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Nature, ISSN 0028-0836, 2014, Volume 510, Issue 7504, pp. 298 - 302
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7690, pp. 128 - 132
Folates enable the activation and transfer of one-carbon units for the biosynthesis of purines, thymidine and methionine(1-3). Antifolates are important... 
CHAIN | HYPERTROPHIC CARDIOMYOPATHY | SERINE HYDROXYMETHYLTRANSFERASE | METABOLISM | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | DEFECT | LACTIC-ACIDOSIS | MUTATIONS | IDENTIFICATION | ANTICODON WOBBLE NUCLEOTIDE | Mitochondria - enzymology | Electron Transport | Protein Biosynthesis | Humans | Ribosomes - metabolism | Sarcosine - metabolism | Multifunctional Enzymes - metabolism | Thymine Nucleotides - biosynthesis | Oxidative Phosphorylation - drug effects | Glycine Hydroxymethyltransferase - deficiency | HEK293 Cells | RNA, Transfer - genetics | Codon - genetics | RNA, Transfer - chemistry | Leucine - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Biocatalysis | RNA, Transfer - metabolism | HCT116 Cells | Mitochondria - metabolism | Mitochondria - drug effects | Glycine Hydroxymethyltransferase - metabolism | Guanosine - metabolism | Tetrahydrofolates - metabolism | Lysine - genetics | Carrier Proteins - metabolism | Methylation - drug effects | Folic Acid - metabolism | Aminohydrolases - metabolism | Folic Acid Antagonists - pharmacology | GTP-Binding Proteins - metabolism | Mitochondria | Physiological aspects | Genetic aspects | Methylation | Observations | Genetic translation | Folic acid | Transfer RNA | Phosphorylation | Inborn errors of metabolism | Peptides | Serine | Biosynthesis | Mitochondrial DNA | Thymidine | Catalytic activity | Leucine | Cytosol | Experiments | Anticancer properties | Proteins | Purines | Antitumor agents | Metabolites | Lymphocytes | Vitamin B | Catalysis | Enzymes | Translation | tRNA Ala | tRNA | Methionine | Metabolism | Carbon | Immunosuppression | Oxidative phosphorylation | Lysine | Proteomics | Electron transport | Respiration | Codons | Cancer | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2016, Volume 23, Issue 6, pp. 1140 - 1153
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 10/2018, Volume 57, Issue 10, pp. 1342 - 1357
Ewing sarcoma (EWS) is a soft tissue and bone tumor that occurs primarily in adolescents and young adults. In most cases of EWS, the chimeric transcription... 
de novo serine‐glycine biosynthesis | Ewing sarcoma | metabolism | glutamine | ROS | de novo serine-glycine biosynthesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | MULTICELLULAR TUMOR SPHEROIDS | PROLIFERATION | BREAST-CANCER | LUNG-CANCER | AMINO-ACID | ONCOLOGY | PROSTATE-CANCER | GROWTH | TRANSCRIPTIONAL TARGET | EXPRESSION | ONE-CARBON METABOLISM | Multifunctional Enzymes - genetics | Oncogene Proteins, Fusion - metabolism | Humans | Gene Expression Regulation, Neoplastic | Sarcoma, Ewing - pathology | Cell Survival - genetics | Glutamine - metabolism | Multienzyme Complexes - metabolism | Apoptosis - genetics | Serine - biosynthesis | Aminohydrolases - genetics | Multifunctional Enzymes - metabolism | Bone Neoplasms - pathology | Bone Neoplasms - metabolism | Proto-Oncogene Protein c-fli-1 - metabolism | HEK293 Cells | Minor Histocompatibility Antigens - genetics | Bone Neoplasms - genetics | Amino Acid Transport System ASC - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Sarcoma, Ewing - metabolism | Phosphoglycerate Dehydrogenase - metabolism | Proto-Oncogene Protein c-fli-1 - genetics | HCT116 Cells | RNA-Binding Protein EWS - genetics | Glycine - biosynthesis | Amino Acid Transport System ASC - metabolism | Multienzyme Complexes - genetics | RNA-Binding Protein EWS - metabolism | Phosphoglycerate Dehydrogenase - genetics | Formate-Tetrahydrofolate Ligase - metabolism | Minor Histocompatibility Antigens - metabolism | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Formate-Tetrahydrofolate Ligase - genetics | Aminohydrolases - metabolism | Sarcoma, Ewing - genetics | Glucose metabolism | International trade | Enzymes | Sarcoma | Analysis | Amino acids | Carbon cycle (Biogeochemistry) | Adolescence | Reactive oxygen species | Serine | DNA damage | Biosynthesis | Bone tumors | Glycine | Ewing's sarcoma | Proteins | Transcription activation | Adolescents | Redox properties | Damage accumulation | Deoxyribonucleic acid--DNA | Cell survival | Young adults | Risk groups | Metabolism | Nutrient uptake | Gene expression | Survival | Carbon cycle | Gene silencing | Adults | Transporter | Tumors | Apoptosis | Glutamine | Index Medicus
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2007, Volume 69, Issue 1, pp. 167 - 175
Purpose To investigate the expression pattern of hypoxia-induced proteins identified as being involved in malignant progression of head-and-neck squamous cell... 
