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Neuron, ISSN 0896-6273, 08/2012, Volume 75, Issue 4, pp. 618 - 632
Mitochondrial abnormalities have been documented in Alzheimer’s disease and related neurodegenerative disorders, but the causal relationship between... 
ALZHEIMERS-DISEASE BRAIN | DOMINANT OPTIC ATROPHY | MITOCHONDRIAL-FUNCTION | MOUSE MODEL | LIGHT-CHAIN | FRONTOTEMPORAL DEMENTIA | AXONAL-TRANSPORT | NEUROSCIENCES | DYNAMIN-RELATED PROTEIN | PHOSPHORYLATION SITES | TRANSGENIC MICE | Neurons - pathology | Microtubule-Associated Proteins - genetics | Tauopathies - genetics | Cytoskeletal Proteins - genetics | Gelsolin - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Actins - metabolism | Tauopathies - pathology | Cytoplasm - metabolism | MicroRNAs - metabolism | Green Fluorescent Proteins - genetics | Mitochondrial Proteins - genetics | Drosophila Proteins - metabolism | GTP-Binding Proteins - genetics | Nerve Degeneration - metabolism | Neurons - ultrastructure | tau Proteins - genetics | Cell Death - genetics | Mitochondria - genetics | Mitochondrial Proteins - metabolism | ATP Synthetase Complexes - metabolism | Cell Cycle Proteins - genetics | Tauopathies - complications | Cytoskeletal Proteins - metabolism | Myosins - metabolism | Cytoplasm - genetics | RNA Interference - physiology | Disease Models, Animal | In Situ Nick-End Labeling | Green Fluorescent Proteins - metabolism | Animals, Genetically Modified | Gene Expression Regulation - genetics | Drosophila | Cell Cycle Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Mutation - genetics | Animals | GTP Phosphohydrolases - metabolism | Analysis of Variance | GTP Phosphohydrolases - genetics | Gelsolin - genetics | Mice | Drosophila Proteins - genetics | Nerve Degeneration - etiology | Voltage-Dependent Anion Channels - metabolism | GTP-Binding Proteins - metabolism | Nervous system diseases | Actin | Neurons | Utrophin | Myosin | Mitochondrial DNA | Alzheimer's disease | Proteins | Phosphorylation | Mitochondria | Neurotoxicity | Insects | Microscopy | Neurodegeneration | Pathogenesis | Morphology | Mutation | Defects | Index Medicus
Journal Article
EMBO reports, ISSN 1469-221X, 11/2017, Volume 18, Issue 11, pp. 2051 - 2066
Endocytic processes are facilitated by both curvature‐generating BAR ‐domain proteins and the coordinated polymerization of actin filaments. Under... 
protein Bin1 | tau | BAR | Alzheimer's disease | actin binding | genetic risk factor | N-BAR protein Bin1 | PROTEIN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CROSS-LINKING | FILAMENT TURNOVER | TAU PATHOLOGY | CELL BIOLOGY | SKELETAL-MUSCLE | STRUCTURAL BASIS | SYNAPTIC VESICLE ENDOCYTOSIS | MEMBRANE CURVATURE | SH3 DOMAIN | Tauopathies - genetics | Humans | Actins - metabolism | Tauopathies - pathology | tau Proteins - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Actins - genetics | Drosophila melanogaster - metabolism | Protein Isoforms - metabolism | tau Proteins - genetics | Tumor Suppressor Proteins - genetics | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Binding Sites | Actin Cytoskeleton - genetics | Disease Models, Animal | Recombinant Proteins - metabolism | Gene Expression | Tumor Suppressor Proteins - metabolism | Actin Cytoskeleton - metabolism | Genetic Vectors - chemistry | Gene Expression Regulation | Genetic Vectors - metabolism | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Tauopathies - metabolism | Animals | Carrier Proteins - metabolism | Escherichia coli - genetics | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Protein Isoforms - genetics | Membranes | Neurodegenerative diseases | Drosophila | Health risks | Polymerization | Rods | Bundles | Risk factors | Membrane proteins | Bundling | Proteins | Depolymerization | Insects | Tau protein | Filaments | Neurodegeneration | Actin | Isoforms | BAR protein | Cytoskeleton | Alzheimers disease | Curvature | Index Medicus | N‐BAR protein Bin1 | Neuroscience | Cell Adhesion, Polarity & Cytoskeleton
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 11/2018, Volume 27, Issue 22, pp. 3951 - 3963
Journal Article
