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Science, ISSN 0036-8075, 8/2000, Volume 289, Issue 5481, pp. 950 - 953
Wnts are secreted signaling proteins that regulate developmental processes. Here we show that Wnt signaling, likely mediated by Wnt-10b, is a molecular switch... 
3T3 L1 cells | NIH 3T3 cells | Genetic vectors | Cell lines | Retroviridae | Reports | Adipocytes | Lipogenesis | Cellular differentiation | Synapses | Myoblasts | BINDING-PROTEIN-ALPHA | 3T3-L1 ADIPOCYTES | FAT PADS | REGULATOR | TRANSCRIPTIONAL ACTIVATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ADIPOCYTE DIFFERENTIATION | PPAR-GAMMA | BETA-CATENIN | FIBROBLASTS | Repressor Proteins | Adipocytes - cytology | Wnt Proteins | Mesoderm - cytology | CCAAT-Enhancer-Binding Proteins | DNA-Binding Proteins - metabolism | Retroviridae - genetics | TCF Transcription Factors | Cytoskeletal Proteins - metabolism | Cell Differentiation | Muscles - metabolism | Nuclear Proteins - genetics | Proto-Oncogene Proteins - metabolism | Gene Transfer Techniques | Retroviridae - physiology | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | beta Catenin | Trans-Activators | Zebrafish Proteins | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factor 7-Like 2 Protein | Proteins - genetics | Transcription Factors - metabolism | Cell Lineage | Animals | Proteins - metabolism | Mice, Nude | Adipocytes - metabolism | Nuclear Proteins - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Axin Protein | Mice | Genetic Vectors | 3T3 Cells | Muscles - cytology | Receptors, Cytoplasmic and Nuclear - metabolism | Cell research | Fat cells | Research | Analysis | Wnt-10b protein | PPAR^g protein | adipogenesis | peroxisome proliferator-activated receptor ^g | CCAAT/enhancer binding protein ^a | C/EBP^a protein | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 10/2012, Volume 31, Issue 41, pp. 4472 - 4483
Elevated levels of the oncoprotein, osteopontin (OPN), are associated with poor outcome of several types of cancers including melanoma. We have previously... 
SPP1 | GSK3b | cancer | PP2A | DNAJB6 | OPN | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN PHOSPHATASE 2A | CELL BIOLOGY | BREAST-CANCER | METASTATIC MELANOMA | J-DOMAIN | ONCOLOGY | MRJ CO-CHAPERONE | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | GSK3 beta | WNT | EXPRESSION | T-CELLS | PROGRESSION | Osteopontin - genetics | Neoplasm Transplantation | Okadaic Acid - pharmacology | Phosphorylation | Molecular Chaperones - metabolism | Oligonucleotide Array Sequence Analysis | HSC70 Heat-Shock Proteins - metabolism | Humans | Lymphoid Enhancer-Binding Factor 1 - genetics | Gene Expression Regulation, Neoplastic | Transcriptome | Glycogen Synthase Kinase 3 beta | Osteopontin - metabolism | Epithelial-Mesenchymal Transition | Female | Transcription, Genetic | Protein Interaction Domains and Motifs | T Cell Transcription Factor 1 - metabolism | Melanoma - metabolism | Protein Structure, Tertiary | Skin Neoplasms - pathology | HSP40 Heat-Shock Proteins - metabolism | Nerve Tissue Proteins - physiology | HSP40 Heat-Shock Proteins - genetics | Protein Phosphatase 2 - antagonists & inhibitors | Down-Regulation | Molecular Chaperones - genetics | Glycogen Synthase Kinase 3 - metabolism | Lymphoid Enhancer-Binding Factor 1 - metabolism | Molecular Chaperones - physiology | Nerve Tissue Proteins - genetics | beta Catenin - metabolism | Melanoma - secondary | Skin Neoplasms - metabolism | T Cell Transcription Factor 1 - genetics | Nerve Tissue Proteins - metabolism | Animals | Mice, Nude | HSP40 Heat-Shock Proteins - physiology | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Protein Binding | Mice | Protein Processing, Post-Translational | Index Medicus | Transcription | Wnt protein | Tumor cells | catenin | Melanoma | Glycogen synthase kinase 3 | Heat shock proteins | Osteopontin | Lymphocytes T | Malignancy | Tcf protein | Chaperones | Dephosphorylation | Hsp40 protein | protein phosphatase | LEF protein | Enhancers | Hsc70 protein | Cancer | Tumors | GSK3β
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, pp. 22113 - 22113
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2007, Volume 402, Issue 3, pp. 515 - 523
Wnt-5a is a representative ligand that activates a beta-catenin-independent pathway in Writ signalling. In the present paper, the roles of the... 
