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1. Full Text Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile
by Hrkach, Jeffrey and Von Hoff, Daniel and Ali, Mir Mukkaram and Andrianova, Elizaveta and Auer, Jason and Campbell, Tarikh and De Witt, David and Figa, Michael and Figueiredo, Maria and Horhota, Allen and Low, Susan and McDonnell, Kevin and Peeke, Erick and Retnarajan, Beadle and Sabnis, Abhimanyu and Schnipper, Edward and Song, Jeffrey J and Song, Young Ho and Summa, Jason and Tompsett, Douglas and Troiano, Greg and Hoven, Tina Van Geen and Wright, Jim and LoRusso, Patricia and Kantoff, Philip W and Bander, Neil H and Sweeney, Christopher and Farokhzad, Omid C and Langer, Robert and Zale, Stephen
Science Translational Medicine, ISSN 1946-6234, 04/2012, Volume 4, Issue 128, pp. 128ra39 - 128ra39
We describe the development and clinical translation of a targeted polymeric nanoparticle (TNP) containing the chemotherapeutic docetaxel (DTXL) for the... 
MEDICINE, RESEARCH & EXPERIMENTAL | MEMBRANE ANTIGEN | SOLID TUMORS | DRUG-DELIVERY | IN-VIVO | PROSTATE-CANCER | SURFACE | PEG NANOPARTICLES | LIPID-LIKE MATERIALS | CANCER-THERAPY | POLYMER HYBRID NANOPARTICLES | CELL BIOLOGY | Taxoids - chemistry | Taxoids - pharmacology | Nanoparticles - chemistry | Humans | Rats | Male | Taxoids - pharmacokinetics | Xenograft Model Antitumor Assays | Taxoids - administration & dosage | Animals | Glutamate Carboxypeptidase II - metabolism | Antigens, Surface - metabolism | Cell Line, Tumor | Polymers - chemistry | Mice | Nanoparticles - administration & dosage | Index Medicus
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2. Full Text Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel
by Cho, Hyun-Jong and Yoon, Hong Yeol and Koo, Heebeom and Ko, Seung-Hak and Shim, Jae-Seong and Lee, Ju-Hee and Kim, Kwangmeyung and Chan Kwon, Ick and Kim, Dae-Duk
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 29, pp. 7181 - 7190
Abstract Hyaluronic acid-ceramide (HA-CE)-based self-assembled nanoparticles were developed for intravenous docetaxel (DCT) delivery. In this study,... 
Advanced Basic Science | Dentistry | Hyaluronic acid-ceramide | Nanoparticle | CD44 | Poloxamer | Docetaxel | GOLD NANOPARTICLES | THERAPEUTICS | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | INTRACELLULAR DRUG-DELIVERY | ANTITUMOR-ACTIVITY | IN-VITRO | PHARMACOKINETICS | TISSUE DISTRIBUTION | LIPID EMULSION | COPOLYMER MICELLES | MDR CANCER-CELLS | Taxoids - chemistry | Taxoids - pharmacology | Nanoparticles - chemistry | Hyaluronic Acid - chemistry | Materials Testing | Antineoplastic Agents - therapeutic use | Cell Line, Tumor - drug effects | Ceramides - chemistry | Taxoids - metabolism | Antineoplastic Agents - chemistry | Drug Carriers - chemistry | Drug Delivery Systems | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Taxoids - therapeutic use | Animals | Antineoplastic Agents - pharmacology | Mice | Molecular Structure | Poloxalene - chemistry | Index Medicus
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3. Full Text Cabazitaxel in patients with advanced solid tumours: Results of a Phase I and pharmacokinetic study
by Diéras, V and Lortholary, A and Laurence, V and Delva, R and Girre, V and Livartowski, A and Assadourian, S and Semiond, D and Pierga, J.Y
European Journal of Cancer, ISSN 0959-8049, 2012, Volume 49, Issue 1, pp. 25 - 34
Abstract Background Although the taxanes paclitaxel and docetaxel are among the most active agents for the treatment of a wide range of cancers, tumours often... 
