetry | Protein disulfide-isomerase | Titration | Alzheimers disease | Endoplasmic reticulum | Scanning microscopy | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal Article