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1. Full Text Cellular and clinical pharmacology of the taxanes docetaxel and paclitaxel – a review
by de Weger, Vincent A and Beijnen, Jos H and Schellens, Jan H.M
Anti-cancer drugs, ISSN 0959-4973, 06/2014, Volume 25 Update on Taxanes in Cancer Therapy, Issue 5, pp. 488 - 494
P-glycoprotein | P450 cytochrome | Docetaxel | Paclitaxel | Taxane pharmacology | Protein binding | Pharmacology & Pharmacy | Oncology | Life Sciences & Biomedicine | Science & Technology | Neoplasms - metabolism | Paclitaxel - pharmacology | Taxoids - pharmacology | Administration, Metronomic | Humans | Antineoplastic Agents - therapeutic use | Paclitaxel - pharmacokinetics | Paclitaxel - therapeutic use | Neoplasms - drug therapy | Taxoids - pharmacokinetics | Taxoids - therapeutic use | Maximum Tolerated Dose | Drug Interactions | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Index Medicus
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2. Full Text Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B
by Lianne Fuino and Purva Bali and Sylvie Wittmann and Sreenivas Donapaty and Fei Guo and Hirohito Yamaguchi and Hong-Gang Wang and Peter Atadja and Kapil Bhalla
Molecular cancer therapeutics, ISSN 1535-7163, 10/2003, Volume 2, Issue 10, pp. 971 - 984
Life Sciences & Biomedicine | Oncology | Science & Technology | Chromatin - metabolism | Phosphorylation | Taxoids - pharmacology | Coloring Agents - pharmacology | Annexin A5 - pharmacology | Humans | Epothilones - pharmacology | Multienzyme Complexes - metabolism | Deoxycytidine - pharmacology | Proteasome Endopeptidase Complex | Dose-Response Relationship, Drug | Antibodies, Monoclonal, Humanized | Sepharose - pharmacology | Cysteine Endopeptidases - metabolism | Flow Cytometry | Cyclins - metabolism | Time Factors | Antimetabolites, Antineoplastic - pharmacology | Antineoplastic Agents - pharmacology | Hydroxamic Acids - pharmacology | Detergents - pharmacology | Receptor, ErbB-2 - biosynthesis | Cyclin-Dependent Kinase Inhibitor p21 | Antibodies, Monoclonal - pharmacology | Down-Regulation | Enzyme Inhibitors - pharmacology | Tetrazolium Salts - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Blotting, Western | Precipitin Tests | Blotting, Northern | Cell Line, Tumor | Histone Deacetylase Inhibitors | Thiazoles - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Deoxycytidine - analogs & derivatives | Microscopy, Fluorescence | Trastuzumab | Apoptosis | Index Medicus
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3. Full Text Vitamin E TPGS coated liposomes enhanced cellular uptake and cytotoxicity of docetaxel in brain cancer cells
by Muthu, Madaswamy S and Kulkarni, Sneha A and Xiong, Jiaqing and Feng, Si-Shen
International journal of pharmaceutics, ISSN 0378-5173, 12/2011, Volume 421, Issue 2, pp. 332 - 340
Cancer nanotechnology | PEGylation | Molecular biomaterials | Nanomedicine | Stealth liposomes | Taxotere | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Taxoids - pharmacology | Humans | Vitamin E - analogs & derivatives | Coumarins - chemistry | Polyethylene Glycols - chemistry | Brain Neoplasms | Microscopy, Atomic Force | Antineoplastic Agents - pharmacology | Vitamin E - chemistry | Polyethylene Glycols - pharmacology | Taxoids - chemistry | Cell Survival - drug effects | Microscopy, Electron, Transmission | Antineoplastic Agents - chemistry | Coumarins - pharmacology | Particle Size | Microscopy, Confocal | Liposomes - chemistry | Glioma | Cell Line, Tumor | Absorption - drug effects | Thiazoles - chemistry | Thiazoles - pharmacology | Liposomes - pharmacology | Liposomes - ultrastructure | Vitamin E - pharmacology | Antimitotic agents | Biological products | Antineoplastic agents | Vitamin E | Cancer | Encapsulation | Cell culture | Solvents | Particle size | Brain tumors | Cytotoxicity | Drug delivery | Coatings | Transmission electron microscopy | Polyethylene glycol | Zeta potential | Glioma cells | Liposomes | Index Medicus
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4. Full Text Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, Tween-80 and Tween-20
by Weiszhár, Zsóka and Czúcz, Judit and Révész, Csaba and Rosivall, László and Szebeni, János and Rozsnyay, Zoltán
European journal of pharmaceutical sciences, ISSN 0928-0987, 03/2012, Volume 45, Issue 4, pp. 492 - 498
