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1. Full Text Tear Cytokine Profiles in Dysfunctional Tear Syndrome
by Lam, Helene and Bleiden, Lauren and de Paiva, Cintia S and Farley, William and Stern, Michael E and Pflugfelder, Stephen C
American Journal of Ophthalmology, ISSN 0002-9394, 2009, Volume 147, Issue 2, pp. 198 - 205.e1
Purpose To compare tear cytokine and chemokine concentrations in asymptomatic control and Dysfunctional Tear syndrome (DTS) patients and determine the... 
Ophthalmology | NEUROPATHIC PAIN | MULTICENTER | WORKSHOP 2007 | SUBCOMMITTEE | KERATOCONJUNCTIVITIS SICCA | CCR5 EXPRESSION | SJOGRENS-SYNDROME | GENE-EXPRESSION | OPHTHALMOLOGY | DRY EYE DISEASE | CONJUNCTIVAL EPITHELIUM | Severity of Illness Index | Tumor Necrosis Factor-alpha - metabolism | Prospective Studies | Cytokines - metabolism | Humans | Middle Aged | Tears - metabolism | Epidermal Growth Factor - metabolism | Male | Dry Eye Syndromes - diagnosis | Interferon-gamma - metabolism | Eyelid Diseases - metabolism | Immunoenzyme Techniques | Interleukins - metabolism | Eye Proteins - metabolism | Meibomian Glands - metabolism | Dry Eye Syndromes - metabolism | Chemokine CCL3 - metabolism | Female | Surveys and Questionnaires | Chemokine CCL5 - metabolism | Chemokines - metabolism | Dry Eye Syndromes - classification | Cytokines | Epidermal growth factor | Disease | Medical treatment | Rodents | Standard deviation | Chemokines | Index Medicus | Abridged Index Medicus
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2. Full Text Inhibition of 5-LOX, COX-1, and COX-2 Increases Tendon Healing and Reduces Muscle Fibrosis and Lipid Accumulation After Rotator Cuff Repair
by Oak, Nikhil R and Gumucio, Jonathan P and Flood, Michael D and Saripalli, Anjali L and Davis, Max E and Harning, Julie A and Lynch, Evan B and Roche, Stuart M and Bedi, Asheesh and Mendias, Christopher L
The American Journal of Sports Medicine, ISSN 0363-5465, 12/2014, Volume 42, Issue 12, pp. 2860 - 2868
Background: The repair and restoration of function after chronic rotator cuff tears are often complicated by muscle atrophy, fibrosis, and fatty degeneration... 
fatty degeneration | rotator cuff | myosteatosis | licofelone | SPORT SCIENCES | REGENERATION | CYCLOOXYGENASE | PROTEIN-SYNTHESIS | INFILTRATION | SKELETAL-MUSCLE | TEARS | MYOSTATIN-DEFICIENT MICE | 5-LIPOXYGENASE | ORTHOPEDICS | Muscle Fibers, Fast-Twitch - drug effects | Vesicular Transport Proteins - metabolism | Male | Muscle, Skeletal - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | PPAR gamma - metabolism | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Rotator Cuff - surgery | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Interleukin-10 - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Wound Healing - drug effects | Fibrocartilage - pathology | PPAR gamma - genetics | Beclin-1 | Rotator Cuff - pathology | Hydroxyproline - metabolism | Vesicular Transport Proteins - genetics | Enzyme Inhibitors - pharmacology | Phosphoproteins - genetics | Rats, Sprague-Dawley | Apoptosis Regulatory Proteins - metabolism | Acetyl-CoA C-Acetyltransferase - genetics | Muscle Proteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Biomechanical Phenomena | Pyrroles - pharmacology | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Autophagy-Related Protein 5 | Diacylglycerol O-Acyltransferase - genetics | Muscle Contraction - drug effects | Interleukin-10 - genetics | Fibrosis | Lipid Metabolism - drug effects | Wound Healing - physiology | Muscle, Skeletal - pathology | Acetyl-CoA C-Acetyltransferase - metabolism | Diacylglycerol O-Acyltransferase - metabolism | Perilipin-1 | Wound healing | Inhibitor drugs | Rodents | Biochemistry | Nonsteroidal anti-inflammatory drugs | Sports medicine | Tendons | Index Medicus
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3. Full Text Analysis of Th17-associated cytokines and clinical correlations in patients with dry eye disease
by Liu, Rongjun and Gao, Caifeng and Chen, Huijin and Li, Yaxin and Jin, Ying and Qi, Hong
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0173301 - e0173301
We aimed to investigate the expressions of three Th17-associated cytokines, interleukin (IL)-17A, IL-6 and IL-23, in protein and mRNA levels and their... 
