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1. Full Text Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood–Brain Barrier
by Kanamitsu, Kayoko and Kusuhara, Hiroyuki and Schuetz, John D and Takeuchi, Kenji and Sugiyama, Yuichi
Journal of pharmaceutical sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2566 - 2575
blood-brain barrier | P-glycoprotein | MRP | ABC transporters | cerebrospinal fluid | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Central Nervous System - metabolism | Humans | 2,4-Dichlorophenoxyacetic Acid - chemistry | Ochratoxins - chemistry | Male | Thiophenes - metabolism | Ochratoxins - metabolism | Pravastatin - chemistry | Brain - metabolism | Uric Acid - chemistry | Biological Transport | Quinazolines - metabolism | Tetrahydroisoquinolines - chemistry | Adenosine Triphosphate - metabolism | Cyclic GMP - chemistry | Multidrug Resistance-Associated Proteins - genetics | Quinazolines - chemistry | Methotrexate - chemistry | 2,4-Dichlorophenoxyacetic Acid - metabolism | Acridines - chemistry | Methotrexate - metabolism | Uric Acid - metabolism | Acridines - metabolism | Pravastatin - metabolism | Mice, Inbred C57BL | Quinolines - chemistry | Blood-Brain Barrier - metabolism | Quinolines - metabolism | Animals | Cyclic GMP - metabolism | Tetrahydroisoquinolines - metabolism | Kinetics | Adenosine Triphosphate - chemistry | Thiophenes - chemistry | Multidrug Resistance-Associated Proteins - metabolism | Index Medicus | Blood–brain barrier
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2. Full Text Structure of the human κ-opioid receptor in complex with JDTic
by Wu, Huixian and Wacker, Daniel and Mileni, Mauro and Katritch, Vsevolod and Han, Gye Won and Vardy, Eyal and Liu, Wei and Thompson, Aaron A and Huang, Xi-Ping and Carroll, F. Ivy and Mascarella, S. Wayne and Westkaemper, Richard B and Mosier, Philip D and Roth, Bryan L and Cherezov, Vadim and Stevens, Raymond C
Nature (London), ISSN 0028-0836, 05/2012, Volume 485, Issue 7398, pp. 327 - 332
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Structure of solids and liquids; crystallography | Structure of specific crystalline solids | Physics | Exact sciences and technology | Condensed matter: structure, mechanical and thermal properties | Organic compounds | Naltrexone - analogs & derivatives | Humans | Naltrexone - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Diterpenes, Clerodane - chemistry | Receptors, Adrenergic, beta-2 - chemistry | Piperidines - pharmacology | Tetrahydroisoquinolines - chemistry | Receptors, Opioid, kappa - chemistry | Binding Sites | Receptors, Opioid, kappa - genetics | Naltrexone - metabolism | Morphinans - chemistry | Tetrahydroisoquinolines - pharmacology | Piperidines - chemistry | Receptors, Opioid, kappa - antagonists & inhibitors | Mutagenesis, Site-Directed | Receptors, Opioid, kappa - metabolism | Models, Molecular | Receptors, CXCR4 - metabolism | Guanidines - chemistry | Diterpenes, Clerodane - metabolism | Diterpenes, Clerodane - pharmacology | Protein Conformation | Receptors, CXCR4 - chemistry | Index Medicus
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3. Full Text Two Annulated Azaheterocyclic Cores Readily Available from a Single Tetrahydroisoquinolonic Castagnoli-Cushman Precursor
by Karchuganova, Elizaveta and Bakulina, Olga and Dar'in, Dmitry and Krasavin, Mikhail
Molecules (Basel, Switzerland), ISSN 1420-3049, 05/2020, Volume 25, Issue 9, p. 2049
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Magnetic Resonance Spectroscopy | Quinolines - chemistry | Sulfides - chemistry | Hydroxamic Acids - chemistry | Lactams | Chemistry, Pharmaceutical | Isoquinolines - chemistry | Chemistry, Organic | Cyclization | Tetrahydroisoquinolines - chemistry | Nitrogen Compounds - chemistry | Drug Design | Molecular Structure | Indole Alkaloids - chemistry | Indoles - chemistry | Sulfide | Solvents | Reduction | Ammonium | Acids | Dehydrogenation | Decarboxylation | Tetrahydroisoquinoline | Carboxylic acids | Sulfur | Sodium sulfide | Index Medicus | tetrahydroisoquinolonic acid | cryptolepine | nitroarene reduction | hydroxamic acid | indoloisoquinoline | Castagnoli–Cushman reaction | Communication | heteroannulation | dibenzonaphthyridine
