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Nature, ISSN 0028-0836, 2012, Volume 486, Issue 7405, pp. 104 - 108
Journal Article
Cell Metabolism, ISSN 1550-4131, 02/2013, Volume 17, Issue 2, pp. 225 - 235
Bile acids are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile acids. Bile acid synthesis is under... 
ACTIVATION | DISRUPTION | STEROIDS | LIVER | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | FARNESOID-X-RECEPTOR | GERM-FREE | ABSORPTION | DIFFERENTIAL REGULATION | BINDING | CELL BIOLOGY | Organ Specificity - drug effects | Taurocholic Acid - metabolism | Fibroblast Growth Factors - genetics | Ileum - metabolism | Gene Expression Profiling | Fibroblast Growth Factors - metabolism | Organ Specificity - genetics | Ileum - drug effects | Metagenome - genetics | Absorption | Liver - drug effects | Taurocholic Acid - analogs & derivatives | Taurocholic Acid - pharmacology | Metagenome - drug effects | Liver - metabolism | Gastrointestinal Tract - microbiology | Bile Acids and Salts - metabolism | Gastrointestinal Tract - drug effects | Gene Expression Regulation - drug effects | Cholesterol 7-alpha-Hydroxylase - genetics | Animals | Cholesterol 7-alpha-Hydroxylase - metabolism | Models, Biological | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Feedback, Physiological - drug effects | Anti-Bacterial Agents - pharmacology | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Fibroblast growth factors | Universities and colleges | Cytochrome P-450 | Deoxycholic acid | Index Medicus | Biological Sciences | Clinical Medicine | Naturvetenskap | Medical and Health Sciences | Endokrinologi och diabetes | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Cellbiologi | Klinisk medicin | Cell Biology | Endocrinology and Diabetes
Journal Article
Gastroenterology, ISSN 0016-5085, 2006, Volume 130, Issue 6, pp. 1793 - 1806
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1308 - 1314
Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic... 
RAT | SEVERE RHABDOMYOLYSIS | COMBINATION THERAPY | LIVER | PHARMACOLOGY & PHARMACY | CERIVASTATIN | HEPATIC-UPTAKE | TRANSPLANT RECIPIENTS | ROSUVASTATIN | POLYPEPTIDE | FAMILY | Organic Anion Transporters, Sodium-Independent - genetics | Fatty Acids, Monounsaturated - pharmacology | Cricetulus | Hypolipidemic Agents - metabolism | Hypoglycemic Agents - metabolism | Taurocholic Acid - metabolism | Humans | Hepatocytes - metabolism | Simvastatin - pharmacology | Organic Anion Transporters - metabolism | Chromans - metabolism | Hepatocytes - cytology | Indoles - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Anticholesteremic Agents - metabolism | Chromans - pharmacology | Fatty Acids, Monounsaturated - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Indoles - pharmacology | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Pravastatin - pharmacology | Recombinant Proteins - metabolism | Taurocholic Acid - pharmacology | Cell Line | Cricetinae | Pravastatin - metabolism | Simvastatin - metabolism | Gemfibrozil - pharmacokinetics | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Thiazolidinediones - metabolism | Hypoglycemic Agents - pharmacology | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Protein Binding | Fatty Acids, Monounsaturated - pharmacokinetics | Indoles - pharmacokinetics | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Anticholesteremic Agents - pharmacology | Gemfibrozil - metabolism | Index Medicus
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 8/2017, Volume 34, Issue 8, pp. 1601 - 1614
To assess the use of glycochenodeoxycholate-3-sulfate (GCDCA-S) and chenodeoxycholate 3- or 24-glucuronide (CDCA-3G or -24G) as surrogate endogenous substrates... 
Biochemistry, general | Biomedical Engineering | organic anion transporting polypeptide (OATP) | Biomedicine | drug–drug interaction | bile acids | Pharmacy | endogenous substrates | Medical Law | Pharmacology/Toxicology | hepatobiliary transport | GENETIC POLYMORPHISMS | SALT EXPORT PUMP | HUMANS | BILE-ACID SYNTHESIS | HEPATIC-UPTAKE | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | ORGANIC-ANIONS | PHARMACOLOGY & PHARMACY | RESISTANCE-ASSOCIATED PROTEIN-2 | HUMAN LIVER | drug-drug interaction | TRANSPORTER INHIBITION | Taurocholic Acid - pharmacology | Solute Carrier Organic Anion Transporter Family Member 1B3 - metabolism | Bile Acids and Salts - blood | Atorvastatin - metabolism | Humans | Pioglitazone | Male | Hepatocytes - metabolism | Symporters - metabolism | Liver-Specific Organic Anion Transporter 1 - metabolism | Young Adult | Glycochenodeoxycholic Acid - analogs & derivatives | Drug Interactions | Glucuronides - metabolism | Chenodeoxycholic Acid - metabolism | HEK293 Cells | Adult | Rifampin - pharmacology | Thiazolidinediones - pharmacology | Organic Anion Transporters, Sodium-Dependent - metabolism | Glycochenodeoxycholic Acid - metabolism | Complications and side effects | Bile acids | Sulfates | Rifampin | Drug interactions | Investigations | Liver | Substrates | Chenodeoxycholate | Acids | Metabolites | Hepatocytes | Cryopreservation | Atorvastatin | Drug interaction | Inhibition | Sulfate | Probes | Bile | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2011, Volume 108, Issue 4, pp. 1403 - 1408
This study describes a unique function of taurocholate in bile canalicular formation involving signaling through a cAMP-Epac-MEK-Rap1-LKB1-AMPK pathway. In rat... 
P-glycoprotein | Primary hepatocytes | Occludin | ACTIVATED PROTEIN-KINASE | RAT HEPATOCYTES | primary hepatocytes | SANDWICH CONFIGURATION | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | LKB1 | SIGNAL-TRANSDUCTION | MAINTENANCE | occludin | IN-VITRO | EPITHELIAL-CELLS | CAMP PRODUCTION | Cholagogues and Choleretics - pharmacology | Mitogen-Activated Protein Kinase Kinases - genetics | Bile Acids and Salts - pharmacology | Green Fluorescent Proteins - genetics | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Mitogen-Activated Protein Kinase Kinases - metabolism | Hepatocytes - cytology | Guanine Nucleotide Exchange Factors - metabolism | Adenylate Kinase - metabolism | Chenodeoxycholic Acid - pharmacology | Cell Polarity - drug effects | Cyclic AMP - metabolism | Hepatocytes - drug effects | Protein-Serine-Threonine Kinases - metabolism | Taurocholic Acid - pharmacology | Green Fluorescent Proteins - metabolism | rap1 GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Rats | Imines - pharmacology | Rats, Sprague-Dawley | Blotting, Western | Microscopy, Confocal | Ursodeoxycholic Acid - pharmacology | Animals | Signal Transduction - drug effects | Models, Biological | Adenylate Kinase - antagonists & inhibitors | Adenylate Kinase - genetics | rap1 GTP-Binding Proteins - genetics | Measurement | Bile acids | Physiological aspects | Polarity (Biology) | Glycoproteins | Properties | Health aspects | Liver cells | Studies | Enzymes | Cell culture | Molecular structure | Rodents | Cells | Index Medicus | Biological Sciences
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 02/2017, Volume 91, Issue 2, pp. 110 - 122
Journal Article
Hepatology, ISSN 0270-9139, 01/2012, Volume 55, Issue 1, pp. 267 - 276
Journal Article
Journal Article
Diabetes, obesity & metabolism, ISSN 1462-8902, 2016, Volume 18, Issue 6, pp. 571 - 580
Journal Article