TEARS | INTERLEUKIN-17 | SIGNS | MULTIDISCIPLINARY SCIENCES | PATHOGENIC T(H)17 CELLS | SYMPTOMS | DIAGNOSTIC-TESTS | DIFFERENTIATION | SJOGREN-SYNDROME | Biomarkers - metabolism | Cytokines - metabolism | Humans | Middle Aged | Tears - metabolism | Sjogren's Syndrome - metabolism | RNA, Messenger - metabolism | Case-Control Studies | Conjunctiva - metabolism | Cornea - metabolism | Interleukin-17 - metabolism | Interleukin-23 - metabolism | Th17 Cells - metabolism | Dry Eye Syndromes - metabolism | Female | Aged | Interleukin-6 - metabolism | Fluorescein - metabolism | Eye diseases | Care and treatment | Genetic aspects | Research | Interleukins | Gene expression | Pathogenesis | Chains (polymeric) | Assaying | Metastases | Eye | Proteins | Signal transduction | Histopathology | Surgery | Classification | Tubes | Eye (anatomy) | Breakup | Bioindicators | Diagnosis | Public health | Antigens | Bovine serum albumin | Evaluation | Cytokines | Interleukin 12 | Time measurement | Epithelium | Patients | Interleukin 17 | Studies | Hospitals | Biomarkers | Collection | Infiltration | Colitis | Cornea | Sjogren's syndrome | Conferences | Transforming growth factor-b | Glands | Antibodies | Staining | Clinical trials | Scoring | mRNA | Infections | Tissues | Inflammatory diseases | Interleukin 6 | Biomedical materials | Lymphocytes | Rodents | Quality | Interleukin 1 | Tumor necrosis factor-TNF | Children | Rubber | Interleukin 8 | Hypertension | Desiccants | Diabetes mellitus | Inflammation | Evaporation | Chronic fatigue syndrome | CD4 antigen | Blindness | In vivo methods and tests | Differentiation | Index Medicus
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4. Full Text Isolation and Characterization of Human Mesenchymal Stem Cells Derived From Shoulder Tissues Involved in Rotator Cuff Tears
by Utsunomiya, Hajime and Uchida, Soshi and Sekiya, Ichiro and Sakai, Akinori and Moridera, Kuniaki and Nakamura, Toshitaka
The American Journal of Sports Medicine, ISSN 0363-5465, 3/2013, Volume 41, Issue 3, pp. 657 - 668
Background: Recent studies report a relatively high failure rate for tendon-bone healing after rotator cuff repair. Several studies have investigated... 