Nanoimmunosafety | Micelle | Drug carrier | Complement system | Taxane formulation | Infusion hypersensitivity | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Paclitaxel - pharmacology | Polysorbates - pharmacology | Taxoids - pharmacology | Humans | Antineoplastic Agents - pharmacology | Glycerol - pharmacology | Glycerol - analogs & derivatives | Complement Activation - drug effects | Surface-Active Agents - pharmacology | Drugs | Lectins | Thrombin | Drug delivery systems | Surface active agents | Vehicles | Index Medicus
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5. Full Text Survival analysis of carboplatin added to an anthracycline/taxane-based neoadjuvant chemotherapy and HRD score as predictor of response-final results from GeparSixto
by Loibl, S and Weber, K E and Timms, K M and Elkin, E P and Hahnen, E and Fasching, P A and Lederer, B and Denkert, C and Schneeweiss, A and Braun, S and Salat, C T and Rezai, M and Blohmer, J U and Zahm, D M and Jackisch, C and Gerber, B and Klare, P and Kümmel, S and Schem, C and Paepke, S and Schmutzler, R and Rhiem, K and Penn, S and Reid, J and Nekljudova, V and Hartman, A -R and von Minckwitz, G and Untch, M and Arbeitsgemeinschaft Gynakologische and GBG
Annals of oncology, ISSN 0923-7534, 12/2018, Volume 29, Issue 12, pp. 2341 - 2347
Neoadjuvant chemotherapy | Carboplatin | Homologuous recombinant deficiency | Survival | Triple-negative breast cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Doxorubicin - therapeutic use | Paclitaxel - pharmacology | Prognosis | Taxoids - pharmacology | Follow-Up Studies | Breast - surgery | Humans | Middle Aged | Polyethylene Glycols - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Taxoids - therapeutic use | Carboplatin - therapeutic use | Anthracyclines - pharmacology | Bridged-Ring Compounds - pharmacology | Doxorubicin - analogs & derivatives | Triple Negative Breast Neoplasms - pathology | Mastectomy | Female | Breast - pathology | Polyethylene Glycols - pharmacology | Bridged-Ring Compounds - therapeutic use | Recombinational DNA Repair - genetics | Triple Negative Breast Neoplasms - mortality | Paclitaxel - therapeutic use | Triple Negative Breast Neoplasms - therapy | BRCA1 Protein - genetics | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | Triple Negative Breast Neoplasms - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoadjuvant Therapy - methods | Survival Analysis | Anthracyclines - therapeutic use | Mutation | Carboplatin - pharmacology | BRCA2 Protein - genetics | Doxorubicin - pharmacology | Index Medicus
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6. Full Text Microtubule dynamics as a target in oncology
by Risinger, April L and Giles, Francis J and Mooberry, Susan L
Cancer treatment reviews, ISSN 0305-7372, 2008, Volume 35, Issue 3, pp. 255 - 261
Hematology, Oncology and Palliative Medicine | 2-Methoxyestradiol | Discodermolide | Microtubule-targeting agent | Epothilone | Halichondrin B | Microtubule | Taxane | Colchicine | Vinca alkaloid | Taccalonolide | Life Sciences & Biomedicine | Oncology | Science & Technology | Colchicine - pharmacology | Taxoids - pharmacology | Tubulin Modulators - pharmacology | Colchicine - therapeutic use | Humans | Epothilones - pharmacology | Epothilones - therapeutic use | Lactones - pharmacology | Drug Delivery Systems | Taxoids - therapeutic use | Neoplasms - genetics | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Microtubules - drug effects | Vinca Alkaloids - pharmacology | Microtubules - ultrastructure | Macrolides - pharmacology | Steroids - pharmacology | Steroids - therapeutic use | Antineoplastic Agents, Phytogenic - therapeutic use | Microtubules - physiology | Clinical Trials as Topic | Vinca Alkaloids - therapeutic use | Cell Division - drug effects | Lactones - therapeutic use | Tubulin Modulators - therapeutic use | Neoplasms - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Antineoplastic Agents, Phytogenic - pharmacology | Macrolides - therapeutic use | Neoplasms - pathology | Drug Screening Assays, Antitumor | Development and progression | Care and treatment | Leukemia | Analysis | Cancer | Index Medicus | Microtubule-Targeting Agent | Vinca Alkyloid
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7. Full Text Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs
by Frömberg, Anja and Frömberg, Anja and Gutsch, Daniela and Gutsch, Daniela and Schulze, Daniel and Schulze, Daniel and Vollbracht, Claudia and Vollbracht, Claudia and Weiss, Gabriele and Weiss, Gabriele and Czubayko, Frank and Czubayko, Frank and Aigner, Achim and Aigner, Achim
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 5/2011, Volume 67, Issue 5, pp. 1157 - 1166
Prostate carcinoma | Medicine & Public Health | Paclitaxel | Cancer Research | Oncology | Ascorbate | Pharmacology/Toxicology | Dehydroascorbate | 5-FU | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Gynecology. Andrology. Obstetrics | Pharmacology. Drug treatments | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Antineoplastic agents | Male genital diseases | Tumors | Cell Survival - drug effects | Taxoids - pharmacology | Apoptosis - drug effects | Humans | Male | Organoplatinum Compounds - pharmacology | Drug Synergism | Prostatic Neoplasms | Vinblastine - analogs & derivatives | Ascorbic Acid - pharmacology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Dehydroascorbic Acid - pharmacology | Vinblastine - pharmacology | Cell Cycle - drug effects | Camptothecin - pharmacology | Camptothecin - analogs & derivatives | Epirubicin - pharmacology | Drugs | Antimitotic agents | Care and treatment | Anthracyclines | Cell cycle | Drug therapy | Organic acids | Cancer | Index Medicus | Original
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8. Full Text Novel Therapies for Metastatic Castrate-Resistant Prostate Cancer
by Dayyani, Farshid and Gallick, Gary E and Logothetis, Christopher J and Corn, Paul G
JNCI : Journal of the National Cancer Institute, ISSN 0027-8874, 11/2011, Volume 103, Issue 22, pp. 1665 - 1675
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Tumors | Cancer Vaccines - pharmacology | Humans | Male | Antineoplastic Agents - therapeutic use | Bevacizumab | Prostatic Neoplasms - immunology | RANK Ligand - pharmacology | Receptors, Androgen - drug effects | Treatment Failure | Prostatic Neoplasms - drug therapy | Phenylthiohydantoin - pharmacology | Tumor Microenvironment - drug effects | Dasatinib | Antibodies, Monoclonal - pharmacology | Angiogenesis Inhibitors - pharmacology | Clusterin - pharmacology | Pyrimidines - pharmacology | Denosumab | Prostate-Specific Antigen - blood | Orchiectomy | Signal Transduction - drug effects | Anilides - pharmacology | Mice | Receptor Cross-Talk - drug effects | Endothelin-1 - antagonists & inhibitors | Immunotherapy - methods | Taxoids - pharmacology | Ipilimumab | Tissue Extracts - pharmacology | Bone Remodeling - drug effects | Pyrrolidines - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Molecular Targeted Therapy - methods | Prostatic Neoplasms - pathology | Antineoplastic Agents, Hormonal - pharmacology | Androstenols - pharmacology | Androstenes | Clinical Trials as Topic | Mice, SCID | Phenylthiohydantoin - analogs & derivatives | Biomarkers, Tumor - blood | Xenograft Model Antitumor Assays | Cancer Vaccines - immunology | Pyrroles - pharmacology | Animals | RANK Ligand - antagonists & inhibitors | Pyridines - pharmacology | Thiazoles - pharmacology | Immune response | Development and progression | Cellular signal transduction | Research | Drug therapy | Health aspects | Prostate cancer | Risk factors | Metastasis | Cancer therapies | Index Medicus | Review
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9. Full Text Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
by Andrea E. Prota and Katja Bargsten and Didier Zurwerra and Jessica J. Field and José Fernando Díaz and Karl-Heinz Altmann and Michel O. Steinmetz
Science (American Association for the Advancement of Science), ISSN 0036-8075, 2/2013, Volume 339, Issue 6119, pp. 587 - 590
Trucks | Taxoids | Molecular structure | Microtubules | REPORTS | Atoms | Ligands | Biochemistry | Molecular mechanisms of action | Epothilones | Crystal structure | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Taxoids - chemistry | Tubulin Modulators - chemistry | Taxoids - pharmacology | Protein Structure, Secondary | Epothilones - chemistry | Tubulin Modulators - pharmacology | Epothilones - pharmacology | Crystallography, X-Ray | Antineoplastic Agents - chemistry | Animals | Bridged-Ring Compounds - chemistry | Macrolides - chemistry | Cattle | Microtubules - drug effects | Chickens | Bridged-Ring Compounds - pharmacology | Macrolides - pharmacology | Antineoplastic Agents - pharmacology | Tubulin - chemistry | Binding Sites | Antimitotic agents | Care and treatment | Drug interactions