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Blood, ISSN 0006-4971, 2016, Volume 127, Issue 7, pp. 869 - 881
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, pp. e0179501 - e0179501
Innovative therapies for solid tumors are urgently needed. Recently, therapies that harness the host immune system to fight cancer cells have successfully... 
CD2 | THERAPY | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | GENES | IMMUNOMODULATORY ACTION | MECHANISMS | MOLECULES | SGI-110 | Colonic Neoplasms - genetics | DNA Methylation - immunology | DNA, Neoplasm - metabolism | Humans | Antigens, Neoplasm - biosynthesis | Ovarian Neoplasms - pathology | Male | Colonic Neoplasms - metabolism | Testicular Neoplasms - pathology | Ovarian Neoplasms - genetics | Colonic Neoplasms - immunology | Female | Ovarian Neoplasms - metabolism | Caco-2 Cells | Antigens, Neoplasm - genetics | Testicular Neoplasms - genetics | Antigens, Neoplasm - immunology | Testicular Neoplasms - metabolism | Antigen Presentation - genetics | DNA Methylation - genetics | Testicular Neoplasms - immunology | Animals | Colonic Neoplasms - pathology | DNA, Neoplasm - immunology | Mice | DNA, Neoplasm - genetics | Ovarian Neoplasms - immunology | Colon cancer | Tumor antigens | Physiological aspects | Development and progression | Genetic aspects | Research | Methylation | Ovarian cancer | Therapy | Biotechnology | Animal models | Ovarian carcinoma | CD58 antigen | Antigen processing | Genomes | Tissues | Cancer therapies | Immunotherapy | Surgery | Cell cycle | DNA methylation | Inhibition | Colon | Drug dosages | Deoxyribonucleic acid--DNA | Immune system | Antigen presentation | Antigens | Tumor cells | Melanoma | Tumor cell lines | Gene expression | Ribonucleic acid--RNA | Patients | Immune systems | Medicine | Inhibitors | Epigenetics | Solid tumors | Tumors | Cancer | Index Medicus | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2017, Volume 76, pp. 1 - 7
Abstract Introduction Treatment options for patients with platinum refractory metastatic germ cell tumours (GCT) relapsing after high-dose chemotherapy and... 
Hematology, Oncology and Palliative Medicine | Germ cell cancer | Immunotherapy | PD-L1 | Checkpoint inhibition | Platinum refractory disease | Testicular cancer | PD-1 | LONG-TERM SURVIVAL | PD-L1 EXPRESSION | TUMORS | ONCOLOGY | NIVOLUMAB | CARCINOMA | Lung Neoplasms - drug therapy | Seminoma - diagnostic imaging | Teratoma | Endodermal Sinus Tumor - drug therapy | Compassionate Use Trials | Choriocarcinoma, Non-gestational - secondary | Humans | Middle Aged | Neoplasm Recurrence, Local - drug therapy | Antibodies, Monoclonal - therapeutic use | Male | Tomography, X-Ray Computed | Transplantation, Autologous | Testicular Neoplasms - pathology | Seminoma - metabolism | Stem Cell Transplantation | Mediastinal Neoplasms - drug therapy | Lung Neoplasms - secondary | Adult | Neoplasms, Germ Cell and Embryonal - drug therapy | Retrospective Studies | Choriocarcinoma, Non-gestational - metabolism | Endodermal Sinus Tumor - secondary | Endodermal Sinus Tumor - diagnostic imaging | Ifosfamide - therapeutic use | Antibodies, Monoclonal, Humanized - therapeutic use | Seminoma - drug therapy | Testicular Neoplasms - metabolism | Programmed Cell Death 1 Receptor - metabolism | Etoposide - therapeutic use | Neoplasms, Germ Cell and Embryonal - metabolism | Treatment Outcome | Choriocarcinoma, Non-gestational - diagnostic imaging | Endodermal Sinus Tumor - metabolism | Neoplasms, Germ Cell and Embryonal - diagnostic imaging | Cisplatin - therapeutic use | Testicular Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mediastinal Neoplasms - pathology | Lung Neoplasms - diagnostic imaging | Mediastinal Neoplasms - metabolism | Platinum Compounds - administration & dosage | Seminoma - secondary | Choriocarcinoma, Non-gestational - drug therapy | Neoplasms, Germ Cell and Embryonal - secondary | Viral antibodies | Medical research | Relapse | Chemotherapy | Stem cells | Medicine, Experimental | Antibodies | Transplantation | Metastasis | Diseases | Cancer | Apoptosis | Autografts | Cell survival | PD-1 protein | Toxicity | Mortality | Clinical trials | Stem cell transplantation | Patients | Metastases | Inhibitors | Immune checkpoint | Platinum | Cell death | PD-L1 protein | Tumors | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 1 - 15
Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic... 
