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Journal of Biological Chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 14, pp. 10959 - 10968
Angiogenin (ANG) is a secreted ribonuclease that cleaves tRNA to initiate a stress-response program in mammalian cells. Here we show that ANG inhibits protein... 
SURVIVAL | EUKARYOTIC TRANSLATION INITIATION | PROCESSING BODIES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRODUCT PATEAMINE-A | ENDOTHELIAL-CELLS | INHIBITS TRANSLATION | CELL-PROLIFERATION | AMYOTROPHIC-LATERAL-SCLEROSIS | EXPRESSION | Arsenites - pharmacology | Protein Biosynthesis | Oxidative Stress | Humans | RNA, Messenger - metabolism | Bone Neoplasms - pathology | Bone Neoplasms - metabolism | Epoxy Compounds - pharmacology | Ribonuclease, Pancreatic - pharmacology | Teratogens - pharmacology | Carrier Proteins - pharmacology | Cytoplasmic Granules - metabolism | Eukaryotic Initiation Factor-2 - metabolism | Macrolides - pharmacology | RNA, Transfer - genetics | Bone Neoplasms - genetics | Phosphorylation - drug effects | Tumor Cells, Cultured | RNA, Transfer - chemistry | Osteosarcoma - metabolism | Eukaryotic Initiation Factor-2 - antagonists & inhibitors | RNA, Transfer - metabolism | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Fluorescent Antibody Technique | Thiazoles - pharmacology | Osteosarcoma - genetics | Osteosarcoma - pathology | Modification | Translation | MicroRNA | RNA | Neurodegeneration | Initiation Factors | Metabolism | Cell Biology | Diseases | Transfer RNA
Journal Article
Toxicological Sciences, ISSN 1096-6080, 06/2005, Volume 85, Issue 2, pp. 935 - 943
The presence of high affinity ligands for the aryl hydrocarbon receptor (AhR) in cell culture medium has generally been overlooked. Such compounds may confound... 
Tryptophan | Aryl hydrocarbon receptor | 6-formylindolo[3,2-b]carbazole | Light | CYP1A1 MESSENGER-RNA | TRANSIENT INDUCTION | HEPATOCYTES | HIGH-AFFINITY | AH RECEPTOR | aryl hydrocarbon receptor | GENE | light | LIVER | SINGLET OXYGEN | ULTRAVIOLET-B | TOXICOLOGY | EXPRESSION | tryptophan | Carbazoles - chemistry | Cytochrome P-450 CYP1A1 - radiation effects | Tryptophan - chemistry | Riboflavin - pharmacology | Tryptophan - metabolism | Carbazoles - radiation effects | Liver Neoplasms, Experimental - metabolism | Photosensitizing Agents - pharmacology | Spectrometry, Mass, Electrospray Ionization | Teratogens - pharmacology | Culture Media | Polychlorinated Dibenzodioxins - pharmacology | Receptors, Aryl Hydrocarbon - radiation effects | Enzyme Inhibitors - chemistry | Enzyme Induction - drug effects | Receptors, Aryl Hydrocarbon - metabolism | Indoles - pharmacology | Photochemistry | Indoles - radiation effects | Enzyme Inhibitors - pharmacology | Rats | Receptors, Aryl Hydrocarbon - drug effects | Enzyme Inhibitors - radiation effects | Cytochrome P-450 CYP1A1 - metabolism | Animals | Cell Line, Tumor | Cytochrome P-450 CYP1A1 - biosynthesis | Carbazoles - pharmacology | Indoles - chemistry | Teratogens | Cytochrome P-450 CYP1A1/biosynthesis/metabolism/radiation effects | Enzyme Inhibitors/chemistry/pharmacology/radiation effects | Spectrometry; Mass; Electrospray Ionization | Biology | Chemical Sciences | Indoles/chemistry/pharmacology/radiation effects | Analytical Chemistry | Enzyme Induction/drug effects | Biochemistry and Molecular Biology | Biologi | Natural Sciences | Biological Sciences | Riboflavin/pharmacology | Photosensitizing Agents/pharmacology | Liver Neoplasms; Experimental/metabolism | Receptors; Aryl Hydrocarbon/drug effects/metabolism/radiation effects | Tryptophan/chemistry/metabolism | Chemistry | Naturvetenskap | Biokemi och molekylärbiologi | Kemi | Biologiska vetenskaper | Cell Line; Tumor | Cell and molecular biology | Analytisk kemi | Carbazoles/chemistry/pharmacology/radiation effects | Cell- och molekylärbiologi
Journal Article
Regulatory Toxicology and Pharmacology, ISSN 0273-2300, 2006, Volume 46, Issue 3, pp. 167 - 192
Licorice (or ‘liquorice’) is a plant of ancient origin and steeped in history. Licorice extracts and its principle component, glycyrrhizin, have extensive use... 
