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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2566 - 2575
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, p. e0158808
Many G protein-coupled receptors have been shown to be sensitive to the presence of sodium ions (Na+). Using radioligand competition binding assays, we have... 
Nitriles - pharmacology | Humans | Receptors, Dopamine D3 - metabolism | Piperazines - metabolism | Piperazines - chemistry | Sodium - metabolism | Receptors, Dopamine D2 - metabolism | Biphenyl Compounds - metabolism | Spodoptera | Receptors, Dopamine D3 - genetics | Indoles - metabolism | Sf9 Cells | Biphenyl Compounds - pharmacology | Piperidines - pharmacology | Tetrahydroisoquinolines - chemistry | Dopamine Antagonists - metabolism | Indoles - pharmacology | Molecular Structure | Biphenyl Compounds - chemistry | Radioligand Assay | Dopamine Agonists - metabolism | Binding, Competitive | Indans - chemistry | Dopamine Agonists - pharmacology | Nitriles - metabolism | Tetrahydroisoquinolines - pharmacology | Piperidines - chemistry | Piperidines - metabolism | Receptors, Dopamine D2 - agonists | Indans - metabolism | Ions - metabolism | Piperazines - pharmacology | Receptors, Dopamine D2 - genetics | Receptors, Dopamine D3 - agonists | Animals | Dopamine Antagonists - pharmacology | Tetrahydroisoquinolines - metabolism | Dopamine D2 Receptor Antagonists - metabolism | Nitriles - chemistry | Cell Line, Tumor | Dopamine D2 Receptor Antagonists - pharmacology | Ligands | Mutation | Indoles - chemistry | Indans - pharmacology | G protein-coupled receptors | Mental disorders | Infections | Antagonists | Assaying | Proteins | Psychosis | Psychotropic drugs | Signal transduction | Receptors | Drug therapy | Buffers | Dopamine D2 receptors | Binding | Dopamine | Therapeutic applications | Cloning | Dopamine D3 receptors | Ions | Clozapine | Spiperone | Sensitivity | Sodium | Ionic strength | Pharmacy | Inverse agonists | Affinity | Cations
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 11/2007, Volume 35, Issue 11, pp. 2076 - 2085
P-glycoprotein (P-gp)-mediated efflux at the blood-brain barrier has been implicated in limiting the brain distribution of many anti-HIV1 drugs, primarily... 
RABBIT BRAIN | HIV-1 PROTEASE INHIBITORS | CF-1 MICE DEFICIENT | IN-VITRO | REVERSE-TRANSCRIPTASE INHIBITORS | PHARMACOLOGY & PHARMACY | INFECTED PATIENTS | ZIDOVUDINE TRANSPORT | MULTIDRUG-RESISTANCE | CEREBROSPINAL-FLUID | ANTIRETROVIRAL TREATMENT | Vinblastine - metabolism | Zidovudine - metabolism | Dibenzocycloheptenes - chemistry | Area Under Curve | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Zidovudine - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Reverse Transcriptase Inhibitors - chemistry | Vinblastine - pharmacokinetics | Brain - metabolism | Quinolines - pharmacokinetics | Biological Transport, Active | Reverse Transcriptase Inhibitors - pharmacokinetics | ATP-Binding Cassette Transporters - genetics | Tetrahydroisoquinolines - chemistry | Dibenzocycloheptenes - metabolism | ATP-Binding Cassette Transporters - metabolism | Acridines - pharmacokinetics | Cell Membrane - metabolism | Molecular Structure | Anti-HIV Agents - metabolism | Acridines - chemistry | Dideoxynucleosides - metabolism | Cell Line | Vinblastine - chemistry | Acridines - metabolism | Dibenzocycloheptenes - pharmacokinetics | Quinolines - chemistry | Adenosine Triphosphatases - metabolism | Mice, Inbred Strains | Dideoxynucleosides - chemistry | Zidovudine - chemistry | Mice, Knockout | Dideoxynucleosides - pharmacokinetics | Quinolines - metabolism | Anti-HIV Agents - chemistry | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Tetrahydroisoquinolines - metabolism | Anti-HIV Agents - pharmacokinetics | Tetrahydroisoquinolines - pharmacokinetics | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Mice | Reverse Transcriptase Inhibitors - metabolism | ATP Binding Cassette Transporter, Sub-Family B - genetics
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 01/2015, Volume 16, Issue 1, pp. 2252 - 2268
TIPP is a novel thymic immunosuppressive pentapeptide originally obtained from calf thymic immunosuppressive extract. The present study aimed to investigate... 