rotator cuff repair surgery | synovial mesenchymal stem cells (MSCs) | regeneration therapy of shoulder | biological augmentation | PROGENITOR CELLS | SUPRASPINATUS TENDON | SPORT SCIENCES | FULL-THICKNESS TEARS | REPAIR INTEGRITY | REGENERATION | ACUTE INJURY | OSTEOBLAST-LINEAGE CELLS | BONE | DIFFERENTIATION | ORTHOPEDICS | MARROW STROMAL CELLS | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Male | Nerve Growth Factors - metabolism | Rotator Cuff - surgery | Intercellular Signaling Peptides and Proteins - metabolism | Mesenchymal Stromal Cells - cytology | Rotator Cuff Injuries | Tendons - cytology | Arthroscopy | Serrate-Jagged Proteins | Shoulder Joint - cytology | Bone Morphogenetic Protein 2 - metabolism | Female | Colony-Forming Units Assay | Membrane Proteins - metabolism | Chondrogenesis | Chemokine CXCL2 - metabolism | Mesenchymal Stromal Cells - physiology | Shoulder Joint - metabolism | Adipogenesis | Calcium-Binding Proteins - metabolism | CD56 Antigen - metabolism | S100 Calcium Binding Protein beta Subunit | Cell Survival | Tendons - metabolism | Cells, Cultured | S100 Proteins - metabolism | Epitopes | Synovial Membrane - metabolism | Connexins - metabolism | Connexin 26 | Insulin-Like Growth Factor I - metabolism | Osteogenesis | Synovial Membrane - cytology | Usage | Care and treatment | Patient outcomes | Stem cells | Physiological aspects | Research | Shoulder injuries | Rotator cuff repair | Shoulder | Tendons | Sports medicine | Index Medicus
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5. Full Text Biomarkers in ocular chronic graft versus host disease: Tear cytokine- and chemokine-based predictive model
by Cocho, Lidia and Fernández, Itziar and Calonge, Margarita and Martínez, Verónica and González-García, María J and Caballero, Dolores and López-Corral, Lucía and García-Vázquez, Carmen and Vázquez, Lourdes and Stern, Michael E and Enríquez-de-Salamanca, Amalia
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 2016, Volume 57, Issue 2, pp. 746 - 758
PURPOSE. To develop a tear molecule level-based predictive model based on a panel of tear cytokines and their correlation with clinical features in ocular... 
Biomarker | Ocular chronic GVHD | Dry eye | Tears | Cytokine | cytokine | CRITERIA | MIGRATION | DIAGNOSIS | tears | VALIDATION | GVHD | dry eye | biomarker | CONSENSUS DEVELOPMENT PROJECT | ocular chronic GVHD | CLINICAL-TRIALS | OPHTHALMOLOGY | STEM-CELL TRANSPLANTATION | DRY EYE PATIENTS | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Predictive Value of Tests | Humans | Middle Aged | Tears - metabolism | Male | Graft vs Host Disease - metabolism | Interferon-gamma - metabolism | Case-Control Studies | Interleukins - metabolism | Adult | Female | Eye Diseases - pathology | Biomarkers - metabolism | Cytokines - metabolism | Chemokine CCL11 - metabolism | Eye Diseases - etiology | Epidermal Growth Factor - metabolism | Eye Diseases - metabolism | Graft vs Host Disease - pathology | Models, Biological | Dry Eye Syndromes - metabolism | Aged | Chemokines - metabolism | Cohort Studies | Index Medicus
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6. Full Text The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-FcαRI binding and serum killing of bacteria
by Langley, Ries and Wines, Bruce and Willoughby, Natasha and Basu, Indira and Proft, Thomas and Fraser, John D
Journal of Immunology, ISSN 0022-1767, 03/2005, Volume 174, Issue 5, pp. 2926 - 2933
The staphylococcal superantigen-like proteins (SSLs) are close relatives of the superantigens but are coded for by a separate gene cluster within a 19-kb... 
DOMAIN | IMMUNOGLOBULIN-A | PATHOGENICITY | EVOLUTION | RECEPTOR | AUREUS | IMMUNOLOGY | IDENTIFICATION | CD89 | RESIDUES | GENOME | Humans | Receptors, Fc - metabolism | Molecular Sequence Data | Tears - metabolism | Immunoglobulin A, Secretory - metabolism | Exotoxins - metabolism | Superantigens - metabolism | Antigens, CD - metabolism | Hemolysis - immunology | Receptors, Fc - antagonists & inhibitors | Cattle | Serum Bactericidal Test | Swine | Binding, Competitive - immunology | Milk, Human - metabolism | Saliva - immunology | Amino Acid Sequence | Rabbits | Complement C5 - metabolism | Immunoglobulin A - metabolism | Colostrum - metabolism | Rats | Exotoxins - pharmacology | Pan troglodytes | Tears - immunology | Protein Binding - immunology | Colostrum - immunology | Papio | Bacterial Proteins - pharmacology | Animals | Saliva - metabolism | Immunoglobulin A - blood | Bacterial Proteins - metabolism | Sheep | Staphylococcus aureus - immunology | Mice | Superantigens - pharmacology | Milk, Human - immunology | Staphylococcus aureus - growth & development | Index Medicus | Abridged Index Medicus
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7. Full Text Evaluation of biomarkers of inflammation in response to benzalkonium chloride on corneal and conjunctival epithelial cells
by Epstein, Seth P and Chen, Dongmei and Asbell, Penny A
Journal of Ocular Pharmacology and Therapeutics, ISSN 1080-7683, 10/2009, Volume 25, Issue 5, pp. 415 - 424
Purpose: Most eye drops contain preservatives; benzalkonium chloride (BAK) is most common. Recent data demonstrated BAK adding to toxicity. BAK is degraded... 
