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chemistry, organic (24) 24
tetrahydropyran-4-ones (18) 18
construction (9) 9
cyclization (8) 8
ketones (8) 8
maitland-japp reaction (8) 8
derivatives (6) 6
diastereoselective synthesis (6) 6
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piperidines (5) 5
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organic-synthesis (4) 4
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synthesis (4) 4
-centrolobine (3) 3
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medicinal chemistry (3) 3
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gold (2) 2
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lycopodium-hamiltonii (2) 2
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maitland–japp (2) 2
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pase (2) 2
petasis-ferrier rearrangement (2) 2
quaternary ammonium compounds - chemistry (2) 2
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-jiadifenin (1) 1
-pederin (1) 1
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ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 2016, Volume 14, Issue 28, pp. 6840 - 6852
6-Substituted-2H-dihydropyran-4-one products of the Maitland-Japp reaction have been converted into tetrahydropyrans containing uncommon substitution patterns.... 
HIGHLY SUBSTITUTED TETRAHYDROPYRAN-4-ONES | LEUCASCANDROLIDE-A | DIELS-ALDER REACTIONS | DIASTEREOSELECTIVE SYNTHESIS | MICHAEL | CONSTRUCTION | CHEMISTRY, ORGANIC | STEREOSELECTIVE-SYNTHESIS | FUNCTIONALIZED TETRAHYDROPYRAN-4-ONES | CONJUGATE ADDITION | PRINS CYCLIZATION
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 07/2016, Volume 14, Issue 28, pp. 6840 - 6852
6-Substituted-2H-dihydropyran-4-one products of the Maitland-Japp reaction have been converted into tetrahydropyrans containing uncommon substitution patterns.... 
Biological Products - chemical synthesis | Pyrans - chemical synthesis | Biological Products - chemistry | Chemistry Techniques, Synthetic | Cyclization | Pyrans - chemistry | Stereoisomerism | Boranes - chemistry | Boranes - chemical synthesis
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2007, Volume 48, Issue 30, pp. 5209 - 5212
The diastereoselective pot, atom and step economic (PASE) synthesis of highly functionalized piperidines has been realized. The procedure simply involves... 
One-pot | Piperidines | PASE | Multi-component | one-pot | AMINES | MAITLAND-JAPP REACTION | TETRAHYDROPYRAN-4-ONES | CONSTRUCTION | piperidines | CHEMISTRY, ORGANIC | multi-component | IDEAL SYNTHESIS | WATER
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 08/2017, Volume 2017, Issue 28, pp. 4121 - 4129
A highly efficient synthetic method for the preparation of of 6‐trifluoromethylated pyrimidines was developed. The reaction of CF3‐substituted ynones and... 
Michael addition | Synthetic methods | Nitrogen heterocycles | Fluorine | Alkynes | AMINO-ALCOHOLS | AMIDINES | ALPHA-BROMOENONES | CHEMISTRY, ORGANIC | HYDRAZINES | KETONES | TETRAHYDROPYRAN-4-ONES | CHEMISTRY | BEARING | DERIVATIVES | Economic aspects | Pyrimidines
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 09/2018, Volume 16, Issue 36, pp. 6663 - 6674
2-Spiropiperidines are a highly desirable, yet under represented structure in drug discovery. 2-Spiropiperidines were synthesised in either a two-pot or... 
MEDICINAL CHEMISTRY | N-BOC-IMINES | MAITLAND-JAPP REACTION | ONE-POT | TETRAHYDROPYRAN-4-ONES | NANKAKURINE-A | CHEMISTRY, ORGANIC | PIPERIDINES | ECONOMIC PASE SYNTHESIS | 5-COMPONENT CONDENSATION | LYCOPODIUM-HAMILTONII
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2018, Volume 16, Issue 36, pp. 6663 - 6674
2-Spiropiperidines are a highly desirable, yet under represented structure in drug discovery. 2-Spiropiperidines were synthesised in either a two-pot or... 
Journal Article
Synlett, ISSN 0936-5214, 01/2010, Volume 2010, Issue 2, pp. 240 - 246
Abstract A novel one-pot N-heterocyclic carbene catalyzed synthesis of aldol products and their application to a facile and highly CIS-selective synthesis of... 
letter | Enals | Aldols | Umpolung | Epoxides | Tetrahydropyran-4- ones | N-heterocyclic carbenes | DIELS-ALDER REACTIONS | ONE-POT | umpolung | CHEMISTRY, ORGANIC | ALDEHYDES | EXPEDITIOUS SYNTHESIS | DIASTEREOSELECTIVE SYNTHESIS | SUBSTITUTED TETRAHYDROPYRAN-4-ONES | CONJUGATE UMPOLUNG | CONSTRUCTION | aldols | tetrahydropyran-4-ones | epoxides | STEREOSELECTIVE-SYNTHESIS | PRINS CYCLIZATIONS | enals
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 07/2017, Volume 23, Issue 39, pp. 9262 - 9265
A general two‐step synthesis of 2‐spiropiperidines has been developed. δ‐Amino‐β‐ketoesters can be reacted with cyclic ketones to generate 2‐spiropiperidines... 
