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1. Full Text Effects of rectal administration of taurocholic acid on glucagon‐like peptide‐1 and peptide YY secretion in healthy humans
by Wu, T and Bound, M. J and Standfield, S. D and Gedulin, B and Jones, K. L and Horowitz, M and Rayner, C. K
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 05/2013, Volume 15, Issue 5, pp. 474 - 477
Glucagon‐like peptide‐1 ( GLP ‐1) and peptide YY ( PYY ), secreted by enteroendocrine L‐cells located most densely in the colon and rectum, are of fundamental... 
glucagon‐like peptide 1 | peptide | bile salt | Bile salt | Peptide YY | Glucagon-like peptide 1 | GLUCOSE-HOMEOSTASIS | TRANSIT | FOOD-INTAKE | VOLUNTEERS | INSULIN-SECRETION | ENDOCRINOLOGY & METABOLISM | glucagon-like peptide 1 | peptide YY | APPETITE | Body Mass Index | Taurocholic Acid - pharmacology | Glucagon-Like Peptide 1 - drug effects | Cholagogues and Choleretics - administration & dosage | Cholagogues and Choleretics - pharmacology | Peptide YY - drug effects | Obesity - drug therapy | Humans | Appetite Regulation - drug effects | Administration, Rectal | Male | Obesity - physiopathology | Treatment Outcome | Peptide YY - secretion | Glucagon-Like Peptide 1 - secretion | Enema | Blood Glucose - drug effects | Diabetes Mellitus, Type 2 - physiopathology | Taurocholic Acid - administration & dosage | Adult | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Glucagon | Analysis | Peptides | Bile
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2. Full Text Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: The effect of cholate type, particle size and administered dose
by Niu, Mengmeng and Lu, Yi and Hovgaard, Lars and Guan, Peipei and Tan, Yanan and Lian, Ruyue and Qi, Jianping and Wu, Wei
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 06/2012, Volume 81, Issue 2, pp. 265 - 272
Oral administration of rhINS-loaded bile salt liposomes induced sustained hypoglycemic effect in parallel with increased blood rhINS level. The size effect as... 
Liposomes | Oral | Bioavailability | Insulin | Sodium glycocholate | Bile salts | SALMON-CALCITONIN | GLYCOCHOLATE | THERAPEUTIC PEPTIDES | MUCOUS/GLYCOCALYX LAYERS | DELIVERY | INTESTINAL-ABSORPTION | NANOPARTICLES | IMMUNIZATION | STABILIZED VESICLES BILOSOMES | IN-VITRO CHARACTERIZATION | PHARMACOLOGY & PHARMACY | Rats, Wistar | Liposomes - administration & dosage | Bile Acids and Salts - chemistry | Deoxycholic Acid - chemistry | Drug Carriers - administration & dosage | Biological Availability | Male | Drug Carriers - chemistry | Hypoglycemic Agents - administration & dosage | Bile Acids and Salts - administration & dosage | Glycocholic Acid - administration & dosage | Bile Acids and Salts - pharmacokinetics | Deoxycholic Acid - administration & dosage | Taurocholic Acid - chemistry | Hypoglycemic Agents - pharmacokinetics | Administration, Oral | Rats | Insulin - administration & dosage | Hypoglycemic Agents - chemistry | Mice, Inbred ICR | Particle Size | Liposomes - chemistry | Animals | Taurocholic Acid - administration & dosage | Glycocholic Acid - chemistry | Insulin - chemistry | Mice | Insulin - pharmacokinetics | Liposomes - pharmacokinetics | Drugs | Drug delivery systems | Vehicles
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3. Full Text Oral delivery of taurocholic acid linked heparin–docetaxel conjugates for cancer therapy
by Khatun, Zehedina and Nurunnabi, Md and Reeck, Gerald R and Cho, Kwang Jae and Lee, Yong-kyu
Journal of Controlled Release, ISSN 0168-3659, 08/2013, Volume 170, Issue 1, pp. 74 - 82
We have synthesized taurocholic acid (TCA) linked heparin–docetaxel (DTX) conjugates for oral delivery of anticancer drug. The ternary biomolecular conjugates... 