OCULAR SURFACE | INTERLEUKIN-1 | OXIDATIVE STRESS | CHANG CONJUNCTIVAL | TEAR FLUID | PRESERVATIVES | CYTO-TOXICITY | SJOGRENS-SYNDROME | OPHTHALMOLOGY | PHARMACOLOGY & PHARMACY | AGENTS | DRY-EYE | Tumor Necrosis Factor-alpha - metabolism | Endophthalmitis - chemically induced | Epithelial Cells - metabolism | Preservatives, Pharmaceutical - metabolism | Epithelium, Corneal - cytology | Humans | Endophthalmitis - metabolism | Benzalkonium Compounds - metabolism | Preservatives, Pharmaceutical - toxicity | Conjunctiva - metabolism | C-Reactive Protein - metabolism | Interleukin-1beta - metabolism | Interleukin-10 - metabolism | Ophthalmic Solutions | Cornea - cytology | Epithelial Cells - cytology | Conjunctiva - cytology | Biomarkers - metabolism | Cell Line | Interleukin-1 - metabolism | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Hydrogen Peroxide - pharmacology | Interleukin-12 - metabolism | Cornea - metabolism | Benzalkonium Compounds - toxicity | Epithelium, Corneal - metabolism | Index Medicus | Original
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8. Full Text Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca
by de Paiva, Cintia S and Volpe, Eugene A and Gandhi, Niral B and Zhang, Xiaobo and Zheng, Xiaofen and Pitcher, John D and Farley, William J and Stern, Michael E and Niederkorn, Jerry Y and Li, De-Quan and Flavell, Richard A and Pflugfelder, Stephen C
PLoS ONE, ISSN 1932-6203, 12/2011, Volume 6, Issue 12, pp. e29017 - e29017
Background: TGF-beta is a pleiotropic cytokine that can have pro- or anti-inflammatory effects depending on the context. Elevated levels of bioactive TGF-beta... 
BARRIER DISRUPTION | GROWTH-FACTOR-BETA | DESICCATING STRESS | TEAR FLUID | INTERFERON-GAMMA | EXPERIMENTAL DRY EYE | BIOLOGY | REGULATORY T-CELLS | SJOGRENS-SYNDROME | CORNEAL EPITHELIUM | SALIVARY-GLANDS | Eye - pathology | Inflammation - pathology | Homeodomain Proteins - metabolism | Humans | Aging - drug effects | Adoptive Transfer | CD4-Positive T-Lymphocytes - pathology | Conjunctiva - metabolism | Dry Eye Syndromes - pathology | Conjunctiva - pathology | Inflammation - metabolism | Transforming Growth Factor beta - drug effects | Keratoconjunctivitis Sicca - complications | Eye - drug effects | Mucous Membrane - drug effects | Autoimmune Diseases - metabolism | Autoimmune Diseases - pathology | Protein-Serine-Threonine Kinases - metabolism | Eye - metabolism | Epithelium - drug effects | Epithelium - pathology | Epithelium - metabolism | Receptors, Chemokine - metabolism | Autoimmune Diseases - complications | Keratoconjunctivitis Sicca - metabolism | Aging - pathology | Mice, Knockout | Mucous Membrane - metabolism | Cell Movement - drug effects | Transforming Growth Factor beta - pharmacology | Mucous Membrane - pathology | Animals | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Conjunctiva - drug effects | Dry Eye Syndromes - metabolism | Keratoconjunctivitis Sicca - pathology | Cell Proliferation - drug effects | Mice | Genes, Dominant - genetics | Transforming Growth Factor beta - metabolism | CD4-Positive T-Lymphocytes - drug effects | Cornea | Sjogren's syndrome | Physicians | Glands | Helper cells | Interleukin 23 | Lymphocytes T | Kinases | Cell density | Eye | Keratoconjunctivitis | Lymphocytes | Rodents | Age | Scopolamine | Cytokines | Desiccants | Salivary glands | Inflammation | Conjunctiva | Disease control | Smoothness | Gelatinase B | CD4 antigen | Medicine | Signaling | RAG1 protein | γ-Interferon | Eye diseases | Infiltration | Interferon | Disruption | Tears | Index Medicus