Hematology, Oncology and Palliative Medicine | Clinical trial, Phase I | Maximum tolerated dose | Taxoids | Pharmacokinetics | Cabazitaxel | CELLS | DOCETAXEL TAXOTERE(R) | PACLITAXEL | EVERY 3 WEEKS | ONCOLOGY | PROSTATE-CANCER | RESISTANCE | TAXANE | Area Under Curve | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Neoplasms - drug therapy | Taxoids - pharmacokinetics | Taxoids - administration & dosage | Taxoids - therapeutic use | Maximum Tolerated Dose | Antineoplastic Agents - adverse effects | Adult | Female | Aged | Antineoplastic Agents - pharmacokinetics | Taxoids - adverse effects | Clinical trials | Analysis | Index Medicus
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4. Full Text Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
by Herbst, Roy S, Prof and Baas, Paul, Prof and Kim, Dong-Wan, MD and Felip, Enriqueta, MD and Pérez-Gracia, José L, MD and Han, Ji-Youn, Prof and Molina, Julian, MD and Kim, Joo-Hang, Prof and Arvis, Catherine Dubos, MD and Ahn, Myung-Ju, Prof and Majem, Margarita, MD and Fidler, Mary J, MD and de Castro, Gilberto, MD and Garrido, Marcelo, MD and Lubiniecki, Gregory M, MD and Shentu, Yue, PhD and Im, Ellie, MD and Dolled-Filhart, Marisa, PhD and Garon, Edward B, MD
Lancet, The, ISSN 0140-6736, 2015, Volume 387, Issue 10027, pp. 1540 - 1550
Summary Background Despite recent advances in the treatment of advanced non-small-cell lung cancer, there remains a need for effective treatments for... 
Internal Medicine | CRITERIA | MEDICINE, GENERAL & INTERNAL | ANTI-PD-L1 ANTIBODY | THERAPY | NSCLC | IMMUNOTHERAPY | PD-L1 | BLOCKADE | NIVOLUMAB | CHEMOTHERAPY | Lung Neoplasms - drug therapy | Carcinoma, Non-Small-Cell Lung - chemistry | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Molecular Targeted Therapy | Patient Selection | Taxoids - therapeutic use | Antibodies, Monoclonal, Humanized - administration & dosage | Antineoplastic Agents - adverse effects | Adult | Female | Taxoids - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Drug Administration Schedule | Lung Neoplasms - chemistry | Kaplan-Meier Estimate | Treatment Outcome | Disease-Free Survival | Taxoids - administration & dosage | Aged | B7-H1 Antigen - analysis | Carcinoma, Non-Small-Cell Lung - drug therapy | Antimitotic agents | Medical colleges | Lung cancer, Non-small cell | Antineoplastic agents | Analysis | Chemotherapy | Biopsy | Genes | Lung cancer | Clinical trials | Oncology | Mutation | Tumors | Slopes | Cell survival | Medical treatment | Medical services | FDA approval | Survival | Patients | Medical centres | Pembrolizumab | Randomization | Interactive systems | Immunotherapy | Risk assessment | PD-L1 protein | Biomarkers | Index Medicus | Abridged Index Medicus
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5. Full Text Mechanism-based tumor-targeting drug delivery system. Validation of efficient vitamin receptor-mediated endocytosis and drug release
by Chen, Shuyi and Zhao, Xianrui and Chen, Jingyi and Chen, Jin and Kuznetsova, Larisa and Wong, Stanislaus S and Ojima, Iwao and BROOKHAVEN NATIONAL LABORATORY (BNL)
Bioconjugate Chemistry, ISSN 1043-1802, 05/2010, Volume 21, Issue 5, pp. 979 - 987
An efficient mechanism-based tumor-targeting drug delivery system. based on tumor-specific vitamin-receptor mediated endocytosis, has been developed. The... 