spirocyclic | piperidine | scaffolds | medicinal chemistry | Maitland–Japp | DRUG DISCOVERY | SNAP REAGENTS | 3-DIMENSIONALITY | CHEMISTRY, MULTIDISCIPLINARY | ECONOMIC PASE SYNTHESIS | ATOM | POT | TETRAHYDROPYRAN-4-ONES | Maitland-Japp | SATURATED N-HETEROCYCLES | PIPERIDINES | 5-COMPONENT CONDENSATION | Drug discovery | Ketoesters | Synthesis | Ketones | Scaffolds
Journal Article
Synthetic Communications, ISSN 0039-7911, 11/2010, Volume 40, Issue 24, pp. 3728 - 3733
A rapid, efficient, convenient and cost-effective procedure has been developed for the synthesis of 3,5-bis-(arylmethylidene)-tetrahydropyran-4-ones by the... 
Araldehydes | iodine | 3,5-bis-(arylmethylidene)-tetrahydropyran-4-ones | tetrahydropyran-4-one | POTENT | SOLVENT-FREE CONDITION | HIV-1 INTEGRASE | 5-bis-(arylmethylidene)-tetrahydropyran-4-ones | CHEMISTRY, ORGANIC | INHIBITORS
Journal Article
Tetrahedron, ISSN 0040-4020, 2011, Volume 67, Issue 27, pp. 4960 - 4966
A highly enantioselective synthesis of functionalized tetrahydropyran-4-ones has been achieved by the development of a catalytic asymmetric Maitland–Japp... 
Asymmetric | Maitland–Japp reaction | Tetrahydropyran-4-ones | Chan’s diene | Maitland-Japp reaction | Chan's diene | CORE | CONCISE | COMPLEX | ONE-POT | CHEMISTRY, ORGANIC | (+/-)-CENTROLOBINE | TRANSANNULAR CONJUGATE ADDITION | PRODUCTS | CONSTRUCTION | CONDENSATION | Synthesis (chemistry) | Asymmetry | Catalysts | Tetrahedrons | Catalysis | Nucleophiles | Dienes
Journal Article
Synthetic Communications, ISSN 0039-7911, 09/2014, Volume 44, Issue 17, pp. 2458 - 2467
A gold(I)-catalyzed regioselective method for the preparation of 3-bromo/iodo-tetrahydropyran-4-one derivatives from homopropargyl acetal is reported. A... 
Gold | Petasis-Ferrier rearrangement | homopropargyl acetals | 3-halogenated tetrahydropyran-4-ones | ALCOHOLS | KETONES | CARBONATES | 2-STEP | CHEMISTRY, ORGANIC | ALKYNES | CYCLIZATION | GOLD-CATALYZED SYNTHESIS
Journal Article
Journal of Heterocyclic Chemistry, ISSN 0022-152X, 11/2012, Volume 49, Issue 6, pp. 1346 - 1351
The one‐pot, three‐component Mannich reactions of thiopyran‐4‐one 1 with different aromatic aldehydes and aniline derivatives in the presence of catalytic... 
BRONSTED ACID | AMINO CARBONYL-COMPOUNDS | ALDOL | KETONES | ACTIVATION | ENOL ETHERS | TETRAHYDROPYRAN-4-ONES | CHEMISTRY, ORGANIC | ALDEHYDES | CATALYST
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 11/2010, Volume 75, Issue 21, pp. 7491 - 7493
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 06/2011, Volume 50, Issue 26, pp. 5892 - 5895
Journal Article
Tetrahedron, ISSN 0040-4020, 2005, Volume 61, Issue 23, pp. 5433 - 5438
Application of our one-pot, three-component variation of the Maitland–Japp reaction has led to the formation of a tetrahydropyran-4-one, which was converted in... 
Tetrahydropyran | Multi-component | Maitland–Japp | Centrolobine | Maitland-Japp | KETONES | CYCLIZATIONS | TETRAHYDROPYRAN-4-ONES | CONSTRUCTION | CHEMISTRY, ORGANIC | tetrahydropyran Maitland-Japp | (-)-CENTROLOBINE | centrolobine | multi-component | DERIVATIVES
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2010, Volume 51, Issue 36, pp. 4731 - 4733
Studies on the synthesis of the anticancer natural products, the phorboxazoles have led to the synthesis of the C21–C32 penta-substituted tetrahydropyran core... 
HIGHLY SUBSTITUTED TETRAHYDROPYRAN-4-ONES | SPONGE PHORBAS SP | ASYMMETRIC ALDOL REACTION | (+)-PHORBOXAZOLE-A | 2ND-GENERATION TOTAL-SYNTHESIS | ABSOLUTE-CONFIGURATION | MAITLAND-JAPP REACTION | CHEMISTRY, ORGANIC | RHIZOXIN-D | SUBUNITS | MARINE SPONGE | Chemical synthesis
Journal Article
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