Posttranslational modification | Frizzled 5 (Fz5) | Glycosylation | Palmitoylation | Wnt-5a | PROTEIN | PHOSPHORYLATION | frizzled 5 (Fz5) | BIOCHEMISTRY & MOLECULAR BIOLOGY | glycosylation | post-translational modification | BETA-CATENIN | INVASION | PATHWAY | CELL-MIGRATION | GROWTH | FOCAL ADHESION KINASE | DEPENDENT ACTIVATION | EXPRESSION | palmitoylation | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Signal Transduction | Humans | Molecular Sequence Data | Proto-Oncogene Proteins - genetics | Proto-Oncogene Proteins - chemistry | Wnt-5a Protein | Wnt Proteins - metabolism | Transcription Factor 7-Like 2 Protein | Wnt Proteins - chemistry | Wnt Proteins - isolation & purification | TCF Transcription Factors - metabolism | Sequence Alignment | Animals | Wnt Proteins - genetics | Fatty Acids, Monounsaturated - metabolism | Protein Binding | Mice | Protein Processing, Post-Translational | Proto-Oncogene Proteins - isolation & purification | Cell Movement | Index Medicus | HEK-293T cells, HEK-293 cells expressing the large T-antigen of SV40 (simian virus 40) | CM, conditioned medium | WT, wild-type | ECM, extracellular matrix | NLK, Nemo-like kinase | LRP5 | JNK, c-Jun N-terminal kinase | GFP, green fluorescent protein | Fz, Frizzled | PKC, protein kinase C | FAK, focal adhesion kinase | CRD, cysteine-rich domain | Lef, lymphoid enhancer factor | MALDI–TOF-MS, matrix-assisted laser-desorption ionization–time-of-flight MS | 6, lipoprotein receptor-related protein 5 | siRNA, small interfering RNA | Tcf, T-cell factor | PNGase F, peptide N-glycosidase F | HEK-293, human embryonic kidney-293 | TFA, trifluoroacetic acid
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 02/2004, Volume 24, Issue 4, pp. 1439 - 1452
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
TRANSCRIPTION FACTOR SCL | HEMATOPOIETIC-CELLS | LOOP-HELIX PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-PROTEIN INTERACTION | C-KIT EXPRESSION | T-CELL LEUKEMIA | ZINC-FINGER PROTEIN | GENE-EXPRESSION | ACTIVITY IN-VIVO | RED-BLOOD-CELLS | CELL BIOLOGY | Transcription Factors - chemistry | Molecular Sequence Data | Sp1 Transcription Factor - metabolism | Proto-Oncogene Proteins - chemistry | Promoter Regions, Genetic - genetics | DNA-Binding Proteins - metabolism | GATA1 Transcription Factor | Metalloproteins - metabolism | Base Sequence | TCF Transcription Factors | Electrophoretic Mobility Shift Assay | Binding Sites | T-Cell Acute Lymphocytic Leukemia Protein 1 | Basic Helix-Loop-Helix Transcription Factors | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | LIM Domain Proteins | Response Elements | Gene Expression Regulation | Transcription Factor 7-Like 1 Protein | Glycophorin - genetics | Hematopoietic Stem Cells - metabolism | Reverse Transcriptase Polymerase Chain Reaction | DNA-Binding Proteins - chemistry | Macromolecular Substances | Transcription Factors - metabolism | Adaptor Proteins, Signal Transducing | Animals | Protein Binding | Erythroid-Specific DNA-Binding Factors | Mice | Glycophorin A | SCL protein | E47 protein | TAL1 protein | GPA gene | Ldb1 protein | FOG protein | LMO2 protein | Index Medicus | Transcriptional Regulation
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7409, pp. 106 - 110
Medulloblastomas are themost commonmalignant brain tumours in children(1). Identifying and understanding the genetic events that drive these tumours is... 
COMPLEX | STRUCTURAL BASIS | LANDSCAPE | CHILDHOOD | MULTIDISCIPLINARY SCIENCES | GENES | Transcription Factors - chemistry | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Tumor Suppressor Protein p53 - genetics | TCF Transcription Factors - metabolism | Patched Receptors | Cerebellar Neoplasms - classification | DEAD-box RNA Helicases - metabolism | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DEAD-box RNA Helicases - chemistry | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | DNA Helicases - chemistry | Histone-Lysine N-Methyltransferase - genetics | Signal Transduction | Models, Molecular | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Protein Structure, Tertiary - genetics | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nuclear Proteins - chemistry | beta Catenin - metabolism | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Histone-Lysine N-Methyltransferase - metabolism | LIM Domain Proteins - genetics | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Nucleotide sequencing | Metastasis | DNA sequencing | Cancer | Index Medicus
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 03/2000, Volume 24, Issue 3, pp. 245 - 250
The Wnt signalling pathway is essential for development and organogenesis. Wnt signalling stabilizes β-catenin, which accumulates in the cytoplasm, binds to... 