Nanoparticles | Taurocholic acid | Cancer therapy | Oral delivery | DEOXYCHOLIC-ACID | BILE-ACID | TRANSPORTERS | PHARMACOLOGY & PHARMACY | ABSORPTION | CHEMISTRY, MULTIDISCIPLINARY | Taxoids - chemistry | Cell Survival - drug effects | Administration, Oral | Humans | Heparin, Low-Molecular-Weight - chemistry | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - chemistry | Drug Delivery Systems | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Taxoids - administration & dosage | Animals | Taurocholic Acid - administration & dosage | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Female | Mice | Taurocholic Acid - chemistry | Heparin, Low-Molecular-Weight - administration & dosage | Neoplasms - pathology | Antimitotic agents | Care and treatment | Glycosaminoglycans | Anticoagulants (Medicine) | Antineoplastic agents | Health aspects | Cancer
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4. Full Text Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration
by Lanzini, A and De Tavonatti, M G and Panarotto, B and Scalia, S and Mora, A and Benini, F and Baisini, O and Lanzarotto, F
Gut, ISSN 0017-5749, 09/2003, Volume 52, Issue 9, pp. 1371 - 1375
Background: Whether ileal absorption of bile acid is up or downregulated in chronic cholestasis is still debated, and most evidence has come from animal... 
Studies | Liver diseases | Acids | Rodents | Gallbladder diseases | Retention | Patients | Bile
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5. Full Text New therapeutic concepts in bile acid transport and signaling for management of cholestasis
by Trauner, Michael and Fuchs, Claudia Daniela and Halilbasic, Emina and Paumgartner, Gustav
Hepatology, ISSN 0270-9139, 04/2017, Volume 65, Issue 4, pp. 1393 - 1404
The identification of the key regulators of bile acid (BA) synthesis and transport within the enterohepatic circulation has revealed potential targets for... 
HEPATITIS-B-VIRUS | SCLEROSING CHOLANGITIS | GLUCAGON-LIKE PEPTIDE-1 | URSODEOXYCHOLIC ACID | PRIMARY BILIARY-CIRRHOSIS | GROWTH-FACTOR 19 | FARNESOID-X-RECEPTOR | PLACEBO-CONTROLLED TRIAL | GASTROENTEROLOGY & HEPATOLOGY | FAMILIAL INTRAHEPATIC CHOLESTASIS | NUCLEAR RECEPTOR | Liver Circulation - physiology | Severity of Illness Index | Signal Transduction | Humans | Bile Acids and Salts - metabolism | Treatment Outcome | Cholestasis - physiopathology | Animals | Taurocholic Acid - administration & dosage | Biological Transport - drug effects | Cholestasis - drug therapy | Cohort Studies | Disease Models, Animal | Rodents | Liver diseases | Bile
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6. Full Text Oral absorption mechanism and anti-angiogenesis effect of taurocholic acid-linked heparin-docetaxel conjugates
by Khatun, Zehedina and Nurunnabi, Md and Cho, Kwang Jae and Byun, Youngro and Bae, You Han and Lee, Yong-kyu
Journal of Controlled Release, ISSN 0168-3659, 03/2014, Volume 177, Issue 1, pp. 64 - 73
Oral delivery is the preferred route to deliver therapeutics via nanoparticles due to ease of administration and patient acceptance. Here, we report on the... 