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9. Full Text Acute and late changes in intraarticular cytokine levels following anterior cruciate ligament injury
by Bigoni, Marco and Sacerdote, Paola and Turati, Marco and Franchi, Silvia and Gandolla, Marta and Gaddi, Diego and Moretti, Sarah and Munegato, Daniele and Augusti, Carlo A and Bresciani, Elena and Omeljaniuk, Robert J and Locatelli, Vittorio and Torsello, Antonio
Journal of Orthopaedic Research, ISSN 0736-0266, 02/2013, Volume 31, Issue 2, pp. 315 - 321
Surgical reconstruction of the anterior cruciate ligament (ACL) does not necessarily decrease the risk of developing osteoarthritis (OA). The inflammatory... 
knee | cytokines | synovial | osteoarthritis | ACL tear | RHEUMATOID-ARTHRITIS | HUMAN ARTICULAR CHONDROCYTES | INTERLEUKIN-10 | ANTI-INTERLEUKIN-6 RECEPTOR ANTIBODY | CARTILAGE | TUMOR NECROSIS FACTOR | DEFICIENT KNEE | INFLAMMATORY CYTOKINES | ORTHOPEDICS | Tumor Necrosis Factor-alpha - metabolism | Cytokines - metabolism | Anterior Cruciate Ligament Injuries | Humans | Synovial Fluid - metabolism | Knee Injuries - metabolism | Male | Cartilage, Articular - metabolism | Interleukin-1beta - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | Adolescent | Adult | Female | Knee Injuries - complications | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Osteoarthritis - etiology | Index Medicus
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10. Full Text Role of the IL-6 classic-and trans-signaling pathways in corneal sterile inflammation and wound healing
by Ebihara, Nobuyuki and Matsuda, Akira and Nakamura, Shinji and Matsuda, Hironori and Murakami, Akira
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 11/2011, Volume 52, Issue 12, pp. 8549 - 8557
PURPOSE. To investigate the role of the IL-6 classic-and transsignaling pathways in corneal sterile inflammation and wound healing. METHODS. To assess the... 
TEARS | LEUKOCYTE RECRUITMENT | ANTAGONIST | PROTEIN | SOLUBLE INTERLEUKIN-6 RECEPTOR | EPIDERMAL-GROWTH-FACTOR | EPITHELIAL MIGRATION | OPHTHALMOLOGY | MICE | CELL INFILTRATION | FACTOR-ALPHA | Phosphorylation - physiology | Keratitis - immunology | Keratitis - pathology | Epithelial Cells - metabolism | Humans | Vascular Endothelial Growth Factor A - metabolism | Epithelium, Corneal - pathology | Cell Movement - physiology | Necrosis | Signal Transduction - immunology | Chemokine CCL2 - metabolism | Epithelium, Corneal - immunology | Interleukin-6 - metabolism | Corneal Keratocytes - metabolism | STAT3 Transcription Factor - metabolism | Corneal Keratocytes - pathology | Cytokine Receptor gp130 - metabolism | Interleukin-6 - genetics | Receptors, Interleukin-6 - genetics | Epithelial Cells - pathology | Wound Healing - immunology | Epithelial Cells - immunology | Keratitis - metabolism | Epithelium, Corneal - metabolism | Corneal Keratocytes - immunology | Primary Cell Culture | Receptors, Interleukin-6 - metabolism | Index Medicus
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11. Full Text Relationship of age and body mass index to the expression of obesity and osteoarthritis-related genes in human meniscus
by Rai, M.F and Sandell, L.J and Cheverud, J.M and Brophy, R.H
International Journal of Obesity, ISSN 0307-0565, 09/2013, Volume 37, Issue 9, pp. 1238 - 1246
OBJECTIVE: Aging and obesity contribute to the initiation and progression of osteoarthritis with little information on their relation to gene expression in... 
