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1. Full Text Syndromes of telomere shortening
by Armanios, Mary
Annual Review of Genomics and Human Genetics, ISSN 1527-8204, 09/2009, Volume 10, Issue 1, pp. 45 - 61
Telomeres and telomerase were initially discovered in pursuit of questions about how the ends of chromosomes are maintained. The implications of these... 
Cryptogenic liver cirrhosis | Interstitial lung disease | Dyskerin | Stem cell | Shelterin | shelterin | HOYERAAL-HREIDARSSON-SYNDROME | BONE-MARROW-TRANSPLANTATION | dyskerin | DOMINANT DYSKERATOSIS-CONGENITA | REVERSE-TRANSCRIPTASE | TERMINAL TRANSFERASE | RIBOSOMAL-RNA | SACCHAROMYCES-CEREVISIAE | cryptogenic liver cirrhosis | stem cell | interstitial lung disease | HEMATOPOIETIC STEM-CELLS | GENETICS & HEREDITY | IDIOPATHIC PULMONARY-FIBROSIS | APLASTIC-ANEMIA | Genetic Predisposition to Disease | Humans | Pulmonary Fibrosis - genetics | Dyskeratosis Congenita - genetics | Syndrome | Telomerase - deficiency | Dyskeratosis Congenita - physiopathology | Telomere - chemistry | Animals | Telomerase - genetics | Pulmonary Fibrosis - physiopathology | Telomerase - metabolism | Telomere - metabolism | Telomere - genetics | Telomeres | Genetic disorders | Epithelial cells | Abnormalities | Medical genetics | Causes of | Development and progression | Genetic aspects | Research | Health aspects | Human genetics
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2. Full Text Telomere shortening in human diseases
by Kong, Chiou Mee and Lee, Xiao Wen and Wang, Xueying
The FEBS Journal, ISSN 1742-464X, 07/2013, Volume 280, Issue 14, pp. 3180 - 3193
The discovery of telomeres dates back to the early 20th century. In humans, telomeres are heterochromatic structures with tandem DNA repeats of 5′‐TTAGGG‐3′ at... 
Werner Syndrome | telomerase | Fanconi anemia | telomere attrition/shortening | Nijmegen breakage syndrome | Bloom Syndrome | Dyskeratosis congenita | Ataxia‐telangiectasia | human diseases | premature aging | Ataxia-telangiectasia | SYSTEMIC-LUPUS-ERYTHEMATOSUS | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATAXIA-TELANGIECTASIA CELLS | TOPOISOMERASE III-ALPHA | telomere attrition | HUMAN CANCER-CELLS | shortening | BLOOM-SYNDROME HELICASE | IDIOPATHIC PULMONARY-FIBROSIS | WERNER-SYNDROME HELICASE | BONE-MARROW FAILURE | Idiopathic Pulmonary Fibrosis - genetics | Telomere Shortening | Animals | Neoplasms - genetics | Humans | Metabolic Diseases - genetics | Dyskeratosis Congenita - genetics | DNA Repair-Deficiency Disorders - genetics | Anemia, Aplastic - genetics | Proteins | Chromosomes | Telomerase | Fanconi's anemia | Index Medicus
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3. Full Text ATF7 mediates TNF-α-induced telomere shortening
by Maekawa, Toshio and Liu, Binbin and Nakai, Daisuke and Yoshida, Keisuke and Nakamura, Ken-ichi and Yasukawa, Mami and Koike, Manabu and Takubo, Kaiyo and Chatton, Bruno and Ishikawa, Fuyuki and Masutomi, Kenkichi and Ishii, Shunsuke
Nucleic Acids Research, ISSN 0305-1048, 05/2018, Volume 46, Issue 9, pp. 4487 - 4504
Abstract Telomeres maintain the integrity of chromosome ends and telomere length is an important marker of aging. The epidemiological studies suggested that... 
Phosphorylation | Humans | Mice, Inbred C57BL | Activating Transcription Factors - physiology | Ku Autoantigen - metabolism | Mice, Knockout | Telomere Shortening | Animals | Activating Transcription Factors - genetics | Activating Transcription Factors - metabolism | Tumor Necrosis Factor-alpha - physiology | Fibroblasts | Telomerase - metabolism | Telomere - metabolism | HeLa Cells | Histones - metabolism | Genome Integrity, Repair and
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4. Full Text Telomere Length Shortening and Alzheimer Disease—A Mendelian Randomization Study
by Zhan, Yiqiang and Song, Ci and Karlsson, Robert and Tillander, Annika and Reynolds, Chandra A and Pedersen, Nancy L and Hägg, Sara
JAMA Neurology, ISSN 2168-6149, 10/2015, Volume 72, Issue 10, pp. 1202 - 1203
LOCI | IDENTIFICATION | ASSOCIATION | CLINICAL NEUROLOGY | Alzheimer Disease - diagnosis | Alzheimer Disease - complications | Genetic Testing | Humans | Mendelian Randomization Analysis | Polymorphism, Single Nucleotide - genetics | Risk | Alzheimer Disease - genetics | Telomere - genetics
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5. Full Text Accelerated Telomere Shortening in Response to Life Stress
by Elissa S. Epel and Elizabeth H. Blackburn and Jue Lin and Firdaus S. Dhabhar and Nancy E. Adler and Jason D. Morrow and Richard M. Cawthon
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2004, Volume 101, Issue 49, pp. 17312 - 17315
Numerous studies demonstrate links between chronic stress and indices of poor health, including risk factors for cardiovascular disease and poorer immune... 