Glycyrrhizin | Toxicity | Burdock | Enzyme | Hypermineralocorticoid | Generally recognized as safe | Cytotoxicity | Licorice | Cortisol | Food additive | Mutagen | Flavor | JECFA | Additive | FEMA | 11β-Hydroxysteroid dehydrogenase | Sweetener | Teratogen | Safety | GRAS | Carcinogenicity | Food | toxicity | food additive | CARBENOXOLONE SODIUM | generally recognized as safe | PHARMACOLOGY & PHARMACY | TOXICOLOGY | glycyrrhizin | cytotoxicity | enzyme | hypermineralocorticoid | MEDICINE, LEGAL | mutagen | safetyl | AMMONIATED GLYCYRRHIZIN | CHRONIC HEPATITIS-C | teratogen | licorice | sweetener | RAT-LIVER MICROSOMES | food | carcinogenicity | additive | flavor | cortisol | PLANT HERB EXTRACTS | 11 beta-hydroxysteroid dehydrogenase | DOUBLE-BLIND TRIAL | GASTROINTESTINAL ABSORPTION | GLYCYRRHETINIC ACID | 18-BETA-GLYCYRRHETINIC ACID | MINERALOCORTICOID ACTIVITY | Plant Extracts - toxicity | Plant Extracts - pharmacology | Consumer Product Safety | Humans | Plant Roots - toxicity | Risk Factors | Glycyrrhiza - chemistry | Glycyrrhizic Acid - chemistry | Glycyrrhizic Acid - metabolism | Biological Availability | Male | Glycyrrhiza - metabolism | Food Industry - legislation & jurisprudence | No-Observed-Adverse-Effect Level | Animals | Glycyrrhiza - toxicity | Plant Roots - chemistry | Food Industry - standards | Female | Molecular Structure | Glycyrrhizic Acid - toxicity | Antiviral agents | Safety and security measures | Corticosteroids | Flavoring essences | Food additives industry
Journal Article
Drug and chemical toxicology, ISSN 0148-0545, 1978
Journal
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 12/2003, Volume 285, Issue 6, pp. 2316 - 2326
Pentose phosphate pathway (PPP) inhibitors, 6-aminonicotinamide (6-AN) and epiandrosterone (Epi), were employed to examine whether changes in NADP(H) redox... 
Calcium | Redox signaling | Vasodilator mechanisms | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | calcium | CALCIUM CHANNELS | VENTRICULAR MYOCYTES | vasodilator mechanisms | redox signaling | INFLUX | CA2 | K+-CHANNEL | PERIPHERAL VASCULAR DISEASE | RABBIT | BINDING | SMOOTH-MUSCLE CELLS | HYPOXIC PULMONARY VASOCONSTRICTION | OXIDANTS | Calcium-Transporting ATPases - antagonists & inhibitors | Free Radical Scavengers - pharmacology | Pentose Phosphate Pathway - drug effects | Tetraethylammonium - pharmacology | Calcium - metabolism | Glutathione - metabolism | Glutathione Disulfide - metabolism | Serotonin - pharmacology | Adenylyl Cyclase Inhibitors | Arteries - metabolism | Coronary Vessels - metabolism | Teratogens - pharmacology | Cattle | Potassium Chloride - pharmacology | Superoxides - metabolism | Fura-2 | NADP - metabolism | Vasodilation - physiology | Potassium Channel Blockers - pharmacology | Dithiothreitol - pharmacology | Vasoconstrictor Agents - pharmacology | Calcium - pharmacology | Pentose Phosphate Pathway - physiology | Soluble Guanylyl Cyclase | 6-Aminonicotinamide - pharmacology | Sarcoplasmic Reticulum Calcium-Transporting ATPases | Androsterone - pharmacology | Hydrogen Peroxide - metabolism | Animals | Guanylate Cyclase | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Vasodilation - drug effects
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2003, Volume 35, Issue 1, pp. 102 - 113
We have recently found evidence for impairment of nitric oxide (NO) formation and induction of oxidative stress in residents of an endemic area of chronic... 
Free radicals | Arsenate | Tetrahydrobiopterin | Nitric oxide | Oral exposure | Vasoconstriction | Rabbit | Superoxide | free radicals | nitric oxide | tetrahydrobiopterin | SUPEROXIDE ANIONS | BIOLOGICAL-FLUIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPERCHOLESTEROLEMIC RABBITS | oral exposure | BLOOD-PRESSURE | FREE-RADICALS | PERFORMANCE LIQUID-CHROMATOGRAPHY | rabbit | L-ARGININE | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | vasoconstriction | HYDROGEN-PEROXIDE | superoxide | DRINKING-WATER | arsenate | Water | Teratogens - toxicity | Oxidative Stress | Arsenates - administration & dosage | Nitric Oxide Synthase - antagonists & inhibitors | Arsenates - toxicity | Endothelium, Vascular - drug effects | Male | Aorta - metabolism | Cyclic GMP - blood | Biopterin - analogs & derivatives | Biopterin - metabolism | Superoxides - metabolism | Hydrogen Peroxide - urine | Ionophores - pharmacology | Superoxide Dismutase - metabolism | Xanthine Oxidase - antagonists & inhibitors | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Nitric Oxide - blood | Rabbits | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Administration, Oral | Nitric Oxide - antagonists & inhibitors | Liver - metabolism | Enzyme Inhibitors - pharmacology | Onium Compounds - pharmacology | Calcimycin - pharmacology | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | New Zealand | Animals | Endothelium, Vascular - metabolism | Allopurinol - pharmacology | Nitric Oxide Synthase - metabolism
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