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1. Full Text Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile
by Hrkach, Jeffrey and Von Hoff, Daniel and Ali, Mir Mukkaram and Andrianova, Elizaveta and Auer, Jason and Campbell, Tarikh and De Witt, David and Figa, Michael and Figueiredo, Maria and Horhota, Allen and Low, Susan and McDonnell, Kevin and Peeke, Erick and Retnarajan, Beadle and Sabnis, Abhimanyu and Schnipper, Edward and Song, Jeffrey J and Song, Young Ho and Summa, Jason and Tompsett, Douglas and Troiano, Greg and Hoven, Tina Van Geen and Wright, Jim and LoRusso, Patricia and Kantoff, Philip W and Bander, Neil H and Sweeney, Christopher and Farokhzad, Omid C and Langer, Robert and Zale, Stephen
Science translational medicine, ISSN 1946-6234, 04/2012, Volume 4, Issue 128, pp. 128ra39 - 128ra39
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Taxoids - chemistry | Taxoids - pharmacology | Nanoparticles - chemistry | Humans | Docetaxel | Rats | Male | Taxoids - pharmacokinetics | Xenograft Model Antitumor Assays | Taxoids - administration & dosage | Animals | Glutamate Carboxypeptidase II - metabolism | Antigens, Surface - metabolism | Cell Line, Tumor | Polymers - chemistry | Mice | Nanoparticles - administration & dosage | Index Medicus
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2. Full Text Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel
by Cho, Hyun-Jong and Yoon, Hong Yeol and Koo, Heebeom and Ko, Seung-Hak and Shim, Jae-Seong and Lee, Ju-Hee and Kim, Kwangmeyung and Chan Kwon, Ick and Kim, Dae-Duk
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 29, pp. 7181 - 7190
Advanced Basic Science | Dentistry | Hyaluronic acid-ceramide | Nanoparticle | CD44 | Poloxamer | Docetaxel | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Taxoids - chemistry | Taxoids - pharmacology | Nanoparticles - chemistry | Hyaluronic Acid - chemistry | Materials Testing | Antineoplastic Agents - therapeutic use | Cell Line, Tumor - drug effects | Ceramides - chemistry | Taxoids - metabolism | Antineoplastic Agents - chemistry | Drug Carriers - chemistry | Drug Delivery Systems | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Taxoids - therapeutic use | Animals | Antineoplastic Agents - pharmacology | Mice | Molecular Structure | Poloxalene - chemistry | Index Medicus
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3. Full Text Lactoferrin bioconjugated solid lipid nanoparticles: a new drug delivery system for potential brain targeting
by Singh, Indu and Swami, Rajan and Pooja, Deep and Jeengar, Manish Kumar and Khan, Wahid and Sistla, Ramakrishna
Journal of drug targeting, ISSN 1061-186X, 03/2016, Volume 24, Issue 3, pp. 212 - 223
lactoferrin | nanoparticles | Blood-brain barrier | brain | docetaxel | conjugation | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Taxoids - chemistry | Nanoparticles - chemistry | Apoptosis - drug effects | Drug Stability | Lactoferrin - pharmacokinetics | Brain Neoplasms - drug therapy | Brain Neoplasms - metabolism | Lactoferrin - administration & dosage | Taxoids - pharmacokinetics | Brain - metabolism | Particle Size | Tissue Distribution | Lactoferrin - chemistry | Taxoids - administration & dosage | Taxoids - therapeutic use | Animals | Cell Line, Tumor | Drug Liberation | Female | Mice | Nanoparticles - administration & dosage | Radioligand Assay | Drug Delivery Systems - methods | Taxoids - blood | Index Medicus
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4. Full Text A multicenter phase II study of XRP6258 administered as a 1-h i.v. infusion every 3 weeks in taxane-resistant metastatic breast cancer patients
by Pivot, X and Koralewski, P and Hidalgo, J.L and Chan, A and Gonçalves, A and Schwartsmann, G and Assadourian, S and Lotz, J.P
Annals of oncology, ISSN 0923-7534, 09/2008, Volume 19, Issue 9, pp. 1547 - 1552