Taurocholic acid | Bile acid transporters | Anti-angiogenesis | Oral delivery | CONTROLLED-RELEASE | CHEMISTRY, MULTIDISCIPLINARY | CANCER-THERAPY | DEOXYCHOLIC-ACID | TRACT | FORMULATIONS | GRAPHENE QUANTUM DOTS | PHARMACOLOGY & PHARMACY | DRUG-DELIVERY SYSTEMS | CHITOSAN-DNA NANOPARTICLES | Human Umbilical Vein Endothelial Cells - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | Heparin - administration & dosage | Extracellular Signal-Regulated MAP Kinases - metabolism | Heparin - pharmacokinetics | Intestinal Absorption | Tissue Distribution | Angiogenesis Inhibitors - administration & dosage | Female | Taurocholic Acid - chemistry | Vascular Endothelial Growth Factor A - pharmacology | Caco-2 Cells | Taxoids - chemistry | Human Umbilical Vein Endothelial Cells - drug effects | Administration, Oral | Cells, Cultured | Angiogenesis Inhibitors - pharmacokinetics | Taxoids - pharmacokinetics | Taurocholic Acid - pharmacokinetics | Taxoids - administration & dosage | Animals | Taurocholic Acid - administration & dosage | Mice, Nude | Mice | Nanoparticles - administration & dosage | Heparin - chemistry | Angiogenesis Inhibitors - chemistry | Antimitotic agents | Ethylene glycol | Glycosaminoglycans | Analysis | Fluorescence | Anticoagulants (Medicine) | Permeability | Antineoplastic agents
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7. Full Text Diabetes development increased concentrations of the conjugated bile acid, taurocholic acid in serum, while treatment with microencapsulated-taurocholic acid exerted no hypoglycaemic effects
by Mathavan, Sangeetha and Mikov, Momir and Golocorbin-Kon, Svetlana and Al-Salami, Hani
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 08/2017, Volume 106, pp. 1 - 9
The bile acid taurocholic acid (TCA) is endogenously produced, and has shown formulation-stabilising effects when incorporated into microcapsules containing... 
Taurocholic acid | Microencapsulation | Inflammation | Bile acids | Type 1 diabetes | Diabetes mellitus | STABILITY | RATS | RELEASE | HEALTHY | FORMULATION | GLICLAZIDE | ARTIFICIAL-CELL MICROENCAPSULATION | PROBUCOL MICROCAPSULES | TARGETED ORAL DELIVERY | PHARMACOLOGY & PHARMACY | PERMEATION | Alginic Acid - chemistry | Taurocholic Acid - pharmacology | Chemistry, Pharmaceutical - methods | Chromatography, High Pressure Liquid - methods | Rats, Wistar | Administration, Oral | Blood Glucose - chemistry | Drug Stability | Rats | Capsules - chemistry | Male | Taurocholic Acid - blood | Diabetes Mellitus, Type 1 - drug therapy | Hypoglycemic Agents - pharmacology | Taurocholic Acid - adverse effects | Hypoglycemic Agents - blood | Animals | Taurocholic Acid - administration & dosage | Hypoglycemic Agents - administration & dosage | Drug Liberation | Rheology - methods | Hypoglycemic Agents - adverse effects | Tandem Mass Spectrometry - methods | Blood sugar | Analysis | Liver | Spectrum analysis | Hypoglycemic agents | X-ray spectroscopy | Mass spectrometry | Calcium chloride | Protein binding | Deoxycholic acid | Index Medicus
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8. Full Text Reduced graphene oxide nanosheets coated with an anti-angiogenic anticancer low-molecular-weight heparin derivative for delivery of anticancer drugs
by Shim, Gayong and Kim, Ji-Young and Han, Jeonghoon and Chung, Seung Woo and Lee, Soondong and Byun, Youngro and Oh, Yu-Kyoung
Journal of Controlled Release, ISSN 0168-3659, 09/2014, Volume 189, pp. 80 - 89
Here, we report reduced graphene oxide (rGO) nanosheets coated with an anti-angiogenic anticancer taurocholate derivative of low-molecular-weight heparin... 
