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Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6081, pp. 593 - 597
The telomere end-protection problem is defined by the aggregate of DNA damage signaling and repair pathways that require repression at telomeres. To define the... 
Telomeres | Yeasts | Quantification | Lymphocytes | DNA | DNA damage | REPORTS | Cell cycle | Ataxia telangiectasia | Repression | Chromosomes | JOINING PATHWAY | POT1 PROTEINS | MAMMALIAN TELOMERES | SGS1 | MULTIDISCIPLINARY SCIENCES | DYSFUNCTIONAL TELOMERES | DOUBLE-STRAND BREAKS | HOMOLOGOUS RECOMBINATION | NHEJ | YEAST KU | Telomere - ultrastructure | Antigens, Nuclear - metabolism | Telomeric Repeat Binding Protein 1 - genetics | Telomeric Repeat Binding Protein 1 - metabolism | Homologous Recombination | DNA Breaks, Double-Stranded | DNA Ligases - metabolism | DNA-Binding Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | Telomere - metabolism | Telomere-Binding Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Cells, Cultured | Ataxia Telangiectasia Mutated Proteins | Xenopus Proteins | DNA-Binding Proteins - genetics | Telomere Homeostasis | Mice, Knockout | Poly(ADP-ribose) Polymerases - metabolism | Animals | Antigens, Nuclear - genetics | Cell Cycle | Ku Autoantigen | DNA Repair | DNA Ligase ATP | Telomeric Repeat Binding Protein 2 - metabolism | Mice | Poly (ADP-Ribose) Polymerase-1 | Telomeric Repeat Binding Protein 2 - genetics | Tumor Suppressor p53-Binding Protein 1 | Proteins | Physiological aspects | Research | Health aspects | DNA repair | Telomerase
Journal Article
GENES & DEVELOPMENT, ISSN 0890-9369, 11/2014, Volume 28, Issue 22, pp. 2477 - 2491
Journal Article
Science, ISSN 0036-8075, 2/2008, Volume 319, Issue 5866, pp. 1092 - 1096
Mammalian telomeres are protected by a six-protein complex: shelterin. Shelterin contains two closely related proteins (TRF1 and TRF2), which recruit various... 
Proteins | Telomeres | Colors | Atomic interactions | Amino acids | Reports | Grants | Electrostatics | Binding sites | Crystal structure | COMPLEX | DNA | INTERACTS | MULTIDISCIPLINARY SCIENCES | POLYMERASE | APOLLO | TIN2 | Humans | Molecular Sequence Data | Telomeric Repeat Binding Protein 1 - metabolism | Crystallography, X-Ray | TATA Box Binding Protein-Like Proteins - metabolism | Telomeric Repeat Binding Protein 1 - chemistry | Telomere-Binding Proteins - genetics | Inhibitor of Apoptosis Proteins - chemistry | TATA Box Binding Protein-Like Proteins - genetics | Tumor Suppressor Proteins - chemistry | TATA Box Binding Protein-Like Proteins - chemistry | Inhibitor of Apoptosis Proteins - metabolism | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Protein Structure, Secondary | Telomeric Repeat Binding Protein 2 | Models, Molecular | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Amino Acid Motifs | Hydrogen Bonding | Mutant Proteins - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Binding | Protein Conformation | Telomere-Binding Proteins - chemistry | Cellular proteins | Evaluation | Thyrotropin releasing factor | Influence | Properties | Protein binding | Protons | Biochemistry
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2005, Volume 7, Issue 7, pp. 712 - 718
Journal Article
Science, ISSN 0036-8075, 02/2017, Volume 355, Issue 6325, pp. 638 - 8
Journal Article
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 2017, Volume 24, Issue 12, pp. 1073 - 1080
Journal Article
Genes and Development, ISSN 0890-9369, 09/2009, Volume 23, Issue 17, pp. 2060 - 2075
The telomere repeat-binding factor 1 (TERF1, referred to hereafter as TRF1) is a component of mammalian telomeres whose role in telomere biology and disease... 
Telomeres | Chromosomal instability | Conditional knockout mice | DNA damage | TRF1 | Cancer | STEM-CELLS | COMPLEX | MAMMALIAN TELOMERES | RNA | DNA-DAMAGE | LENGTH | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | chromosomal instability | DYSKERATOSIS-CONGENITA | DYSFUNCTIONAL TELOMERES | GENETICS & HEREDITY | conditional knockout mice | cancer | PROTEINS | PULMONARY-FIBROSIS | Telomeric Repeat Binding Protein 1 - deficiency | Skin Diseases - genetics | Hyperpigmentation - etiology | Telomeric Repeat Binding Protein 1 - genetics | Telomeric Repeat Binding Protein 1 - metabolism | Neoplasm Proteins - metabolism | Neoplasms - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | DNA Damage - genetics | Fibroblasts - metabolism | Telomere - genetics | Cell Line | Epidermis - pathology | Protein Deficiency - complications | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | E2F1 Transcription Factor - metabolism | Hyperpigmentation - genetics | Mutation - genetics | Mice, Knockout | Skin Diseases - etiology | Chromosome Fragility | Animals | Skin Neoplasms - genetics | Cell Cycle - physiology | Stem Cells - pathology | Fibroblasts - cytology | Mice | Skin Neoplasms - etiology | Aging - metabolism | Epidermis - cytology | Analysis | Genetic aspects | Research | Telomerase | Diseases | Research Paper
Journal Article