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1. Full Text Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: The effect of cholate type, particle size and administered dose
by Niu, Mengmeng and Lu, Yi and Hovgaard, Lars and Guan, Peipei and Tan, Yanan and Lian, Ruyue and Qi, Jianping and Wu, Wei
European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, 06/2012, Volume 81, Issue 2, pp. 265 - 272
Liposomes | Oral | Bioavailability | Insulin | Sodium glycocholate | Bile salts | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Rats, Wistar | Liposomes - administration & dosage | Bile Acids and Salts - chemistry | Deoxycholic Acid - chemistry | Drug Carriers - administration & dosage | Biological Availability | Male | Drug Carriers - chemistry | Hypoglycemic Agents - administration & dosage | Bile Acids and Salts - administration & dosage | Glycocholic Acid - administration & dosage | Bile Acids and Salts - pharmacokinetics | Deoxycholic Acid - administration & dosage | Taurocholic Acid - chemistry | Hypoglycemic Agents - pharmacokinetics | Administration, Oral | Rats | Insulin - administration & dosage | Hypoglycemic Agents - chemistry | Mice, Inbred ICR | Particle Size | Liposomes - chemistry | Animals | Taurocholic Acid - administration & dosage | Glycocholic Acid - chemistry | Insulin - chemistry | Mice | Insulin - pharmacokinetics | Liposomes - pharmacokinetics | Drugs | Drug delivery systems | Vehicles | Index Medicus
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2. Full Text Oral delivery of taurocholic acid linked heparin–docetaxel conjugates for cancer therapy
by Khatun, Zehedina and Nurunnabi, Md and Reeck, Gerald R and Cho, Kwang Jae and Lee, Yong-kyu
Journal of controlled release, ISSN 0168-3659, 08/2013, Volume 170, Issue 1, pp. 74 - 82
Nanoparticles | Taurocholic acid | Cancer therapy | Oral delivery | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Taxoids - chemistry | Cell Survival - drug effects | Administration, Oral | Humans | Heparin, Low-Molecular-Weight - chemistry | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - chemistry | Drug Delivery Systems | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Taxoids - administration & dosage | Animals | Taurocholic Acid - administration & dosage | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Female | Mice | Taurocholic Acid - chemistry | Heparin, Low-Molecular-Weight - administration & dosage | Neoplasms - pathology | Antimitotic agents | Care and treatment | Glycosaminoglycans | Anticoagulants (Medicine) | Antineoplastic agents | Health aspects | Cancer | Index Medicus
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3. Full Text Diabetes development increased concentrations of the conjugated bile acid, taurocholic acid in serum, while treatment with microencapsulated-taurocholic acid exerted no hypoglycaemic effects
by Mathavan, Sangeetha and Mikov, Momir and Golocorbin-Kon, Svetlana and Al-Salami, Hani
European journal of pharmaceutical sciences, ISSN 0928-0987, 08/2017, Volume 106, pp. 1 - 9
Taurocholic acid | Microencapsulation | Inflammation | Bile acids | Type 1 diabetes | Diabetes mellitus | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Alginic Acid - chemistry | Taurocholic Acid - pharmacology | Chemistry, Pharmaceutical - methods | Chromatography, High Pressure Liquid - methods | Rats, Wistar | Administration, Oral | Blood Glucose - chemistry | Drug Stability | Rats | Capsules - chemistry | Male | Taurocholic Acid - blood | Diabetes Mellitus, Type 1 - drug therapy | Hypoglycemic Agents - pharmacology | Taurocholic Acid - adverse effects | Hypoglycemic Agents - blood | Animals | Taurocholic Acid - administration & dosage | Hypoglycemic Agents - administration & dosage | Drug Liberation | Rheology - methods | Hypoglycemic Agents - adverse effects | Tandem Mass Spectrometry - methods | Blood sugar | Analysis | Liver | Spectrum analysis | Hypoglycemic agents | X-ray spectroscopy | Mass spectrometry | Calcium chloride | Protein binding | Deoxycholic acid | Index Medicus
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4. Full Text Oral absorption mechanism and anti-angiogenesis effect of taurocholic acid-linked heparin-docetaxel conjugates
by Khatun, Zehedina and Nurunnabi, Md and Cho, Kwang Jae and Byun, Youngro and Bae, You Han and Lee, Yong-kyu
Journal of controlled release, ISSN 0168-3659, 03/2014, Volume 177, Issue 1, pp. 64 - 73