Anticancer effect | Reduced graphene oxide | Doxorubicin | Anti-angiogenic anticancer low molecular weight heparin derivative | Dispersion stability | DISPERSIONS | VIVO | CHEMISTRY, MULTIDISCIPLINARY | FUNCTIONALIZATION | IN-VITRO | CO-DELIVERY | THERAPY | TAUROCHOLATE CONJUGATE | PHARMACOLOGY & PHARMACY | BIOMEDICAL APPLICATIONS | Heparin, Low-Molecular-Weight - analogs & derivatives | Humans | Drug Carriers - administration & dosage | Doxorubicin - chemistry | Antineoplastic Agents - administration & dosage | Drug Carriers - chemistry | Graphite - administration & dosage | Female | Taurocholic Acid - chemistry | Graphite - chemistry | Taurocholic Acid - analogs & derivatives | Doxorubicin - administration & dosage | Cell Survival - drug effects | Oxidation-Reduction | Drug Stability | Heparin, Low-Molecular-Weight - chemistry | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Taurocholic Acid - administration & dosage | Adsorption | Tumor Burden - drug effects | Mice, Nude | Nanostructures - administration & dosage | Cell Line, Tumor | Nanostructures - chemistry | Mice, Inbred BALB C | Heparin, Low-Molecular-Weight - administration & dosage | Neoplasms - pathology | Antimitotic agents | Glycosaminoglycans | Graphene | Fluorescein | Graphite | Anticoagulants (Medicine) | Antineoplastic agents | Anthracyclines | Pharmacy | Fluorescence | Tumors | Index Medicus
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9. Full Text Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier
by Atsushi Ose and Hiroyuki Kusuhara and Chihiro Endo and Kimio Tohyama and Mari Miyajima and Satoshi Kitamura and Yuichi Sugiyama
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
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10. Full Text Enhanced Anti-Angiogenic Effect of Low Molecular Weight Heparin-Bile Acid Conjugates by Co-Administration of a Selective COX-2 Inhibitor
by Kim, Ji-young and Chung, Seung Woo and Kim, Sang Yoon and Byun, Youngro
Pharmaceutical Research, ISSN 0724-8741, 7/2015, Volume 32, Issue 7, pp. 2318 - 2327
To overcome definite limitations of angiogenesis inhibitors such as insufficient therapeutic efficacy as a single drug and resisting or conflicting effect... 
Biochemistry, general | Biomedical Engineering | hypoxia | Biomedicine | Pharmacy | angiogenesis | cyclooxygenase-2 | Medical Law | combination therapy | heparin conjugate | Pharmacology/Toxicology | Angiogenesis | Hypoxia | Cyclooxygenase-2 | Combination therapy | Heparin conjugate | PATHWAYS | METASTASIS | MACROPHAGES | TUMOR ANGIOGENESIS | CELECOXIB | CHEMISTRY, MULTIDISCIPLINARY | CELL CARCINOMA | ANTIANGIOGENIC THERAPY | INFLAMMATION | PHARMACOLOGY & PHARMACY | CANCER PREVENTION | Human Umbilical Vein Endothelial Cells | Celecoxib - administration & dosage | Heparin, Low-Molecular-Weight - pharmacology | Heparin, Low-Molecular-Weight - analogs & derivatives | Humans | Male | Celecoxib - chemistry | Heparin, Low-Molecular-Weight - therapeutic use | Neovascularization, Pathologic - pathology | Cyclooxygenase 2 - biosynthesis | Dose-Response Relationship, Drug | Angiogenesis Inhibitors - administration & dosage | Cyclooxygenase 2 Inhibitors - therapeutic use | Angiogenesis Inhibitors - therapeutic use | Taurocholic Acid - chemistry | Drug Therapy, Combination | Taurocholic Acid - analogs & derivatives | Taurocholic Acid - pharmacology | Cell Hypoxia - drug effects | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 Inhibitors - administration & dosage | Angiogenesis Inhibitors - pharmacology | Heparin, Low-Molecular-Weight - chemistry | Celecoxib - pharmacology | Celecoxib - therapeutic use | Mice, Inbred Strains | Xenograft Model Antitumor Assays | Animals | Taurocholic Acid - administration & dosage | Neovascularization, Pathologic - drug therapy | Taurocholic Acid - therapeutic use | Neovascularization, Pathologic - metabolism | Heparin, Low-Molecular-Weight - administration & dosage | Angiogenesis Inhibitors - chemistry | Drugstores | COX-2 inhibitors | Neovascularization | Angiogenesis inhibitors | Deoxycholic acid | Inhibitor drugs | Pharmaceutical sciences | Tumors
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11. Full Text Understanding the influence of surface properties of nanoparticles and penetration enhancers for improving bioavailability in eye tissues in vivo
by Mahaling, Binapani and Katti, Dhirendra S
International Journal of Pharmaceutics, ISSN 0378-5173, 03/2016, Volume 501, Issue 1-2, pp. 1 - 9
Nanoparticulate drug delivery systems, mucoadhesive polymers and penetration enhancers have been used individually to overcome ocular barriers and increase... 
