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Cell Metabolism, ISSN 1550-4131, 06/2016, Volume 23, Issue 6, pp. 1140 - 1153
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 11, pp. E1470 - E1478
Journal Article
PLoS ONE, ISSN 1932-6203, 2009, Volume 4, Issue 12, p. e8445
MicroRNAs (miRNAs) are predicted to regulate approximately 30% of all human genes; however, only a few miRNAs have been assigned their targets and specific... 
MIRNA EXPRESSION | THYMIDYLATE SYNTHASE | MULTIDISCIPLINARY SCIENCES | GENES | PHARMACOGENOMICS | DIHYDROFOLATE-REDUCTASE | DIFFERENTIATION | IDENTIFICATION | CELL | BINDING | MICRORNA POLYMORPHISMS | Methotrexate - pharmacology | NIH 3T3 Cells | Colorectal Neoplasms - genetics | Humans | 3' Untranslated Regions - genetics | MicroRNAs - metabolism | G2 Phase - drug effects | Cell Cycle Proteins - genetics | Gene Expression Regulation, Neoplastic - drug effects | Colorectal Neoplasms - enzymology | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Cell Adhesion - drug effects | Down-Regulation - drug effects | Tetrahydrofolate Dehydrogenase - metabolism | Cell Shape - drug effects | Animals | Cell Differentiation - drug effects | Cell Line, Tumor | Polymorphism, Single Nucleotide - genetics | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | S Phase - drug effects | Colorectal Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | Tetrahydrofolate Dehydrogenase - genetics | MicroRNA | Genes | Colorectal cancer | Genetic aspects | Dihydrofolate reductase | Tumor proteins | Cancer | Cell proliferation | Biotechnology | Cell culture | GTP-binding protein | Transformation | Deregulation | Laboratories | Colorectal carcinoma | p53 Protein | Gene regulation | Oncology | Metastasis | Epidemiology | Medical schools | Cell growth | Precision medicine | Cell cycle | miRNA | Methotrexate | Null cells | Deoxyribonucleic acid--DNA | Medical research | Enzymes | Pharmacology | Dentistry | Gene expression | Pathology | Cyclin-dependent kinase inhibitor p21 | Gene amplification | 3' Untranslated regions | MicroRNAs | Stem cells | Biomarkers | Tumor suppressor genes | Tumors | Polymorphism | Reductase | Deoxyribonucleic acid | DNA
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 02/2014, Volume 34, Issue 3, pp. 498 - 509
Journal Article
International Journal for Parasitology, ISSN 0020-7519, 07/2016, Volume 46, Issue 8, pp. 527 - 535
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/2011, Volume 31, Issue 10, pp. 2223 - 2231
Journal Article
Drug Resistance Updates, ISSN 1368-7646, 2016, Volume 28, pp. 82 - 90
Abstract The genus Burkholderia comprises metabolically diverse and adaptable Gram-negative bacteria, which thrive in often adversarial environments. A few... 
Infectious Disease | Hematology, Oncology and Palliative Medicine | Melioidosis | Glanders | Burkholderia | Antibiotics resistance | Burkholderia cepacia complex | OPRB EFFLUX PUMP | DRUG-RESISTANCE | GYRASE GYRA GENE | BPEAB-OPRB | GRAM-NEGATIVE BACTERIA | CYSTIC-FIBROSIS PATIENTS | PSEUDOMONAS-AERUGINOSA | PHARMACOLOGY & PHARMACY | BETA-LACTAMASES | CEPACIA COMPLEX | IN-VITRO ACTIVITY | Burkholderia mallei - drug effects | Humans | Porins - metabolism | Burkholderia mallei - genetics | Burkholderia - pathogenicity | Porins - antagonists & inhibitors | Burkholderia pseudomallei - drug effects | Burkholderia pseudomallei - growth & development | Burkholderia Infections - pathology | Burkholderia pseudomallei - pathogenicity | Burkholderia mallei - growth & development | Burkholderia pseudomallei - genetics | Melioidosis - microbiology | Burkholderia Infections - microbiology | Burkholderia - drug effects | Glanders - drug therapy | Burkholderia - genetics | Porins - genetics | Genes, MDR | Glanders - pathology | Bacterial Proteins - genetics | Tetrahydrofolate Dehydrogenase - metabolism | DNA Gyrase - metabolism | Melioidosis - pathology | Animals | Burkholderia mallei - pathogenicity | DNA Gyrase - genetics | Melioidosis - drug therapy | Burkholderia Infections - drug therapy | Glanders - microbiology | Horses | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Drug Resistance, Multiple, Bacterial - genetics | Gene Expression Regulation, Bacterial | Burkholderia - growth & development | Tetrahydrofolate Dehydrogenase - genetics | Medical colleges | Drug resistance in microorganisms | Cystic fibrosis | Bacteria | Beta lactamases | Dihydrofolate reductase | Antibacterial agents | glanders | melioidosis | antibiotics resistance
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 08/2014, Volume 90, Issue 3, pp. 226 - 234
Basal-like breast cancer (BLBC) remains a great challenge because of its clinically aggressive nature and lack of effective targeted therapy. We analyzed the... 