Caregivers | Psychological stress | T lymphocytes | Oxidative stress | Telomeres | Body mass index | Biological Sciences | Somatic cells | Cellular senescence | Chronic diseases | Age | Telomere length | Telomerase | ACTIVATION | telomerase | PERIPHERAL-BLOOD CELLS | GLUCOCORTICOIDS | OXIDATIVE DNA-DAMAGE | psychological stress | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | LENGTH | telomere length | oxidative stress | AGE | Age Factors | Oxidative Stress | Premenopause | Telomere - ultrastructure | Humans | Middle Aged | Mothers | Leukocytes, Mononuclear - physiology | Cellular Senescence | Stress, Psychological | Adult | Female | Telomere - metabolism | Research
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6. Full Text The THO complex component Thp2 counteracts telomeric R‐loops and telomere shortening
by Pfeiffer, Verena and Crittin, Jérôme and Grolimund, Larissa and Lingner, Joachim
The EMBO Journal, ISSN 0261-4189, 10/2013, Volume 32, Issue 21, pp. 2861 - 2871
Telomere maintenance by the conventional DNA replication machinery and telomerase is assisted by specialized DNA helicases, nucleases and telomere binding... 
TERRA | telomere instability | THO | R‐loops | DNA replication stress | R-loops | REPEAT-CONTAINING RNA | DNA-POLYMERASE-ALPHA | MAMMALIAN TELOMERES | BIOCHEMISTRY & MOLECULAR BIOLOGY | SACCHAROMYCES-CEREVISIAE | RNA/DNA HYBRIDS | CELL BIOLOGY | YEAST | GENOME INSTABILITY | FILL-IN | REPLICATION FORK | LAGGING-STRAND SYNTHESIS | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Telomere - chemistry | DNA, Fungal - genetics | Saccharomyces cerevisiae - genetics | Saccharomyces cerevisiae Proteins - metabolism | Nuclear Proteins - metabolism | Telomere - physiology | Telomere Shortening - genetics | Enzymes | Molecular biology | Ribonucleic acid--RNA | Genomics | Deoxyribonucleic acid--DNA
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7. Full Text Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening
by Stuart, Bridget D and Choi, Jungmin and Zaidi, Samir and Xing, Chao and Holohan, Brody and Chen, Rui and Choi, Mihwa and Dharwadkar, Pooja and Torres, Fernando and Girod, Carlos E and Weissler, Jonathan and Fitzgerald, John and Kershaw, Corey and Klesney-Tait, Julia and Mageto, Yolanda and Shay, Jerry W and Ji, Weizhen and Bilguvar, Kaya and Mane, Shrikant and Lifton, Richard P and Garcia, Christine Kim
Nature Genetics, ISSN 1061-4036, 05/2015, Volume 47, Issue 5, pp. 512 - 517
Idiopathic pulmonary fibrosis (IPF) is an age-related disease featuring progressive lung scarring. To elucidate the molecular basis of IPF, we performed exome... 
DE-NOVO MUTATIONS | GENE | DYSKERATOSIS-CONGENITA | AUTISTIC SPECTRUM | DISEASE | GENETICS & HEREDITY | INTERSTITIAL PNEUMONIA | MATURATION | Amino Acid Sequence | Exoribonucleases - genetics | Genetic Predisposition to Disease | Idiopathic Pulmonary Fibrosis - genetics | Genetic Association Studies | Humans | Middle Aged | Cells, Cultured | Molecular Sequence Data | Male | Leukocytes - physiology | Case-Control Studies | Lod Score | Exome - genetics | Telomere Shortening | DNA Mutational Analysis | Pedigree | Aged, 80 and over | Idiopathic Pulmonary Fibrosis - pathology | Adult | Female | Aged | DNA Helicases - genetics | Telomere - genetics | Pulmonary fibrosis | Gene mutations | Exome sequencing | Development and progression | Genetic aspects | Identification and classification | Health aspects | Methods | Proteins | Genealogy | Genomics | Lung diseases | Expected values | Genomes | Mutation | Gene expression | Telomerase
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8. Full Text Telomere Shortening in Familial and Sporadic Pulmonary Fibrosis
by Cronkhite, Jennifer T and Xing, Chao and Raghu, Ganesh and Chin, Kelly M and Torres, Fernando and Rosenblatt, Randall L and Garcia, Christine Kim
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2008, Volume 178, Issue 7, pp. 729 - 737
Rationale: Heterozygous mutations in the coding regions of the telomerase genes, TERT and TERC, have been found in familial and sporadic cases of idiopathic... 