Taurocholic acid | Bile acid transporters | Anti-angiogenesis | Oral delivery | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Human Umbilical Vein Endothelial Cells - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | Heparin - administration & dosage | Extracellular Signal-Regulated MAP Kinases - metabolism | Heparin - pharmacokinetics | Intestinal Absorption | Tissue Distribution | Angiogenesis Inhibitors - administration & dosage | Female | Taurocholic Acid - chemistry | Vascular Endothelial Growth Factor A - pharmacology | Caco-2 Cells | Taxoids - chemistry | Human Umbilical Vein Endothelial Cells - drug effects | Administration, Oral | Cells, Cultured | Angiogenesis Inhibitors - pharmacokinetics | Taxoids - pharmacokinetics | Taurocholic Acid - pharmacokinetics | Taxoids - administration & dosage | Animals | Taurocholic Acid - administration & dosage | Mice, Nude | Mice | Nanoparticles - administration & dosage | Heparin - chemistry | Angiogenesis Inhibitors - chemistry | Antimitotic agents | Ethylene glycol | Glycosaminoglycans | Analysis | Fluorescence | Anticoagulants (Medicine) | Permeability | Antineoplastic agents | Index Medicus
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5. Full Text Understanding the influence of surface properties of nanoparticles and penetration enhancers for improving bioavailability in eye tissues in vivo
by Mahaling, Binapani and Katti, Dhirendra S
International journal of pharmaceutics, ISSN 0378-5173, 03/2016, Volume 501, Issue 1-2, pp. 1 - 9
Nanoparticles | Capric acid | Pluronic F68 | Non-invasive | Sodium taurocholate | Penetration enhancer | Benzalkonium chloride | EDTA | Ocular drug delivery | Sodium glycocholate | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Nanoparticles - chemistry | Biological Availability | Coumarins - chemistry | Glycolates - chemistry | Drug Delivery Systems | Surface Properties | Decanoic Acids - chemistry | Eye - drug effects | Taurocholic Acid - chemistry | Glutaral - chemistry | Gelatin - chemistry | Eye - metabolism | Cell Line | Cell Survival - drug effects | Rabbits | Glycolates - administration & dosage | Microscopy, Electron, Scanning | Permeability - drug effects | Nanoparticles - ultrastructure | Benzalkonium Compounds - administration & dosage | Benzalkonium Compounds - chemistry | Decanoic Acids - administration & dosage | Mucins - chemistry | Edetic Acid - administration & dosage | Animals | Edetic Acid - chemistry | Taurocholic Acid - administration & dosage | Polymers - chemistry | Thiazoles - chemistry | Mice | Nanoparticles - administration & dosage | Drugs | Drug delivery systems | Surface active agents | Ophthalmic drugs | Permeability | Saturated fatty acids | Vehicles | Index Medicus
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6. Full Text Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers
by Tian, Cihui and Asghar, Sajid and Wu, Yifan and Chen, Zhipeng and Jin, Xin and Yin, Lining and Huang, Lin and Ping, Qineng and Xiao, Yanyu
International journal of nanomedicine, ISSN 1176-9114, 10/2017, Volume 12, pp. 7897 - 7911
Nanostructured lipid carriers | Taurocholic acid | Curcumin | Bioavailability | Pharmacokinetics | Oral administration | Pharmacology & Pharmacy | Science & Technology - Other Topics | Nanoscience & Nanotechnology | Life Sciences & Biomedicine | Science & Technology | Administration, Oral | Curcumin - pharmacokinetics | Intestinal Absorption - drug effects | Drug Carriers - administration & dosage | Biological Availability | Male | Polyethylene Glycols - chemistry | Permeability | Curcumin - administration & dosage | Rats, Sprague-Dawley | Drug Carriers - chemistry | Particle Size | Lipids - chemistry | Animals | Nanostructures - administration & dosage | Nanostructures - chemistry | Drug Carriers - pharmacokinetics | Taurocholic Acid - chemistry | Turmeric | Epithelial cells | Analysis | Chemical properties | Health aspects | Patient compliance | Drugs | Drug delivery systems | Nuclear magnetic resonance--NMR | Laboratories | Hemodialysis | Glycerol | Lipids | Cancer therapies | Molecular weight | Nanoparticles | Polyethylene glycol | Ligands | Physiology | Bile | Pharmaceuticals | Index Medicus
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7. Full Text Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver
by Sanoh, Seigo and Tamura, Yuka and Fujino, Chieri and Sugahara, Go and Yoshizane, Yasumi and Yanagi, Ami and Kisoh, Keishi and Ishida, Yuji and Tateno, Chise and Ohta, Shigeru and Kotake, Yaichiro
Biological & pharmaceutical bulletin, ISSN 0918-6158, 08/2019, Volume 42, Issue 8, pp. 1366 - 1375
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Rifampin - pharmacokinetics | Bile Acids and Salts - blood | Cholestasis - metabolism | Rifampin - blood | Humans | Liver - metabolism | Ketoconazole - pharmacokinetics | Bile Acids and Salts - metabolism | Ketoconazole - blood | Male | Alanine Transaminase - blood | Cholestasis - chemically induced | Cholestasis - blood | Rifampin - adverse effects | Animals | Aspartate Aminotransferases - blood | Liver - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Mice | Ketoconazole - adverse effects | Chemical and Drug Induced Liver Injury - blood | Alkaline Phosphatase - blood | Alkaline phosphatase | Taurocholic acid | Bile acids | Ketoconazole | Liver | Clinical trials | Gallbladder diseases | Mass spectroscopy | mRNA | Drug development | Taurodeoxycholic acid | Side effects | Acids | Biomarkers | In vivo methods and tests | Human behavior | Mass spectrometry | Rifampin | Cholestasis | Bile | Index Medicus
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8. Full Text Promotion of classic neutral bile acids synthesis pathway is responsible for cholesterol-lowing effect of Si-miao-yong-an decoction: Application of LC–MS/MS method to determine 6 major bile acids in rat liver and plasma
by Liu, Ziying and Zhang, Yu and Zhang, Ruowen and Gu, Liqiang and Chen, Xiaohui
Journal of pharmaceutical and biomedical analysis, ISSN 0731-7085, 02/2017, Volume 135, pp. 167 - 175
Bile acids | Hyperlipidemia | LC–MS/MS | Si-miao-yong-an decoction | cholic acid | taurocholic acid | low-density lipoprotein cholesterol | ALT | glutamic oxalacetic transaminase | total cholesterol | GCDCA | high-density lipoprotein cholesterol | SMYAD | CDCA | AST | GCA | LDL-c | glycocholic acid | traditional Chinese medicine | TCDCA | total triglyceride | HDL-c | glyco chenodeoxycholic acid | glutamic pyruvic transaminase | taurochenodeoxycholic acid | TCA | chenodeoxycholic acid | TCM | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Chemistry, Analytical | Life Sciences & Biomedicine | Science & Technology | Bile Acids and Salts - blood | Administration, Oral | Anticholesteremic Agents - blood | Cholesterol - blood | Liver - metabolism | Rats | Bile Acids and Salts - metabolism | Male | Plasma - drug effects | Random Allocation | Cholesterol - metabolism | Drugs, Chinese Herbal - metabolism | Rats, Sprague-Dawley | Plasma - metabolism | Animals | Anticholesteremic Agents - metabolism | Liver - drug effects | Anticholesteremic Agents - administration & dosage | Metabolic Networks and Pathways - physiology | Bile Acids and Salts - analysis | Drugs, Chinese Herbal - administration & dosage | Metabolic Networks and Pathways - drug effects | Chromatography, Liquid - methods | Tandem Mass Spectrometry - methods | Cholesterol | Methods | Taurine | Analysis and chemistry | Low density lipoproteins | Liver | Physiological aspects | Glycine | Blood | Deoxycholic acid | Index Medicus
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9. Full Text Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier
by Atsushi Ose and Hiroyuki Kusuhara and Chihiro Endo and Kimio Tohyama and Mari Miyajima and Satoshi Kitamura and Yuichi Sugiyama
Drug metabolism and disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism | Index Medicus
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10. Full Text New therapeutic concepts in bile acid transport and signaling for management of cholestasis
by Trauner, Michael and Fuchs, Claudia Daniela and Halilbasic, Emina and Paumgartner, Gustav
Hepatology (Baltimore, Md.), ISSN 0270-9139, 04/2017, Volume 65, Issue 4, pp. 1393 - 1404
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Liver Circulation - physiology | Severity of Illness Index | Signal Transduction | Humans | Bile Acids and Salts - metabolism | Treatment Outcome | Cholestasis - physiopathology | Animals | Taurocholic Acid - administration & dosage | Biological Transport - drug effects | Cholestasis - drug therapy | Cohort Studies | Disease Models, Animal | Liver diseases | Bile | Index Medicus
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