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International Journal of Cancer, ISSN 0020-7136, 01/2014, Volume 134, Issue 2, pp. 467 - 477
Preclinical studies with recombinant murine interleukin 4 (IL4) in models of cancer have shown potent tumor growth inhibition. However, systemic administration... 
interleukin‐12 | immunocytokines | vascular targeting | oncofetal fibronectin | interleukin‐4 | interleukin-4 | interleukin-12 | RECOMBINANT HUMAN INTERLEUKIN-4 | NECROSIS-FACTOR-ALPHA | COMBINATION | RENAL-CELL CARCINOMA | PHASE-II TRIAL | SOUTHWEST-ONCOLOGY-GROUP | ONCOLOGY | FUSION PROTEIN | FIBRONECTIN | NON-HODGKIN-LYMPHOMA | IMMUNOCYTOKINE L19-IL2 | Fibrosarcoma - blood supply | Colonic Neoplasms - prevention & control | Humans | Single-Chain Antibodies - administration & dosage | Fibrosarcoma - immunology | Male | Teratocarcinoma - blood supply | Tissue Distribution | Colonic Neoplasms - immunology | Testicular Neoplasms - prevention & control | Teratocarcinoma - immunology | Female | Lymphoma - pathology | Neovascularization, Pathologic - prevention & control | Disease Models, Animal | Colonic Neoplasms - blood supply | Lymphoma - immunology | Antibodies, Monoclonal - pharmacokinetics | Interleukin-4 - immunology | Testicular Neoplasms - immunology | Animals | Interleukin-12 - administration & dosage | Immunoconjugates | Antibodies, Monoclonal - administration & dosage | Interleukin-4 - administration & dosage | Lymphoma - prevention & control | Testicular Neoplasms - blood supply | Fluorescent Antibody Technique | Interleukin-12 - immunology | Mice | Mice, Inbred BALB C | Teratocarcinoma - prevention & control | Fibrosarcoma - prevention & control | Viral antibodies | Fibronectins | Colon cancer | Interleukins | Antibodies | Models | Lymphomas | T cells | Cancer | Medical research | Drug therapy | Tumors | Alternative splicing | Index Medicus
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 06/2008, Volume 122, Issue 11, pp. 2405 - 2413
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/1998, Volume 17, Issue 11, pp. 3005 - 3015
Journal Article
Cancer Research, ISSN 0008-5472, 05/2007, Volume 67, Issue 10, pp. 4940 - 4948
Journal Article
Journal Article
Blood, ISSN 0006-4971, 03/2002, Volume 99, Issue 5, pp. 1659 - 1665
Journal Article
Journal Article
Integrative Biology, ISSN 1757-9694, 04/2011, Volume 3, Issue 4, pp. 468 - 478
The antibody-mediated targeted delivery of cytokines, growth factors and immunomodulators offers great potential for the therapy of cancer and other serious... 
B-CELL LYMPHOMA | HEPATOCELLULAR-CARCINOMA | INDUCED ANTITUMOR VACCINATION | MESSENGER-RNA | SOLID TUMORS | NECROSIS-FACTOR-ALPHA | MONOCLONAL-ANTIBODY | FIBRONECTIN SPLICE VARIANTS | EXTRA-DOMAIN | IFN-ALPHA | CELL BIOLOGY | Neoplasms - metabolism | Recombinant Fusion Proteins - immunology | Melanoma - blood supply | Recombinant Fusion Proteins - pharmacology | Blood Vessels - metabolism | Humans | Recombinant Fusion Proteins - therapeutic use | Immunoconjugates - pharmacokinetics | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Mice, 129 Strain | Teratocarcinoma - blood supply | Muramidase - immunology | Immunoconjugates - immunology | Tissue Distribution | Immunoconjugates - pharmacology | Single-Chain Antibodies - genetics | Interferon-alpha - genetics | Immunoconjugates - therapeutic use | Female | Melanoma - metabolism | Teratocarcinoma - metabolism | Fibronectins - immunology | Interferon-alpha - therapeutic use | Neoplasms - blood supply | Treatment Outcome | Melanoma - pathology | Teratocarcinoma - drug therapy | Teratocarcinoma - pathology | Neoplasms - drug therapy | Interferon-alpha - administration & dosage | Cell Movement - drug effects | Leukocytes, Mononuclear - pathology | Animals | Neovascularization, Pathologic - drug therapy | Immunoconjugates - genetics | Melanoma - drug therapy | Recombinant Fusion Proteins - pharmacokinetics | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Animal Structures - metabolism | Single-Chain Antibodies - immunology
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e80555
Object: Antiangiogenic treatments are beginning to give promising outcomes in many vascular diseases including tumor angiogenesis. In this current study the... 
ALPHA-3 CHAIN | NONCOLLAGENOUS DOMAIN | ANTITUMOR PROPERTIES | MULTIDISCIPLINARY SCIENCES | IV COLLAGEN | MICROVASCULAR ENDOTHELIAL-CELLS | MACULAR DEGENERATION | NC1 DOMAIN | ALPHA-1-BETA-1 INTEGRIN | TUMOR ANGIOGENESIS | CHOROIDAL NEOVASCULARIZATION | Fas Ligand Protein - metabolism | Skin Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Caspase 8 - metabolism | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Endothelium, Vascular - drug effects | fas Receptor - metabolism | Teratocarcinoma - blood supply | Caspase 8 - genetics | Collagen Type IV - pharmacology | Caspase 3 - genetics | Fas Ligand Protein - agonists | fas Receptor - genetics | Skin Neoplasms - blood supply | Teratocarcinoma - genetics | Skin Neoplasms - pathology | Signal Transduction | Endothelial Cells - metabolism | Angiogenesis Inhibitors - pharmacology | Cell Adhesion - drug effects | Teratocarcinoma - drug therapy | Teratocarcinoma - pathology | Protein Isoforms - pharmacology | Cell Movement - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Endothelium, Vascular - metabolism | Skin Neoplasms - genetics | Cell Line, Tumor | Endothelium, Vascular - pathology | Cell Proliferation - drug effects | Mice | Endothelial Cells - pathology | Fas Ligand Protein - genetics | Endothelial Cells - drug effects | Viral antibodies | Blood circulation disorders | Medical research | Peptides | Metabolites | Analysis | Medicine, Experimental | Antibodies | Apoptosis | Diabetic retinopathy | Laboratories | Immunoblotting | Kinases | Caspase-3 | Cell adhesion & migration | Anticancer properties | Macular degeneration | Proteins | Angiogenesis | Cell growth | Vascular diseases | Rodents | Penicillin | Vascular endothelial growth factor | Age | Cloning | Caspase | Poly(ADP-ribose) polymerase | Endothelial cells | Studies | Caspase-8 | FasL protein | Antiangiogenics | Collagen | Antitumor activity | Microvasculature | Cancer | Tumors
Journal Article
Cancer Cell, ISSN 1535-6108, 2003, Volume 3, Issue 1, pp. 75 - 88
Inactivation of the von Hippel-Lindau (VHL) gene is associated with the development of highly vascularized tumors. pVHL targets the α subunits of hypoxia... 
HYPOXIA-INDUCIBLE TRANSCRIPTION | FACTOR 1-ALPHA | MESSENGER-RNA | ONCOLOGY | SUPPRESSOR PROTEIN | PROLYL HYDROXYLATION | BINDING-PROTEIN | HIPPEL-LINDAU PROTEIN | RENAL-CARCINOMA | GENE-PRODUCT | REGULATE HIF | CELL BIOLOGY
Journal Article