Meniscus tear | body mass index | osteoarthritis | age | gene expression | TOTAL MENISCECTOMY | INJURIES | meniscus tear | APELIN | RISK | BIOMECHANICS | REPAIR | NUTRITION & DIETETICS | ARTICULAR-CARTILAGE | HIP OSTEOARTHRITIS | ENDOCRINOLOGY & METABOLISM | KNEE OSTEOARTHRITIS | United States - epidemiology | Humans | Middle Aged | Male | Gene Expression Profiling | I-kappa B Proteins - metabolism | Obesity - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Osteoarthritis - epidemiology | Procollagen N-Endopeptidase - metabolism | Cartilage, Articular - metabolism | Adult | Female | Interleukin-8 - metabolism | Tibial Meniscus Injuries | Real-Time Polymerase Chain Reaction | Apelin | Body Mass Index | NF-KappaB Inhibitor alpha | Menisci, Tibial - metabolism | Gene Expression Regulation | Osteoarthritis - metabolism | NF-kappa B p52 Subunit - metabolism | Osteoarthritis - genetics | ADAMTS4 Protein | Obesity - metabolism | ADAM Proteins - metabolism | Obesity - epidemiology | Adolescent | Protein Array Analysis | Aged | Matrix Metalloproteinase 1 - metabolism | Aging - metabolism | Body mass index | Obesity | Demographic aspects | Physiological aspects | Genetic aspects | Research | Gene expression | Osteoarthritis | Age | Index Medicus | obesity
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12. Full Text Evaluation of galectin-1 and galectin-3 as prospective biomarkers in keratoconus
by Andrade, Frans Eberth Costa and Covre, Joyce Luciana and Ramos, Lisandra and Hazarbassanov, Rossen Mihaylov and Santos, Myrna Serapião dos and Campos, Mauro and Gomes, José Álvaro Pereira and Gil, Cristiane Damas
British Journal of Ophthalmology, ISSN 0007-1161, 05/2018, Volume 102, Issue 5, pp. 700 - 707
AimsTo evaluate the expression of β-galactoside-binding proteins galectin (Gal)-1 and Gal-3 in patients with keratoconus (KC) and postcorneal collagen... 
immunocytochemistry | impression cytology | galectins | crosslinking | CORNEAL | MURINE MODEL | TEARS | AUTOIMMUNE | INFLAMMATORY MOLECULES | EPITHELIUM | DISEASE | AIRWAY INFLAMMATION | OPHTHALMOLOGY | EXPRESSION | SEVERITY | Biomarkers - metabolism | Prospective Studies | Cytokines - metabolism | Keratoconus - drug therapy | Cross-Linking Reagents - pharmacology | Humans | Galectin 3 - metabolism | Tears - metabolism | Galectin 1 - metabolism | Male | Corneal Keratocytes - drug effects | Keratoconus - metabolism | Riboflavin - pharmacology | Case-Control Studies | Conjunctiva - metabolism | Collagen - metabolism | Cornea - metabolism | Photosensitizing Agents - pharmacology | Ultraviolet Rays | Adult | Female | Corneal Keratocytes - metabolism | Cornea | Cellular biology | Disease | Cytokines | Pathogenesis | Rodents | Biomarkers | Tumor necrosis factor-TNF | Inflammation | Ophthalmology | Index Medicus
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