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4. Full Text Computational planning of the synthesis of complex natural products
by Mikulak-Klucznik, Barbara and Gołębiowska, Patrycja and Bayly, Alison A and Popik, Oskar and Klucznik, Tomasz and Szymkuć, Sara and Gajewska, Ewa P and Dittwald, Piotr and Staszewska-Krajewska, Olga and Beker, Wiktor and Badowski, Tomasz and Scheidt, Karl A and Molga, Karol and Mlynarski, Jacek and Mrksich, Milan and Grzybowski, Bartosz A
Nature (London), ISSN 0028-0836, 12/2020, Volume 588, Issue 7836, pp. 83 - 88
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Chemistry, Organic - methods | Artificial Intelligence - standards | Sesquiterpenes - chemical synthesis | Tetrahydroisoquinolines - chemical synthesis | Chemistry Techniques, Synthetic - standards | Chemistry Techniques, Synthetic - methods | Benzylisoquinolines - chemistry | Lactones - chemical synthesis | Indole Alkaloids - chemical synthesis | Macrolides - chemistry | Tetrahydroisoquinolines - chemistry | Automation - methods | Chemistry, Organic - standards | Indole Alkaloids - chemistry | Lactones - chemistry | Software - standards | Indans - chemistry | Knowledge Bases | Reproducibility of Results | Sesquiterpenes - chemistry | Automation - standards | Benzylisoquinolines - chemical synthesis | Biological Products - chemical synthesis | Macrolides - chemical synthesis | Indans - chemical synthesis | Design | Organic chemistry | Knowledge bases (artificial intelligence) | Algorithms | Cost estimates | Natural products | Computation | Chemists | Computer applications | Logic | Artificial intelligence | Optimization | Index Medicus
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5. Full Text The Pictet–Spengler Reaction in Nature and in Organic Chemistry
by Stöckigt, Joachim and Antonchick, Andrey P and Wu, Fangrui and Waldmann, Herbert
Angewandte Chemie (International ed.), ISSN 1433-7851, 09/2011, Volume 50, Issue 37, pp. 8538 - 8564
tetrahydroisoquinoline | pictet‐spengler reaction | asymmetric synthesis | pictet‐spenglerase | tetrahydrocarboline | pictet-spengler reaction | pictet-spenglerase | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Biological Products - chemical synthesis | Biological Products - chemistry | Chemistry, Organic | Humans | Molecular Conformation | Models, Molecular | Alkaloids - chemical synthesis | Alkaloids - therapeutic use | Drug Discovery | Alkaloids - chemistry | Biological Products - therapeutic use | Natural products | Corporate profiles | Index Medicus
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6. Full Text Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions
by Shukla, Suneet and Abel, Biebele and Chufan, Eduardo E and Ambudkar, Suresh V
The Journal of biological chemistry, ISSN 0021-9258, 04/2017, Volume 292, Issue 17, pp. 7066 - 7076
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Acridines - chemistry | Dibenzocycloheptenes - chemistry | Baculoviridae - metabolism | Detergents - chemistry | Humans | Insecta | Quinolines - chemistry | ATP Binding Cassette Transporter, Subfamily B - chemistry | Peptides, Cyclic - chemistry | Drug Delivery Systems | Verapamil - chemistry | Hydrolysis | Animals | Tetrahydroisoquinolines - chemistry | Micelles | Glucosides - chemistry | Inhibitory Concentration 50 | Protein Binding | Ligands | Mice | Adenosine Triphosphate - chemistry | Drug Evaluation, Preclinical | Binding Sites | Index Medicus | P-glycoprotein | docking | ATP hydrolysis | molecular modeling | multidrug transporter | Membrane Biology | proteoliposomes | nanodiscs | drug resistance | ABC transporter | detergent micelles
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7. Full Text Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics
by Le, V. H and Inai, M and Williams, R. M and Kan, T
Natural product reports, ISSN 0265-0568, 1/2015, Volume 32, Issue 2, pp. 328 - 347
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Marine Biology | Tetrahydroisoquinolines - pharmacology | Animals | Tetrahydroisoquinolines - chemistry | Dioxoles - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Antineoplastic Agents - chemistry | Trabectedin | Dioxoles - chemistry | Urochordata - chemistry | Index Medicus
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