Dihydrofolate reductase (DHFR) | Mice | Sanguinarine | Basal-like breast cancer | STAT3 | Apoptosis | CARCINOMA-CELLS | SUBTYPE | ACTIVATION | BENZOPHENANTHRIDINE ALKALOID SANGUINARINE | PHOSPHORYLATION | PHENOTYPE | TUMOR-CELLS | PHARMACOLOGY & PHARMACY | CYCLIN-D1 | EXPRESSION | Methotrexate - pharmacology | Neoplasm Transplantation | Isoquinolines - adverse effects | Tetrahydrofolate Dehydrogenase - chemistry | Apoptosis - drug effects | Humans | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Necrosis | Folic Acid Antagonists - therapeutic use | Breast Neoplasms - enzymology | Isoquinolines - pharmacology | Benzophenanthridines - therapeutic use | Neoplasms, Basal Cell - enzymology | Female | Neoplasms, Basal Cell - drug therapy | Antineoplastic Agents, Phytogenic - therapeutic use | Folic Acid Antagonists - adverse effects | Antineoplastic Agents, Phytogenic - adverse effects | Cell Survival - drug effects | Benzophenanthridines - adverse effects | Neoplasms, Basal Cell - pathology | Random Allocation | Mice, Inbred Strains | Breast Neoplasms - drug therapy | Benzophenanthridines - pharmacology | Tetrahydrofolate Dehydrogenase - metabolism | Cell Movement - drug effects | Animals | Tumor Burden - drug effects | Breast Neoplasms - pathology | Cell Line, Tumor | Isoquinolines - therapeutic use | Antineoplastic Agents, Phytogenic - pharmacology | Folic Acid Antagonists - pharmacology | Breast cancer | Dihydrofolate reductase
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2008, Volume 105, Issue 26, pp. 9059 - 9064
Journal Article
Developmental Biology, ISSN 0012-1606, 09/2015, Volume 405, Issue 1, pp. 108 - 122
Folate deficiency has been associated with numerous diseases and birth defects including orofacial defects. However, whether folate has a role in the face... 
Xenopus | DHFR | Orofacial development | Retinoic acid and primary palate | Folate | OXIDATIVE STRESS | FACIAL CLEFTS | NEURAL-TUBE DEFECTS | DEVELOPMENTAL BIOLOGY | HISTONE BIOSYNTHESIS | FOLIC-ACID | DNA MISMATCH REPAIR | RETINOIC ACID | CRANIOFACIAL DEFECTS | DIHYDROFOLATE-REDUCTASE | CELL-CYCLE | Methotrexate - pharmacology | Apoptosis - drug effects | Cartilage - pathology | Cartilage - drug effects | Embryo, Nonmammalian - drug effects | Muscles - pathology | Neural Crest - metabolism | Tretinoin - metabolism | Biomarkers - metabolism | Cell Survival - drug effects | Cartilage - embryology | Oligonucleotides, Antisense - pharmacology | Embryo, Nonmammalian - pathology | Mouth - embryology | Muscles - embryology | Xenopus laevis | Gene Expression Regulation, Developmental - drug effects | Cleft Palate - embryology | Mouth - metabolism | Receptors, Retinoic Acid - antagonists & inhibitors | Receptors, Retinoic Acid - metabolism | Neural Crest - drug effects | Tetrahydrofolate Dehydrogenase - metabolism | Embryo, Nonmammalian - abnormalities | Animals | Signal Transduction - drug effects | Models, Biological | Muscles - drug effects | Morpholinos - pharmacology | Folic Acid - metabolism | Cell Proliferation - drug effects | Cleft Palate - metabolism | Face - embryology | DNA Damage | Cell Cycle - drug effects | DNA Methylation - drug effects | Leucovorin - pharmacology | Physiological aspects | Dihydrofolate reductase | Methylation | Folic acid | orofacial development | retinoic acid and primary palate
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 04/2008, Volume 73, Issue 4, pp. 1290 - 1300
Because the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib and the multitargeted antifolate pemetrexed are registered in the... 
PHASE-III TRIAL | GEFITINIB | MESSENGER-RNA EXPRESSION | CYCLIN D1 | THYMIDYLATE SYNTHASE | COLORECTAL-CANCER | PHARMACOLOGY & PHARMACY | DETERMINES RESPONSE | ANTITUMOR-ACTIVITY | CLINICAL-RESPONSE | GEMCITABINE | Erlotinib Hydrochloride | Guanine - analogs & derivatives | Humans | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Guanine - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | RNA, Messenger - genetics | Morpholines - pharmacology | Thymidylate Synthase - metabolism | E2F1 Transcription Factor - metabolism | Pemetrexed | Thymidylate Synthase - genetics | Tetrahydrofolate Dehydrogenase - metabolism | Drug Synergism | Catalysis - drug effects | Glutamates - pharmacology | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Extracts | Carcinoma, Non-Small-Cell Lung - enzymology | Cell Cycle - drug effects | E2F1 Transcription Factor - genetics | Quinazolines - pharmacology | Folic Acid Antagonists - pharmacology | Drug Screening Assays, Antitumor | Tetrahydrofolate Dehydrogenase - genetics | Index Medicus
Journal Article