taxane | chemotherapy | resistance | taxoid | metastatic breast cancer | XRP6258 | Resistance | Metastatic breast cancer | Taxoid | Chemotherapy | Taxane | Life Sciences & Biomedicine | Oncology | Science & Technology | Gynecology. Andrology. Obstetrics | Mammary gland diseases | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | Confidence Intervals | Adenocarcinoma - pathology | Prognosis | Taxoids - pharmacology | Humans | Middle Aged | Drug Resistance, Neoplasm | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Bridged-Ring Compounds - pharmacology | Adult | Female | Drug Administration Schedule | Risk Assessment | Kaplan-Meier Estimate | Treatment Outcome | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Adenocarcinoma - secondary | Taxoids - administration & dosage | Maximum Tolerated Dose | Breast Neoplasms - pathology | Survival Analysis | Breast Neoplasms - mortality | Aged | Infusions, Intravenous | Neoplasm Staging | Adenocarcinoma - mortality | Index Medicus | Adenocarcinoma | Antineoplastic Agents | Breast Neoplasms | Life Sciences | Immunology | Taxoids | Bridged Compounds | Kaplan-Meiers Estimate
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5. Full Text Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
by Herbst, Roy S, Prof and Baas, Paul, Prof and Kim, Dong-Wan, MD and Felip, Enriqueta, MD and Pérez-Gracia, José L, MD and Han, Ji-Youn, Prof and Molina, Julian, MD and Kim, Joo-Hang, Prof and Arvis, Catherine Dubos, MD and Ahn, Myung-Ju, Prof and Majem, Margarita, MD and Fidler, Mary J, MD and de Castro, Gilberto, MD and Garrido, Marcelo, MD and Lubiniecki, Gregory M, MD and Shentu, Yue, PhD and Im, Ellie, MD and Dolled-Filhart, Marisa, PhD and Garon, Edward B, MD
The Lancet (British edition), ISSN 0140-6736, 2015, Volume 387, Issue 10027, pp. 1540 - 1550
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Lung Neoplasms - drug therapy | Carcinoma, Non-Small-Cell Lung - chemistry | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Molecular Targeted Therapy | Patient Selection | Taxoids - therapeutic use | Antibodies, Monoclonal, Humanized - administration & dosage | Antineoplastic Agents - adverse effects | Adult | Female | Taxoids - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Drug Administration Schedule | Lung Neoplasms - chemistry | Docetaxel | Kaplan-Meier Estimate | Treatment Outcome | Disease-Free Survival | Taxoids - administration & dosage | Aged | B7-H1 Antigen - analysis | Carcinoma, Non-Small-Cell Lung - drug therapy | Antimitotic agents | Medical colleges | Lung cancer, Non-small cell | Antineoplastic agents | Analysis | Chemotherapy | Biopsy | Genes | Lung cancer | Clinical trials | Oncology | Mutation | Tumors | Cell survival | Medical treatment | FDA approval | Health care facilities | Survival | Patients | Evidence-based medicine | Pembrolizumab | Randomization | Interactive systems | Immunotherapy | Risk assessment | PD-L1 protein | Biomarkers | Index Medicus | Abridged Index Medicus
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6. Full Text Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: Preparation, in vitro and in vivo evaluation
by He, Zhijian and Schulz, Anita and Wan, Xiaomeng and Seitz, Joshua and Bludau, Herdis and Alakhova, Daria Y and Darr, David B and Perou, Charles M and Jordan, Rainer and Ojima, Iwao and Kabanov, Alexander V and Luxenhofer, Robert
Journal of controlled release, ISSN 0168-3659, 06/2015, Volume 208, pp. 67 - 75
In vivo | Multi-drug resistance | Taxoids | Poly(2-oxazoline) | Orthotopic tumor model | Paclitaxel | LCC6 | Drug delivery | Nanomedicine | In vitro | In vivo LCC6 | Taxoids - chemistry | Cell Survival - drug effects | Taxoids - pharmacology | Humans | Antineoplastic Agents, Phytogenic - chemistry | Breast Neoplasms - drug therapy | Chemistry, Pharmaceutical | Oxazoles - chemistry | Particle Size | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Micelles | Cell Line, Tumor | Female | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Delayed-Action Preparations | Drug resistance | Index Medicus | multi-drug resistance | paclitaxel, taxoids | in vitro | poly(2-oxazoline) | nanomedicine | in vivo | drug delivery | orthotopic tumor model
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7. Full Text PEI-derivatized fullerene drug delivery using folate as a homing device targeting to tumor
by Shi, Jinjin and Zhang, Hongling and Wang, Lei and Li, Lulu and Wang, Honghong and Wang, Zhenzhen and Li, Zhi and Chen, Chengqun and Hou, Lin and Zhang, Chaofeng and Zhang, Zhenzhong
Biomaterials, ISSN 0142-9612, 2012, Volume 34, Issue 1, pp. 251 - 261