by Hoglinger, Gunter and Melhem, Nadine and Dickson, Dennis and Sleiman, Patrick and Wang, L.-S and Klei, Lambertus and Rademakers, Rosa and Silva, Rohan and Litvan, Irene and Riley, David and Swieten, John and Heutink, Peter and Wszolek, Zbigniew and Uitti, Ryan and Vanovcova, Jana and Hurtig, Howard and Gross, Rachel and Maetzler, Walter and Goldwurm, Stefano and Tolosa, E and Borroni, Barbara and Pastor, Pau and Cantwell, Laura and Han, M.R and Dillman, Allissa and Brug, Marcel and Gibbs, Raphael and Cookson, Mark and Hernandez, Dena and Singleton, Anew and Farrer, Matthew and Yu, Changen and Golbe, Lawrence and Revesz, Tamas and Hardy, John and Lees, Anew and Devlin, Bernie and Hakonarson, Hakon and Müller, Ulrich and Schellenberg, Gerard and Albin, Roger and Alonso, Elena and Apfelbacher, Manuela and Arnold, Steven and Avila, Jesús and Beach, Thomas and Beecher, Sherry and Berg, Daniela and Bird, Thomas and Bogdanović, Nenad and Boon, Anea and Bordelon, Yvette and Brice, Alexis and Budka, Herbert and Canesi, Margherita and Chiu, Wang Zheng and Cilia, Roberto and Colosimo, Carlo and Deyn, Peter and Yebenes, J.G and Donker Kaat, Laura and Duara, Ranjan and Durr, A and Engelborghs, Sebastiaan and Fabbrini, Giovanni and Finch, Nicole and Flook, Robyn and Frosch, Matthew and Gaig, C and Galasko, Douglas and Gasser, Thomas and Gearing, Marla and Geller, Evan and Ghetti, Bernardino and Graff-Radford, Neill and Grossman, Murray and Hall, Deborah and Hazrati, L.-N and Höllerhage, Matthias and Jankovic, Joseph and Juncos, Jorge and Karydas, Anna and Kretzschmar, Hans and Leber, Isabelle and Lee, Virginia and Lieberman, Anew and Lyons, Kelly and Mariani, Claudio and Masliah, Eliezer and Massey, Luke and McLean, Catriona and Meucci, Nicoletta and Miller, Bruce and Mollenhauer, Brit and Möller, Jens and Morris, Huw and O'Sullivan, Sean and Oertel, W and Ottaviani, Donatella and Padovani, Alessano and ... and PSP Genetics Study Grp and PSP Genetics Study Group
Nature Genetics, ISSN 1061-4036, 07/2011, Volume 43, Issue 7, pp. 699 - 705
Journal Article
Neurology, ISSN 0028-3878, 2005, Volume 65, Issue 10, pp. 1636 - 1638
Neurofibrillary degeneration (NFD) occurs in the brains of patients with myotonic dystrophy (DM) type 1. The authors report a similar tau pathology in the CNS... 
RNA | MYOTONIC-DYSTROPHY TYPE-1 | CLINICAL NEUROLOGY | Immunohistochemistry | Neurons - pathology | RNA-Binding Proteins - genetics | Neurofibrillary Tangles - genetics | Myotonic Dystrophy - diagnosis | tau Proteins - immunology | Humans | Middle Aged | tau Proteins - metabolism | Male | Antibody Specificity - genetics | Brain - metabolism | Epitopes - immunology | tau Proteins - genetics | DNA Mutational Analysis | Female | Neurons - metabolism | Tauopathies - physiopathology | Neurofibrillary Tangles - immunology | Neurofibrillary Tangles - pathology | Genetic Predisposition to Disease - genetics | Myotonic Dystrophy - classification | Myotonin-Protein Kinase | Brain - physiopathology | Protein-Serine-Threonine Kinases - genetics | Exons - genetics | Hippocampus - pathology | Epitopes - genetics | Mutation - genetics | Tauopathies - classification | Hippocampus - metabolism | Myotonic Dystrophy - physiopathology | Tauopathies - diagnosis | Brain - pathology | Inclusion Bodies - pathology | Aged | Hippocampus - physiopathology | Index Medicus | Abridged Index Medicus | Antibody Specificity/genetics | Comparative Study | Neurofibrillary Tangles/genetics/immunology/pathology | Neurons/metabolism/pathology | Mutation/genetics | Genetic Predisposition to Disease/genetics | RNA-Binding Proteins/genetics | Myotonic Dystrophy/classification/diagnosis/physiopathology | Protein-Serine-Threonine Kinases/genetics | Epitopes/genetics/immunology | Tauopathies/classification/diagnosis/physiopathology | Hippocampus/metabolism/pathology/physiopathology | tau Proteins/genetics/immunology/metabolism | Research Support; Non-U.S. Gov't | Brain/metabolism/pathology/physiopathology | Exons/genetics | Inclusion Bodies/pathology
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 8, pp. 881 - 885
Journal Article
PLoS Genetics, ISSN 1553-7390, 07/2017, Volume 13, Issue 7, pp. e1006849 - e1006849
The unfolded protein response (UPR) in the endoplasmic reticulum (ER) and the cytoplasmic heat stress response are two major stress response systems necessary... 