Radiology | Hematology, Oncology and Palliative Medicine | Head-and-neck cancer | Hypoxia | Prognosis | Marker panel | CANCER PATIENTS | BREAST-CANCER | ENDOGENOUS MARKERS | TUMOR HYPOXIA | EPH RECEPTORS | ANGIOGENESIS | ONCOLOGY | OXYGENATION | GROWTH | GENE-EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | RADIATION-THERAPY | Cell Hypoxia - physiology | Ephrin-A1 - metabolism | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Galectin 1 - metabolism | Male | Osteopontin - metabolism | Neoplasm Proteins - metabolism | Head and Neck Neoplasms - metabolism | Oxygen - metabolism | Carbonic Anhydrases - metabolism | Carcinoma, Squamous Cell - mortality | I-kappa B Kinase - metabolism | Antigens, Neoplasm - metabolism | Biomarkers, Tumor - metabolism | Female | Membrane Proteins - metabolism | Carbonic Anhydrase IX | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Disease Progression | Head and Neck Neoplasms - pathology | Tetrahydrofolate Dehydrogenase - metabolism | Analysis of Variance | Partial Pressure | Protein-Lysine 6-Oxidase - metabolism | Cell Line, Tumor | Head and Neck Neoplasms - mortality | Proteins | Development and progression | Squamous cell carcinoma | Index Medicus | HEMOGLOBIN | HEAD | CARBONIC ANHYDRASE | OXYGEN | GROWTH FACTORS | MULTIVARIATE ANALYSIS | THERAPY | OXIDASES | ANOXIA | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | PARTIAL PRESSURE | NECK | CONNECTIVE TISSUE
Journal Article
Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7669, pp. 549 - 554
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 16, pp. 5821 - 5833
Journal Article
Current Genetics, ISSN 0172-8083, 11/2015, Volume 61, Issue 4, pp. 633 - 640
Previous genetic analyses showed phenotypic interactions between 5-amino-4-imidazole carboxamide ribonucleotide 5′-phosphate (AICAR) produced from the purine... 
Biochemistry, general | Cross-pathway regulation | Serine hydroxymethyltransferase | Microbiology | One-carbon units | Amino acids | Nucleotides | Cell Biology | Life Sciences | Microbial Genetics and Genomics | Proteomics | AICAR | Plant Sciences | ACTIVATED PROTEIN-KINASE | TRANSCRIPTION | AGONISTS | YEAST | BAS1P | BIOSYNTHESIS | GENETICS & HEREDITY | GENE-EXPRESSION | AMPK | ONE-CARBON METABOLISM | Leucovorin - metabolism | Saccharomyces cerevisiae - genetics | Transcriptional Activation | Histidine - metabolism | Carbon-Nitrogen Ligases - genetics | Saccharomyces cerevisiae - metabolism | Trans-Activators - genetics | Aminoimidazole Carboxamide - metabolism | Thymidine - metabolism | Gene Expression Regulation, Fungal | Glycine Hydroxymethyltransferase - genetics | Ribonucleotides - metabolism | Carbon-Nitrogen Ligases - metabolism | Methionine - metabolism | Purines - metabolism | Saccharomyces cerevisiae Proteins - genetics | Glycine Hydroxymethyltransferase - metabolism | Tetrahydrofolates - metabolism | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - metabolism | Aminoimidazole Carboxamide - analogs & derivatives | Saccharomyces cerevisiae Proteins - metabolism | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics | Folic Acid - metabolism | Trans-Activators - metabolism | Mutation | Alkaloids | Histidine | Analysis | Serine | Physiological aspects | Leucovorin | Folic acid | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1529 - 9
Journal Article
International Journal of Cancer, ISSN 0020-7136, 02/2014, Volume 134, Issue 4, pp. 799 - 810
Glycine N ‐methyltransferase (GNMT) is a folate binding protein commonly diminished in human hepatoma yet its role in tumor development remains to be... 