Advanced Basic Science | Dentistry | PEI-derivatized fullerene | Drug delivery | Tumor-targeting | Nanoparticle | Folic acid | Docetaxel | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Neoplasms - metabolism | Taxoids - pharmacology | Apoptosis - drug effects | Humans | Body Weight - drug effects | Male | Spectroscopy, Fourier Transform Infrared | Polyethyleneimine - pharmacokinetics | Neoplasms - blood | Polyethyleneimine - chemistry | Female | Folic Acid - chemical synthesis | Fullerenes - chemistry | Taxoids - blood | Polyethyleneimine - chemical synthesis | Taxoids - chemistry | Tissue Distribution - drug effects | Endocytosis - drug effects | Folic Acid - chemistry | Folic Acid - pharmacokinetics | Spectrophotometry, Ultraviolet | Taxoids - pharmacokinetics | Particle Size | Xenograft Model Antitumor Assays | Administration, Intravenous | Animals | Tumor Burden - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Neoplasms - pathology | Drug Delivery Systems - methods | Fullerenes - pharmacokinetics | Drugs | Drug delivery systems | Biological products | Heterocyclic compounds | Analysis | Polymerization | Ethylenediamines | Tumors | Vehicles | Index Medicus
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8. Full Text Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer
by Bowerman, Charles J and Byrne, James D and Chu, Kevin S and Schorzman, Allison N and Keeler, Amanda W and Sherwood, Candice A and Perry, Jillian L and Luft, James C and Darr, David B and Deal, Allison M and Napier, Mary E and Zamboni, William C and Sharpless, Norman E and Perou, Charles M and DeSimone, Joseph M
Nano letters, ISSN 1530-6984, 01/2017, Volume 17, Issue 1, pp. 242 - 248
Nanoparticles | Genetically engineered mouse model | Chemoresistance | Docetaxel | Triple-negative breast cancer | Materials Science | Materials Science, Multidisciplinary | Physics, Condensed Matter | Science & Technology - Other Topics | Chemistry, Physical | Physics | Science & Technology | Physics, Applied | Physical Sciences | Chemistry | Nanoscience & Nanotechnology | Technology | Chemistry, Multidisciplinary | Taxoids - chemistry | A549 Cells | Lactic Acid - chemistry | Nanoparticles - chemistry | Cell Survival | Humans | Drug Resistance, Neoplasm | Bridged-Ring Compounds - metabolism | Taxoids - metabolism | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - chemistry | Triple Negative Breast Neoplasms - drug therapy | Drug Carriers - chemistry | Taxoids - pharmacokinetics | Particle Size | Taxoids - administration & dosage | Animals | Triple Negative Breast Neoplasms - genetics | Mice, Nude | Polyglycolic Acid - chemistry | Surface Properties | Drug Liberation | Female | Antineoplastic Agents - pharmacokinetics | Index Medicus | triple-negative breast cancer | chemoresistance | docetaxel | genetically engineered mouse model
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9. Full Text Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
by Andrea E. Prota and Katja Bargsten and Didier Zurwerra and Jessica J. Field and José Fernando Díaz and Karl-Heinz Altmann and Michel O. Steinmetz
Science (American Association for the Advancement of Science), ISSN 0036-8075, 2/2013, Volume 339, Issue 6119, pp. 587 - 590
Trucks | Taxoids | Molecular structure | Microtubules | REPORTS | Atoms | Ligands | Biochemistry | Molecular mechanisms of action | Epothilones | Crystal structure | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Taxoids - chemistry | Tubulin Modulators - chemistry | Taxoids - pharmacology | Protein Structure, Secondary | Epothilones - chemistry | Tubulin Modulators - pharmacology | Epothilones - pharmacology | Crystallography, X-Ray | Antineoplastic Agents - chemistry | Animals | Bridged-Ring Compounds - chemistry | Macrolides - chemistry | Cattle | Microtubules - drug effects | Chickens | Bridged-Ring Compounds - pharmacology | Macrolides - pharmacology | Antineoplastic Agents - pharmacology | Tubulin - chemistry | Binding Sites | Antimitotic agents | Care and treatment | Drug interactions | Physiological aspects | Research | Antineoplastic agents | Molecular biology | Health aspects | Cancer | Proteins | Chemotherapy | Inhibitor drugs | Index Medicus | Stability | Taxol | Cell division | Assembly | Anticancer properties
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