UNFOLDED-PROTEIN RESPONSE | ALZHEIMERS-DISEASE | ER STRESS | HEAT-SHOCK RESPONSE | MOUSE MODEL | GENETICS & HEREDITY | PAIRED HELICAL FILAMENTS | ENDOPLASMIC-RETICULUM STRESS | ALPHA-SYNUCLEIN | HUNTINGTONS-DISEASE | NEURODEGENERATIVE DISEASES | Neurons - pathology | Transcription Factor CHOP - genetics | Phosphorylation | Tauopathies - genetics | Humans | Tauopathies - pathology | tau Proteins - metabolism | Endoplasmic Reticulum Stress - genetics | Alzheimer Disease - pathology | Heat Shock Transcription Factors | Heat-Shock Proteins - genetics | tau Proteins - genetics | Proteolysis | Neurons - metabolism | Autophagy - genetics | Transcription Factor CHOP - biosynthesis | Protein Aggregation, Pathological - genetics | Unfolded Protein Response - genetics | Gene Expression Regulation | Rats | Transcription Factors - biosynthesis | Hippocampus - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Heat-Shock Response - genetics | Mice, Knockout | Hippocampus - metabolism | Tauopathies - metabolism | Animals | Alzheimer Disease - metabolism | Mice | Alzheimer Disease - genetics | DNA-Binding Proteins - biosynthesis | Advertising executives | Brain | Neurons | Heat shock proteins | Stress (Physiology) | Health aspects | Alzheimer's disease | Target marketing | Genetic aspects | Neural circuitry | Protein folding | Tau proteins | Huntingtons disease | Neurosciences | Animal models | Toxicity | Pathogenesis | Crosstalk | Cognitive ability | Neurobiology | Homeostasis | Homology | Agglomeration | Activation | Biochemistry | CCAAT/enhancer-binding protein | Kinases | Heat shock factors | Degradation | Proteins | Neurodegeneration | Heat stress | Stress response | HSF1 protein | Inducers | Departments | Neurodegenerative diseases | Hsp70 protein | Pharmacology | Pathology | Tau protein | Aberration | Alzheimers disease | Endoplasmic reticulum | Phagocytosis | Apoptosis | Heat shock | Dementia | Index Medicus
Journal Article
Neurology, ISSN 0028-3878, 07/2008, Volume 71, Issue 1, pp. 28 - 34
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2009, Volume 32, Issue 10, pp. 1827 - 1838
Abstract Mitochondrial dysfunction and oxidative stress play an important role in ageing and have been implicated in several age-related neurodegenerative... 
Neurology | Internal Medicine | Oxidative stress | Tau | Mitochondrial dysfunction | Harlequin | Neurodegeneration | AIF | APOPTOSIS-INDUCING FACTOR | COMPLEX-I INHIBITOR | ALZHEIMERS-DISEASE | FRONTOTEMPORAL DEMENTIA | PICKS-DISEASE | RESPIRATORY-CHAIN SUPERCOMPLEXES | NEUROBLASTOMA-CELLS | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | P301L TAU | TRANSGENIC MICE | Silver Staining - methods | Age Factors | Tauopathies - genetics | Electron Transport Complex I - deficiency | Humans | Caspase 3 - metabolism | Nerve Degeneration - genetics | Apoptosis - genetics | Male | Mitochondria - ultrastructure | Proton Pumps - metabolism | Brain - metabolism | Proline - genetics | tau Proteins - genetics | Mitochondria - genetics | Electron Transport Complex I - genetics | Mice, Mutant Strains | Adenosine Triphosphate - metabolism | Brain - ultrastructure | Statistics, Nonparametric | Leucine - genetics | Apoptosis Inducing Factor - metabolism | In Situ Nick-End Labeling | Mitochondrial Diseases - genetics | Genetic Predisposition to Disease | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Oxidative Stress - genetics | Gene Expression Regulation - physiology | Mice, Transgenic | Mutation - genetics | Nerve Tissue Proteins - genetics | Apoptosis Inducing Factor - genetics | Lipid Peroxidation - physiology | Nerve Tissue Proteins - metabolism | Animals | Movement Disorders - physiopathology | Mice | Movement Disorders - genetics | Alzheimer's disease | Analysis | Genetic aspects | Index Medicus
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