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Pharmacological Research, ISSN 1043-6618, 09/2012, Volume 66, Issue 3, pp. 251 - 259
Endocannabinoids exhibit vasodilatory properties and reduce blood pressure . However, the influence and mechanism of action of the prominent endocannabinoid,... 
Endocannabinoid | Abnormal cannabidiol | Pulmonary artery | Anandamide | Endothelium | VIRODHAMINE | VASORELAXATION | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | VESSELS | VASCULATURE | RESISTANCE | PHARMACOLOGY & PHARMACY | CHANNELS | HYPERTENSION | ABNORMAL-CANNABIDIOL | Tetraethylammonium - pharmacology | Endocannabinoids - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Apamin - pharmacology | Receptors, Cannabinoid - metabolism | TRPV Cation Channels - metabolism | Piperidines - pharmacology | Charybdotoxin - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Potassium Chloride - metabolism | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Benzamides - pharmacology | Potassium Channel Blockers - pharmacology | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Receptors, Epoprostenol - metabolism | Rats | Amidohydrolases - antagonists & inhibitors | Capsaicin - analogs & derivatives | Imidazoles - pharmacology | Pulmonary Artery - drug effects | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Receptors, Epoprostenol - antagonists & inhibitors | Animals | Benzyl Compounds - pharmacology | Endothelium, Vascular - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Polyunsaturated Alkamides - pharmacology | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | Hypertension | Enzymes | Vasodilators | Blood vessels | Glycerol | Fatty acids | Pulmonary hypertension | Glycerin | Cannabinoids | Dilatation | Dimethyl sulfoxide | Hydrolases | Indomethacin
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 11/2015, Volume 767, pp. 52 - 60
Journal Article
Hypertension, ISSN 0194-911X, 09/2004, Volume 44, Issue 3, pp. 271 - 276
Journal Article
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 09/2006, Volume 114, Issue 13, pp. 1372 - 1379
Background - At birth, the increase in oxygen causes contraction of the ductus arteriosus, thus diverting blood flow to the lungs. Although this contraction is... 
Oxygen | Ion channels | Vasoconstriction | Ductus arteriosus, patent | Heart defects, congenital | heart defects | CARDIAC & CARDIOVASCULAR SYSTEMS | ductus arteriosus, patent | TRPC1 | RECEPTOR | CLOSURE | congenital | CAPACITATIVE CA2+ ENTRY | PULMONARY VASOCONSTRICTION | CYTOSOLIC CALCIUM | ion channels | CONSTRICTION | PERIPHERAL VASCULAR DISEASE | vasoconstriction | SMOOTH-MUSCLE-CELLS | RABBIT | oxygen | Oxygen - pharmacology | Tetraethylammonium - pharmacology | Calcium Signaling - physiology | Maleimides - pharmacology | Potassium Channels - physiology | Thiourea - pharmacology | Polyunsaturated Alkamides | Isoquinolines - pharmacology | rho-Associated Kinases | Niflumic Acid - pharmacology | Indoles - pharmacology | Endocannabinoids | Ductus Arteriosus - physiology | Boron Compounds - pharmacology | Mibefradil - pharmacology | Nifedipine - pharmacology | Calcium - pharmacology | Oxidation-Reduction | Protein-Serine-Threonine Kinases - physiology | Rabbits - embryology | Calcium Channels, L-Type - physiology | Imidazoles - pharmacology | Calcium Channel Blockers - pharmacology | Potassium Channels - drug effects | Sulfonamides - pharmacology | Arachidonic Acids - pharmacology | Ductus Arteriosus - embryology | Patch-Clamp Techniques | Animals | Menthol - pharmacology | Ruthenium Red - pharmacology | Muscle Contraction - drug effects | Calcium Channels, L-Type - drug effects | Muscle Contraction - physiology | Thapsigargin - pharmacology | Cytosol - metabolism | In Vitro Techniques | Intracellular Signaling Peptides and Proteins - physiology | Thiourea - analogs & derivatives
Journal Article
Neuron, ISSN 0896-6273, 06/1998, Volume 20, Issue 6, pp. 1211 - 1218
The mechanism through which kainate receptors downregulate the release of GABA in the hippocampus is not known. We have found that the action of kainate on the... 