CELLS | ACID | ANTICANCER AGENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TAXOIDS | DOXORUBICIN | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | CHEMISTRY, MULTIDISCIPLINARY | CHEMOTHERAPY | MEDICINAL CHEMISTRY | POTENT | BIOLOGICAL EVALUATION | GSH | Taxoids - chemistry | Cell Survival - drug effects | Taxoids - pharmacology | Biotin - pharmacokinetics | Humans | Leukemia - drug therapy | Antineoplastic Agents - administration & dosage | Neoplasms - drug therapy | Taxoids - pharmacokinetics | Biotin - chemistry | Endocytosis | Cytotoxins - pharmacology | Cytotoxins - chemistry | Biotin - pharmacology | Cell Line, Tumor | Biotin - metabolism | Cytotoxins - pharmacokinetics | Drug Delivery Systems - methods | Proteins | Microscopy | Toxicity | Biochemistry | Vitamins | Cells | Tumors | Index Medicus | SPECIFICITY | BASIC BIOLOGICAL SCIENCES | MICROTUBULES | MATERIALS HANDLING EQUIPMENT | LUNGS | TUMOR CELLS | PROBES | FLUORESCENCE | MONITORS | DRUGS | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | BIOTIN | VITAMINS | LEUKEMIA | PROTEINS | FLUORESCEIN
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6. Full Text PEI-derivatized fullerene drug delivery using folate as a homing device targeting to tumor
by Shi, Jinjin and Zhang, Hongling and Wang, Lei and Li, Lulu and Wang, Honghong and Wang, Zhenzhen and Li, Zhi and Chen, Chengqun and Hou, Lin and Zhang, Chaofeng and Zhang, Zhenzhong
Biomaterials, ISSN 0142-9612, 2012, Volume 34, Issue 1, pp. 251 - 261
Abstract Fullerene (C60) has shown great potential in drug delivery. In this study, firstly, amine-functionalized C60 (C60-NH2 ) was achieved by introducing... 
Advanced Basic Science | Dentistry | PEI-derivatized fullerene | Drug delivery | Tumor-targeting | Nanoparticle | Folic acid | Docetaxel | CELLS | OXIDATIVE STRESS | MATERIALS SCIENCE, BIOMATERIALS | NEOADJUVANT TREATMENT | ENGINEERING, BIOMEDICAL | FOLIC-ACID | CARBON NANOTUBES | BREAST-CANCER | NANOPARTICLES | IN-VITRO | C-60 | Neoplasms - metabolism | Taxoids - pharmacology | Apoptosis - drug effects | Humans | Body Weight - drug effects | Male | Spectroscopy, Fourier Transform Infrared | Polyethyleneimine - pharmacokinetics | Neoplasms - blood | Polyethyleneimine - chemistry | Female | Folic Acid - chemical synthesis | Fullerenes - chemistry | Taxoids - blood | Polyethyleneimine - chemical synthesis | Taxoids - chemistry | Tissue Distribution - drug effects | Endocytosis - drug effects | Folic Acid - chemistry | Folic Acid - pharmacokinetics | Spectrophotometry, Ultraviolet | Taxoids - pharmacokinetics | Particle Size | Xenograft Model Antitumor Assays | Administration, Intravenous | Animals | Tumor Burden - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Neoplasms - pathology | Drug Delivery Systems - methods | Fullerenes - pharmacokinetics | Drugs | Drug delivery systems | Biological products | Heterocyclic compounds | Analysis | Polymerization | Ethylenediamines | Tumors | Vehicles | Index Medicus
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7. Full Text Lactoferrin bioconjugated solid lipid nanoparticles: a new drug delivery system for potential brain targeting
by Singh, Indu and Swami, Rajan and Pooja, Deep and Jeengar, Manish Kumar and Khan, Wahid and Sistla, Ramakrishna
Journal of Drug Targeting, ISSN 1061-186X, 03/2016, Volume 24, Issue 3, pp. 212 - 223
Background: Delivery of drugs to brain is a subtle task in the therapy of many severe neurological disorders. Solid lipid nanoparticles (SLN) easily diffuse... 