Aging | Pulmonary fibrosis | Telomere length | Interstitial lung disease | Idiopathic pulmonary fibrosis | REVERSE-TRANSCRIPTASE | LENGTH | HUMANS | idiopathic pulmonary fibrosis | LOCUS | CHROMOSOME | WOMEN | CIGARETTE-SMOKING | LEUKOCYTES | interstitial lung disease | RESPIRATORY SYSTEM | pulmonary fibrosis | aging | MUTATIONS | APLASTIC-ANEMIA | telomere length | CRITICAL CARE MEDICINE | Genetic Predisposition to Disease - genetics | Humans | Middle Aged | Male | Pulmonary Fibrosis - genetics | Mutation, Missense | Case-Control Studies | RNA - genetics | Telomere - pathology | Telomerase - genetics | Pedigree | Regeneration - genetics | Aged, 80 and over | Adult | Female | Aged | E. Interstitial Lung Disease
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9. Full Text Telomere Shortening and Alzheimer's Disease
by Cai, Zhiyou and Yan, Liang-Jun and Ratka, Anna
NeuroMolecular Medicine, ISSN 1535-1084, 03/2013, Volume 15, Issue 1, pp. 25 - 48
Telomeres, at the ends of chromosomes and strands of genetic material, become shorter as cells divide in the process of aging. Telomere length has been... 
Telomere shortening | Alzheimer's disease | Telomere | OXIDATIVE DNA-DAMAGE | ULCERATIVE-COLITIS | AMYLOID-BETA-PROTEIN | MILD COGNITIVE IMPAIRMENT | HUNTINGTON DISEASE | CELLULAR SENESCENCE | NEUROSCIENCES | PERIPHERAL-BLOOD LEUKOCYTES | IN-VITRO | SMOOTH-MUSCLE-CELLS | TRANSGENIC MOUSE MODEL | Alzheimer Disease - etiology | Phosphorylation | Oxidative Stress | Telomere - ultrastructure | Humans | tau Proteins - metabolism | Molecular Targeted Therapy | Alzheimer Disease - pathology | Inflammation - complications | Inflammation - metabolism | Cognition Disorders - etiology | Amyloid beta-Peptides - metabolism | Alzheimer Disease - psychology | Alzheimer Disease - drug therapy | Mice, Transgenic | Cognition Disorders - genetics | Nerve Tissue Proteins - metabolism | Animals | Models, Biological | Alzheimer Disease - metabolism | Aged | Mice | Protein Processing, Post-Translational | Alzheimer Disease - genetics | Nerve Degeneration | Chronic Disease | Neurosciences | Chromosomes | Amyloid beta-protein | Age
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10. Full Text Telomere shortening rate predicts species life span
by Whittemore, K and Vera, E and Martinez-Nevado, E and Sanpera, C and Blasco, MA
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2019, Volume 116, Issue 30, pp. 15122 - 15127
Telomere shortening to a critical length can trigger aging and shorter life spans in mice and humans by a mechanism that involves induction of a persistent DNA... 
LONGEVITY | OXIDATIVE STRESS | NUMBER | METABOLISM | species | life span | MULTIDISCIPLINARY SCIENCES | telomere | LENGTH | MOUSE | DYNAMICS | DNA-REPAIR | Vultures | Telomeres | Goats | Flamingos | Mice | Gulls | DNA repair | Senescence | Yeast | DNA damage | Birds | Aquatic mammals | Elephants | Marine mammals | Life span | Aging | Dolphins & porpoises | Species | Chromosomes | Viability | Deoxyribonucleic acid--DNA | Dolphins | Biological Sciences
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11. Full Text Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells
by Kulak, Ozlem and Chen, Hua and Holohan, Brody and Wu, Xiaofeng and He, Huawei and Borek, Dominika and Otwinowski, Zbyszek and Yamaguchi, Kiyoshi and Garofalo, Lauren A and Ma, Zhiqiang and Wright, Woodring and Chen, Chuo and Shay, Jerry W and Zhang, Xuewu and Lum, Lawrence
Molecular and Cellular Biology, ISSN 0270-7306, 2015, Volume 35, Issue 14, pp. 2425 - 2435
Maintenance of chromosomal ends (telomeres) directly contributes to cancer cell immortalization. The telomere protection enzymes belonging to the tankyrase... 
THERAPEUTICS | TERT PROMOTER MUTATIONS | STEM-CELLS | MELANOMA | VARIANTS | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADP-RIBOSYLATION | DIFFERENTIATION | CANCER | TRF1 | CELL BIOLOGY | Small Molecule Libraries - pharmacology | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Crystallography, X-Ray | Tankyrases - antagonists & inhibitors | Quinolines - pharmacology | RNA Interference | Enzyme Inhibitors - chemistry | HEK293 Cells | Molecular Structure | Telomere Shortening - drug effects | Imides - pharmacology | Protein Structure, Tertiary | Tankyrases - genetics | Quinolines - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | Tankyrases - chemistry | beta Catenin - metabolism | Blotting, Western | Small Molecule Libraries - chemistry | Imides - chemistry | Wnt Signaling Pathway - drug effects | Heterocyclic Compounds, 3-Ring - chemistry | Cell Line, Tumor | Protein Binding
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