PROTEIN-KINASE-C | GLUTAMATE RECEPTORS | INHIBITION | CA2+ CHANNELS | RAT HIPPOCAMPUS | SYNAPTIC TRANSMISSION | CURRENTS | HIPPOCAMPAL-NEURONS | EXPRESSION | NEUROSCIENCES | BRAIN | Tetraethylammonium - pharmacology | Rats, Wistar | Hippocampus - chemistry | gamma-Aminobutyric Acid - metabolism | Receptors, Metabotropic Glutamate - physiology | Type C Phospholipases - metabolism | Phorbol 12,13-Dibutyrate - pharmacology | Calcium - physiology | Carcinogens - pharmacology | Isoquinolines - pharmacology | Cyclic AMP - analogs & derivatives | Protein Kinase C - metabolism | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Hippocampus - enzymology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Tetrodotoxin - pharmacology | Virulence Factors, Bordetella | Membrane Potentials - drug effects | Sodium - pharmacology | Calcium - pharmacology | Kainic Acid - pharmacology | Enzyme Inhibitors - pharmacology | Pertussis Toxin | Phosphodiesterase Inhibitors - pharmacology | Rats | Excitatory Amino Acid Agonists - pharmacology | Thionucleotides - pharmacology | Enzyme Activation - drug effects | Cyclic AMP - pharmacology | Receptors, Kainic Acid - metabolism | Animals | Sulfonamides | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Second Messenger Systems - physiology | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Staurosporine - pharmacology | Phorbol esters | GABA | Protein kinases
Journal Article
Journal of Endodontics, ISSN 0099-2399, 2011, Volume 37, Issue 3, pp. 353 - 357
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2007, Volume 151, Issue 3, pp. 323 - 331
Background and purpose: Perivascular adipose tissue (PVAT) attenuates vascular contraction, but the mechanisms remain largely unknown. The possible involvement... 
perivascular adipose tissue | endothelium | nitric oxide | rat | potassium channels | hydrogen peroxide | reactive oxygen species | relaxation | aorta | Relaxation | Perivascular adipose tissue | Reactive oxygen species | Hydrogen peroxide | Rat | Nitric oxide | Aorta | Potassium channels | Endothelium | CELLS | PORCINE CORONARY-ARTERIES | MECHANISMS | RELEASE | CONTRACTION | INDICATORS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | Tetraethylammonium - pharmacology | Adipose Tissue - physiology | Muscle, Smooth, Vascular - metabolism | Rats, Wistar | Potassium Channels - physiology | Nitric Oxide Synthase - antagonists & inhibitors | Male | Guanylate Cyclase - antagonists & inhibitors | Serotonin - pharmacology | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Adipose Tissue - metabolism | Vasoconstriction - physiology | Phenylephrine - pharmacology | Aorta, Thoracic - physiology | Muscle, Smooth, Vascular - blood supply | Aorta, Thoracic - drug effects | Nitric Oxide Donors - pharmacology | Muscle, Smooth, Vascular - physiology | Potassium Channel Blockers - pharmacology | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Aorta, Thoracic - metabolism | Rats | Guanylate Cyclase - metabolism | Vasoconstriction - drug effects | Nitroarginine - pharmacology | Animals | Adrenergic alpha-Agonists - pharmacology | Vasodilation - drug effects | In Vitro Techniques | Research Papers
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2001, Volume 134, Issue 5, pp. 1003 - 1012
The effects of the endocannabinoid, anandamide, and its metabolically stable analogue, methanandamide, on induced tone were examined in sheep coronary artery... 
endothelium | sheep coronary arteries | arachidonic acid metabolites, K+ channels | relaxation | Anandamide | Arachidonic acid metabolites | Relaxation | Sheep coronary arteries | Endothelium | arachidonic acid metabolites | CELLS | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSORY NERVES MEDIATE | CANNABINOID RECEPTORS | ISOLATED MESENTERIC-ARTERY | HYPERPOLARIZING FACTOR | VASORELAXANT | VANILLOID RECEPTORS | K+ channels | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | anandamide | TRANSPORT INHIBITOR | Tetraethylammonium - pharmacology | Arachidonic Acid - metabolism | Cytochrome P-450 Enzyme Inhibitors | Capsaicin - pharmacology | Potassium Channels - physiology | Nitric Oxide Synthase - antagonists & inhibitors | Apamin - pharmacology | Cannabinoid Receptor Modulators | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Polyunsaturated Alkamides | Glyburide - pharmacology | Piperidines - pharmacology | Phenylmethylsulfonyl Fluoride - pharmacology | Potassium Channel Blockers | 4-Aminopyridine - pharmacology | Endocannabinoids | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Vasoconstrictor Agents - pharmacology | Coronary Vessels - drug effects | Coronary Vessels - physiology | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Fatty Acids, Unsaturated - pharmacology | Barium - pharmacology | Calcium Channel Blockers - pharmacology | Potassium - pharmacology | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Cannabinoids - pharmacology | Peptides - pharmacology | Animals | Miconazole - pharmacology | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Sheep | Vasodilation - drug effects | In Vitro Techniques | Receptors, Drug - antagonists & inhibitors | Papers
Journal Article
Neuron, ISSN 0896-6273, 03/2012, Volume 73, Issue 6, pp. 1159 - 1172
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2006, Volume 530, Issue 1, pp. 144 - 151
The mechanisms underlying transient receptor potential vanilloid receptor type 1 (TRPV1)-independent relaxation elicited by capsaicin were studied by measuring... 