lactoferrin | nanoparticles | Blood-brain barrier | brain | docetaxel | conjugation | CELLS | PROTEIN | VIVO | BARRIER | RECEPTOR | COLLOIDAL STABILITY | IN-VITRO | MODIFIED GOLD NANOPARTICLES | ANNEXIN-V | PHARMACOLOGY & PHARMACY | Taxoids - chemistry | Nanoparticles - chemistry | Apoptosis - drug effects | Drug Stability | Lactoferrin - pharmacokinetics | Brain Neoplasms - drug therapy | Brain Neoplasms - metabolism | Lactoferrin - administration & dosage | Taxoids - pharmacokinetics | Brain - metabolism | Particle Size | Tissue Distribution | Lactoferrin - chemistry | Taxoids - administration & dosage | Taxoids - therapeutic use | Animals | Cell Line, Tumor | Drug Liberation | Female | Mice | Nanoparticles - administration & dosage | Radioligand Assay | Drug Delivery Systems - methods | Taxoids - blood | Index Medicus
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8. Full Text Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: Preparation, in vitro and in vivo evaluation
by He, Zhijian and Schulz, Anita and Wan, Xiaomeng and Seitz, Joshua and Bludau, Herdis and Alakhova, Daria Y and Darr, David B and Perou, Charles M and Jordan, Rainer and Ojima, Iwao and Kabanov, Alexander V and Luxenhofer, Robert
Journal of Controlled Release, ISSN 0168-3659, 06/2015, Volume 208, pp. 67 - 75
The clinically and commercially successful taxanes, paclitaxel and docetaxel suffer from two major drawbacks, namely their very low aqueous solubility and the... 
In vivo | Multi-drug resistance | Taxoids | Poly(2-oxazoline) | Orthotopic tumor model | Paclitaxel | LCC6 | Drug delivery | Nanomedicine | In vitro | In vivo LCC6 | DRUG | NAB-PACLITAXEL | DELIVERY-SYSTEMS | NANOPARTICLE | BIODISTRIBUTION | ANTITUMOR-ACTIVITY | CHEMISTRY, MULTIDISCIPLINARY | BREAST | NK105 | PHARMACOLOGY & PHARMACY | PHASE-I | CYTOTOXICITY | Taxoids - chemistry | Cell Survival - drug effects | Taxoids - pharmacology | Humans | Antineoplastic Agents, Phytogenic - chemistry | Breast Neoplasms - drug therapy | Chemistry, Pharmaceutical | Oxazoles - chemistry | Particle Size | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Micelles | Cell Line, Tumor | Female | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Delayed-Action Preparations | Drug resistance | Index Medicus | multi-drug resistance | paclitaxel, taxoids | in vitro | poly(2-oxazoline) | nanomedicine | in vivo | drug delivery | orthotopic tumor model
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9. Full Text Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
by Andrea E. Prota and Katja Bargsten and Didier Zurwerra and Jessica J. Field and José Fernando Díaz and Karl-Heinz Altmann and Michel O. Steinmetz
Science, ISSN 0036-8075, 2/2013, Volume 339, Issue 6119, pp. 587 - 590
Microtubule-stabilizing agents (MSAs) are efficacious chemotherapeutic drugs widely used for the treatment of cancer. Despite the importance of MSAs for... 
Trucks | Taxoids | Molecular structure | Microtubules | REPORTS | Atoms | Ligands | Biochemistry | Molecular mechanisms of action | Epothilones | Crystal structure | ELECTRON CRYSTALLOGRAPHY | BINDING MODE | COMPLEX | ALPHA-BETA-TUBULIN | DIMER | TAXOL | MULTIDISCIPLINARY SCIENCES | RESOLUTION | GDP-TUBULIN | EPOTHILONE-A | Taxoids - chemistry | Tubulin Modulators - chemistry | Taxoids - pharmacology | Protein Structure, Secondary | Epothilones - chemistry | Tubulin Modulators - pharmacology | Epothilones - pharmacology | Crystallography, X-Ray | Antineoplastic Agents - chemistry | Animals | Bridged-Ring Compounds - chemistry | Macrolides - chemistry | Cattle | Microtubules - drug effects | Chickens | Bridged-Ring Compounds - pharmacology | Macrolides - pharmacology | Antineoplastic Agents - pharmacology | Tubulin - chemistry | Binding Sites | Antimitotic agents | Care and treatment | Drug interactions | Physiological aspects | Research | Antineoplastic agents | Molecular biology | Health aspects | Cancer | Proteins | Chemotherapy | Inhibitor drugs | Index Medicus | Stability | Taxol | Cell division | Assembly | Anticancer properties
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10. Full Text Formulation of Docetaxel by folic acid-conjugated d -α-tocopheryl polyethylene glycol succinate 2000 (Vitamin E TPGS2k ) micelles for targeted and synergistic chemotherapy
by Mi, Yu and Liu, Yutao and Feng, Si-Shen
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 16, pp. 4058 - 4066
Abstract Although high efficacy has been showed, Paclitaxel and Docetaxel cause serious side effects due to the adjuvant used in their clinical formulation... 