BETA-CATENIN GENE | APOPTOSIS | ACTIVATION | EXON-3 | APC | PATHWAY | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | ADENOVIRUS | Colorectal Neoplasms - genetics | Humans | Neoplasm Proteins - physiology | Repressor Proteins | Gene Expression Regulation, Neoplastic | Recombinant Fusion Proteins - physiology | Apoptosis - genetics | Glycogen Synthase Kinase 3 | Wnt Proteins | Adenomatous Polyposis Coli Protein | Genes, APC | Polymorphism, Single-Stranded Conformational | Transfection | DNA Mutational Analysis | Carcinoma, Hepatocellular - genetics | Adenoviridae - genetics | TCF Transcription Factors | Cytoskeletal Proteins - metabolism | Cytoskeletal Proteins - physiology | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Colorectal Neoplasms - metabolism | Calcium-Calmodulin-Dependent Protein Kinases - physiology | Protein Structure, Tertiary | Proteins - physiology | Genetic Predisposition to Disease | Liver Neoplasms - genetics | beta Catenin | Trans-Activators | Zebrafish Proteins | Proto-Oncogene Proteins - genetics | Transcription Factor 7-Like 2 Protein | Genetic Vectors - genetics | Macromolecular Substances | Proteins - genetics | Transcription Factors - metabolism | Axin Protein | Liver Neoplasms - metabolism | Proto-Oncogene Proteins - physiology | Signal Transduction - physiology | DNA, Neoplasm - genetics | Colorectal Neoplasms - pathology | Carcinoma, Hepatocellular - metabolism | Gene mutations | Cancer cells | Physiological aspects | Genetic aspects | Research | Hepatoma | Diagnosis | Identification and classification | CTNNB1 gene | b-catenin | lymphocyte enhancer-binding factor | Wnt protein | adenomatous polyposis coli | APC gene | AXIN1 gene | Index Medicus
Journal Article
Genes and Development, ISSN 0890-9369, 07/2000, Volume 14, Issue 14, pp. 1741 - 1749
Wnt signaling has an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with... 
β-catenin | Signaling | Wnt | TCF | ICAT | beta-catenin | signaling | FUNCTIONAL INTERACTION | TRANSCRIPTION | DEVELOPMENTAL BIOLOGY | AXIN HOMOLOG | DROSOPHILA | XENOPUS-EMBRYOS | APC | WINGLESS | GENETICS & HEREDITY | TUMOR-SUPPRESSOR PROTEIN | LEF-1 | Body Patterning - drug effects | Luciferases - metabolism | Cytoskeletal Proteins - genetics | Homeodomain Proteins - metabolism | Humans | Repressor Proteins | Molecular Sequence Data | Immunoblotting | Wnt Proteins | Xenopus - embryology | Dose-Response Relationship, Drug | Transfection | Genes, Dominant | Cell Division | Muscle Proteins - metabolism | TCF Transcription Factors | Cytoskeletal Proteins - metabolism | Transcription, Genetic | Cytoskeletal Proteins - physiology | Tumor Cells, Cultured | Muscle Proteins - physiology | Amino Acid Sequence | Proto-Oncogene Proteins - antagonists & inhibitors | Gene Library | Signal Transduction | beta Catenin | Trans-Activators | Gene Expression Regulation, Developmental - drug effects | Zebrafish Proteins | Intracellular Signaling Peptides and Proteins | Xenopus Proteins | Transcription Factor 7-Like 2 Protein | Precipitin Tests | Muscle Proteins - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | Animals | Mutagenesis | Mice | Cell Cycle Proteins | Goosecoid Protein | Xenopus | Cell proliferation | Proteins | Embryology, Experimental | Developmental biology | Physiological aspects | Heredity | Genetic aspects | Cellular signal transduction | Research | Cytochemistry | b-catenin-interacting protein | b-catenin | TCF-4 protein | ICAT-1 protein | Index Medicus | Research Paper
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 2001, Volume 29, Issue 7, pp. 1410 - 1419
Journal Article
Journal Article