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Chemical Research in Toxicology, ISSN 0893-228X, 05/2013, Volume 26, Issue 5, pp. 750 - 758
Cigarette smoke, diesel exhaust, and other combustion-derived particles activate the calcium channel transient receptor potential ankyrin-1 (TRPA1), causing... 
OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | NEUROGENIC INFLAMMATION | FINE-PARTICLE | DNA-DAMAGE | CHEMISTRY, MULTIDISCIPLINARY | AIR-POLLUTION | FIREPLACE COMBUSTION | ORGANIC-COMPOUNDS | COVALENT MODIFICATION | CHANNELS | TOXICOLOGY | HEALTH | Transient Receptor Potential Channels - antagonists & inhibitors | Calcium Channels - metabolism | Humans | Neurons - cytology | Dicarboxylic Acids - pharmacology | Lung - cytology | Prosopis - chemistry | Transient Receptor Potential Channels - biosynthesis | Particulate Matter - chemistry | Particulate Matter - pharmacology | Aldehydes - pharmacology | Carboxylic Acids - chemistry | Surface Properties | HEK293 Cells | Lung - metabolism | Neurons - metabolism | Transient Receptor Potential Channels - metabolism | Neurons - drug effects | Calcium Channels - genetics | Carboxylic Acids - pharmacology | Diterpenes - chemistry | Diterpenes - pharmacology | Pinus - chemistry | Nerve Tissue Proteins - antagonists & inhibitors | Acetanilides - pharmacology | Purines - pharmacology | Smoke - adverse effects | Nerve Tissue Proteins - agonists | Phenalenes - pharmacology | Nerve Tissue Proteins - genetics | Phenalenes - chemistry | Transient Receptor Potential Channels - agonists | Dicarboxylic Acids - chemistry | Nerve Tissue Proteins - metabolism | Animals | Models, Biological | Tetrahydronaphthalenes - chemistry | Tetrahydronaphthalenes - pharmacology | Transient Receptor Potential Channels - genetics | Lung - drug effects | TRPA1 Cation Channel | Wood - chemistry | Cell Line, Tumor | Mice | Trigeminal Nerve - cytology | Aldehydes - chemistry | Index Medicus | transient receptor potential ankyrin-1 (TRPA1) | Wood smoke particulate material | combustion-derived particulate material
Journal Article
Medicinal Research Reviews, ISSN 0198-6325, 09/2008, Volume 28, Issue 5, pp. 746 - 772
Medicinal plants have been traditionally used for treating liver diseases since centuries. Several leads from plant sources have been found as potential... 
phyllanthin | picroside | silymarin | neoandrographolide | kutkoside | hepatoprotective | glycyrrhizin | andrographolide | curcumin | hypophyllanthin | Glycyrrhizin | Hepatoprotective | Kutkoside | Silymarin | Phyllanthin | Neoandrographolide | Curcumin | Andrographolide | Hypophyllanthin | Picroside | ANDROGRAPHIS-PANICULATA NEES | CHEMISTRY, MEDICINAL | RAT HEPATOCYTES | INDUCED HEPATIC DAMAGE | neoandrogapholide | INDUCED LIVER-DAMAGE | ANTIHEPATOTOXIC PRINCIPLES | PHYLLANTHUS-AMARUS | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | PICRORHIZA-KURROOA | INDUCED HEPATOTOXICITY | PICROSIDE-I | Silymarin - toxicity | Plant Extracts - toxicity | Diterpenes - toxicity | Plant Extracts - pharmacology | Humans | Protective Agents - chemistry | Curcumin - metabolism | Silymarin - chemistry | Lignans - pharmacology | Plant Extracts - metabolism | Glycyrrhizic Acid - pharmacology | Liver - drug effects | Glucosides - chemistry | Cinnamates - chemistry | Phytotherapy | Diterpenes - pharmacology | Glucosides - toxicity | Liver - metabolism | Curcumin - pharmacology | Lignans - metabolism | Plants | Cinnamates - pharmacology | Glucosides - metabolism | Tetrahydronaphthalenes - metabolism | Tetrahydronaphthalenes - pharmacology | Liver Diseases - drug therapy | Glycyrrhizic Acid - toxicity | Plant Extracts - therapeutic use | Curcumin - chemistry | Tetrahydronaphthalenes - toxicity | Protective Agents - metabolism | Protective Agents - therapeutic use | Lignans - toxicity | Protective Agents - pharmacology | Cinnamates - metabolism | Cinnamates - toxicity | Silymarin - metabolism | Silymarin - pharmacology | Diterpenes - metabolism | Diterpenes - chemistry | Glucosides - pharmacology | Cytokines - metabolism | Lignans - chemistry | Glycyrrhizic Acid - chemistry | Glycyrrhizic Acid - metabolism | Animals | Curcumin - toxicity | Tetrahydronaphthalenes - chemistry | Liver Diseases - metabolism | Protective Agents - toxicity
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY, ISSN 0968-0896, 03/2010, Volume 18, Issue 5, pp. 1749 - 1760
We report on a series of hybrid compounds structurally derived from donepezil and AP2238. This study was aimed at improving the activities of the reference... 
AChE | BUTYRYLCHOLINESTERASE | CHEMISTRY, MEDICINAL | CATION-PI | BIOCHEMISTRY & MOLECULAR BIOLOGY | Indanone | CHEMISTRY, ORGANIC | HUMAN ACETYLCHOLINESTERASE | CHOLINESTERASE-INHIBITORS | PEPTIDE | Hybrid molecules | CHOLINERGIC HYPOTHESIS | BETA-AMYLOID AGGREGATION | PERIPHERAL ANIONIC SITE | PI INTERACTIONS | A beta inhibition | Alzheimer's disease | BINDING | Benzylamines - chemical synthesis | Humans | Tetrahydronaphthalenes - chemical synthesis | Cholinesterase Inhibitors - chemistry | Tetrahydronaphthalenes - therapeutic use | Coumarins - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Indans - therapeutic use | Acetylcholinesterase - genetics | Bleomycin | Stilbenes | Computer Simulation | Amyloid beta-Peptides - metabolism | Lomustine | Methotrexate | Binding Sites | Indans - chemistry | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Piperidines - chemistry | Alzheimer Disease - drug therapy | Antineoplastic Combined Chemotherapy Protocols | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Acetylcholinesterase - chemistry | Coumarins - therapeutic use | Benzylamines - chemistry | Piperidines - therapeutic use | Tetrahydronaphthalenes - chemistry | Cholinesterase Inhibitors - therapeutic use | Benzylamines - therapeutic use | Acetylcholinesterase - metabolism | Aβ inhibition
Journal Article
Inorganic Chemistry, ISSN 0020-1669, 10/2014, Volume 53, Issue 19, pp. 10632 - 10641
Hydrogen atom transfer with a tunneling effect (H-tunneling) has been proposed to be involved in aliphatic hydroxylation reactions catalyzed by cytochrome P450... 
Cations - chemistry | Hydroxylation | Free Radicals - chemistry | Tetrahydronaphthalenes - chemistry | Xanthenes - chemistry | Iron - chemistry | Metalloporphyrins - chemistry | Oxygen - chemistry | Molecular Structure | Kinetics | Hydrogen - chemistry
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2016, Volume 24, Issue 10, pp. 2318 - 2329