Advanced Basic Science | Dentistry | Cancer nanotechnology | Pharmaceutical nanotechnology | Drug formulation | Chemotherapeutic engineering | Nanomedicine | Biodegradable polymers | DIBLOCK COPOLYMERS | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | BLOCK-COPOLYMER MICELLES | ENDOCYTOSIS | CANCER | PACLITAXEL | NANOPARTICLES | IN-VITRO | E ANALOGS | Taxoids - chemistry | Cell Survival - drug effects | NIH 3T3 Cells | Taxoids - pharmacology | Humans | Folic Acid - chemistry | Vitamin E - analogs & derivatives | Polyethylene Glycols - chemistry | Taxoids - pharmacokinetics | Microscopy, Confocal | Animals | Micelles | Cell Line, Tumor | Polymers - chemistry | Mice | Vitamin E - chemistry | Nanotechnology | Index Medicus
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11. Full Text Liposome-based co-delivery of siRNA and docetaxel for the synergistic treatment of lung cancer
by Qu, Mei-Hua and Zeng, Rui-Fang and Fang, Shi and Dai, Qiang-Sheng and Li, He-Ping and Long, Jian-Ting
International Journal of Pharmaceutics, ISSN 0378-5173, 10/2014, Volume 474, Issue 1-2, pp. 112 - 122
Combination of more than one therapeutic strategy is the standard treatment in clinics. Co-delivery of chemotherapeutic drug and small interfering RNA (siRNA)... 
siRNA | Liposomes | Lung cancer | Docetaxel | Antitumor | THERAPEUTICS | CELLS | PROTEIN | ACID | RELEASE | LRP | RNA-INTERFERENCE | CHALLENGES | BREAST-CANCER | NANOPARTICLES | PHARMACOLOGY & PHARMACY | Lung Neoplasms - drug therapy | Taxoids - pharmacology | Apoptosis - drug effects | Humans | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Taxoids - therapeutic use | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | RNA, Small Interfering - pharmacokinetics | RNA, Small Interfering - pharmacology | Rats | Rats, Sprague-Dawley | Taxoids - pharmacokinetics | Drug Synergism | Taxoids - administration & dosage | Animals | Mice, Nude | RNA, Small Interfering - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | RNA, Small Interfering - administration & dosage | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Antimitotic agents | Care and treatment | Respiratory agents | Drug therapy | Antineoplastic agents | Cancer | Index Medicus
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12. Full Text Preparation and evaluation in vitro and in vivo of docetaxel loaded mixed micelles for oral administration
by Dou, Jinfeng and Zhang, Mengyu and Zhang, Haiqun and Liu, Xiuju and Zhai, Guangxi
Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, 02/2014, Volume 114, pp. 20 - 27
A mixed micelle that comprised of monomethylol poly(ethylene glycol)-poly( , -lactic acid) (MPP), -α-tocopheryl polyethylene glycol 1000 succinate (TPGS) and... 
mPEG-PLA | Micelles | CSO-SA | Docetaxel | TPGS | MPEG-PLA | MATERIALS SCIENCE, BIOMATERIALS | VITAMIN-E-TPGS | GENE DELIVERY | DRUG-DELIVERY | CELLULAR INTERNALIZATION | CHEMISTRY, PHYSICAL | ANTICANCER DRUG | POLYMERIC MICELLES | P-GLYCOPROTEIN | PACLITAXEL | NANOPARTICLES | BIOPHYSICS | COPOLYMER MICELLES | Microscopy, Electron, Transmission | Molecular Weight | Taxoids - pharmacology | Magnetic Resonance Spectroscopy | Rats, Wistar | Administration, Oral | Stearic Acids - chemical synthesis | Rats | Gastrointestinal Tract - drug effects | Male | Stearic Acids - chemistry | Taxoids - pharmacokinetics | Oligosaccharides - chemical synthesis | Taxoids - administration & dosage | Animals | Chitosan - chemistry | Time Factors | Oligosaccharides - chemistry | Vitamin E - chemistry | Taxoids - blood | Chitosan - chemical synthesis | Antimitotic agents | Drugstores | Antineoplastic agents | Index Medicus
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