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Nature cell biology, ISSN 1476-4679, 2018, Volume 20, Issue 8, pp. 954 - 965
.... We identified two previously uncharacterized proteins, C2Oorf196 and FAM35A, whose inactivation confers strong PARP-inhibitor resistance... 
PATHWAY CHOICE | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | 53BP1 | CLASS-SWITCH RECOMBINATION | FANCONI-ANEMIA | DIFFERENTIAL EXPRESSION ANALYSIS | POLYMERASE-ZETA | TELOMERES | CELL BIOLOGY | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Inhibitors | Prostate | Viability | Tumors | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2012, Volume 336, Issue 6081, pp. 593 - 597
.... The data reveal two DNA damage response pathways not previously observed upon deletion of individual shelterin proteins... 
Telomeres | Yeasts | Quantification | Lymphocytes | DNA | DNA damage | REPORTS | Cell cycle | Ataxia telangiectasia | Repression | Chromosomes | JOINING PATHWAY | POT1 PROTEINS | MAMMALIAN TELOMERES | SGS1 | MULTIDISCIPLINARY SCIENCES | DYSFUNCTIONAL TELOMERES | DOUBLE-STRAND BREAKS | HOMOLOGOUS RECOMBINATION | NHEJ | YEAST KU | Telomere - ultrastructure | Antigens, Nuclear - metabolism | Telomeric Repeat Binding Protein 1 - genetics | Telomeric Repeat Binding Protein 1 - metabolism | Homologous Recombination | DNA Breaks, Double-Stranded | DNA Ligases - metabolism | DNA-Binding Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | Telomere - metabolism | Telomere-Binding Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Cells, Cultured | Ataxia Telangiectasia Mutated Proteins | Xenopus Proteins | DNA-Binding Proteins - genetics | Telomere Homeostasis | Mice, Knockout | Poly(ADP-ribose) Polymerases - metabolism | Animals | Antigens, Nuclear - genetics | Cell Cycle | Ku Autoantigen | DNA Repair | DNA Ligase ATP | Telomeric Repeat Binding Protein 2 - metabolism | Mice | Poly (ADP-Ribose) Polymerase-1 | Telomeric Repeat Binding Protein 2 - genetics | Tumor Suppressor p53-Binding Protein 1 | Proteins | Physiological aspects | Research | Health aspects | DNA repair | Telomerase
Journal Article
The Journal of cell biology, ISSN 1540-8140, 2013, Volume 202, Issue 7, pp. 1023 - 1039
.... In metazoans, telomere clustering is dynein and microtubule dependent and requires Sun1, an inner nuclear membrane protein... 
CELLS | SUN1 | ATTACHMENT | ACTIN | BOUQUET | SPINDLE POLE BODY | CENTROSOME | ENVELOPE | BINDING | NUCLEAR-MEMBRANE PROTEIN | CELL BIOLOGY | Meiosis - physiology | RNA, Small Interfering - genetics | Spermatocytes - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Molecular Sequence Data | Male | Immunoenzyme Techniques | Cell Cycle Proteins - antagonists & inhibitors | Telomere-Binding Proteins - genetics | Microtubules - metabolism | Cell Nucleus - metabolism | HEK293 Cells | Cell Cycle Proteins - genetics | Female | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Real-Time Polymerase Chain Reaction | Cytoplasmic Dyneins - metabolism | Telomere - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Membrane Proteins - genetics | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Cells, Cultured | Cytoplasmic Dyneins - genetics | In Situ Hybridization, Fluorescence | Nuclear Proteins - metabolism | Microtubule-Associated Proteins - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Telomere-Binding Proteins - antagonists & inhibitors | Blotting, Western | Sequence Homology, Amino Acid | Nuclear Envelope - metabolism | Animals | Cell Nucleus - genetics | Membrane Proteins - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Cytoskeleton - metabolism | Spermatocytes - cytology | Mice | HeLa Cells | Chromosome Pairing | Chromosomes | Analysis | Dynein | Protein binding
Journal Article
Molecular cell, ISSN 1097-2765, 2013, Volume 49, Issue 1, pp. 172 - 185
The metabolism of glucose and glutamine, primary carbon sources utilized by mitochondria to generate energy and macromolecules for cell growth, is directly regulated by mTORC1... 
TARGET | RAPTOR | TEL2 | TUMOR-SUPPRESSOR COMPLEX | RAG GTPASES | PROTEIN-KINASE | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | CELL-CYCLE PROGRESSION | NUTRIENT | CELL BIOLOGY | Glutamine - deficiency | Humans | Multiprotein Complexes | Protein Multimerization | Stress, Physiological | Breast Neoplasms - metabolism | Mechanistic Target of Rapamycin Complex 1 | Telomere-Binding Proteins - genetics | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Lysosomes - metabolism | Adenosine Triphosphate - metabolism | Adenylate Kinase - metabolism | Tumor Suppressor Proteins - genetics | Statistics, Nonparametric | Female | Telomere-Binding Proteins - metabolism | DNA Helicases - genetics | ATPases Associated with Diverse Cellular Activities | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cells, Cultured | Citric Acid Cycle | Mice, Knockout | Protein Transport | Carrier Proteins - genetics | DNA Helicases - metabolism | Glucose - deficiency | Animals | Breast Neoplasms - genetics | Carrier Proteins - metabolism | Proteins - metabolism | Energy Metabolism | Monomeric GTP-Binding Proteins - metabolism | Protein Binding | Carcinoma - genetics | Mice | TOR Serine-Threonine Kinases | Carcinoma - metabolism | Proteins | Glucose metabolism | Physiological aspects | Stress (Physiology) | Mitochondrial DNA | Glucose | Cells | Dextrose | Glutamine
Journal Article
Nature cell biology, ISSN 1476-4679, 2009, Volume 11, Issue 8, pp. 980 - 987
.... In this study, we show by single cell analysis that in the absence of telomerase, a single short telomere is sufficient to induce the recruitment of checkpoint and recombination proteins... 