RBL-2H3 cell | Allergy | NF-κB | TIPP | IgE | MAP kinases | ALLERGIC INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAST-CELLS | allergy | RECEPTOR | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | NF-kappa B | CHALONES | CALCIUM | NF-KAPPA-B | LYMPHOCYTE-TRANSFORMATION | EXTRACT | Calcium - metabolism | NF-kappa B - metabolism | Protein Transport - drug effects | RNA, Messenger - metabolism | Histamine - metabolism | Cell Membrane Structures - metabolism | Cell Nucleus - metabolism | Tetrahydroisoquinolines - chemistry | Inflammation Mediators - metabolism | Mast Cells - metabolism | Antigen-Antibody Complex - metabolism | Cell Death - drug effects | Cytokines - genetics | Immunosuppressive Agents - pharmacology | Oligopeptides - chemistry | Cell Line | Tetrahydroisoquinolines - pharmacology | Cell Membrane Structures - drug effects | Cytokines - metabolism | beta-N-Acetylhexosaminidases - metabolism | Immunoglobulin E - metabolism | RNA, Messenger - genetics | Rats | Mast Cells - physiology | Thymus Gland - drug effects | Enzyme Activation - drug effects | Mast Cells - drug effects | Animals | Cyclooxygenase 2 - metabolism | Thymus Gland - immunology | Cell Nucleus - drug effects | Oligopeptides - pharmacology | Cell Degranulation - drug effects | Mitogen-Activated Protein Kinases - metabolism | Fluorescence | Signal transduction | Cytokines | Peptides | Kinases | Allergies
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2013, Volume 23, Issue 2, pp. 249 - 262
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2632 - 2641
Regorafenib is a multikinase inhibitor orally administered to colorectal cancer patients, and is known to often exhibit dermal toxicity. The purpose of this... 
P-glycoprotein | skin | tissue partition | ABC transporters | transporters | BCRP | MULTICENTER | CHEMISTRY, MEDICINAL | TRANSDERMAL ABSORPTION | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | POLYMORPHISMS | COLORECTAL-CANCER | PHASE-3 TRIAL | PHARMACOLOGY & PHARMACY | FOOT SKIN REACTION | EXPRESSION | BRAIN | Diketopiperazines - chemistry | Pyridines - chemistry | Skin - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | Phenylurea Compounds - toxicity | Heterocyclic Compounds, 4 or More Rings - pharmacology | Breast Neoplasms - metabolism | Antineoplastic Agents - metabolism | Tissue Distribution | Protein Kinase Inhibitors - chemistry | Biological Transport | Tetrahydroisoquinolines - chemistry | Phenylurea Compounds - chemistry | Antineoplastic Agents - pharmacology | Phenylurea Compounds - metabolism | Acridines - chemistry | Tetrahydroisoquinolines - pharmacology | Acridines - metabolism | Heterocyclic Compounds, 4 or More Rings - chemistry | Diketopiperazines - pharmacology | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Animals | Pyridines - metabolism | Pyridines - toxicity | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Heterocyclic Compounds, 4 or More Rings - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Diketopiperazines - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2012, Volume 109, Issue 22, pp. 8540 - 8545
Nonribosomal peptide synthetases (NRPSs) usually catalyze the biosynthesis of peptide natural products by sequential selection, activation, and condensation of... 
Enzymes | Antibiotics | Amino acids | Multigene family | Biosynthesis | Biochemistry | Biochemical pathways | Tetrahydroisoquinolines | Ketoses | Assembly lines | Primary metabolism | Fructose-6-phosphate | Xylulose-5-phosphate | Secondary metabolism | SYNTHASE EXTENDER UNITS | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | SAFRAMYCIN | BIOSYNTHETIC-PATHWAY | BRANCHED-CHAIN | TETRAHYDROISOQUINOLINE ANTITUMOR ANTIBIOTICS | GENE-CLUSTER | secondary metabolism | NAPHTHYRIDINOMYCIN | POLYKETIDE | SYNTHETASE | primary metabolism | xylulose-5-phosphate | fructose-6-phosphate | Multigene Family | Models, Chemical | Peptides - genetics | Molecular Sequence Data | Substrate Specificity | Peptide Synthases - genetics | Streptomyces - metabolism | Peptides - metabolism | Tetrahydroisoquinolines - chemistry | Molecular Structure | Amino Acid Sequence | Naphthyridines - chemistry | Magnetic Resonance Spectroscopy | Peptides - chemistry | Streptomyces - genetics | Ketoses - chemistry | Streptomyces - chemistry | Acyl Carrier Protein - metabolism | Electrophoresis, Polyacrylamide Gel | Bacterial Proteins - genetics | Biosynthetic Pathways | Peptide Synthases - metabolism | Sequence Homology, Amino Acid | Ketoses - metabolism | Tetrahydroisoquinolines - metabolism | Transketolase - metabolism | Acyl Carrier Protein - genetics | Transketolase - genetics | Bacterial Proteins - metabolism | Kinetics | Mutation | Naphthyridines - metabolism | Physiological aspects | Peptides | Metabolism | Health aspects | Sugars | Monosaccharides | Biological Sciences
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 02/2016, Volume 101, pp. 40 - 53
P-glycoprotein (P-gp) is a member of the ATP-binding cassette transporter superfamily. This multidrug transporter utilizes energy from ATP hydrolysis for the... 