Capsaicin | Intestine | Capsazepine | K + channel | Myosin light chain | channel | CELLS | intestine | GENE-RELATED PEPTIDE | MECHANISM | KINASE | VANILLOID RECEPTOR | TETRAETHYLAMMONIUM | RELEASE | K+ channel | SIGNAL-TRANSDUCTION | SMOOTH-MUSCLE | myosin light chain | INHIBITION | capsaicin | capsazepine | PHARMACOLOGY & PHARMACY | Diclofenac - pharmacology | Tetraethylammonium - pharmacology | Calcium - metabolism | Capsaicin - pharmacology | Potassium Channels - physiology | Dimethyl Sulfoxide - pharmacology | Male | Peptide Fragments - pharmacology | Apamin - pharmacology | Dose-Response Relationship, Drug | Muscle, Smooth - drug effects | Ileum - drug effects | Glyburide - pharmacology | Piperidines - pharmacology | Charybdotoxin - pharmacology | Potassium Chloride - pharmacology | rho-Associated Kinases | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Caffeine - pharmacology | Muscle, Smooth - physiology | Phosphorylation - drug effects | Benzopyrans - pharmacology | 4-Aminopyridine - pharmacology | Potassium Channel Blockers - pharmacology | Pyrazoles - pharmacology | Diterpenes - pharmacology | Guinea Pigs | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Calcitonin Gene-Related Peptide - pharmacology | Enzyme Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins | Phosphodiesterase Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Papaverine - pharmacology | Barium - pharmacology | Nitroarginine - pharmacology | Animals | Ileum - physiology | Myosin Light Chains - metabolism | Capsaicin - antagonists & inhibitors | Muscle Relaxation - drug effects | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Guanethidine - pharmacology | Acetylcholine | Peptides | Glibenclamide | Muscle proteins | Myosin
Journal Article
Annals of Neurology, ISSN 0364-5134, 09/2005, Volume 58, Issue 3, pp. 371 - 382
The hypothalamic hamartoma (HH) is a rare developmental malformation often characterized by gelastic seizures, which are usually refractory to medical therapy.... 
CHILDHOOD ABSENCE EPILEPSY | GLUTAMATE RECEPTORS | TRANSCALLOSAL RESECTION | DISSOCIATED DOPAMINERGIC-NEURONS | ACTIVATED INWARD CURRENT | STATUS EPILEPTICUS | GELASTIC EPILEPSY | GABA(B) RECEPTORS | PRECOCIOUS PUBERTY | SPONTANEOUS SPIKE | NEUROSCIENCES | CLINICAL NEUROLOGY | Tetraethylammonium - pharmacology | Humans | Child, Preschool | Electrophysiology | Infant | Male | Phosphopyruvate Hydratase - metabolism | Glial Fibrillary Acidic Protein - metabolism | Anesthetics, Local - pharmacology | Patch-Clamp Techniques - methods | Hamartoma - pathology | Neurons - classification | Drug Interactions | Hypothalamus - surgery | Isoenzymes - metabolism | Hamartoma - surgery | Neurons - physiology | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Adult | Female | Hamartoma - metabolism | Neurons - metabolism | Tetrodotoxin - pharmacology | Cadmium Chloride - pharmacology | Child | Potassium Channel Blockers - pharmacology | Bicuculline - analogs & derivatives | Glutamic Acid - pharmacology | Kainic Acid - pharmacology | Valine - analogs & derivatives | Hamartoma - physiopathology | Periodicity | gamma-Aminobutyric Acid - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Hypothalamus - pathology | Bicuculline - pharmacology | Membrane Potentials - physiology | Hypothalamus - physiopathology | GABA Antagonists - pharmacology | Immunohistochemistry - methods | Hypothalamus - metabolism | Adolescent | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Glutamate Decarboxylase - metabolism | Valine - pharmacology | In Vitro Techniques
Journal Article