REPAIR | KU HETERODIMER | COLOCALIZATION | DYSFUNCTIONAL TELOMERES | DOUBLE-STRAND BREAKS | S-PHASE | YEAST TELOMERES | BINDING PROTEIN | SACCHAROMYCES-CEREVISIAE | G-TAILS | CELL BIOLOGY | Saccharomyces cerevisiae - genetics | Recombinant Fusion Proteins - metabolism | DNA, Single-Stranded - genetics | Nuclear Pore Complex Proteins - genetics | Saccharomyces cerevisiae - metabolism | Haploidy | Telomere-Binding Proteins - genetics | Telomerase - genetics | Chromatin Immunoprecipitation | Rad52 DNA Repair and Recombination Protein - metabolism | Replication Protein A - genetics | S Phase | Cell Cycle Proteins - genetics | G2 Phase | Telomerase - metabolism | Telomere - metabolism | Telomere-Binding Proteins - metabolism | Telomere - genetics | Nuclear Pore Complex Proteins - metabolism | Cell Cycle Proteins - metabolism | Replication Protein A - metabolism | Saccharomyces cerevisiae Proteins - genetics | Nuclear Pore - metabolism | Rad52 DNA Repair and Recombination Protein - genetics | DNA Repair | Adaptor Proteins, Signal Transducing - genetics | Saccharomyces cerevisiae Proteins - metabolism | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | DNA Damage | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Physiological aspects | DNA replication | Research | Telomerase | DNA damage | Index Medicus
Journal Article
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 03/2017, Volume 65, Issue 5, pp. 801 - 817.e4
Telomeres employ TRF2 to protect chromosome ends from activating the DNA damage sensor MRE11-RAD50-NBS1 (MRN), thereby repressing ATM-dependent DNA damage... 
NUCLEAR TARGETING SUBUNIT | MEDIATED REPAIR | DAMAGE RESPONSE | PROTEIN PHOSPHATASE 1 | MAMMALIAN TELOMERES | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRAND-BREAK REPAIR | JOINING PATHWAYS | HOMOLOGOUS-RECOMBINATION | CELL-CYCLE CONTROL | DNA-END RESECTION | CELL BIOLOGY | Serine Proteases - genetics | Phosphorylation | Ataxia Telangiectasia Mutated Proteins - metabolism | Inhibitor of Apoptosis Proteins - genetics | Humans | DNA Repair Enzymes - genetics | Structure-Activity Relationship | Telomeric Repeat Binding Protein 2 - chemistry | DNA Breaks, Double-Stranded | Cell Cycle Proteins - chemistry | Telomere-Binding Proteins - genetics | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - metabolism | DNA End-Joining Repair | S Phase | DNA Repair Enzymes - metabolism | Cell Cycle Proteins - genetics | G2 Phase | Inhibitor of Apoptosis Proteins - metabolism | Protein Interaction Domains and Motifs | Telomere - metabolism | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Aminopeptidases - metabolism | Binding Sites | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics | DNA-Binding Proteins | Telomere - genetics | Serine Proteases - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Aminopeptidases - genetics | HCT116 Cells | Cell Cycle Proteins - metabolism | Cyclin-Dependent Kinase 2 - genetics | Models, Molecular | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | G1 Phase | Telomere - pathology | Protein Binding | Telomeric Repeat Binding Protein 2 - metabolism | Telomeric Repeat Binding Protein 2 - genetics | Ataxia Telangiectasia Mutated Proteins - genetics | Medical colleges | Telomeres | Crystals | Sensors | Structure | Molecular biology | Cells | BASIC BIOLOGICAL SCIENCES
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2009, Volume 64, Issue 2, pp. 173 - 187
.... Although dynein, Lis1, and other cytoplasmic proteins are known for their roles in connecting microtubules to the nucleus during interkinetic nuclear migration (INM... 
CELLBIO | DEVBIO | LAMIN | NESPRIN-2 | LOCALIZATION | ANCHORAGE | DYNEIN | ROLES | MEMBRANE PROTEIN | ENVELOPE | LIS1 | MECHANISMS | NEUROSCIENCES | Cell Proliferation | Microtubule-Associated Proteins - metabolism | Nerve Tissue Proteins - deficiency | Neurons - cytology | Protein Transport - physiology | Cell Movement - genetics | Cell Movement - physiology | Neurogenesis - genetics | Exploratory Behavior - physiology | Membrane Proteins - deficiency | Cell Nucleus - metabolism | Neurons - ultrastructure | Nuclear Proteins - deficiency | Female | Membrane Proteins - metabolism | Bromodeoxyuridine - metabolism | Microtubule-Associated Proteins - deficiency | Telomere-Binding Proteins - metabolism | Dyneins - metabolism | Brain - cytology | Mice, Inbred C57BL | Cells, Cultured | Behavior, Animal - physiology | Mice, Transgenic | Nuclear Proteins - metabolism | Protein Structure, Tertiary - genetics | Telomere-Binding Proteins - deficiency | Electroporation - methods | Centrosome - metabolism | Nerve Tissue Proteins - metabolism | Pregnancy | Protein Interaction Mapping - methods | Animals | Neurogenesis - physiology | Mice | Proteins | Neurosciences | Neurons | Developmental biology | Dynein | Neurogenesis | Colleges & universities | Cell adhesion & migration | Brain | nuclear envelope | UNC-84 | interkinetic nuclear movement | learning and memory | KASH domain | nucleokinesis
Journal Article
Journal Article