Drug-binding site | ABC transporter | Multidrug resistance | Modulators | Structural motifs | ABCB1 | TURNOVER | PHARMACOLOGY & PHARMACY | BINDING | TARIQUIDAR | RESIDUES | CATALYTIC CYCLE | Dibenzocycloheptenes - chemistry | Membrane Transport Modulators - chemistry | Hydrolysis - drug effects | Humans | Molecular Conformation | ATP Binding Cassette Transporter, Sub-Family B - chemistry | Quinolines - pharmacology | Tetrahydroisoquinolines - chemistry | Biocatalysis - drug effects | Dibenzocycloheptenes - metabolism | Adenosine Triphosphate - metabolism | Membrane Transport Modulators - pharmacology | Dibenzocycloheptenes - pharmacology | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Binding Sites | Mutant Proteins - antagonists & inhibitors | Acridines - chemistry | Recombinant Proteins - metabolism | Tetrahydroisoquinolines - pharmacology | Acridines - metabolism | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Amino Acid Motifs | Quinolines - metabolism | Membrane Transport Modulators - metabolism | Animals | Hydrogen Bonding | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Mutant Proteins - chemistry | Lepidoptera | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Ligands | Molecular Docking Simulation | HeLa Cells | Adenosine Triphosphate - chemistry | ATP Binding Cassette Transporter, Sub-Family B - genetics | Amino Acid Substitution | Hydrolysis | Hydrogen | Cells | Protein binding | multidrug resistance | structural motifs | modulators | drug-binding site
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2015, Volume 459, Issue 3, pp. 361 - 366
Journal Article
Kidney International, ISSN 0085-2538, 01/2002, Volume 61, Issue 1, pp. 186 - 194
Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: Effects of ACEI and ARB. Angiotensin II (Ang II) can up-regulate nicotinamide adenine... 
nitric oxide | nitrotyrosine | superoxide anion | proteinuria | reactive oxygen species | AT1 receptor | Superoxide anion | Reactive oxygen species | Nitrotyrosine | receptor | Nitric oxide | Proteinuria | NADPH OXIDASE | PROTEIN-KINASE-C | MESSENGER-RNA EXPRESSION | TUBULOGLOMERULAR FEEDBACK | nitrotyiosine | GLOMERULAR HYPERFILTRATION | AT receptor | RANDOMIZED CONTROLLED TRIAL | NAD(P)H OXIDASE | ENDOTHELIAL-CELLS | UROLOGY & NEPHROLOGY | IMMUNOHISTOCHEMICAL COLOCALIZATION | Receptor, Angiotensin, Type 1 | Receptors, Angiotensin - metabolism | Antihypertensive Agents - pharmacology | Reactive Oxygen Species - metabolism | Tetrazoles - pharmacology | Angiotensin Receptor Antagonists | Oxidative Stress - physiology | NADPH Oxidases - metabolism | Diabetic Nephropathies - drug therapy | Tyrosine - analogs & derivatives | Kidney - metabolism | Isoquinolines - pharmacology | Nitric Oxide Synthase Type I | Superoxides - metabolism | Female | Albuminuria - metabolism | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Tetrahydroisoquinolines | Phosphoproteins - biosynthesis | Diabetic Nephropathies - metabolism | Nitric Oxide Synthase Type III | Proteinuria - metabolism | Rats | Rats, Sprague-Dawley | Hydrogen Peroxide - metabolism | Lipid Peroxidation - physiology | Tyrosine - metabolism | Animals | Proteinuria - drug therapy | Albuminuria - drug therapy | Benzimidazoles - pharmacology | Nitric Oxide Synthase - metabolism | Nitric Oxide - metabolism
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 06/2016, Volume 162, pp. 1 - 9
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e69394