Nanoparticles | Capric acid | Pluronic F68 | Non-invasive | Sodium taurocholate | Penetration enhancer | Benzalkonium chloride | EDTA | Ocular drug delivery | Sodium glycocholate | PERMEATION ENHANCERS | DRUG-DELIVERY | CHITOSAN NANOPARTICLES | POLYCAPROLACTONE | MICROPARTICLES | GLUTARALDEHYDE | CORNEAL | TRANSPORT | PHARMACOLOGY & PHARMACY | ABSORPTION PROMOTERS | PLGA NANOPARTICLES | Nanoparticles - chemistry | Biological Availability | Coumarins - chemistry | Glycolates - chemistry | Drug Delivery Systems | Surface Properties | Decanoic Acids - chemistry | Eye - drug effects | Taurocholic Acid - chemistry | Glutaral - chemistry | Gelatin - chemistry | Eye - metabolism | Cell Line | Cell Survival - drug effects | Rabbits | Glycolates - administration & dosage | Microscopy, Electron, Scanning | Permeability - drug effects | Nanoparticles - ultrastructure | Benzalkonium Compounds - administration & dosage | Benzalkonium Compounds - chemistry | Decanoic Acids - administration & dosage | Mucins - chemistry | Edetic Acid - administration & dosage | Animals | Edetic Acid - chemistry | Taurocholic Acid - administration & dosage | Polymers - chemistry | Thiazoles - chemistry | Mice | Nanoparticles - administration & dosage | Drugs | Drug delivery systems | Surface active agents | Ophthalmic drugs | Permeability | Saturated fatty acids | Vehicles
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12. Full Text Dietary nitrate increases gastric mucosal blood flow and mucosal defense
by Petersson, Joel and Phillipson, Mia and Jansson, Emmelie Å and Patzak, Andreas and Lundberg, Jon O and Holm, Lena and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinsk cellbiologi
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 03/2007, Volume 292, Issue 3, pp. G718 - G724
Salivary nitrate from dietary or endogenous sources is reduced to nitrite by oral bacteria. In the acidic stomach, nitrite is further reduced to bioactive... 