uracil misincorporation | methyltransferase | glycine | pyrimidine synthesis | purine synthesis | transmethylation metabolic kinetics | stable isotopic tracer studies | N | nuclear folate metabolism | glycine-N methyltransferase | RAT-LIVER | FOLATE-DEFICIENCY | KNOCKOUT MOUSE MODEL | PERFORMANCE LIQUID-CHROMATOGRAPHY | GLYCINE-N-METHYLTRANSFERASE | HEPATOCELLULAR-CARCINOMA | IN-VITRO | ONCOLOGY | METHIONINE METABOLISM | ONE-CARBON METABOLISM | S-Adenosylhomocysteine - metabolism | Liver - pathology | Folic Acid - pharmacology | Minor Histocompatibility Antigens | Humans | Hepatocytes - pathology | Male | Homocysteine - metabolism | Chromatography, High Pressure Liquid | Hepatocytes - metabolism | Pyrimidines - metabolism | DNA Methylation | Cell Nucleus - metabolism | Tetrahydrofolates | Carcinoma, Hepatocellular - genetics | Female | Liver Neoplasms - pathology | Fluorescent Antibody Technique, Indirect | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Liver Neoplasms - genetics | Purines - metabolism | Liver - metabolism | Cells, Cultured | Mice, Knockout | Protein Transport | Animals | Glycine N-Methyltransferase - physiology | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Adenosine - metabolism | Uracil - metabolism | Mice | DNA Damage | Dietary Supplements | S-Adenosylmethionine - metabolism | Carbon Radioisotopes | Carcinoma, Hepatocellular - metabolism | Development and progression | DNA damage | DNA | Folic acid | Tumors | Protein binding | Proteins | DNA methylation | Biosynthesis | Rodents | Vitamin B | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Plant Physiology, ISSN 0032-0889, 2/2013, Volume 161, Issue 2, pp. 971 - 989
Investigations into the biochemical processes and regulatory mechanisms of nitrogen (N) utilization can aid in understanding how N is used efficiently in... 
Phenotypes | Photorespiration | Genes | Plant roots | Amino acids | Nitrates | Complementation | Plants | BIOCHEMISTRY AND METABOLISM | Nitrogen | Seedlings | GLYCINE DECARBOXYLASE | PEA LEAF MITOCHONDRIA | SERINE HYDROXYMETHYLTRANSFERASE | NITRATE TRANSPORTER NRT2.1 | LATERAL ROOT INITIATION | GLUTAMINE SYNTHETASE | FUNCTIONAL-ANALYSIS | TETRAHYDROFOLATE POLYGLUTAMATES | TANDEM MASS-SPECTROMETRY | ONE-CARBON METABOLISM | PLANT SCIENCES | Glycine - metabolism | Arabidopsis - growth & development | Starch - metabolism | Plant Roots - genetics | Seedlings - genetics | Immunoblotting | Mitochondrial Proteins - genetics | Peptide Synthases - genetics | Seedlings - growth & development | Arabidopsis Proteins - metabolism | Amino Acids - metabolism | Time Factors | Gene Expression Regulation, Developmental | Mitochondrial Proteins - metabolism | Gene Expression Regulation, Plant | Plant Roots - growth & development | Carbon - metabolism | Arabidopsis Proteins - genetics | Nitrogen - metabolism | Plant Roots - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Anthocyanins - metabolism | Arabidopsis - metabolism | Peptide Synthases - metabolism | Arabidopsis - genetics | Folic Acid - metabolism | Mutation | Seedlings - metabolism | Arabidopsis thaliana | Plant mitochondria | Ligases | Development | Genetic aspects | Research | Properties | Index Medicus
Journal Article