LUNG-CANCER | TERT-CLPTM1L LOCUS | VARIANTS | GENE | PROMOTES GROWTH | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | SUSCEPTIBILITY LOCI | ZBP-89 | GENOME-WIDE ASSOCIATION | TELOMERE LENGTH | RNA, Small Interfering - genetics | Pancreatic Neoplasms - metabolism | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Male | Genetic Loci | Testicular Neoplasms - pathology | DNA-Binding Proteins - metabolism | Telomerase - genetics | Melanoma - genetics | Female | Telomerase - metabolism | Lung Neoplasms - genetics | Melanoma - metabolism | Skin Neoplasms - pathology | Genetic Predisposition to Disease | Genome-Wide Association Study | Testicular Neoplasms - genetics | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | Pancreatic Neoplasms - pathology | Testicular Neoplasms - metabolism | Pancreatic Neoplasms - genetics | Transcription Factors - antagonists & inhibitors | Chromosome Mapping | Melanoma - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Telomere Homeostasis | Chromosomes, Human, Pair 5 | Skin Neoplasms - metabolism | Transcription Factors - metabolism | Histones - genetics | Skin Neoplasms - genetics | Alleles | Cell Line, Tumor | Polymorphism, Single Nucleotide | Histones - metabolism | Telomerase - antagonists & inhibitors | RNA, Small Interfering - metabolism | Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Surgery | Kirurgi
Journal Article
Nature, ISSN 0028-0836, 11/2016, Volume 540, Issue 7631, pp. 114 - 118
Journal Article
Journal Article
American Journal of Surgical Pathology, ISSN 0147-5185, 06/2007, Volume 31, Issue 6, pp. 836 - 845
The core embryonic stem cell transcription factors (TFs) OCT3/4 (OCT4), NANOG, and SOX2 have shared as well as nonoverlapping roles in stem cell growth and... 
Germ cell tumor | Immunohistochemistry | Seminoma | Transcription factor | Stem cell | Embryonal carcinoma | SURGERY | transcription factor | CD30 | MARKER | ALKALINE-PHOSPHATASE | TESTICULAR CANCER | OCT4 IMMUNOHISTOCHEMISTRY | PLURIPOTENCY | embryonal carcinoma | PATHOLOGY | germ cell tumor | stem cell | NANOG | immunohistochemistry | seminoma | EXPRESSION | CARCINOMA | Embryonic Stem Cells - metabolism | Homeodomain Proteins - metabolism | Humans | Male | Carcinoma, Embryonal - metabolism | Neoplasms, Germ Cell and Embryonal - diagnosis | Retroperitoneal Neoplasms - diagnosis | Seminoma - diagnosis | DNA-Binding Proteins - metabolism | Seminoma - metabolism | Sensitivity and Specificity | HMGB Proteins - metabolism | Seminoma - classification | SOXB1 Transcription Factors | Testicular Neoplasms - classification | Testicular Neoplasms - diagnosis | Diagnosis, Differential | Nanog Homeobox Protein | Retroperitoneal Neoplasms - classification | Biomarkers, Tumor - analysis | Testicular Neoplasms - metabolism | Neoplasms, Germ Cell and Embryonal - metabolism | Retroperitoneal Neoplasms - metabolism | Transcription Factors - metabolism | Carcinoma, Embryonal - classification | Carcinoma, Embryonal - diagnosis | Octamer Transcription Factor-3 - metabolism | Neoplasms, Germ Cell and Embryonal - classification | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 06/2009, Volume 124, Issue 12, pp. 2893 - 2898
CT45 is a cancer/testis gene that we previously identified by massively parallel signature sequencing. Encoded by a multigene family on chromosome X, CT45... 