Rats | Laser-Doppler flowmetry | Endothelial nitric oxide synthase deficient | chromium-labeled EDTA clearance | Gastric mucus | Nitrite | PHYSIOLOGY | INTRAGASTRIC NITRIC-OXIDE | ACID | RAT | PERMEABILITY | PROTECTION | BICARBONATE | laser-Doppler flowmetry | endothelial nitric oxide synthase deficient | gastric mucus | nitrite | IN-VIVO | LASER-DOPPLER | rats | GASTROENTEROLOGY & HEPATOLOGY | STOMACH | THICKNESS | Diclofenac - pharmacology | Nitrates - pharmacology | Nitrites - metabolism | Male | Mucus - drug effects | Stomach - metabolism | Nitrites - administration & dosage | Vascular Resistance - physiology | Regional Blood Flow - drug effects | Gastric Mucosa - drug effects | Vascular Resistance - drug effects | Mucus - metabolism | Blood Pressure - drug effects | Stomach - drug effects | Gastric Mucosa - blood supply | Taurocholic Acid - pharmacology | Permeability - drug effects | Administration, Oral | Mice, Inbred C57BL | Nitric Oxide Synthase Type III | Nitrites - pharmacology | Rats, Sprague-Dawley | Nitrates - administration & dosage | Mice, Knockout | Animals | Taurocholic Acid - administration & dosage | Nitric Oxide Synthase Type II - genetics | Gastric Mucosa - physiology | Mice | Mucus - chemistry | Diclofenac - administration & dosage | Nitric Oxide - metabolism | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICINE | Nitric Oxide/metabolism | Mice; Inbred C57BL | Nitric Oxide Synthase Type II/genetics | Gastric Mucosa/blood supply/drug effects/physiology | Diclofenac/administration & dosage/pharmacology | Regional Blood Flow/drug effects | Rats; Sprague-Dawley | Administration; Oral | Taurocholic Acid/administration & dosage/pharmacology | Mice; Knockout | Mucus/chemistry/drug effects/metabolism | Nitrites/administration & dosage/metabolism/pharmacology | Permeability/drug effects | Blood Pressure/drug effects | MEDICIN | Stomach/drug effects/metabolism | Vascular Resistance/drug effects/physiology | Nitrates/administration & dosage/pharmacology
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13. Full Text Functionalized heparin-protamine based self-assembled nanocomplex for efficient anti-angiogenic therapy
by Alam, Farzana and Al-Hilal, Taslim A and Chung, Seung Woo and Park, Jooho and Mahmud, Foyez and Seo, Donghyun and Kim, Han Sung and Lee, Dong Soo and Byun, Youngro
Journal of Controlled Release, ISSN 0168-3659, 01/2015, Volume 197, pp. 180 - 189
Angiogenesis is a key feature of cancer development, thus it is a good target for cancer therapy. However, drugs that have been designed to block angiogenesis... 
Anti-angiogenesis | Heparin conjugate | Protamine | Self-assembled nanocomplex | SYSTEM | CHITOSAN | POLYELECTROLYTE COMPLEXES | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | HETEROGENEITY | BIOMARKERS | NANOPARTICLES | SULFATE | PHARMACOLOGY & PHARMACY | TUMOR MICROENVIRONMENT | Heparin, Low-Molecular-Weight - analogs & derivatives | Protamines - toxicity | Humans | Male | Polyethylene Glycols - chemistry | Neovascularization, Pathologic - pathology | Angiogenesis Inhibitors - administration & dosage | Protamines - administration & dosage | Taurocholic Acid - chemistry | Taurocholic Acid - analogs & derivatives | Protamines - chemistry | Heparin, Low-Molecular-Weight - toxicity | Heparin, Low-Molecular-Weight - chemistry | Angiogenesis Inhibitors - pharmacokinetics | Taurocholic Acid - toxicity | Rats, Sprague-Dawley | Mice, Inbred C3H | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Taurocholic Acid - pharmacokinetics | Heparin, Low-Molecular-Weight - pharmacokinetics | Animals | Taurocholic Acid - administration & dosage | Angiogenesis Inhibitors - toxicity | Tumor Burden - drug effects | Mice, Nude | Nanostructures - administration & dosage | Neovascularization, Pathologic - drug therapy | Protamines - pharmacokinetics | Cell Line, Tumor | Nanostructures - chemistry | Heparin, Low-Molecular-Weight - administration & dosage | Nanostructures - toxicity | Neoplasms - pathology | Angiogenesis Inhibitors - chemistry | Drugs | Drug delivery systems | Glycosaminoglycans | Polyelectrolytes | Anticoagulants (Medicine) | Polyols | Vehicles | Polyethylene glycol | Collagen | Biomedical engineering | Pharmaceutical biotechnology
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