Cancer/testis antigen | Cancer vaccine | Tumor antigen | NY-ESO-1 | IMMUNE-RESPONSE | cancer vaccine | HUMAN TUMOR-ANTIGENS | IDENTIFICATION | MAGE-3 PROTEIN | tumor antigen | T-CELL RESPONSES | MELANOMA | ONCOLOGY | GENES | cancer/testis antigen | ANTIBODY-RESPONSES | LYMPHOCYTES | Prognosis | Tissue Array Analysis | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Lung Neoplasms - metabolism | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Male | RNA, Messenger - metabolism | Testicular Neoplasms - pathology | Breast Neoplasms - metabolism | Ovarian Neoplasms - genetics | Adenocarcinoma - metabolism | Antigens, Neoplasm - metabolism | Biomarkers, Tumor - metabolism | Female | Adenocarcinoma - genetics | Ovarian Neoplasms - metabolism | Antibodies, Monoclonal - immunology | Lung Neoplasms - genetics | Recombinant Proteins - metabolism | Antigens, Neoplasm - genetics | Testicular Neoplasms - genetics | Antigens, Neoplasm - immunology | Testicular Neoplasms - metabolism | Recombinant Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - secondary | Animals | Breast Neoplasms - genetics | Recombinant Proteins - immunology | Breast Neoplasms - pathology | Carcinoma, Squamous Cell - secondary | Biomarkers, Tumor - genetics | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2009, Volume 106, Issue 52, pp. 22232 - 22328
Dmrt1 (doublesex and mab-3 related transcription factor 1) is a conserved transcriptional regulator of male differentiation required for testicular development... 
Teratoma | Germ cells | Somatic cells | Stem cells | Cell lines | Mice | Testes | Pluripotent stem cells | Sertoli cells | Tumors | Germ cell tumor | Testicular teratoma | GDNF | Embryonal carcinoma | METHYLATION IMPRINT | TESTIS DIFFERENTIATION | testicular teratoma | 129.MOLF-CHR19 MOUSE STRAIN | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | embryonal carcinoma | germ cell tumor | TUMORS | HUMAN SPERMATOCYTIC SEMINOMAS | CONGENITAL TESTICULAR TERATOMAS | GENE | EMBRYONIC STEM-CELLS | MICE | Proto-Oncogene Proteins c-ret - metabolism | Cell Proliferation | Fetal Stem Cells - cytology | Spermatogenesis - genetics | Fetal Stem Cells - metabolism | Humans | Male | Neoplasms, Germ Cell and Embryonal - genetics | Neoplasm Proteins - metabolism | Testicular Neoplasms - pathology | Teratoma - metabolism | Cell Differentiation | Neoplasm Proteins - genetics | Genes, Tumor Suppressor | PTEN Phosphohydrolase - genetics | Gene Expression | Testicular Neoplasms - genetics | Transcription Factors - physiology | Pluripotent Stem Cells - cytology | Mice, Inbred C57BL | Testicular Neoplasms - metabolism | PTEN Phosphohydrolase - metabolism | Neoplasms, Germ Cell and Embryonal - metabolism | Gene Dosage | Transcription Factors - genetics | Mice, Knockout | Pluripotent Stem Cells - metabolism | Phenotype | Spermatogenesis - physiology | Teratoma - pathology | Animals | Teratoma - genetics | Mutation | Neoplasms, Germ Cell and Embryonal - pathology | Proto-Oncogene Proteins c-ret - genetics | Cell proliferation | Physiological aspects | Transcription factors | Genetic aspects | Research | Proteins | Chromatin | Gene expression | Rodents | Index Medicus | Biological Sciences
Journal Article